Chondroitin Sulfate Iron Colloid as MR Contrast Agent in Differentiation between Hepatocellular Carcinoma and Adenomatous Hyperplasia

1993 ◽  
Vol 34 (3) ◽  
pp. 226-229 ◽  
Author(s):  
Y. Suto ◽  
T. Kato ◽  
T. Matsuo ◽  
M. Kamba ◽  
Y. Shimatani ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chondroitin Sulfate ◽  
The Other ◽  
Adenomatous Hyperplasia ◽  
Cellular Functions ◽  
Visual Evaluation ◽  
Significant Difference ◽  
Before And After ◽  
T1 And T2 ◽  
T2 Weighted Images

Using a 1.5 T MR imaging unit, T1- and T2-weighted images were obtained before and after i.v. administration of chondroitin sulfate iron colloid (CSIC) in order to differentiate hepatocellular carcinoma (n = 20) from adenomatous hyperplasia without atypia (n = 16). Differentiation was made from the tumor-liver contrast to noise ratio (CNR) and visual evaluation of the nodule, with reference to signal intensity relative to that of the surrounding liver. The CNR of adenomatous hyperplasia was on T1-weighted images significantly decreased after CSIC administration (p < 0.01). On T2-weighted images, there was no significant difference in CNR after CSIC administration. On the other hand, the CNR of hepatocellular carcinoma was significantly increased after CSIC administration on both T1- and T2-weighted images (p < 0.01). CSIC reflects intratumor reticuloendothelial cellular functions, and is therefore useful in differentiating hepatocellular carcinoma from adenomatous hyperplasia without atypia.

scholarly journals The Effect of Geogebra on Students’ Conceptual and Procedural Knowledge: The Case of Applications of Derivative

2017 ◽  
Vol 7 (2) ◽  
pp. 67 ◽  
Author(s):  
Mehmet Fatih Ocal
Keyword(s):  
Conceptual Knowledge ◽  
Teaching And Learning ◽  
Procedural Knowledge ◽  
Dynamic Geometry ◽  
The Other ◽  
Control Group ◽  
Other Hand ◽  
Significant Difference ◽  
Before And After ◽  
Post Test

Integrating the properties of computer algebra systems and dynamic geometry environments, Geogebra became an effective and powerful tool for teaching and learning mathematics. One of the reasons that teachers use Geogebra in mathematics classrooms is to make students learn mathematics meaningfully and conceptually. From this perspective, the purpose of this study was to investigate whether instruction with Geogebra has effect on students’ achievements regarding their conceptual and procedural knowledge on the applications of derivative subject. This study adopted the quantitative approach with pre-test post-test control group true experimental design. The participants were composed of two calculus classrooms involving 31 and 24 students, respectively. The experimental group with 31 students received instruction with Geogebra while the control group received traditional instruction in learning the applications of derivative. Independent samples t-test was used in the analysis of the data gathered from students’ responses to Applications of Derivative Test which was subjected to them before and after teaching processes. The findings indicated that instruction with Geogebra had positive effect on students’ scores regarding conceptual knowledge and their overall scores. On the other hand, there was no significant difference between experimental and control group students’ scores regarding procedural knowledge. It could be concluded that students in both groups were focused on procedural knowledge to be successful in learning calculus subjects including applications of derivative in both groups. On the other hand, instruction with Geogebra supported students’ learning these subjects meaningfully and conceptually.

scholarly journals A COMPARATIVE CLINICAL STUDY TO EVALUATE THE EFFICACY OF DARVYADI LEHYA AND DRAKSHADI LEHYA IN PANDU ROGA W.S.R TO I.D.A

2020 ◽  
Vol 8 (9) ◽  
pp. 4324-4328
Author(s):  
Karthika Raj ◽  
Susheel Shetty
Keyword(s):  
Clinical Practice ◽  
Clinical Study ◽  
Data Base ◽  
Clinical Features ◽  
The Other ◽  
Significant Difference ◽  
The World ◽  
Before And After ◽  
Comparative Clinical Study ◽  
Global Data

