The Effect of Body Mass Index on Posttraumatic Transfusion after Pelvic Trauma

2015 ◽  
Vol 81 (3) ◽  
pp. 239-244 ◽  
Author(s):  
Justin E. Richards ◽  
Brent J. Morris ◽  
Oscar D. Guillamondegui ◽  
Kyle R. Sweeney ◽  
Marc A. Tressler ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Morbid Obesity ◽  
Risk Factor ◽  
Blood Transfusion ◽  
Body Mass ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Pelvic Trauma ◽  
Fracture Patterns ◽  
To Receive

The impact of body mass index (BMI) on posttraumatic blood transfusion after pelvic trauma is not well known. We conducted a retrospective review of trauma registry data over a 5-year period. Patients were stratified by BMI as normal: less than 25 kg/m2, overweight: 25 to 29.9 kg/m2, obese: 30 to 39.9 kg/m2, and morbidly obese: 40 kg/m2 or greater. Fractures were identified as “likely to receive transfusion” based on literature. Multivariable logistic regression modeling evaluated the relationship between BMI and initial posttraumatic transfusion. A second regression model was created to test the effect of BMI after adjusting for fractures “less likely to receive transfusion.” Sixty-six of 244 patients (27.3%) received transfusion (mean: 1.1 ± 2.3 units). Morbid obesity was associated with transfusion (less than 55.6 vs 24.8%; P < 0.05) and units of total blood transfused (2.2 ± 2.9 vs 1.0 ± 2.2 mL; P < 0.05). The average age of patients who received a blood transfusion was significantly older compared with patients who did not receive a transfusion (45.4 ± 18.8 vs 36.1 ± 16.1 years; P < 0.05). After adjusting for potential confounders, morbid obesity was a significant risk factor for transfusion (odds ratio [OR], 4.1; 95% confidence interval [CI], 1.4 to 12.0). Adjusting by age and fracture patterns “less likely to receive transfusion,” morbid obesity remained a risk factor for transfusion (OR, 4.5; 95% CI, 1.5 to 12.9). Morbid obesity represented a significant risk factor for posttraumatic transfusion in isolated pelvic trauma, even for fracture patterns “less likely to receive transfusion.”

Proteinuria and decreased body mass index as a significant risk factor in developing end-stage renal disease

2008 ◽  
Vol 12 (5) ◽  
pp. 363-369 ◽  
Author(s):  
Kunitoshi Iseki ◽  
Kaori Tokashiki ◽  
Chiho Iseki ◽  
Kentaro Kohagura ◽  
Kozen Kinjo ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Risk Factor ◽  
Renal Disease ◽  
Body Mass ◽  
End Stage Renal Disease ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Clinical and histopathological characteristics in patients with postmenopausal bleeding

2013 ◽  
Vol 21 (1) ◽  
pp. 5-10 ◽  
Author(s):  
Aljosa Mandic ◽  
Bojana Gutic ◽  
Tatjana Kapicl-Ivkovic ◽  
Ljiljana Segedi-Mladenovic ◽  
Mihaela Mocko-Kacanski
Keyword(s):  
Body Mass Index ◽  
Risk Factor ◽  
Endometrial Carcinoma ◽  
Body Mass ◽  
Transvaginal Ultrasound ◽  
Significant Risk ◽  
Histopathological Analysis ◽  
Postmenopausal Bleeding ◽  
Postmenopausal Period ◽  
Increased Risk

Background: Incidence of endometrial carcinoma in Vojvodina is 15-20/100 000. In 75% cases, endometrial carcinoma is diagnosed in postmenopausal period. In 90 % of patients, the first clinical sign is postmenopausal bleeding. The aim of the study was to investigate clinical and histopathological characteristics in patients with postmenopausal bleeding. Methods: The study included 122 patients with postmenopausal bleeding. All of these patients underwent gynecological examination and vaginal ultrasound. We obtained materials for histopathological analysis by fractionate explorative curettage. Once we had definitive histopathological findings, we divided patients in two groups A (endometrial carcinoma) and B (benign changes). Results: We confirmed significant statistical differences between examined group A and B, including age (64.49 compared with 58.81 years), postmenopausal period (13.67 instead 9.11 years), and length of uterine corpus (6.41 instead 5.25 cm). Conclusion: Elderly women with longer postmenopausal interval and postmenopausal bleeding had increased risk for endometrial carcinoma. Measurement of endometrial thickness by transvaginal ultrasound appeared to be insufficient parameter for differentiating the benign from the malignant changes of endometrium. Patients with endometrial carcinoma had significantly longer corpus of uterus comparing to patients with benign changes. Body mass index was not found to be significant risk factor in development of endometrial carcinoma in the examined groups. Obesity was diagnosed in both groups, suggesting that increased body mass index is a risk factor for development of pathological changes in endometrium, which could lead to postmenopausal bleeding.

