Crista Neglecta in Man

1978 ◽  
Vol 87 (3) ◽  
pp. 306-312 ◽  
Author(s):  
Yasumasa Okano ◽  
Isamu Sando ◽  
Eugene N. Myers
Keyword(s):  
Nerve Fibers ◽  
Transitional Epithelium ◽  
Fetal Life ◽  
Main Trunk ◽  
Average Width ◽  
Posterior Canal ◽  
Small Branch ◽  
Sensory Hair Cells ◽  
Temporal Bones ◽  
The Relationship

— The prevalence, location, and size of the crista neglecta in man were investigated by examining the histological sections of 223 human temporal bones (137 cases). The relationship between the crista neglecta and the singular nerve was also described. The crista neglecta was observed in 17 cases, ranging in age from 15-week fetal life to 76 years. This structure was located on the wall of the anterolateral quadrant of the posterior canal ampulla, close to the cribriform area of the singular nerve in the area between the utriculoampullar duct and the intermediate portion of the posterior canal crista. The average width, length, and height of the crista neglecta were described. The crista neglecta had a mound-like shape and contained nerve fibers, transitional epithelium, sensory hair cells, and a cupula. The nerve fibers from the crista neglecta were joined to a small branch of the singular nerve at the cribriform area in 5 of 17 crista neglecta cases, and to the main trunk of the singular nerve in the remaining 12 cases.

Microfissure between the round Window Niche and Posterior Canal Ampulla

1977 ◽  
Vol 86 (1) ◽  
pp. 49-57 ◽  
Author(s):  
Yasumasa Okano ◽  
Eugene N. Myers ◽  
David R. Dickson
Keyword(s):  
Round Window ◽  
Pathological Finding ◽  
Anatomical Structure ◽  
Fetal Life ◽  
Human Fetuses ◽  
Posterior Canal ◽  
Mesenchymal Tissue ◽  
One Year ◽  
Round Window Niche ◽  
Temporal Bones

The microfissure between the round window niche and the posterior canal ampulla was examined in fetal, child, and adult human temporal bones. The communication which was filled with mesenchymal tissue and blood vessels extending from the middle ear, was observed between the round window niche and the posterior canal ampulla in 10 to 15-week human fetuses. The mesenchymal tissue in the communication was replaced by cartilage with advancing age of the fetus. No communication was observed at birth. From newborn to 12 months of age, no microfissure was observed. After one year of age, the microflssure was first observed and the frequency of the observation increased with increasing age of the patient. After six years of age, the microfissure was observed bilaterally in 100% of cases studied. The microflssure has its origin from the communication between the round window niche and the posterior canal ampulla in fetal life, and is a normal developmental and anatomical structure, and not a pathological finding.

scholarly journals Meta-Analysis—Correlation between Spiral Ganglion Cell Counts and Speech Perception with a Cochlear Implant

2021 ◽  
Vol 11 (2) ◽  
pp. 220-226
Author(s):  
Yew-Song Cheng ◽  
Mario A. Svirsky
Keyword(s):  
Speech Perception ◽  
Cochlear Implant ◽  
Ganglion Cells ◽  
Meta Analysis ◽  
Spiral Ganglion ◽  
Spiral Ganglion Cell ◽  
Cell Counts ◽  
Temporal Bones ◽  
The Relationship ◽  
Existing Data

The presence of spiral ganglion cells (SGCs) is widely accepted to be a prerequisite for successful speech perception with a cochlear implant (CI), because SGCs provide the only known conduit between the implant electrode and the central auditory system. By extension, it has been hypothesized that the number of SGCs might be an important factor in CI outcomes. An impressive body of work has been published on findings from the laborious process of collecting temporal bones from CI users and counting the number of SGCs to correlate those numbers with speech perception scores, but the findings thus far have been conflicting. We performed a meta-analysis of all published studies with the hope that combining existing data may help us reach a more definitive conclusion about the relationship between SGC count and speech perception scores in adults.

