Smart System for Monitoring Daily Medication Using Swallowable Digital Pill

2020 ◽  
Vol 17 (11) ◽  
pp. 4907-4910
Author(s):  
Vineet Kumar ◽  
K. Mohana Prasad ◽  
R. Sabitha ◽  
K. Ashokkumar

Digital pill is a multichannel sensor that is utilized for wireless biomedical estimations utilizing small scale innovation. This is utilized for the constant estimation parameters, for example, temperature, pH, conductivity and broke up oxygen. The sensors are created utilizing electron shaft and photolithographic design mix. Hardware and smaller than expected mechanical innovation can give get to, break down and control the body from within. Specifically, smart pills for sedate conveyance are a developing innovation; a wide range of ways to deal with nearby medication conveyance have been proposed, including transcutaneous and implantable methods. In any case, swallow capable smart pills for tranquilize conveyance are getting expanding consideration as the oral one is as yet the favored course for sedate organization, because of its high patient acknowledgment and minimal effort. Smart pills for tranquilize conveyance offer various noteworthy open doors for pharmaceutical ventures since they might high patient acknowledgment and minimal effort. Smart pills for tranquilize conveyance offer various critical open doors for pharmaceutical ventures since they might be utilized in a wide scope of uses and empower treatments impractical with traditional methods. The progressions happen in human bodies are observed and sent it to close by screen for specialist checking through wireless.

2021 ◽  
pp. 108128652110207
Author(s):  
Olha Hrytsyna

The relations of a local gradient non-ferromagnetic electroelastic continuum are used to solve the problem of an axisymmetrical loaded hollow cylinder. Analytical solutions are obtained for tetragonal piezoelectric materials of point group 4 mm for two cases of external loads applied to the body surfaces. Namely, the hollow pressurized cylinder and a cylinder subjected to an electrical voltage V across its thickness are considered. The derived solutions demonstrate that the non-uniform electric load causes a mechanical deformation of piezoelectric body, and vice versa, the inhomogeneous radial pressure of the cylinder induces its polarization. Such a result is obtained due to coupling between the electromechanical fields and a local mass displacement being considered. In the local gradient theory, the local mass displacement is associated with the changes to a material’s microstructure. The classical theory does not consider the effect of material microstructure on the behavior of solid bodies and is incapable of explaining the mentioned phenomena. It is also shown that the local gradient theory describes the size-dependent properties of piezoelectric nanocylinders. Analytical solutions to the formulated boundary-value problems can be used in conjunction with experimental data to estimate some higher-order material constants of the local gradient piezoelectricity. The obtained results may be useful for a wide range of appliances that utilize small-scale piezoelectric elements as constituting blocks.


Author(s):  
John A. Roebuck

An integrated system of mobility notation and standard techniques for measurement of spacesuit mobility is described. New terminology is proposed to describe human body movements for engineering workspace analysis and suit mobility specifications. Vector and link concepts are combined in a simplified model of man to describe body positions in terms of orientation of limbs with respect to a tri-planar angular coordinate system conceived as attached to the pelvic region. Numerical coding of the body links and joints is described. The notation system may be used as a basis for mathematical modeling for computer analysis of vehicle workspace geometry and control locations. The system is independent of gravitational reference semantic implications and sufficiently general for a wide range of complexity in kinesiological, medical, and human engineering applications.


2011 ◽  
Vol 45 (4) ◽  
pp. 65-73 ◽  
Author(s):  
James L. Tangorra ◽  
Timo Gericke ◽  
George V. Lauder

AbstractAdvanced propulsors are required to help unmanned undersea vehicles (UUVs) overcome major challenges associated with energy and autonomy. The fins of ray-finned fish provide an excellent model from which to develop propulsors that can create forces efficiently and drive a wide range of behaviors, from hover to low-speed maneuvers to high-speed travel. Although much is known about the mechanics of fins, little is known about the fin’s sensorimotor systems or how fins are regulated in response to external disturbances. This information is crucial for implementing propulsive and control systems that exploit the same phenomena as the biological fins for efficiency, effectiveness, and autonomous regulation. Experiments were conducted to evaluate the in vivo response of the sunfish and its pectoral fins to vortex perturbations applied directly to the fish and to the fins. The fish and the fins responded actively to perturbations that disturbed the motion of the fish body. Surprisingly, perturbations that deformed the fins extensively did not cause a reaction from either the fins or the body. These results indicate that the response of the pectoral fins to large deformations is not reflexive and that fin motions are regulated when it is necessary to correct for disturbances to the motion of the fish. The results also demonstrate a benefit of compliance in propulsors, in that external perturbations can disturb the fins without having its impact be transferred to the fish body.


