Nanomaterials to Fight Cancer: An Overview on Their Multifunctional Exploitability

2021 ◽  
Vol 21 (5) ◽  
pp. 2760-2777
Author(s):  
Rossana Terracciano ◽  
Danilo Demarchi ◽  
Massimo Ruo Roch ◽  
Simone Aiassa ◽  
Guido Pagana
Keyword(s):  
Cancer Detection ◽  
Journal Articles ◽  
Long Term Effects ◽  
Internal Organs ◽  
Future Directions ◽  
Internalization Rate ◽  
Open Issues ◽  
Critical Aspects

In recent years the worldwide research community has highlighted innumerable benefits of nanomaterials in cancer detection and therapy. Nevertheless, the development of cancer nanomedicines and other bionanotechnology requires a huge amount of considerations about the interactions of nanomaterials and biological systems, since long-term effects are not yet fully known. Open issues remain the determination of the nanoparticles distributions patterns and the internalization rate into the tumor while avoiding their accumulation in internal organs or other healthy tissues. The purpose of this work is to provide a standard overview of the most recent advances in nanomaterials to fight cancer and to collect trends and future directions to follow according to some critical aspects still present in this field. Complementary to the very recent review of Wolfram and Ferrari which discusses and classifies successful clinically-approved cancer nanodrugs as well as promising candidates in the pipeline, this work embraces part of their proposed classification system based on the exploitation of multifunctionality and extends the review to peer-reviewed journal articles published in the last 3 years identified through international databases.

scholarly journals Human resource management: the promise, the performance, the consequences

2016 ◽  
Vol 3 (2) ◽  
pp. 181-190 ◽  
Author(s):  
Chris Brewster ◽  
Paul N. Gooderham ◽  
Wolfgang Mayrhofer
Keyword(s):  
Firm Performance ◽  
Journal Articles ◽  
Long Term Effects ◽  
Cross Sectional ◽  
Content Type ◽  
Global Issues ◽  
The Impact ◽  
Practical Implications ◽  
Cross National

Purpose – The dominant focus of HRM research has been that of “strategic HRM”, that is a focus on the impact of HRM on firm performance. The authors argue that not only are the cumulative results of this “dominant research orthodoxy” disappointing in terms of their external validity, but also they are of limited practical value. Further, it has failed not only in terms of its narrow firm performance-oriented agenda, but also the tenets of its agenda have contributed to serious levels of employee dissatisfaction and to the failure to deal with pressing global issues. The paper aims to discuss these issues. Design/methodology/approach – In order to assess the contribution of the dominant research orthodoxy the authors analyse the 16 most cited journal articles in the field of HRM. Findings – The authors find a predominance of US-centric studies and therefore a questionable cross-national generalizability of the dominant research orthodoxy. The use of cross-sectional data means that long-term effects cannot be gauged. The authors observe a lack of consensus on how to operationalize HRM and firm performance. National context is generally absent. Practical implications – The authors show that for HRM to realize its potential for governments, media, or philanthropic agencies, HRM must abandon its restricted scope and mono-dimensional sources of inspiration. Originality/value – The authors not only point to the shortcomings of the dominant research orthodoxy within HRM, but the authors point to how HRM could become significantly more “centre-staged” by addressing the actors searching for contributions to the big questions of the world – the governments, media, and philanthropic agencies.

After the Dance is over: Some Issues and Suggestions for Follow-up Assessment in Behavior Therapy

1977 ◽  
Vol 41 (3_suppl) ◽  
pp. 1287-1308 ◽  
Author(s):  
Eric J. Mash ◽  
Leif G. Terdal
Keyword(s):  
Behavior Therapy ◽  
Intervention Programs ◽  
Long Term Effects ◽  
Long Time ◽  
Time Periods ◽  
Research Recommendations ◽  
Selection Of

Behavioral intervention programs have thus far failed to provide sufficient follow-up information for the evaluation of long-term effects. This omission is believed to be related to an inadequate conceptualization of follow-up assessment, as well as to the methodological and practical difficulties inherent in assessing behavior over long time periods. A framework for follow-up assessment that is consistent with current behavioral efforts to program generalization is described and is contrasted with traditional views of follow-up that look for effects following the termination of treatment. Several methodological features of follow-up assessment are discussed, along with research recommendations, including the determination of length of appropriate follow-up intervals, the frequency of follow-up assessments, the need for standardization of measures both within and between studies, reactivity of follow-up assessment, the selection of follow-up measures and attrition of subjects.