Morbid Obesity in Revision Total Knee Arthroplasty: A Significant Risk Factor for Re-Operation

2019 ◽  
Vol 34 (5) ◽  
pp. 932-938 ◽  
Author(s):  
Zachary W. Sisko ◽  
Edward M. Vasarhelyi ◽  
Lyndsay E. Somerville ◽  
Douglas D. Naudie ◽  
Steven J. MacDonald ◽  
...  
Keyword(s):  
Morbid Obesity ◽  
Total Knee Arthroplasty ◽  
Risk Factor ◽  
Knee Arthroplasty ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Revision Total Knee Arthroplasty ◽  
Total Knee

scholarly journals Obesity, Aspirin, and Risk of Colorectal Cancer in Carriers of Hereditary Colorectal Cancer: A Prospective Investigation in the CAPP2 Study

2015 ◽  
Vol 33 (31) ◽  
pp. 3591-3597 ◽  
Author(s):  
Mohammad Movahedi ◽  
D. Timothy Bishop ◽  
Finlay Macrae ◽  
Jukka-Pekka Mecklin ◽  
Gabriela Moeslein ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Body Mass Index ◽  
Body Mass ◽  
Reference Group ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Normal Weight ◽  
Obese People ◽  
Msh6 Mutation

Purpose In the general population, increased adiposity is a significant risk factor for colorectal cancer (CRC), but whether obesity has similar effects in those with hereditary CRC is uncertain. This prospective study investigated the association between body mass index and cancer risk in patients with Lynch syndrome (LS). Patients and Methods Participants with LS were recruited to the CAPP2 study, in which they were randomly assigned to receive aspirin 600 mg per day or aspirin placebo, plus resistant starch 30 g per day or starch placebo (2 × 2 factorial design). Mean intervention period was 25.0 months, and mean follow-up was 55.7 months. Results During follow-up, 55 of 937 participants developed CRC. For obese participants, CRC risk was 2.41× (95% CI, 1.22 to 4.85) greater than for underweight and normal-weight participants (reference group), and CRC risk increased by 7% for each 1-kg/m2 increase in body mass index. The risk of all LS-related cancers in obese people was 1.77× (95% CI, 1.06 to 2.96; P = .03) greater than for the reference group. In subgroup analysis, obesity was associated with 3.72× (95% CI, 1.41 to 9.81) greater CRC risk in patients with LS with MLH1 mutation, but no excess risk was observed in those with MSH2 or MSH6 mutation (P = .5). The obesity-related excess CRC risk was confined to those randomly assigned to the aspirin placebo group (adjusted hazard ratio, 2.75; 95% CI, 1.12 to 6.79; P = .03). Conclusion Obesity is associated with substantially increased CRC risk in patients with LS, but this risk is abrogated in those taking aspirin. Such patients are likely to benefit from obesity prevention and/or regular aspirin.

scholarly journals Underweight increases the risk of pulmonary tuberculosis in adult

2017 ◽  
Vol 36 (1) ◽  
pp. 4
Author(s):  
Galuh Chandra Irawan ◽  
Ani Margawati ◽  
Ali Rosidi
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Logistic Regression ◽  
Risk Factor ◽  
Pulmonary Tuberculosis ◽  
Body Mass ◽  
Low Income ◽  
Smoking Behavior ◽  
Significant Risk ◽  
Low Body Mass Index

<p>Background<br />Tuberculosis (TB) is a leading cause of morbidity and mortality, especially in middle- and low-income countries. The risk of developing TB may be related to nutritional status. Socioeconomic and behavioral factors are also shown to increase the susceptibility to TB infection. The objective of this study was to determine nutritional factors as risk factors of pulmonary TB in adult.</p><p>Methods<br />This was an observational study of case control design. The study subjects were community members consisting of 19 adult cases of pulmonary tuberculosis and 38 controls. Data on nutritional intakes were obtained by semiquantitative food frequency questionnaire (FFQ), while smoking behavior, history of DM, body mass index, education, and income were obtained by structured interviews. The data were analyzed by independent t-test and logistic regression for calculation of the odds ratio (OR).</p><p>Results<br />The bivariate test showed that the adequacy levels for energy (OR=6.8; 95% CI: 1.51-30.54), protein (OR=5.1; 95% CI: 1.52-17.14), vitamin A (OR=4.2; 5% CI: 1.31-13.54), vitamin C (OR=3.8;95% CI: 1.21-12.36), selenium (OR=4.2; 95% CI: 1.34-13.58), body mass index (OR=4.4; 95% CI: 1.32-14.35) and smoking behavior (OR=3.7; 95% CI: 1.15-11.9), were significant risk factors for pulmonary tuberculosis. Multiple logistic regression test showed that low body mass index (&lt;18.5 kg/m2) (OR=6.0; 95% CI: 1.32-27.18) was a the most influential risk factor of pulmonary tuberculosis.</p><p>Conclusion<br />Low body mass index is the most influential risk factor for pulmonary tuberculosis incidence in adult. Nutrition profile in adult is an important determinant of TB incidence.</p>