Author(s):  
Kevin M Bakker ◽  
Marisa C Eisenberg ◽  
Robert Woods ◽  
Micaela E Martinez

Abstract Varicella zoster virus (VZV) is a herpesvirus that causes chickenpox and shingles. The biological mechanisms underpinning the multi-decadal latency of VZV in the body and subsequent viral reactivation—which occurs in approximately 30% of individuals—are largely unknown. Because chickenpox and shingles are endemic worldwide, understanding the relationship between VZV transmission and reactivation is important for informing disease treatment and control. While chickenpox is a vaccine-preventable childhood disease with a rich legacy of research, shingles is not a notifiable disease in most countries. To date, population-level studies of shingles have had to rely on small-scale hospital or community-level datasets. Here, we examined chickenpox and shingles notifications from Thailand and found strong seasonal incidence in both diseases, with a 3-month lag between peak chickenpox transmission season and peak shingles reactivation. We tested and fit 14 mathematical models examining the biological driversof chickenpox and shingles over an 8-year period to estimate rates of VZV transmission, reactivation, and immunity boosting, wherein re-exposure to VZV boosts VZV-specific immunity to reinforce protection against shingles. The models suggested the seasonal cycles of chickenpox and shingles have different underlying mechanisms, with ultraviolet radiation (UV) being correlated with shingles reactivation.


2021 ◽  
Author(s):  
Julissa Rojas-Sandoval

Abstract L. inermis is a small, multi-stemmed shrub or small tree 2-6 m tall, commonly known as henna. It originates from the Persian Gulf region (and possibly northeast Africa) to northwest India and is now cultivated widely throughout the tropics and subtropics. The leaves produce a red dye which is used to paint fingernails, to decorate the body and to dye hair. Henna dye is very important traditionally, being used in Muslim and Hindu marriage ceremonies. In the past, its leaves were widely used to dye silk and wool, and less commonly cotton and leather. The wood of L. inermis is fine-grained and hard, being used for tent pegs and tool handles. A perfume is made from the flowers. Extracts from the leaves (and to a lesser extent the roots) are used in traditional medicine as a panacea against almost any disease. L. inermis is mostly grown on a small scale in gardens (often as a hedge) but is grown commercially in India, Pakistan, Egypt, Libya and Sudan. In African plantations, it is often irrigated and fertilized. It is easily grown as a short-lived perennial crop from seed and transplanted, or propagated by cuttings. It is adapted to a wide range of environmental conditions, but requires high temperatures for good growth. Henna is an important natural dye. To increase the potential of the crop, selection and breeding are needed to increase the content of the pigment lawsone (2-hydroxy-1,4-naphthoquinone) in the leaves. Many cultivars already exist locally, having being selected for their leaves or flowers. Research is also neeeded on ways to improve drying and processing of the leaves.


2017 ◽  
Vol 63 (6) ◽  
pp. 1083-1093 ◽  
Author(s):  
David S Hage

Abstract BACKGROUND The interactions between biochemical and chemical agents in the body are important in many clinical processes. Affinity chromatography and high-performance affinity chromatography (HPAC), in which a column contains an immobilized biologically related binding agent, are 2 methods that can be used to study these interactions. CONTENT This review presents various approaches that can be used in affinity chromatography and HPAC to characterize the strength or rate of a biological interaction, the number and types of sites that are involved in this process, and the interactions between multiple solutes for the same binding agent. A number of applications for these methods are examined, with an emphasis on recent developments and high-performance affinity methods. These applications include the use of these techniques for fundamental studies of biological interactions, high-throughput screening of drugs, work with modified proteins, tools for personalized medicine, and studies of drug–drug competition for a common binding agent. SUMMARY The wide range of formats and detection methods that can be used with affinity chromatography and HPAC for examining biological interactions makes these tools attractive for various clinical and pharmaceutical applications. Future directions in the development of small-scale columns and the coupling of these methods with other techniques, such as mass spectrometry or other separation methods, should continue to increase the flexibility and ease with which these approaches can be used in work involving clinical or pharmaceutical samples.


