Adoption of Ultrasonic Imaging Diagnosis Under Machine Learning Algorithm in Treatment of Pregnancy-Induced Hypertension and Nursing

2021 ◽  
Vol 11 (1) ◽  
pp. 268-275
Author(s):  
Wei Gao ◽  
Ani Zhou
Keyword(s):  
Machine Learning ◽  
Pregnant Women ◽  
Learning Algorithm ◽  
Resistance Index ◽  
Nursing Intervention ◽  
Control Group ◽  
Pregnancy Induced Hypertension ◽  
Induced Hypertension ◽  
Omaha System ◽  
Ultrasonic Images

In order to study the application of doppler ultrasound in monitoring the changes of important vascular hemodynamic indexes in pregnant women with Pregnancy-induced Hypertension (PIH) during pregnancy under the Omaha systematic nursing intervention (NI), in this study, 83 PIH pregnant women were taken as the study object. First, 60 normal pregnant women were taken as the control group (CG). Ultrasonic images of the uterine artery (UA) and middle cerebral artery (MCA) were collected. The machine learning (ML) algorithm was used to detect the edge of the target vessel in the UA image. The hemodynamic indexes of UA and MCA were compared between the two groups. Then, according to the routine NI and the NI method based on the Omaha system, 83 PIH pregnant women were divided into the routine group (RG) (n = 35) and the observation group (OG) (n = 48). The differences in UA hemodynamic parameters and quality of life (QOL) scores were compared between the two groups at 6 d after surgery. The results showed that pre-pregnancy BMI, mean artery pressure (MAP), and uric acid content in the CG were significantly lower than those in the PIH group (P < 0.05); the content of serum albumin in the CG was significantly higher than that in the PIH group (P < 0.05); compared with Sobel operator, edge detection (ED) based on ML algorithm was more coherent; in the CG, the systolic peak velocity (PSV), acceleration index (AI), pulse index (PI), and resistance index (RI) were significantly lower than those in the PIH group (P < 0.05); the values of PI and RI in MCA of CG were significantly higher than those in PIH group (P < 0.05); after NI, PSV, PI, RI, and AI values in the OG were significantly lower than those in the RG (P < 0.05); the health status, trunk pain, social function, emotional function, vitality, mental health, and total score of the OG were significantly higher than that of the RG (P < 0.05), which indicated that ultrasonic detection based on ML algorithm can be used in monitoring the changes of hemodynamic indexes of PIH pregnant women during NI, and the NI based on the Omaha system can effectively improve the QOL of PIH pregnant women.

scholarly journals Comparison of the Antioxidant Nutrient Profile among Normal Pregnant Women and Women having Pregnancy Induced Hypertension

2021 ◽  
Vol 10 (4) ◽  
pp. 246-251
Author(s):  
Kausar Aamir ◽  
Arfa Azhar ◽  
Fatima Abid ◽  
Shamaila Khalid ◽  
Fiza Ali Khan
Keyword(s):  
Vitamin E ◽  
Pregnant Women ◽  
Cell Damage ◽  
Alpha Tocopherol ◽  
Control Group ◽  
P Value ◽  
Pregnancy Induced Hypertension ◽  
Nutrient Profile ◽  
Induced Hypertension ◽  
Mild Hypertensive

Background: Preeclampsia is a multifactorial disorder comprising many organs. Oxidative stress (OS) has been intensely linked to its occurrence. Vitamin E, a lipophilic chain breaking antioxidant has been proved to suppress the OS. Present study was designed to investigate antioxidant nutrient profile in patients with different grades of pregnancy induced hypertension (PIH) and to compare them with normal pregnant controls. Methods: The study group comprised 110 patients divided in three groups as Group A (n=40) Normotensive patients, Group B (n=40) Mild hypertensive, Group C (n=30) Severe hypertensive. Vitamin A, B-Carotene, serum alpha tocopherol (vitamin E) and vitamin C levels were analysed. Results: Serum alpha tocopherol (vitamin E) was significantly low in severe and mild cases (0.32±0.00 mg/dl, 0.74±0.03 mg/dl respectively), when compared with normal pregnant women levels (0.78±0.040). All other nutrients were also found to be in reduced quantity for Group C when compared to control group (P value <0.001). Conclusion: It was therefore concluded that in patients with risk of preeclampsia (PE) adequate antioxidant nutrients may have a role in cessation of free radical-mediated cell disturbances, and thereby protecting against endothelial cell damage, which is the key factor in PE development.

scholarly journals Hypo-magnesium and Hyperlipidemia Responsible for Hypertensive Status of Pregnant Women in Pakistani Population