scholarly journals Obesity Increases the Severity and Mortality of Influenza and COVID-19: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 11 ◽  
Author(s):  
Xue Zhao ◽  
Xiaokun Gang ◽  
Guangyu He ◽  
Zhuo Li ◽  
You Lv ◽  
...  
Keyword(s):  
Systematic Review ◽  
Morbid Obesity ◽  
Risk Factor ◽  
Confidence Intervals ◽  
Web Of Science ◽  
Meta Analysis ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Systematic Search ◽  
Odds Ratios

Since December 2019, COVID-19 has aroused global attention. Studies show the link between obesity and severe outcome of influenza and COVID-19. Thus, we aimed to compare the impacts of obesity on the severity and mortality of influenza and COVID-19 by performing a meta-analysis. A systematic search was performed in MEDLINE, EMASE, ClinicalTrials.gov, and Web of Science from January 2009 to July 2020. The protocol was registered onto PROSPERO (CRD42020201461). After selection, 46 studies were included in this meta-analysis. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were analyzed. We found obesity was a risk factor for the severity and mortality of influenza (ORsevere outcome = 1.56, CI: 1.28-1.90; ORmortality = 1.99, CI: 1.15-3.46). For COVID-19, obesity was a significant risk factor only for severe outcome (OR = 2.07, CI: 1.53-2.81) but not for mortality (OR = 1.57, CI: 0.85-2.90). Compared with obesity, morbid obesity was linked with a higher risk for the severity and mortality of both influenza (OR = 1.40, CI: 1.10-1.79) and COVID-19 (OR = 3.76, CI: 2.67-5.28). Thus, obesity should be recommended as a risk factor for the prognosis assessment of COVID-19. Special monitoring and earlier treatment should be implemented in patients with obesity and COVID-19.

scholarly journals The Association between Body Mass Index and Mortality on Peritoneal Dialysis: A Prospective Cohort Study

2014 ◽  
Vol 34 (4) ◽  
pp. 383-389 ◽  
Author(s):  
Yong Kyun Kim ◽  
Su-Hyun Kim ◽  
Hyung Wook Kim ◽  
Young Ok Kim ◽  
Dong Chan Jin ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Cohort Study ◽  
Peritoneal Dialysis ◽  
Body Mass ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Cox Regression ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Cox Regression Analysis

BackgroundPrevious studies have demonstrated that increased body mass index (BMI) is associated with decreased mortality in hemodialysis (HD) patients. However, the association between BMI and survival has not been well established in patients undergoing peritoneal dialysis (PD). The aim of the study was to determine the association between BMI and mortality in the PD population using the Clinical Research Center (CRC) registry for end-stage renal disease (ESRD) cohort in Korea.MethodsPrevalent patients with PD were selected from the CRC registry for ESRD, a prospective cohort study on dialysis patients in Korea. Patients were categorized into four groups by quartiles of BMI. Cox regression analysis was used to calculate the adjusted hazard ratio (HR) of mortality with a BMI of quartile 2 (21.4 - 23.5 kg/m2) as the reference.ResultsA total of 900 prevalent patients undergoing PD were included. The median follow-up period was 24 months. The multivariate Cox proportional hazard model showed that the lowest quartile of BMI was associated with higher mortality (HR 3.00,95% confidence interval (CI), 1.26 - 7.15). However, the higher quartiles of BMI were not associated with mortality compared with the reference category of BMI quartile 2 (Quartile 3: HR 1.11, 95% CI, 0.43 - 2.85, Quartile 4: H R 1.64,95% CI, 0.66 - 4.06) after adjustment for clinical variables.ConclusionsLower BMI was a significant risk factor for death, but increased BMI was not associated with mortality in Korean PD patients.

Statewide Collaboration to Evaluate the Effects of Blood Loss and Transfusion on Surgical Site Infection after Hysterectomy

2012 ◽  
Vol 33 (1) ◽  
pp. 90-93 ◽  
Author(s):  
Heather Young ◽  
Crystal Berumen ◽  
Bryan Knepper ◽  
Amber Miller ◽  
Morgan Silverman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Blood Transfusion ◽  
Blood Loss ◽  
Surgical Site Infection ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Abdominal Hysterectomy ◽  
Public Reporting ◽  
Site Infection

We used mandatory public reporting as an impetus to perform a statewide study to define risk factors for surgical site infection. Among women who underwent abdominal hysterectomy, blood transfusion was a significant risk factor for surgical site infection in patients who experienced blood loss of less than 500 mL.Infect Control Hosp Epidemiol 2012;33(1):90-93

scholarly journals HUBUNGAN BMI DENGAN KADAR KOLESTEROL TOTAL DARAH PADA WANITA DEWASA