Pandu is a Pitta Pradhana Tridoshaja Vikara affecting the Rasavaha srotas causing Sapta Dhatu Kshaya and Ojokshaya1. The disease is characterized by Panduvamata and Arohana Ayasa. Karnakshweda, Agnimandya, Daurbalya, Annadwesha, Srama, Bhrama, Gathrashoola, Arohanaayasa, Aruchi, Gaurava etc. are the other symptoms commonly found in the patients of Pandu. In the Present era, Anaemia is a burning issue around the world and W.H.O Global data base 2011 reveals that, in a 120 million population, 83% people are suffering from anaemia2.Present study was conducted on 60 diagnosed patients of Panduwho were randomly allocated with 30 each in two groups. Darvyadhi Lehya was given for one group and Drakshadhi Lehya a widely used formulation in clinical practice was given for another group. The study was conducted in 60 subjects for a period of 30 days. Clinical features and haematological parameters were documented before and after the treatment. The results of the study showed that, a statistically significant difference was not seen between the effect of Darvyadi and Drakshadilehya in Pandu roga.

scholarly journals p53 immunostaining pattern in Brazilian patients with hepatocellular carcinoma

2004 ◽  
Vol 46 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Venâncio Avancini Ferreira Alves ◽  
Marcelo Eidi Nita ◽  
Flair José Carrilho ◽  
Suzane Kioko Ono-nita ◽  
Alda Wakamatsu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
High Frequency ◽  
Suppressor Gene ◽  
Immunohistochemical Expression ◽  
Adenomatous Hyperplasia ◽  
Altered Expression ◽  
Factors Associated ◽  
Significant Difference ◽  
Liver Cell Dysplasia ◽  
Cirrhotic Patients

Hepatocellular carcinoma (HCC) is an important type of cancer etiologically related to some viruses, chemical carcinogens and other host or environmental factors associated to chronic liver injury in humans. The tumor suppressor gene p53 is mutated in highly variable levels (0-52%) of HCC in different countries. OBJECTIVE: The objective of the present study was to compare the frequency of aberrant immunohistochemical expression of p53 in HCC occurring in cirrhotic or in non-cirrhotic patients as well as in liver cell dysplasia and in adenomatous hyperplasia. We studied 84 patients with HCC or cirrhosis. RESULTS: We detected p53 altered immuno-expression in 58.3% of patients in Grade III-IV contrasting to 22.2% of patients in Grade I-II (p = 0.02). Nontumorous areas either in the vicinity of HCC or in the 30 purely cirrhotic cases showed no nuclear p53 altered expression, even in foci of dysplasia or adenomatous hyperplasia. No significant difference was found among cases related to HBV, HCV or alcohol. CONCLUSION: The high frequency of p53 immunoexpression in this population is closer to those reported in China and Africa, demanding further studies to explain the differences with European and North American reports.

scholarly journals Microleakage of high viscosity glass-ionomer and glass-carbomer with and without coating before and after hydrothermal aging

2019 ◽  
Vol 22 (1) ◽  
pp. Process ◽  
Author(s):  
Asli Patır Münevveroğlu ◽  
Alev Ozsoy ◽  
Beyza Ballı akgol ◽  
Ruhan Bozatlioglu ◽  
Pelin Korkut ◽  
...  
Keyword(s):  
Surface Coating ◽  
Glass Ionomer Cement ◽  
High Viscosity ◽  
The Other ◽  
Blue Dye ◽  
Glass Ionomer ◽  
Hydrothermal Aging ◽  
Dye Penetration ◽  
Significant Difference ◽  
Before And After