2020 ◽  
pp. 61-66
Author(s):  
Asia Parveen ◽  
Khan Farooq ◽  
Fatima Arshad ◽  
Modasrah Mazhar ◽  
Nureen Zahra ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Serum Magnesium ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Case Group ◽  
Pregnancy Induced Hypertension ◽  
Induced Hypertension ◽  
Group A

Background/ Aim: Pregnancy induced hypertension (PIH) has been a leading cause of maternal mortality worldwide. It could be responsible for several complications like hemodilution, altered lipid metabolism and deficiencies of different minerals in body. Although the causes of Pregnancy induced hypertension (PIH) remains indistinct. The aim of our present study was to evaluate the changes in magnesium serum levels and lipid profile in hypertensive and normotensive pregnant women. Materials and Methods: An analytical case control study comprising 60 individuals was designed. From which 30 normotensive pregnant women served as control group (A) and 30 pregnancy induced hypertensive women served as case group (B). Patients with pre-existing hypertension were excluded. Results: The independent t-test was used for comparison of various parameters between group A and B. Triacylglycerol (TAG) and low density lipoprotein cholesterol (LDL-C) levels were significantly high in PIH (B) as compare to normotensive group (A). Mean serum values of TG were measured as (195.73 ± 70.28 vs 156.27 ± 55.60 mg dL-1) and LDL-C vs control (87.33 ± 37.74 vs 69.45 ± 28.58 mg dL-1) in PIH and normotensive groups respectively. HDL-C in PIH vs Control (47.40±1.12 vs 54.43 ±1.27 mg dL-1) and Mg+2 PIH vs control (1.36±0.07 vs 1.94±0.35 mg dL-1) were measured respectively. High density lipoprotein cholesterol (HDL-C) and magnesium Mg+2 levels were significantly reduced in PIH. Conclusion: The lower serum magnesium levels and abnormal lipids profile may indicate their possible role as risk factors in the development of PIH in pregnant women. Hence initial diagnosis of hypomagnesemia in PIH cases may help in minimizing the complications and development of new cure strategies.

Enhancement of plasma corticotropin-releasing hormone in pregnancy-induced hypertension

1990 ◽  
Vol 122 (6) ◽  
pp. 711-714 ◽  
Author(s):  
W. Jeske ◽  
P. Soszyński ◽  
E. Lukaszewicz ◽  
R. Dȩbski ◽  
W. Latoszewska ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Gestational Age ◽  
Placental Tissue ◽  
Normal Pregnancy ◽  
Placental Lactogen ◽  
Control Group ◽  
Pregnancy Induced Hypertension ◽  
Human Placental Lactogen ◽  
Induced Hypertension ◽  
In Pregnancy

Abstract. The role of a high CRH level in normal pregnancy remains unknown. Therefore we evaluated the concentrations of CRH and the related hormones in patients with pregnancy-induced hypertension. Fourteen women with pregnancy-induced hypertension, aged 20-39, at 30-39 gestational week, were investigated. The control group consisted of 20 healthy pregnant women matched according to gestational age. Plasma CRH, β-endorphin-like immunoreactivity, cortisol, and human placental lactogen were measured by radioimmunoassay, ACTH by an immunoradiometric method. It was found that in hypertensive patients the mean CRH concentration was significantly higher (4257±840 (sem) ng/l) than that in healthy pregnant women (1083±227 ng/l, p<0.001). The concentration of ACTH, however, was only slightly higher 65.0±6.0 vs 50.7±2.5 ng/l, p<0.025, whereas the differences in β-endorphin, cortisol and human placental lactogen were not significant. In both groups there was no correlation between the CRH level and those of the related hormones. In healthy pregnant women the CRH level closely correlated with gestational age (r=0.76, p<0.001), whereas in patients with hypertension no such correlation was present (r=0.29). We assume that the marked enhancement of plasma CRH in pregnancy-induced hypertension is probably caused by its decreased breakdown in ischemic placental tissue, but its increased synthesis in the placenta and its indirect counterregulatory hypotensive role must also be considered.

scholarly journals Effect of low dose aspirin on maternal outcome in women at risk for developing pregnancy induced hypertension

2020 ◽  
Vol 9 (4) ◽  
pp. 1590
Author(s):  
Madhusmita Pradhan ◽  
Kishore S. V. ◽  
Jyotiranjan Champatiray
Keyword(s):  
Risk Factors ◽  
High Risk ◽  
Pregnant Women ◽  
Low Dose ◽  
Multiple Pregnancy ◽  
Control Group ◽  
Pregnancy Induced Hypertension ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Induced Hypertension