Long-term effects of the perinatal environment on respiratory control

2008 ◽  
Vol 104 (4) ◽  
pp. 1220-1229 ◽  
Author(s):  
Ryan W. Bavis ◽  
Gordon S. Mitchell
Keyword(s):  
Critical Period ◽  
Developmental Plasticity ◽  
Respiratory Control ◽  
Regulatory System ◽  
Long Term Effects ◽  
Future Directions ◽  
Functional Implications ◽  
Risk Of Disease ◽  
Fine Tune

The respiratory control system exhibits considerable plasticity, similar to other regions of the nervous system. Plasticity is a persistent change in system behavior triggered by experiences such as changes in neural activity, hypoxia, and/or disease/injury. Although plasticity is observed in animals of all ages, some forms of plasticity appear to be unique to development (i.e., “developmental plasticity”). Developmental plasticity is an alteration in respiratory control induced by experiences during “critical” developmental periods; similar experiences outside the critical period will have little or no lasting effect. Thus complementary experiments on both mature and developing animals are generally needed to verify that the observed plasticity is unique to development. Frequently studied models of developmental plasticity in respiratory control include developmental manipulations of respiratory gas concentrations (O2 and CO2). Environmental factors not specifically associated with breathing may also trigger developmental plasticity, however, including psychological stress or chemicals associated with maternal habits (e.g., nicotine, cocaine). Despite rapid advances in describing models of developmental plasticity in breathing, our understanding of fundamental mechanisms giving rise to such plasticity is poor; mechanistic studies of developmental plasticity are of considerable importance. Developmental plasticity may enable organisms to “fine tune” their phenotype to optimize the performance of this critical homeostatic regulatory system. On the other hand, developmental plasticity could also increase the risk of disease later in life. Future directions for studies concerning the mechanisms and functional implications of developmental plasticity in respiratory motor control are discussed.

scholarly journals Resistance Exercise in Prostate Cancer Patients: a Short Review

2021 ◽  
Vol 9 (1) ◽  
pp. 32-39
Author(s):  
Andrej Zdravkovic ◽  
Timothy Hasenoehrl ◽  
Richard Crevenna
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Resistance Exercise ◽  
Short Review ◽  
Long Term Effects ◽  
Mineral Density ◽  
Future Directions ◽  
Positive Effects

Abstract Purpose of Review The aim of this paper is to provide an overview of recent findings concerning the utilization of resistance exercise (RE) in prostate cancer (PCa), in particular as pertaining to the management of cancer therapy side effects. Recent Findings As of late, studies investigating the effects of RE in PCa patients have found positive effects on muscle strength, body composition, physical functioning, quality of life, and fatigue. The combination of RE and impact training appears to decrease the loss of bone mineral density. RE seems to be well accepted and tolerated, even by patients with bone metastatic disease, although a modification of the RE prescription is often necessary. Summary In PCa patients, RE has been well-researched and the data are clear that it is beneficial in multiple ways. Future directions should look at the long-term effects of RE, including mortality and relapse, as well as implementation of exercise programs.

scholarly journals DETERMINATION OF ACUTE AND SUBACUTE TOXICITY OF THE DRUG BASED ON CHLORTETRACYCLINE HYDROCHLORIDE

2020 ◽  
Vol 21 (2) ◽  
pp. 71-75
Author(s):  
І. Ya. Kotsyumbas ◽  
I. P. Patereha ◽  
V. I. Kushnir ◽  
T. V. Yurynets ◽  
S. Ya. Martynyk ◽  
...  
Keyword(s):  
Hemoglobin Concentration ◽  
Control Group ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Hemoglobin ◽  
Internal Organs ◽  
Subacute Toxicity ◽  
White Rats ◽  
Therapeutic Doses

The article presents the results of determination of acute and subacute toxicity of the drug "Chloracil", which was made on the basis of chlortetracycline hydrochloride. In result of the conducted researches, it was found out, that a single intragastric administration of the drug according to SOU 85.2-37-736: 2011 belongs to the 4th class of toxicity - low-toxic substances. In determining the toxicity of the drug by the long-term use, it was found out, that the use of Chloracil in therapeutic and in 10 times higher than the therapeutic doses did not cause death of white rats. The animals of the experimental groups were active, ate well food , and the general condition of the animals did not differ from the condition of the animals of the control group, but there was a tendency to decrease the weights of liver, spleen, heart, lungs, thymus and kidneys on the background of an increase of body weight by 3.4 and 7.3% (p <0.05), compared to the values of the control group. Therefore, the use of the tested drug in above doses for 14 days does not significantly affect on the functional state of the internal organs of experimental animals. The study of the effect of the drug on the hematological parameters of blood by long-term use showed that in therapeutic and in 10-time higher therapeutic doses observed a tendency to decrease the hemoglobin concentration, amount of erythrocytes, leukocytes, hematocrit value, on the background of a slight an increase of platelet. In determining the value of erythrocyte indices, it was noted that the use of the drug "Chloracil" in animals of I and II experiments did not cause significant changes in mean corpuscular hemoglobin (MCH). Mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC) were at the level of the control group. When studying the effect of the drug on the biochemical parameters of blood serum in animals of I and II experimental groups, there was a tendency to decrease the level of creatinine, activity of AST, ALT and LP activity on the background of a slight an increase of total protein content. Analysis of the obtained data shows that the use of the drug "Chloracil" to white rats for 14 days in therapeutic and in 10-time higher therapeutic doses caused a slight decrease in the weight of internal organs, hematological and biochemical parameters of blood, which that in turn did not significantly effect on the general condition of animals.