Objective: The objective of this study was to evaluate the microleakage patterns of GIC and GGC with and without their protective surface coatings on enamel and dentin margins before and after aging. Material and Methods: Two rectangular cavities (height: 2 mm; width: 3 mm; depth: 1.5 mm) were prepared on each tooth at the cemento-enamel junction were prepared on human permanent molars (N=56) and the teeth were randomly assigned to be restored with one of the following: a) high viscosity glass-ionomer cement (GIC) (EQUIA Fil, C Corp., Tokyo, Japan) (n=28), b) glass-carbomer cement (GCC) (Glass Carbomer Products, Leiden, The Netherlands) (n=28). Half of the teeth were further divided into two groups where one group received protective surface coating (SC) (G-Coat Plus, GC Corp) (n=14) and the other group did not (n=14). Half of the teeth were stored for 24 hours (n=7), and the other half was thermocycled (5000 cycles, 5-55°C) (n=7). For microleakage analysis, the teeth were immersed in 5% methylene blue dye for 24 hours, sectioned into two equal halves. Microleakage patterns were evaluated using stereomicroscope and scored on a scale of 0-3 (0: No dye penetration, 1: Dye penetration less than half of the axial wall, 2: Dye penetration more than half the axial wall, 3: Dye penetration spreading along the axial wall). Data were analyzed using Kruskal-Wallis tests at the significance level of 0.05. Results: Compared to 24 h storage, after thermocycling, surface coating on GIC decreased microleakage significantly compared to GCC (p=0.046) but not for GCC. In the thermocycled groups, coated GIC showed significantly less leakage at the enamel margin but no significant difference was found with both GIC and GCC in the dentin margins. Conclusion: The application of surface coating significantly reduced the microleakage scores of GIC but not GCC, within the enamel margins only.KeywordsGlass-carbomer; Glass-ionomer; Microleakage.

scholarly journals Comparison between Ormeloxifene and Norethisterone in reducing menorrhagia in dysfunctional uterine bleeding

2018 ◽  
Vol 7 (12) ◽  
pp. 4966
Author(s):  
Swati Gett ◽  
Shruti Singh
Keyword(s):  
Endometrial Thickness ◽  
Mean Value ◽  
Uterine Bleeding ◽  
The Other ◽  
P Value ◽  
Loss Assessment ◽  
Dysfunctional Uterine Bleeding ◽  
Significant Difference ◽  
Before And After

Background: Dysfunctional Uterine Bleeding (DUB) is a condition that affects nearly every woman at some point in her life. This study aims to compare the efficacy of Ormeloxifene and Norethisterone in reducing menorrhagia in such patients.Methods: This prospective study was done on 100 women presenting with dysfunctional uterine bleeding, of 20-50 years of age, who were ready for follow-up and were allocated into two equal groups, one was given Ormeloxifene and the other was given Norethisterone for a period of 3 months. Haemoglobin levels, endometrial thickness on ultrasound and Pictorial Blood loss Assessment Chart (PBAC) scores were assessed before and after the treatment.Results: It was found that both Ormeloxifene and Norethisterone reduced menorrhagia, with a significant difference in PBAC scores (p value <0.05). There was a notable reduction in PBAC scores in Ormeloxifene group (66.53% change from pretreatment mean value) as compared to Norethisterone group (31.38% change from pretreatment mean value); and same holds true for the change in haemoglobin levels as well as endometrial thickness. Ormeloxifene was found to have a greater effect on heavy menstrual bleeding in comparison to Norethisterone.Conclusions: Ormeloxifene is a new modality and is found to be a better option in reducing menorrhagia in DUB in respect to a greater success rate, better compliance and cost effectiveness.

Effects of Different Molting Procedures on Incidence of Salmonella Infection in Flocks of Naturally Contaminated Laying Hens in a Commercial Egg-Producing Farm by Detection of Yolk Antibodies to Salmonella in Eggs

2006 ◽  
Vol 69 (12) ◽  
pp. 2883-2888 ◽  
Author(s):  
TOSHIYUKI MURASE ◽  
KAORI CHIBA ◽  
TOMOKO SATO ◽  
KOICHI OTSUKI ◽  
PETER S. HOLT
Keyword(s):  
Wheat Bran ◽  
Egg Production ◽  
Egg Yolk ◽  
The Other ◽  
Feed Withdrawal ◽  
Two Samples ◽  
Significant Difference ◽  
Before And After ◽  
Specific Pathogen ◽  
Egg Yolks