2018 ◽  
Vol 12 (1) ◽  
pp. 151-170
Author(s):  
Hannah Vandegrift Eldridge

Abstract In recent years, theories of rhythm have been proposed by a number of different disciplines, including historical poetics, generative metrics, cognitive literary studies, and evolutionary aesthetics. The wide range of fields indicates the transdisciplinary nature of rhythm as a phenomenon, as well as its complexity, highlighting the degree to which many of the central questions surrounding rhythm remain extraordinarily difficult even to state in terms that can traverse the disciplinary boundaries effortlessly transgressed by rhythm as a phenomenon. In particular, any theory of rhythm, whether in music, dance, sociology, or language, must grapple with two quandaries. First, the precise site of rhythm remains opaque: rhythms occur in, affect, and are produced by all of bodies, cultures, and universals (whether metaphysical or species-physiological). What is the relation between species-wide characteristic, individual body, cultural context, and the history of art making in the experience of rhythm? Second, rhythm is simultaneously a phenomenon of fixed, organizing form and one of dynamic, changing flow. How can rhythm encompass both the measurement of regular recurrences across time and the organizing of temporal phenomena as they unfold? In this article, I draw on Emile Benveniste and Henri Meschonnic to elucidate these quandaries or conflicts before turning to Friedrich Nietzsche’s work on rhythm. I argue that Nietzsche’s work with rhythm provides a historically situated model for how we might continue to take the questions and conflicts within rhythm seriously, rather than privileging an abstract and universally applicable theory of rhythm. This model is especially crucial for our own historical moment, when cultural-political emphasis on science and technology at the expense of aesthetics devalues all insights not presented in the form of countable data points or empirically testable facts. Nietzsche is, of course, one of the great critics of positivist-scientistic epistemologies, part of a long tradition questioning the naturalness of natural-scientific paradigms and alerting us to the metaphors at play even in the ›hard sciences‹. I use rhythm as one paradigmatic place to resist the importation of scientistic thought into discussions of language, literature, and culture. I show how Nietzsche’s writings on rhythm prove illuminating for contemporary understandings of rhythm because the tensions in his work are shaped by the quandaries inherent to rhythm that I have used Benveniste and Meschonnic to elaborate, namely the question of rhythm’s site as individual, cultural, or universal, and the conflict between rhythm as form and as flow. The question of the site of rhythm appears in Nietzsche’s discussions of Greek and Latin meters both in his philological works, in his aphorisms, and in his letters: on the one hand, he argues that Greek and Latin metrical and rhythmic resources are irrevocably lost to modern cultures (indicating that rhythm is a product of culture), while on the other, he emphasizes the impact of rhythm on the body and offers advice for replicating Ancient metrical and rhythmic techniques (suggesting that rhythm is based on physiological universals). And the conflict between flow and form appears as Nietzsche praises both the productive constraint created by large-scale, architectonic, or macro-formal rhythms and the freedom from such constraint enabled by small-scale, leitmotiv-based, or micro-formal rhythms. The conflicts in Nietzsche’s work between the loss and recovery of Ancient rhythms and between rhythm as small scale freedom vs. large scale constraint thus represent one particular unfolding of the dilemmas for rhythmical theory worked out by Benveniste and Meschonnic. The various modern disciplines engaged with rhythm will answer different sets of these questions in different ways. Most practitioners of, e. g., evolutionary aesthetics, neuroaesthetics, or cognitive poetics would no doubt contend that they are using the tools of the natural sciences to investigate long-standing humanistic inquiries. Nietzsche, as a critic of his own era’s scientific positivism who allows tensions inherent in these questions to remain open in his own work, is an ideal interlocutor with whom to ask whether even the adoption of these tools ends up placing excessive faith in natural-scientific paradigms and undercutting other—affective, bodily, metaphorical, poetic, etc.—ways of knowing, as I demonstrate briefly in the examples of evolutionary aesthetics and generative metrics. Because Nietzsche leaves open the conflicts over rhythm’s site and its qualities as form or flow, he can use individual bodily experience to make physiological arguments about the effects of rhythm on culture and vice versa: Nietzsche takes his bodily response to be an index of cultural values inherent to rhythmical practices. The particular values that Nietzsche critiques shift across his career—early on he condemns German musical and poetic rhythms for being too rigid, while later he sees them as pathologically heightening affect and emotion. In both cases, detrimental rhythmic practices lead to detrimental bodily practices and to the degeneration of culture, while rhythmic practices work as a bodily and cultural corrective. In his critiques of German forms and praises of Greek forms, and in the moments in which he brings them together, Nietzsche thus asserts the complex interrelation of culture, body, and history.