Electron Microscopic Findings in Presbycusic Degeneration of the Basal Turn of the Human Cochlea

1979 ◽  
Vol 87 (6) ◽  
pp. 818-836 ◽  
Author(s):  
Joseph B. Nadol
Keyword(s):  
Light Microscopy ◽  
Hair Cells ◽  
Basilar Membrane ◽  
Ganglion Cells ◽  
Nerve Fibers ◽  
Degenerative Changes ◽  
Supporting Cells ◽  
Neural Degeneration ◽  
Basal Turn ◽  
Temporal Bones

Three human temporal bones with presbycusis affecting the basal turn of the cochlea were studied by light and electron microscopy. Conditions in two ears examined by light microscopy were typical of primary neural degeneration, with a descending audiometric pattern, loss of cochlear neurons in the basal turn, and preservation of the organ of Corti. Ultrastructural analysis revealed normal hair cells and marked degenerative changes of the remaining neural fibers, especially in the basal turn. These changes included a decrease in the number of synapses at the base of hair cells, accumulation of cellular debris in the spiral bundles, abnormalities of the dendritic fibers and their sheaths in the osseous spiral lamina, and degenerative changes in the spiral ganglion cells and axons. These changes were interpreted as an intermediate stage of degeneration prior to total loss of nerve fibers and ganglion cells as visualized by light microscopy. In the third ear the changes observed were typical of primary degeneration of hair and supporting cells in the basal turn with secondary neural degeneration. Additional observations at an ultrastructural level included maintenance of the tight junctions of the scala media despite loss of both hair and supporting cells, suggesting a capacity for cellular “healing” in the inner ear. Degenerative changes were found in the remaining neural fibers in the osseous spiral lamina. In addition, there was marked thickening of the basilar membrane in the basal turn, which consisted of an increased number of fibrils and an accumulation of amorphous osmiophilic material in the basilar membrane. This finding supports the concept that mechanical alterations may occur in presbycusis of the basal turn.

scholarly journals Recent Advances in Biomarkers and Regenerative Medicine for Diabetic Neuropathy

2021 ◽  
Vol 22 (5) ◽  
pp. 2301
Author(s):  
Yoshikai Fujita ◽  
Tatsufumi Murakami ◽  
Akihiro Nakamura
Keyword(s):  
Diabetic Neuropathy ◽  
Target Gene ◽  
Pathological Condition ◽  
Nerve Fibers ◽  
Nerve Degeneration ◽  
Limb Amputation ◽  
Sensory Impairment ◽  
Mechanical Stimuli ◽  
Pathological Conditions ◽  
The Relationship

Diabetic neuropathy is one of the most common complications of diabetes. This complication is peripheral neuropathy with predominant sensory impairment, and its symptoms begin with hyperesthesia and pain and gradually become hypoesthesia with the loss of nerve fibers. In some cases, lower limb amputation occurs when hypoalgesia makes it impossible to be aware of trauma or mechanical stimuli. On the other hand, up to 50% of these complications are asymptomatic and tend to delay early detection. Therefore, sensitive and reliable biomarkers for diabetic neuropathy are needed for an early diagnosis of this condition. This review focuses on systemic biomarkers that may be useful at this time. It also describes research on the relationship between target gene polymorphisms and pathological conditions. Finally, we also introduce current information on regenerative therapy, which is expected to be a therapeutic approach when the pathological condition has progressed and nerve degeneration has been completed.

scholarly journals Hyaluronan and the Fascial Frontier

2021 ◽  
Vol 22 (13) ◽  
pp. 6845
Author(s):  
Rebecca L. Pratt
Keyword(s):  
Nerve Fibers ◽  
The Body ◽  
Water Volume ◽  
Cell Behavior ◽  
Connective Tissues ◽  
Wide Range ◽  
The World ◽  
Extracellular Microenvironment ◽  
The Impact ◽  
The Relationship

The buzz about hyaluronan (HA) is real. Whether found in face cream to increase water volume loss and viscoelasticity or injected into the knee to restore the properties of synovial fluid, the impact of HA can be recognized in many disciplines from dermatology to orthopedics. HA is the most abundant polysaccharide of the extracellular matrix of connective tissues. HA can impact cell behavior in specific ways by binding cellular HA receptors, which can influence signals that facilitate cell survival, proliferation, adhesion, as well as migration. Characteristics of HA, such as its abundance in a variety of tissues and its responsiveness to chemical, mechanical and hormonal modifications, has made HA an attractive molecule for a wide range of applications. Despite being discovered over 80 years ago, its properties within the world of fascia have only recently received attention. Our fascial system penetrates and envelopes all organs, muscles, bones and nerve fibers, providing the body with a functional structure and an environment that enables all bodily systems to operate in an integrated manner. Recognized interactions between cells and their HA-rich extracellular microenvironment support the importance of studying the relationship between HA and the body’s fascial system. From fasciacytes to chronic pain, this review aims to highlight the connections between HA and fascial health.