Background: Pre-eclampsia is not totally a preventable disease. It is found more related to chains of social ills such as poor maternal nutrition, limited or no antenatal care and poor reproductive education. However, some specific “high-risk” factors leading to pregnancy induced hypertension (PIH) may be identified in individuals which include and not limited to young and elderly primigravida, multiple pregnancy, diabetes, Rh incompatibility, new paternity, pre-existing vascular or renal disease, family history of hypertension, pre-eclampsia and eclampsia, obesity, thrombophilia. Low dose aspirin given in 2nd trimester in these high-risk women is anticipated to prevent the development of PIH.Methods: This prospective randomized controlled trial was conducted in the department of obstetrics and gynecology, SCB MC and Hospital, Cuttack during November 2018 to October 2019. Pregnant women between the gestational age of 13th to 28th weeks were screened for risk factors and included in this study. Low dose aspirin of 60 mg daily till delivery was given to pregnant women who consented to be a part of study randomly with the other group having placebo.Results: Protienuric hypertension was high in control group who did not receive aspirin. Low dose aspirin significantly reduces PIH in high-risk group (3.48% in case versus 23.52% in control). Low dose aspirin was not associated with significant increase in placental bleeding. Low dose aspirin was generally safe for the fetus and new born infant with no evidence of an increased likelihood of bleeding.Conclusions: Low dose aspirin has a definite role in the prevention of PIH in high risk pregnancy. Low dose aspirin reduces the incidence of PIH. Low dose aspirin can be considered a safe drug without any deleterious side effect for mother and the fetus. Benefits of prevention of PIH, justifies its administration in women at high risk.

scholarly journals Copeptin in Patients with Pregnancy-Induced Hypertension

2021 ◽  
Vol 18 (12) ◽  
pp. 6470
Author(s):  
Agnieszka Marek ◽  
Rafał Stojko ◽  
Agnieszka Drosdzol-Cop
Keyword(s):  
Pregnant Women ◽  
First Trimester ◽  
Control Group ◽  
Pregnancy Induced Hypertension ◽  
Serum Samples ◽  
Uterine Arteries ◽  
Induced Hypertension ◽  
Diagnostic Values ◽  
First Trimester Of Pregnancy ◽  
High Concentrations

Pregnancy-induced hypertension (PIH) occurs in 6–8% of pregnancies, and increases the risk of many severe obstetric complications. The etiology of PIH has not been fully explained, and hence, treatment is only palliative in nature, and prevention is not fully effective. It has been proposed that PIH development is influenced by the arginine vasopressin pathway, whose surrogate biomarker is copeptin. The aim of this study is a prospective assessment of the relationship between the level of copeptin in pregnant women and the occurrence of PIH, and to identify its usefulness in predicting complications. The study involved a group of 21 pregnant women who developed PIH and 37 women with uncomplicated pregnancies as a control group. Blood samples were collected at the three trimesters of gestation (<13 HBD, between 13 and 26 and> 26 HBD) and then frozen. Copeptin levels [pg/mL] were measured in serum samples obtained in the first, second and third trimesters of gestation from women in the PIH and control groups. The concentration of copeptin in the second and third trimesters of pregnancy was statistically significantly higher in the PIH group (p < 0.05). For copeptin determined in the first trimester, which could be used to screen for PIH, the area under the ROC curve was 0.650. The highest risk of PIH occurred in patients with high concentrations of copeptin in the first trimester of pregnancy and obesity OR = 5.5 (95% CI 1.0–31.3). The risk of PIH was augmented in patients with high levels of copeptin and an abnormal Doppler result of the uterine arteries OR = 28.4 (95% CI 5.3–152). In conclusion, copeptin levels were found to be elevated in pregnant women before the diagnosis of PIH; however, copeptin should not be used as a stand-alone marker. The combination of copeptin concentration with the other risk factors (diabetes, maternal age and preeclampsia in previous pregnancy) did not improve the diagnostic values of the use of copeptin in the PIH risk assessment, but the combination of copeptin concentration with BMI may be useful in clinical practice. Measurement of copeptin together with a Doppler examination of uterine arteries in the first trimester of pregnancy may be a useful marker in predicting the development of PIH.

scholarly journals Clinical Significance of Detection of Coagulation Indexes, Immune Factors and Inflammatory Factors in Patients with Pregnancy-Induced Hypertension Syndrome in China

2019 ◽  
Author(s):  
Fengmei SHI ◽  
Aijun YU ◽  
Limei YUAN
Keyword(s):  
Pregnant Women ◽  
Clinical Significance ◽  
Reference Value ◽  
Normal Pregnancy ◽  
Immunoglobulin M ◽  
Inflammatory Factors ◽  
Control Group ◽  
Pregnancy Induced Hypertension ◽  
Induced Hypertension ◽  
Immune Factors

