Assessment of the relationship between knee ultrasound and clinical symptoms in patients with thyroid dysfunction

Abstract Objective Numerous studies have identified impaired decision making (DM) under both ambiguity and risk in adult patients with schizophrenia. However, the assessment of DM in patients with adolescent-onset schizophrenia (AOS) has been challenging as a result of the instability and heterogeneity of manifestations. The Iowa Gambling Task (IGT) and Game of Dice Task (GDT), which are frequently used to evaluate DM respectively under ambiguity and risk, are sensitive to adolescents and neuropsychiatric patients. Our research intended to examine the performance of DM in a relatively large sample of patients with AOS using the above-mentioned two tasks. We also aimed to take a closer look at the relationship between DM and symptom severity of schizophrenia. Methods We compared the performance of DM in 71 patients with AOS and 53 well-matched healthy controls using IGT for DM under ambiguity and GDT for DM under risk through net scores, total scores and feedback ration. Neuropsychological tests were conducted in all participants. Clinical symptoms were evaluated by using Positive and Negative Syndrome Scale (PANSS) in 71 patients with AOS. Pearson’s correlation revealed the relationship among total score of DM and clinical and neuropsychological data. Results Compared to healthy controls, patients with AOS failed to show learning effect and had a significant difference on the 5th block in IGT and conducted more disadvantageous choices as well as exhibited worse negative feedback rate in GDT. Apart from DM impairment under risk, diminished DM abilities under ambiguity were found related to poor executive function in AOS in the present study. Conclusions Our findings unveiled the abnormal pattern of DM in AOS, mainly reflected under the risky condition, extending the knowledge on the performance of DM under ambiguity and risk in AOS. Inefficient DM under risk may account for the lagging impulse control and the combined effects of developmental disease. In addition, our study demonstrated that the performance on IGT was related to executive function in AOS.

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The relationship of dexamethasone nonsuppression to clinical symptoms and cognitive performance in treatment-resistant schizophrenics

Schizophrenia Research ◽

10.1016/0920-9964(93)90350-r ◽

1993 ◽

Vol 9 (2-3) ◽

pp. 178 ◽

Cited By ~ 1

Author(s):

A.L. Hoff ◽

S. Espinoza ◽

M. Gustafson ◽

B. Mone ◽

D. DeVilliers ◽

...

Keyword(s):

Cognitive Performance ◽

Clinical Symptoms ◽

Treatment Resistant ◽

Relationship Of ◽

The Relationship

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MECHANISMS IN ENDOCRINOLOGY: Heart failure and thyroid dysfunction

Acta Endocrinologica ◽

10.1530/eje-12-0627 ◽

2012 ◽

Vol 167 (5) ◽

pp. 609-618 ◽

Cited By ~ 121

Author(s):

Bernadette Biondi

Keyword(s):

Heart Failure ◽

Thyroid Dysfunction ◽

Clinical Symptoms ◽

Systolic Function ◽

Evidence Synthesis ◽

The United States ◽

Antithyroid Drugs ◽

Cardiac Symptoms ◽

Appropriate Treatment ◽

Increased Risk

ContextHeart failure (HF) is a major cause of morbidity and mortality in Europe and in the United States. The aim of this review article was to assess the results of the prospective studies that evaluated the risk of HF in patients with overt and subclinical thyroid disease and discuss the mechanism of this dysfunction.Evidence AcquisitionReports published with the following search terms were searched:, thyroid, hypothyroidism, hyperthyroidism, subclinical hyperthyroidism, subclinical hypothyroidism, levothyroxine, triiodothyronine, antithyroid drugs, radioiodine, deiodinases, clinical symptoms, heart rate, HF, systolic function, diastolic function, systemic vascular resistance, endothelial function, amiodarone and atrial fibrillation. The investigation was restricted to reports published in English.Evidence SynthesisThe outcome of this analysis suggests that patients with untreated overt thyroid dysfunction are at increased risk of HF. Moreover, persistent subclinical thyroid dysfunction is associated with the development of HF in patients with serum TSH <0.1 or >10 mU/l.ConclusionsThe timely recognition and effective treatment of cardiac symptoms in patients with thyroid dysfunction is mandatory because the prognosis of HF may be improved with the appropriate treatment of thyroid dysfunction.

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Basal cortisol levels and the relationship with clinical symptoms in multiple sclerosis: a systematic review

Arquivos de Neuro-Psiquiatria ◽

10.1590/0004-282x20180091 ◽

2018 ◽

Vol 76 (9) ◽

pp. 622-634 ◽

Cited By ~ 6

Author(s):

Gabriela Magalhães Pereira ◽

Nayron Medeiros Soares ◽

Andreo Rysdyk de Souza ◽

Jefferson Becker ◽

Alessandro Finkelsztejn ◽

...