The effect of cytochalasin D on preprophase band organization in root tip cells of Allium

1992 ◽  
Vol 103 (4) ◽  
pp. 989-998 ◽  
Author(s):  
E.P. Eleftheriou ◽  
B.A. Palevitz
Keyword(s):  
Preprophase Band ◽  
Cytochalasin D ◽  
Root Tip ◽  
Average Width ◽  
Exact Position ◽  
The Relationship ◽  
Tip Cells ◽  
Root Tip Cells ◽  
Control Samples

The relationship between microfilaments (Mfs) and microtubules (Mts) in the organization of the preprophase band (PPB) was investigated in Allium root tip cells subjected to treatment with cytochalasin D (CD). Mts and Mfs were visualized by indirect immunofluorescence and various parameters such as PPB width were analyzed quantitatively. In control samples, the PPB first appears as a wide Mt band that progressively narrows to an average width of 4 micrometre in mid-prophase. Randomly oriented Mfs are present throughout the cytoplasm of most interphase control cells. Preprophase and prophase cells, however, contain cortical Mfs arranged parallel to the PPB. The Mfs initially occupy much of the cortex but in most cells they progressively become restricted to an area wider than the PPB. In the presence of CD, the PPB fails to narrow and remains at least two-fold wider than in control cells. PPB width expressed as a percentage of nuclear or cell length also increases compared to controls. Widening is concentration dependent, and the effect of 10 micromolar CD is near maximal only 15 min after application of the drug. This rapid response suggests that a rebroadening of already condensed PPBs takes place. After as little as 15 min in CD, Mfs are replaced by many small specks and rods. Dual localizations of both Mts and Mfs show that prophase cells contain broad PPBs without Mfs. The rapid disorganization of Mfs, by CD, therefore coincides with the rebroadening of PPBs. CD-treated cells in metaphase, anaphase and telophase contain larger actin aggregates at the poles, as previously reported. The results indicate that Mfs play an important role in the narrowing of the PPB, which in turn is essential for determination of the exact position of the plane of division. They also indicate that movement of intact Mts is important in PPB organization.

scholarly journals Prenatal and postnatal growth: An ultrasound and clinical investigation

2016 ◽  
Vol 6 ◽  
pp. 147-153
Author(s):  
Shahista Parveen ◽  
Rohan Mascarenhas ◽  
Akhter Husain ◽  
Devadas Acharya
Keyword(s):  
Growth Rate ◽  
Assessment Tool ◽  
Clinical Investigation ◽  
Normal Pregnancy ◽  
Postnatal Growth ◽  
Fetal Life ◽  
Prenatal Growth ◽  
Facial Development ◽  
The Relationship ◽  
Growth Assessment

Background Understanding facial development requires sound knowledge of growth at different stages. Although studies in the past have established the relationship between prenatal and postnatal growth, little research has been done using noninvasive ultrasound. The purpose of this study is to evaluate correlation between prenatal and postnatal growths using ultrasound as a fetal growth assessment tool. Study Settings: It is a hospital-based study where prenatal growth is measured at different intervals of gestational period and compared with the growth at birth. Materials and Methods: Ten subjects with normal pregnancy were studied using ultrasound. Cephalocaudal growth gradient, body proportions of the fetus were assessed and compared at different stages. Growth was also evaluated at birth and compared with the predicted growth. Results The growth rate of estimated fetal weight is at maximum between the 28th and 32nd week of the fetal life (P ≤ 0.001). The growth rate of head circumference, occipitofrontal diameter, and femur length is maximum between the 20th and 28th week of the fetal life (P < 0.001). Cephalocaudal growth gradient decreases with increased age of the fetus. Conclusions Prenatal growth is correlated with postnatal growth. Ultrasound can be used as a tool for the measurement and prediction of prenatal and postnatal growths.

scholarly journals Analysis of tympanic sinus shape for purposes of intraoperative hearing monitoring: a microCT study

2021 ◽  
Author(s):  
Małgorzata Bilińska ◽  
Tomasz Wojciechowski ◽  
Jacek Sokołowski ◽  
Kazimierz Niemczyk
Keyword(s):  
Computed Tomography ◽  
Round Window ◽  
Optimal Placement ◽  
Facial Canal ◽  
Average Width ◽  
Sinus Tympani ◽  
Stapedius Muscle ◽  
Electrode Shape ◽  
Posterior Tympanotomy ◽  
Temporal Bones