2019 ◽  
Vol 3 (2) ◽  
pp. 21
Author(s):  
Radot Ganda Sinurat ◽  
Yunus Elon
Keyword(s):  
Body Mass Index ◽  
Total Cholesterol ◽  
Body Mass ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
The Body ◽  
P Value ◽  
Adult Women ◽  
Cross Sectional ◽  
Cholesterol Levels

Hypercholesterolemia is a state of high total cholesterol levels in the body, which is a significant risk factor for cardiovascular disease which is still the number one cause of death in the world with the same prevalence between men and women. This study aims to determine the relationship of Body Mass Index (BMI) with total cholesterol levels in blood in adult women in Cihanjuang Rahayu Village. This study uses a cross sectional analytic observational design . The number of samples in this study were 45 respondens. As many as 19 or 42 % of respondent fall into the fat category, 31 % or 14 obese respondents, and 27 % are normal. Total cholesterol 76 % or as many as 34 normal respondents , and 24 % or 11 people with hypercholesterolemia. The analysis showed that there was no significant relationship between BMI and cholesterol levels in adult women with p-values.>.05. Conclution: the adult women aged 26 – 45 years BMI status is not related to total cholesterol levels.  Key words: Total Cholesterol, Hypercholesterolemia, Body Mass Index   Abstrak   Hiperkolesterolemia adalah keadaan kadar kolesterol total tinggi di dalam tubuh, yang merupakan faktor resiko signifikan dari penyakit kardiovaskular yang sampai pada saat ini  masih menjadi penyebab nomor satu kematian di dunia dengan prevalensi yang sama antara pria dan wanita. Penelitian ini bertujuan untuk mengetahui adanya hubungan Body Mass Index (BMI) dengan kadar kolesterol total dalam darah pada wanita dewasa di Desa Cihanjuang Rahayu. Penelitian ini menggunakan desain cross sectional yang bersifat analitik observational. Jumlah sampel pada penelitian ini sebanyak 45 responden. Sebanyak 19 atau 42% responden masuk dalam kategori gemuk, 31% atau 14 responden obesitas dan 27% Normal. Total kolesterol 76% atau 34 responden normal, dan 24% atau 11 orang hyperkolesterolemia. Hasil analisis menunjukkan tidak ada hubungan yang signifikan antara BMI dengan kadar total kolesterol pada wanita dewasa dengan nilai p-value >.05. Kesimpulan: pada wanita dewasa usia 26 tahun – 45 tahun status BMI tidak berhubungan dengan kadar kolesterol total. Kata kunci: Kolesterol Total, Hiperkolesterolemia, Indeks Massa Tubuh

Abstract 155: The Impact of Body Mass Index and Gender on Patient Survival After Therapeutic Hypothermia Following Resuscitation

2015 ◽  
Vol 8 (suppl_2) ◽  
Author(s):  
Khadijah Breathett ◽  
Nishaki Mehta Oza ◽  
Vedat Yildiz ◽  
Ryan Ziegler ◽  
Erik Abel ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Cardiac Arrest ◽  
Therapeutic Hypothermia ◽  
Body Mass ◽  
Patient Survival ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Obesity Paradox ◽  
And Gender ◽  
The Impact

Background: Therapeutic hypothermia has been established to improve survival in patients following cardiac arrest; yet the impact of body mass index (BMI) and gender on survival post hypothermia is lesser known. Given the obesity paradox in heart failure and the gender differences in cardiovascular outcomes, we hypothesized that men and higher BMI patients would have better survival post therapeutic hypothermia than women and lower BMI patients. Methods: We retrospectively evaluated 183 patients who underwent therapeutic hypothermia following resuscitation at our two large academic centers from 1/2012 to 9/2014. Logistic regression analysis was used to assess for survival based upon BMI, gender, and comorbidities. Results: The average BMI was 30.5 (standard deviation 9.7 kg/m2). There were 67% men (n=122). Therapeutic hypothermia was performed in 75% patients (n=138) for cardiac arrest, while the rest were cooled for neurologic indications. Mortality post therapeutic hypothermia was 60% (n=110). There was a significantly higher mortality for patients with BMI >30kg/m2 compared to BMI ≤30kg/m2 [Odds Ratio OR 1.94 (95% Confidence Intervals CI 1.04, 3.62), p=0.034]. There was no difference in mortality based upon gender [OR 1.57 (95% CI 0.8, 2.9), p= 0.166] or other comorbidities. Conclusions: BMI >30kg/m2 was a significant risk factor for mortality post therapeutic hypothermia protocol, while gender was not a factor. Larger studies will be needed to validate these findings.

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