Keyword(s):

Multiple Sclerosis ◽

Systematic Review ◽

Neurodegenerative Disease ◽

Web Of Science ◽

Clinical Symptoms ◽

Depression And Anxiety ◽

Basal Cortisol ◽

Cortisol Levels ◽

The Relationship ◽

Pituitary Adrenal Axis

ABSTRACT Multiple sclerosis (MS) is a demyelinating, progressive and neurodegenerative disease. A disturbance on the hypothalamic-pituitary-adrenal axis can be observed in patients with MS, showing altered cortisol levels. We aimed to identify basal cortisol levels and verify the relationship with clinical symptoms in patients with MS. A systematic search was conducted in the databases: Pubmed, Web of Science and SCOPUS. Both higher and lower cortisol levels were associated with MS. Higher cortisol levels were associated with depression and anxiety, while lower levels were associated with depression, fatigue and urinary dysfunction. Higher cortisol levels may be associated with the progression and severity of MS.

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HAEMATURIA AND COLIC CORRELATION AS CLINICAL PREDICTORS IN URETERAL STONES PATIENTS AT UROLOGY OUTPATIENT UNIT SOETOMO HOSPITAL WITHIN JANUARY 2011 - DECEMBER 2015 PERIOD

Indonesian Journal of Urology ◽

10.32421/juri.v24i2.385 ◽

2017 ◽

Vol 24 (2) ◽

Author(s):

Wisnu Laksmana ◽

Johan Renaldo ◽

Tarmono Djojodimedjo

Keyword(s):

Medical Records ◽

Renal Colic ◽

Clinical Symptoms ◽

Ureteral Stones ◽

Clinical Predictors ◽

Design Data ◽

Outpatient Unit ◽

Specificity Test ◽

Sensitivity Specificity ◽

The Relationship

Objective: Determine the relationship between clinical symptoms of colic pain and haematuria as a predictor of ureteral stones incident at Dr Soetomo Hospital within a period of five years. Material & methods: This study is a descriptive analytic study using the sensitivity-specificity test with retrospective design. Data were collected from patient's medical records with a ureteral stone diagnosis at outpatient unit Dr Soetomo Hospital within 2011-2015. Results: Renal colic or ureter colic without haematuria had 88.32% specificity and 53.07% sensitivity in the incidence of ureteral stones at Urology Outpatient Unit Dr Soetomo Hospital within 2011-2015 period. Haematuria without colic complaint had 29.37% sensitivity and 90.17% specificity in the incidence of ureteral stones. Colic and haematuria compared with colic had 55.76% sensitivity for the incidence of ureteral stones and 70.09% specificity. While colic and haematuria compared with haematuria had a sensitivity of 77.41% for the incidence of ureteral stones and 65.92% specificity. Colic and haematuria compared to other complaints has a 58.77% sensitivity for ureteral stones incidence and 94.66% specificity. Conclusion: Colic and haematuria are clinical predictors that have a better value than the complaints of colic without haematuria and haematuria without colic, in the ureteral stones incident at Urology Outpatient Unit Dr Soetomo Hospital within 2011-2015 period. This is consistent with the literature that mentions prominent complaint in the incidence of ureteral stones is their colic pain caused by the stone through the ureteral passage, and followed by haematuria for their mucosal surface injury.

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COVID-19 and Mental Health: Predicted Mental Health Status is Associated with Clinical Symptoms and Pandemic-Related Psychological and Behavioral Responses

10.1101/2021.10.12.21264902 ◽

2021 ◽

Author(s):

Joyce Y Chung ◽

Alison Gibbons ◽

Lauren Atlas ◽

Elizabeth Ballard ◽

Monique Ernst ◽

...

Keyword(s):

Mental Health ◽

Health Status ◽

Outcome Measures ◽

Social Life ◽

Clinical Symptoms ◽

Behavioral Responses ◽

Mental Health Status ◽

Convenience Sample ◽

Social Distancing ◽

The Relationship

Abstract Background: The COVID 19 pandemic led to dramatic threats to health and social life. Study objectives are to develop a prediction model leveraging subsample of known Patient/Controls and evaluate the relationship of predicted mental health status to clinical outcome measures and pandemic-related psychological and behavioral responses during lockdown (spring/summer 2020). Methods: Online cohort study conducted by National Institute of Mental Health Intramural Research Program. Convenience sample of English speaking adults (enrolled 4/4 to 5/16/20; n=1,992). Enrollment measures: demographics, clinical history, functional status, psychiatric and family history, alcohol/drug use. Outcome measures (enrollment and q2 weeks/6 months): distress, loneliness, mental health symptoms, and COVID 19 survey. NIMH IRP Patient/Controls survey responses informed assignment of Patient Probability Scores (PPS) for all participants. Regression models analyzed the relationship between PPS and outcome measures. Outcomes: Mean age 46.0, female (82.4%), white (88.9 %). PPS correlated with distress, loneliness, depression, and mental health factors. PPS associated with negative psychological responses to COVID 19. Worry about mental health (OR 1.46) exceeded worry about physical health (OR 1.13). PPS not associated with adherence to social distancing guidelines but was with stress related to social distancing and worries about infection of self/others. Interpretation: Mental health status (PPS) was associated with concurrent clinical ratings and COVID 19 specific negative responses. A focus on mental health during the pandemic is warranted, especially among those with mental health vulnerabilities. We will include PPS when conducting longitudinal analyses of mental health trajectories and risk and resilience factors that may account for differing clinical outcomes. Funding: NIMH (ZIAMH002922); NCCIH (ZIAAT000030)

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AB0804 The relationship between autoantibodies and clinical symptoms in patients with inflammatory myopathy

10.1136/annrheumdis-2018-eular.6512 ◽

2018 ◽

Author(s):

S. Nakashima ◽

H. Nakaishi ◽

T. Kameda ◽

M. Izumikawa ◽

H. Shimada ◽

...