Abstract Purpose Sinus tympani is the space in the retrotympanum, with variable morphology. Computed tomography is a common tool to investigate sinus tympani anatomy. During cochlear implantation or tympanoplasty, electrocochleography can be used for hearing monitoring. In such a surgical strategy the electrode is placed in the round window’s region throughout posterior tympanotomy. Common accessible needle-shaped electrodes using is difficult in achieving intraoperative stabilization. The aim of the study is to assess the dimensions and shape of sinus tympani, basing on the micro computed tomography scans for purposes of establishing the possible new electrocochleography electrode shape. Materials and methods Sixteen fresh frozen cadaveric temporal bones were dissected. MicroCT measurements included the depth and the width of sinus tympani, width of facial canal with stapedius muscle chamber. Obtained data were analyzed statistically with the use of RStudio 1.3.959 software. Results The highest average width of sinus tympani amounted for 2.68 mm, depth measured at the round window plane for 3.19 mm. Width of facial canal with stapedius muscle chamber highest average values at the round window plane- 3.32 mm. The lowest average minimum and maximum values were calculated at the 1 mm above the round window plane. The highest average posterior tympanotomy width was 2.91 mm. Conclusions The shape of the tympanic sinus is like a trough with the narrowest and deepest dimensions in the middle part. The ST shape and dimensions should be taken into account in constructing the ECochG electrode, designed for optimal placement through posterior tympanotomy approach.

Difference in Attachment of the Tensor Veli Palatini Muscle to the Eustachian Tube Cartilage with Age

2003 ◽  
Vol 112 (5) ◽  
pp. 439-443 ◽  
Author(s):  
Chiaki Suzuki ◽  
Isamu Sando ◽  
Miwa Kitagawa ◽  
Carey D. Balaban ◽  
Kenji Takasaki
Keyword(s):  
Eustachian Tube ◽  
Later Life ◽  
Measurement Methods ◽  
3 Dimensional ◽  
Dimensional Reconstruction ◽  
Tensor Veli Palatini Muscle ◽  
Normal Human ◽  
Development And Aging ◽  
Temporal Bones ◽  
The Relationship

To test a hypothesis that ventilation of the eustachian tube (ET) varies with age, we investigated the relationship between age and the attachment of the tensor veli palatini muscle (TVPM) to the lateral lamina of the ET cartilage in 12 normal human temporal bones obtained from individuals 3 months to 81 years old. We used computer-aided 3-dimensional reconstruction and measurement methods. We found that the length of the TVPM attachment and its ratio to the length of the ET, especially that of the cartilaginous portion of the ET, increases with age from infancy to adulthood, and decreases with age from young adulthood to later life. These findings are thought to be related to postnatal development and aging. The possibility of differences in ventilation function with age is discussed.

scholarly journals Exposure to Famine During Early Life and Abdominal Obesity in Adulthood: Findings from the Great Chinese Famine During 1959–1961

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 903 ◽  
Author(s):  
Dan Liu ◽  
Dong-mei Yu ◽  
Li-yun Zhao ◽  
Hong-yun Fang ◽  
Jian Zhang ◽  
...  
Keyword(s):  
Abdominal Obesity ◽  
Urban Areas ◽  
Early Life ◽  
Healthy Lifestyle ◽  
Positive Association ◽  
Fetal Life ◽  
Cross Sectional ◽  
Famine Exposure ◽  
Nationally Representative ◽  
The Relationship

Undernutrition during early life may lead to obesity in adulthood. This study was conducted to examine the relationship between famine exposure during early life and the risk of abdominal obesity in adulthood. A total of 18,984 and 16,594 adults were surveyed in 2002 and 2010–2012 in two nationally representative cross-sectional surveys, namely China Nutrition and Health Survey, respectively. The risk of abdominal obesity was evaluated for participants born during 1956–1961 and compared with that of participants born during 1962–1964. The overall prevalence of abdominal obesity in adulthood showed a positive association with famine exposure during early life. The odds ratios of famine exposure were 1.31 (1.19–1.44) and 1.28 (1.17–1.40) in 2002 during fetal life and infancy and 1.09 (1.00–1.19) in 2012 during fetal life, respectively. The relationships between famine exposure and abdominal obesity across the famine exposure groups were distinct among females and those who lived in urban areas and were physical inactive (p < 0.05). Exposure to famine during early life was associated with increased risks of abdominal obesity in adulthood, which was partially alleviated by healthy lifestyle factors (e.g., physical activity).

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