Indirect enzyme-linked immunosorbent assays (ELISAs) have been applied to detect immunoglobulin Y antibodies to different serotypes of Salmonella in the yolks of chicken eggs with heat-extracted antigens of Salmonella enterica serotypes Agona (SA), Cerro (SC), Enteritidis (SE), Montevideo (SM), and Putten (SP). The egg yolk samples examined were classified as positive if their ELISA absorbance values exceeded the value for eggs from specific-pathogen-free flocks by more than two standard deviations. Of 30 egg yolk samples from three flocks vaccinated with a killed SE vaccine, 29 were antibody positive by the ELISA assay for the SE antigen. Four to 29 of the 29 yolk samples showed positive results for the other serovars, although the absorbance values for SE were higher than those obtained for the other serotypes in each of the yolk samples. All 30 yolks from three flocks that were not administered any SE vaccines were found to be antibody negative for SE, and two samples were determined to be positive for SC. Thirty-nine or 40 eggs were obtained from each of four layer flocks in a commercial egg production farm where the laying houses were naturally contaminated with SA, SC, SM, SP, Salmonella serovar Infantis (SI), and untypeable strains. The ELISA absorbance values for SM in the egg yolks obtained from the two flocks molted through feed withdrawal when the birds restarted laying were significantly (P &lt; 0.05) higher than those observed in the yolks obtained before the molt. In egg yolks from the two other flocks that were molted through a wheat bran diet, there was no significant difference between the absorbance values before and after the molt. The observations in the present study provide further evidence to suggest that a molt initiated through the administration of a wheat bran diet can reduce the risk for Salmonella problems in a commercial egg-producing setting.

The Impact of Adopting Electronic Trading System on Performance of the Amman Stock Exchange

2013 ◽  
Vol 03 (03) ◽  
pp. 29-36
Author(s):  
Najeb M.H. Masoud
Keyword(s):  
Stock Exchange ◽  
Market Value ◽  
The Other ◽  
Electronic Trading ◽  
Trading System ◽  
Two Samples ◽  
Significant Difference ◽  
Amman Stock Exchange ◽  
Before And After ◽  
The Impact

This study aims to highlight the impact of adopting electronic trading System on performance of the Amman Stock Exchange (ASE) represented in the (value traded) and (market capitalisation) where, for the implementation of that, secondary data were collected from (taken from the monthly statistical bulletins of the Stock Exchange) related to the study variables, where an analysis of the difference between the middle two samples: the first study variables before the introduction of the system, and the other after you have inserted, to find out whether there is a significant difference between the size of the stock exchange in trading before and after the introduction of the electronic trading system, and whether there is a significant difference between the value between the market value of securities listed on the stock exchange before and after the introduction of the system. The results of the study show that the use of the electronic trading system as an alternative to the manual trading system has contributed to raise the volume of trading and the market value of the ASE. We believes that the result of the increase in the degree of transparency and security for traders and investors in the stock market, and give great flexibility and different information to brokers facilitated an analysis of the situation of companies traded faster, which achieved more justice, speed and ease of execution of orders, on the other hand, the system has led to facilitate control over the trading operations and the dissemination of information in real time for both local or foreign investors which contributes to increase the depth and liquidity of the market.

scholarly journals Over-the-scope clip (OTSC) reduces surgery rate in the management of iatrogenic gastrointestinal perforations

2017 ◽  
Vol 05 (05) ◽  
pp. E389-E394 ◽  
Author(s):  
Sherine Khater ◽  
Gabriel Rahmi ◽  
Guillaume Perrod ◽  
Elia Samaha ◽  
Hedi Benosman ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Mortality Rate ◽  
Ureteral Obstruction ◽  
Mortality Rates ◽  
The Other ◽  
Significant Difference ◽  
Before And After ◽  
Over The Scope Clip ◽  
Time Periods ◽  
Second Period