Keyword(s):

Clinical Symptoms ◽

Inflammatory Myopathy ◽

The Relationship

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Gormony zhirovoy tkani i funktsional'nayaaktivnost' shchitovidnoy zhelezy

Obesity and metabolism ◽

10.14341/2071-8713-5081 ◽

2010 ◽

Vol 7 (4) ◽

pp. 8-11 ◽

Cited By ~ 1

Author(s):

N A Petunina ◽

N E Al'tshuler ◽

N G Rakova ◽

L V Trukhina

Keyword(s):

Insulin Resistance ◽

Adipose Tissue ◽

Lipid Metabolism ◽

Subclinical Hypothyroidism ◽

Thyroid Dysfunction ◽

The Impact ◽

The Relationship ◽

Tissue Hormones

The review presents a recent data from the literature on the physiologic and pathophysiologic role of adipose tissue hormones (adiponectin, resistin, leptin). The article details the role of adipocytokines in atherogenesis. It also presents the results of studies depicting the relationship between subclinical hypothyroidism, lipid metabolism and insulin resistance as well as the impact of thyroid dysfunction upon the secretion of adipocytokines.

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Outcomes in treatment-resistant schizophrenia: symptoms, function and clozapine plasma concentrations

Therapeutic Advances in Psychopharmacology ◽

10.1177/20451253211037179 ◽

2021 ◽

Vol 11 ◽

pp. 204512532110371

Author(s):

Amir Krivoy ◽

Eromona Whiskey ◽

Henrietta Webb-Wilson ◽

Dan Joyce ◽

Derek K. Tracy ◽

...

Keyword(s):

Functional Outcome ◽

Clinical Symptom ◽

Clinical Improvement ◽

Clinical Symptoms ◽

Peak Plasma ◽

Plasma Concentrations ◽

Symptom Improvement ◽

Blood Concentrations ◽

Treatment Refractory ◽

The Relationship

Background: Clozapine is the only medication licenced for treating patients with treatment-refractory schizophrenia. However, there are no evidence-based guidelines as to the optimal plasma level of clozapine to aim for, and their association with clinical and functional outcome. Objective: We assessed the relationship between clinical and functional outcome measures and blood concentrations of clozapine among patients with treatment-refractory psychosis. Methods: Data were reviewed in 82 patients with treatment-refractory psychosis admitted to a specialised tertiary-level service and treated with clozapine. Analysis focussed on the relationship between clozapine and norclozapine plasma concentrations and the patient’s clinical symptoms and functional status. Results: Clinical symptom improvement was positively correlated with norclozapine plasma concentrations and inversely correlated with clozapine to norclozapine plasma concentrations ratio. Clozapine concentrations showed a bimodal association with clinical improvement (peaks around 350 and 660 ng/ml). Clinical symptom improvement correlated with functional outcomes, although there was no significant correlation between the latter and clozapine or norclozapine plasma concentrations. Conclusion: Clozapine treatment was associated with optimal clinical improvement at two different peak plasma concentrations around 350 and 650 ng/ml. Clinical improvement was associated with functional outcome; however, functionality was not directly associated with clozapine concentrations. A subset of patients may require higher clozapine plasma concentrations to achieve clinical improvement.

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Comunicare con il vecchio in difficoltŕ

IKON ◽

10.3280/ikr2006-053005 ◽

2009 ◽

pp. 111-149

Author(s):

Carlo Cristini ◽

Marcello Cesa-Bianchi

Keyword(s):

Old Age ◽

Health Workers ◽

Clinical Symptoms ◽

Living Organism ◽

Old People ◽

Behavioral Disturbances ◽

Clinical Pain ◽

Males And Females ◽

Old Age Depression ◽

The Relationship

- Increase aged produces more specific dangers about health and autonomy for many old people; it is possibile to see in aged a life dicotomy: from one side autonomies, creatives, enterprising, propositives old people, from other side old people present loose of physical and mental autonomy. There are many factors that may cause with years disabilities conditions: from changes of living organism in males and females climacteric, from loneliness to alienation, from illness to institutionalized. In old age happen traumatic events, more than other phases of life, as situations about (affective, social, professional and healthy loses) that may produce clinical pain, an affecctive and cognitive decline. In old age depression and dementia represent the more frequent mental and behavioral disturbances. Of course becomes more important to learn, to analyse knolewdge and communication, suffering aged and wih his family. The relationship especially with dement, requires attention, sensitiveness, the decodification of messages, of his identity and of social relationship. Some health workers mind always to some meanings in communication that are to be analysed especially in suffering aged, with dement. Communication and understanding of old people mean give opportunities of support, of changing, of relieving painful and of its clinical symptoms.

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