Author(s):  
Sri Pateda ◽  
Masayuki Sakakibara ◽  
Koichiro Sera

The evaluation of mercury impact on humans is currently nonspecific because the body characteristics (homeostasis) of each human being varies. Therefore, in the early diagnosis of mercury toxicity, one of the most important monitoring parameters is the respiratory function examination. In this study, respiratory function was examined with a portable spirometer and correlated with the mercury levels in hair from the noses and heads of subjects. Samples were taken from artisanal and small-scale gold mining (ASGM) areas (villages of East Tulabolo and Dunggilata) and control areas (villages of Bongo and Longalo) in Gorontalo Province, Indonesia. A statistical analysis with the Mann–Whitney test (alternative) showed significant differences in lung function between the polluted and control areas (α = 0.03). The analysis of nasal and head hair samples with particle-induced X-ray emissions (PIXE) showed that the mercury levels in the ASGM area were considerably higher than in the more homogeneous control areas. This study confirms that a pulmonary function test is a quick and precise alternative way to monitor the impact of mercury on humans, especially atmospheric mercury, because we detected a negative correlation between pulmonary function and the level of mercury in hair.


2017 ◽  
Vol 3 (1) ◽  
pp. 76
Author(s):  
Siti Asiyah ◽  
Dwi Estuning Rahayu ◽  
Wiranti Dwi Novita Isnaeni

The needed of Iron Tablet in pregnancy was increase than mother who not pregnant.  That  cause of  high metabolism at the pregnancy for formed of  fetal organ and energy. One of effort for prevent anemia in mother pregnant with giving the Iron tablet and vitamin c. The reason of  this research in 4 June – 11 July 2014 is for compare the effect of  iron tablet suplementation with and without vitamin C toward Hemoglobin level in mother pregnant With Gestational Age Of 16-32 Weeks In Desa Keniten Kecamatan Mojo Kabupaten Kediri. This research method using comparative analytical.  Research design type of Quasy Eksperiment that have treatment group and control group. Treatment group will giving by Iron tablet and 100 mg vitamin C, and control group just giving by iron tablet during 21 days. Population in this research are all of mother pregnant with Gestational Age Of 16-32 Weeks with Sampling technique is  cluster random sampling is 29 mother pregnant. Comparison analysis of  iron tablet suplementation effect with and without vitamin C toward Hemoglobin level in mother pregnant With Gestational Age Of 16-32 Weeks, data analysis using Mann Whitney U-test and the calculated U value (44,5) less than U-table (51). So there was difference of iron tablet suplementation effect with and without vitamin C toward Hemoglobin level in mother pregnant With Gestational Age Of 16-32 Weeks Therefore, the addition of vitamin C on iron intake is needed to increase the uptake of iron tablets. When the amount of iron uptake increases, the reserves of iron in the body will also increase, so as to prevent anemia in pregnant women; Keywords : Iron Tablet (Fe), Vitamin C, Hemoglobin level, Mother Pregnant


2020 ◽  
Vol 2 (4) ◽  
pp. 14-31
Author(s):  
Élodie Dupey García

This article explores how the Nahua of late Postclassic Mesoamerica (1200–1521 CE) created living and material embodiments of their wind god constructed on the basis of sensory experiences that shaped their conception of this divinized meteorological phenomenon. In this process, they employed chromatic and design devices, based on a wide range of natural elements, to add several layers of meaning to the human, painted, and sculpted supports dressed in the god’s insignia. Through a comparative examination of pre-Columbian visual production—especially codices and sculptures—historical sources mainly written in Nahuatl during the viceregal period, and ethnographic data on indigenous communities in modern Mexico, my analysis targets the body paint and shell jewelry of the anthropomorphic “images” of the wind god, along with the Feathered Serpent and the monkey-inspired embodiments of the deity. This study identifies the centrality of other human senses beyond sight in the conception of the wind god and the making of its earthly manifestations. Constructing these deity “images” was tantamount to creating the wind because they were intended to be visual replicas of the wind’s natural behavior. At the same time, they referred to the identity and agency of the wind god in myths and rituals.


Sign in / Sign up

Export Citation Format

Share Document