Abstract Background and study aims Over-the-scope clip (OTSC) has been recently used in management of gastrointestinal perforations, but data on it are still limited. The aim of this study was to compare management of iatrogenic perforations before and after the OTSC was available in our endoscopy unit. Patients and methods We conducted a monocentric retrospective study from June 2007 to June 2015. All iatrogenic gastrointestinal perforations detected during endoscopy were included. Two time periods were compared in terms of surgery and mortality rates: before use of OTSC (June 2007 to June 2011) and after OTSC became available (June 2011 to June 2015). Results During the first period, 24 perforations were recorded. Fifteen (62.5 %) were managed with surgery. The mortality rate was 8 %. During the second period, 16 perforations occurred. In 11 patients (68.7 %), an OTSC was used to close the perforation, with complete sealing of the perforation in 100 % of cases. However, 2 patients with sigmoid perforation had to undergo surgery due to right ureteral obstruction by the clip in 1 case and to presence of a localized peritonitis in the other. The surgery rate during this period was 12.5 % (2 /16), with a statistically significant difference compared to the first period (P = 0.002). There was no mortality in the second period versus 8 % in the first one (P = 0.23). Conclusions OTSC is effective for endoluminal closure of iatrogenic perforations and results in a significant decrease in surgery rate.

scholarly journals Effect of Triweekly Interdental Brushing on Bleeding Reduction in Adults: A Six-Month Retrospective Study

Healthcare ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1239
Author(s):  
Jae-Young Lee ◽  
Seon-Jip Kim ◽  
Hyo-Jin Lee ◽  
Hyun-Jae Cho
Keyword(s):  
Retrospective Study ◽  
The Other ◽  
Significant Difference ◽  
Before And After ◽  
Interdental Brush

This study assessed the effect of triweekly interdental brushing for a period of 6 months using the bleeding on full-mouth interdental brushing (BOFIB) index. All participants answered questionnaires and were instructed to clean all interdental areas using an interdental brush at least every second day. A dentist assessed the BOFIB index of 28 participants at baseline and at 3- and 6-month follow-up visits. We stratified the participants into three groups: IB-NN, those who used the interdental brush less than three times per week both before and after this program; IB-NY, those who used the interdental brush less than three times per week before the program but at least three times per week after the program; and IB-YY, those who used it at least three times per week both before and after the program. Owing to the weekly number of interdental brushings, the IB-YY and the other two groups showed a significant difference at baseline. At the 6-month follow-up, the weekly number of interdental brushings led to a significant difference between the IB-NN and the other two groups. The BOFIB index was lower among the compliant participants than among the noncompliant participants after 3 and 6 months of triweekly interdental brushing.

scholarly journals Indonesia stock exchange: Abnormal return amid pandemic

2021 ◽  
Vol 6 (01) ◽  
pp. 15-20
Author(s):  
Gunistiyo Gunistiyo ◽  
Jaka Waskito ◽  
Yuni Utami
Keyword(s):  
Abnormal Return ◽  
Time Window ◽  
Stock Exchange ◽  
Abnormal Returns ◽  
Investment Decisions ◽  
The Other ◽  
Market Reactions ◽  
First Case ◽  
Significant Difference ◽  
Before And After

This study aims to reveal the behavior of investors on the Indonesia Stock Exchange (IDX) before and during (early) the COVID-19 pandemic. This study is an extension of references to understand market reactions in response to future crises. This study is an event study with a time window of 76 trading days before and after the first case was officially announced by the authorities in Indonesia. Taking a sample of stocks included in the Liquid Index (LQ) 45, this study measures the abnormal return and transaction volume during the pre and post-first official announced cases and test the whole data by t-test. The results of data analysis indicate that there is no difference in abnormal returns, but there is a significant difference in transaction volume. These findings indicate that, in general, the Indonesian market is quite efficient, as evident from the absence of different abnormal returns. On the other hand, the market also appears to be cautious in making investment decisions amid uncertainty.

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