Background: To investigate the clinical significance of monitoring the coagulation indexes, immune factors and inflammatory factors in pregnancy-induced hypertension syndrome (PIH). Methods: 90 pregnant women with PIH admitted in Weihaiwei People's Hospital of Shandong Province, China from 2016 to 2017 were collected, including 45 cases in mild-moderate group and 45 cases in severe group. Another 45 normal pregnant women at the same period were selected as control group. The immune indexes, four index signs of coagulation bloods and serum inflammatory factors in three groups of subjects were determined. Results: The levels of complement 3 (C3), complement 4 (C4), immunoglobulin A (IgA), immunoglobulin G (IgG) and immunoglobulin M (IgM) were successively increased in severe PIH group, mild-moderate PIH group and normal pregnancy group (P<0.05). Compared with those in normal pregnancy group, the levels of PT, APTT and TT were significantly decreased and Fib levels were significantly increased in PIH groups (P<0.05). Compared with those in normal pregnant women, the levels of TNF-α and IL-6 in pregnant women with PIH were significantly increased (P<0.05), and the changes in severe PIH group were more obvious than those in mild-moderate group. Conclusion: Pregnant women with PIH are in a hypercoagulable state and have a higher risk of thrombus and secondary hyperfibrinolysis. Immune factors and inflammatory factors are also associated with the occurrence and development of the disease. Monitoring the changes in coagulation indexes and levels of immune factors and inflammatory factors provide an important reference value for clinical treatment and prevention of complications.

scholarly journals Platelet count and MPV in women with PIH in their third trimester

2018 ◽  
Vol 8 (1) ◽  
pp. 44
Author(s):  
Suhail Iqbal ◽  
Aditi Sharma
Keyword(s):  
Platelet Count ◽  
Pregnant Women ◽  
Obstetrics And Gynecology ◽  
Control Group ◽  
Pregnancy Induced Hypertension ◽  
Third Trimester ◽  
Platelet Counts ◽  
Medical College ◽  
Induced Hypertension ◽  
And Control

Background: One of the most common and potential life-threatening complications of pregnancy is pregnancy induced hypertension. Though platelet count during pregnancy is within the normal non-pregnant reference values, there is a tendency for the platelet count to fall in late pregnancy. The frequency and intensity of maternal thrombocytopenia varies and is dependent on the intensity and severity of PIH.Methods: This prospective study was conducted in the Department of obstetrics and gynecology in Jhalawar medical college from January 2018 to April 2018.Total 120 pregnant women during third trimester (32-40 weeks) aged 18 to 35 years were selected. Among them 63 were preeclamptic patients and 63 were healthy normotensive control. Subjects and healthy pregnant women (control) visiting the Obstetrics and Gynecology department of Jhalawar Medical College were registered in the study and followed during their pregnancy. Both, subjects and control participants were subject to platelet count manually and MPV was determined by an automated analyser (sysmex XN-1000™) performed using standard methods on.Results: The mean platelet count of the subject group (131.4937±62.05999 lakh/mm3) was significantly lower than that of the control group (324.9683±230.78764 lakh/mm3). This shows that there is thrombocytopenia found in patients with P.I.H in their third trimester. On the other hand, the p value of “mean platelet volume” in patients with preeclampsia was (p<0.0001) which shows that there is no significant difference in MPV of cases (7.1438±2.62 femtolitre) and control (7.8976±3.08 femtolitre) (p>0.142), regular monitoring of platelet counts in women with Pregnancy Induced Hypertension must be subject of the management protocols.Conclusions: In present study we observed that the number of thrombocytopenic subjects was higher in cases of preeclampsia as compared to the control group. These extrapolations indicate that there might be some important mechanism which interferes with platelets life span thus reducing the number of functional platelets in circulation. The platelet count has an association at prediction of increasing grade of PIH. There is an inverse relationship between the severity of PIH and platelet count. The depleted platelet counts are concluded to be consistently associated with clinical groups of severe preeclampsia and the risk of consumptive coagulopathy.