Ovarian Dysfunction in Fetally Irradiated Beagles

1977 ◽  
Vol 35 ◽  
pp. 658-659
Author(s):  
T. M. Seed ◽  
M. H. Sanderson ◽  
D. L. Gutzeit ◽  
T. E. Fritz ◽  
D. V. Tolle ◽  
...  
Keyword(s):  
Gamma Rays ◽  
Low Dose ◽  
Long Term Effects ◽  
Ovarian Dysfunction ◽  
Dose Rates ◽  
Highly Sensitive ◽  
Microscopic Evaluation ◽  
Ovarian Pathology ◽  
Normal Offspring

The developing mammalian fetus is thought to be highly sensitive to ionizing radiation. However, dose, dose-rate relationships are not well established, especially the long term effects of protracted, low-dose exposure. A previous report (1) has indicated that bred beagle bitches exposed to daily doses of 5 to 35 R 60Co gamma rays throughout gestation can produce viable, seemingly normal offspring. Puppies irradiated in utero are distinguishable from controls only by their smaller size, dental abnormalities, and, in adulthood, by their inability to bear young.We report here our preliminary microscopic evaluation of ovarian pathology in young pups continuously irradiated throughout gestation at daily (22 h/day) dose rates of either 0.4, 1.0, 2.5, or 5.0 R/day of gamma rays from an attenuated 60Co source. Pups from non-irradiated bitches served as controls. Experimental animals were evaluated clinically and hematologically (control + 5.0 R/day pups) at regular intervals.

Preparation And elemental analysis of ancient fibers

1987 ◽  
Vol 45 ◽  
pp. 410-411
Author(s):  
Allen Angel ◽  
Kathryn A. Jakes
Keyword(s):  
Cross Sections ◽  
Physical Structure ◽  
Energy Dispersive ◽  
Archaeological Sites ◽  
X Ray ◽  
Long Term Storage ◽  
Backscattered Electron ◽  
Electron Imaging

Fabrics recovered from archaeological sites often are so badly degraded that fiber identification based on physical morphology is difficult. Although diagenetic changes may be viewed as destructive to factors necessary for the discernment of fiber information, changes occurring during any stage of a fiber's lifetime leave a record within the fiber's chemical and physical structure. These alterations may offer valuable clues to understanding the conditions of the fiber's growth, fiber preparation and fabric processing technology and conditions of burial or long term storage (1).Energy dispersive spectrometry has been reported to be suitable for determination of mordant treatment on historic fibers (2,3) and has been used to characterize metal wrapping of combination yarns (4,5). In this study, a technique is developed which provides fractured cross sections of fibers for x-ray analysis and elemental mapping. In addition, backscattered electron imaging (BSI) and energy dispersive x-ray microanalysis (EDS) are utilized to correlate elements to their distribution in fibers.

Ultrastructural investigations of MDL 19,660-induced effects on the canine platelet and megakaryocyte

1990 ◽  
Vol 48 (3) ◽  
pp. 374-375
Author(s):  
D.E. Loudy ◽  
J. Sprinkle-Cavallo ◽  
J.T. Yarrington ◽  
F.Y. Thompson ◽  
J.P. Gibson
Keyword(s):  
Antidepressant Drug ◽  
Beagle Dogs ◽  
Long Term Effects ◽  
Short Term ◽  
Platelet Counts ◽  
Toxicological Studies ◽  
Induced Aggregation ◽  
Internal Architecture

Previous short term toxicological studies of one to two weeks duration have demonstrated that MDL 19,660 (5-(4-chlorophenyl)-2,4-dihydro-2,4-dimethyl-3Hl, 2,4-triazole-3-thione), an antidepressant drug, causes a dose-related thrombocytopenia in dogs. Platelet counts started to decline after two days of dosing with 30 mg/kg/day and continued to decrease to their lowest levels by 5-7 days. The loss in platelets was primarily of the small discoid subpopulation. In vitro studies have also indicated that MDL 19,660: does not spontaneously aggregate canine platelets and has moderate antiaggregating properties by inhibiting ADP-induced aggregation. The objectives of the present investigation of MDL 19,660 were to evaluate ultrastructurally long term effects on platelet internal architecture and changes in subpopulations of platelets and megakaryocytes.Nine male and nine female beagle dogs were divided equally into three groups and were administered orally 0, 15, or 30 mg/kg/day of MDL 19,660 for three months. Compared to a control platelet range of 353,000- 452,000/μl, a doserelated thrombocytopenia reached a maximum severity of an average of 135,000/μl for the 15 mg/kg/day dogs after two weeks and 81,000/μl for the 30 mg/kg/day dogs after one week.

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