Optimisation of tactics of conducting pregnancy and labours at women after auxiliary reproductive technologies

2016 ◽  
pp. 160-164
Author(s):  
D.N. Maslo ◽  
Keyword(s):  
Pregnant Women ◽  
Resistance Index ◽  
First Trimester ◽  
Reproductive Technologies ◽  
Premature Delivery ◽  
Control Group ◽  
Uterine Arteries ◽  
Placental Dysfunction ◽  
Placental Blood ◽  
Two Stages

The objective: frequency decrease perinatal pathologies at women after ART on the basis of studying clinical-ehografical, endocrinological, biochemical, dopplerometrical, cardiotokografical and morphological researches, and also improvement of algorithm of diagnostic and treatment-and-prophylactic actions. Patients and methods. The work basis is made spent by us from 2012 on 2015 by complex inspection of 300 pregnant women from which 250 were after ART and 50 – firstlabours which pragnency without ART, and also their newborns. For the decision of an object in view of research spent to two stages. At 1 stage spent prosperctive research which included 150 pregnant women: з them 100 women pregnancy at which has come out ART (1 group) and 50 healthy women (control group). At 2 stage spent prospective randomization in which result of patients after ART have divided on two equal groups by therapy principle: 2 basic group - 75 pregnant women after ART at which used the algorithm improved by us; 3 group of comparison - 75 pregnant women after ART which have been spent on the standard treatment-and-prophylactic actions. Results. The results suggest that women after using ART is a high frequency of reproductive losses in the first trimester (10.0%), 3.0% of spontaneous abortion from 16 to 22 weeks, and 3.0% "early" premature delivery (22 to 28 weeks of pregnancy). The frequency of violations of the functional state of placenta in women after using IVF is 63.0%, which is the main cause of high levels of perinatal losses (40.0 ‰), and delivery by cesarean section (96.0%). Placental dysfunction in women after using ART characterized by retrohorialnyh hematoma (21.0%); size mismatch fruit (30.0%) and hypertonicity of the uterus (73.0%) against changes in fruit-placental blood flow - increased resistance index in umbilical artery and increased vascular resistance in the uterine arteries. Endocrinological and biochemical changes in placental dysfunction in women after using IVF starting from 28 weeks of pregnancy and are in significant reduction in progesterone, placental b1-microglobulin, B2-microglobulin of fertility and trophic в-glycoprotein. Conclusion. The received results: use of the algorithm of diagnostic and treatment-and-prophylactic actions improved by us allows to lower frequency of spontaneous interruption of pregnancy till 22 weeks – from 13.0% to 5.7%; «early» premature birth – from 3.0% to 1.0%; placentary dysfunction from 63.0% to 40.6%; cesarean sections – from 96.0% to 56.5%, and also perinatal losses – from 40.0‰ to 16.2‰. Key words: pregnancy, childbirth, auxiliary reproductive technologies.

Serum Uric Acid Level as a Predictive Biomarker of Gestational Hypertension Severity; A Prospective Observational Case-Control Study

2020 ◽  
Vol 15 (3) ◽  
pp. 227-239 ◽  
Author(s):  
Hader I. Sakr ◽  
Akef A. Khowailed ◽  
Reham S. Al-Fakharany ◽  
Dina S. Abdel-Fattah ◽  
Ahmed A. Taha
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Case Control Study ◽  
Serum Urate ◽  
Interleukin 1Β ◽  
Pregnancy Induced Hypertension ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Induced Hypertension ◽  
Control Study

Background: Pre-eclampsia poses a significant potential risk of hypertensive disorders during pregnancy, a leading cause of maternal deaths. Hyperuricemia is associated with adverse effects on endothelial function, normal cellular metabolism, and platelet aggregation and adhesion. This study was designed to compare serum urate levels in normotensive pregnant women to those with pregnancy-induced hypertension, and to evaluate its value as a potential predictive marker of hypertension severity during pregnancy. Methods: A prospective, observational, case-control study conducted on 100 pregnant women in their third trimester. Pregnant women were classified into two groups (n=50) according to arterial blood pressure measurements: group I had normal blood pressure, and group II had a blood pressure of ≥ 140/90, which was further subdivided according to hypertension severity into IIa (pregnancy- induced hypertension, IIb (mild pre-eclampsia), and IIc (severe pre-eclampsia). Blood samples were obtained on admission. Serum urate, high sensitive C-reactive protein, and interleukin-1β levels, and lipid profile were compared among the groups. Results: A significant increase in the mean values of serum urate, C-reactive protein, and interleukin- 1β levels was detected in gestational hypertensives. In addition, there was a positive correlation between serum urate levels and C-reactive protein and interleukin-1β, as well as between serum urate levels and hypertension severity. Conclusion: Hyperuricemia and increased C-reactive protein and interleukin-1β serum levels correlate with the severity of pregnancy-induced hypertension, and these biomarkers may play a role in the pathogenesis of pre-eclampsia. Serum urate measurement is sensitive, reliable markers that correlate well with the severity of hypertension in pregnant females with pre-eclampsia.

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