Effect of aqueous extract of Leonotis leonurus (L.) R. Br. leaves in male Wistar rats

2010 ◽  
Vol 29 (5) ◽  
pp. 377-384 ◽  
Author(s):  
SO Oyedemi ◽  
MT Yakubu ◽  
AJ Afolayan
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
Blood Cells ◽  
Density Lipoprotein ◽  
Daily Basis ◽  
Lipoprotein Cholesterol ◽  
Male Rats ◽  
Corpuscular Haemoglobin ◽  
Liver And Kidney ◽  
Mean Corpuscular Haemoglobin

The aqueous extract of the leaves of Leonotis leonurus (L.) R. Br. at the doses of 125, 250 and 500 mg/kg body weight was investigated for toxicity in male rats following administration on daily basis for 21 days. The extract did not significantly (p > .05) alter the levels of haemoglobin, packed cell volume, mean corpuscular volume, red cell distribution width, basophils, total protein, phosphorus, calcium and chloride ions of the animals. Whereas the levels of lymphocytes, eosinophils, monocytes, triacylglycerol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, atherogenic index, albumin as well as alkaline phosphatase and gamma glutamyl transferase activity were decreased by the extract, those of neutrophil, magnesium, total and conjugated bilirubin, alanine and aspartate aminotransferase as well as liver and kidney body weight ratios increased. There was decrease in the mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration and cholesterol only at the 500 mg/kg body weight of the extract, whereas the large unstained cells, sodium ions, white blood cells and uric acid increased only at 250 and 500 mg/kg body weight of the extract, respectively. The urea, creatinine and potassium increased only at 125 mg/kg body weight of the extract while the globulin content was elevated only at 500 mg/kg body weight of the extract. The doses did not produce any definite pattern of effect on the red blood cells and platelets. These alterations by the aqueous extract of L. leonurus leaves on the haematological together with the liver and kidney functional indices suggests parameter and dose-selective effects of the extract and will have consequential effects on the normal functioning of the blood system, kidney and liver of the animals. The extract is also unlikely to predispose the animals to cardiovascular risk when repeatedly consumed on daily basis at the doses investigated for 21 days. Therefore, the aqueous extract of L. leonurus leaves may not be ‘safe’ as oral remedy in male rats.

Studies on the toxicological effect of the aqueous extract of the fresh, dried and boiled berries of Solanum aculeastrum Dunal in male Wistar rats

2009 ◽  
Vol 28 (12) ◽  
pp. 765-775 ◽  
Author(s):  
OM Aboyade ◽  
MT Yakubu ◽  
DS Grierson ◽  
AJ Afolayan
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Haemoglobin Concentration ◽  
Weight Ratio ◽  
The Body ◽  
Corpuscular Haemoglobin ◽  
Toxicological Effect ◽  
Male Wistar Rats ◽  
Mean Corpuscular Haemoglobin

The toxicological effect of the aqueous extract of fresh, dried and boiled berries of Solanum aculeastrum Dunal at 1, 10 and 25 mg/kg body weight was investigated in male Wistar rats for 28 days. The parameters used were the body weight of the animals and absolute weights of the organs, haematological parameters, renal and liver functional endpoints. The animals gained appreciable weight and showed no signs of clinical toxicity. The dried (DB), boiled dried (BDB), fresh (FB) and boiled fresh berry (BFB) extracts reduced (p < .05) the heart-, liver-and spleen-body weight ratio of the animals whereas that of the lung was not altered. The kidney and testes-body weight ratios were specifically altered by the different extract. All these were not accompanied by any histomorphological changes. The extracts did not alter (p > .05) the levels of RBC, Hb, PCV and albumin of the animals. The platelets were decreased by the DB and FB whereas BFB increased this parameter. The FB and BFB at all the doses also reduced the mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) of the animals. With the exception of the FB where the creatinine and chloride levels decreased, other extracts did not alter the level of these kidney parameters. Only FB increased the levels of uric acid and urea. All the extract decreased the serum alanine aminotransferase (ALT) of the animal. The levels of total protein, globulin, total and conjugated bilirubin were not altered by DB and BDB whereas these indices were increased by FB and BFB. The DB and BDB increased the serum alkaline phosphatase (ALP) activity whereas FB decreased the activity of the enzyme. In contrast, DB and BDB decreased the serum aspartate aminotransferase (AST) activity of the animals whereas FB and BFB increased the activity of the enzyme. The FB and BFB also increased the levels of potassium, magnesium and phosphorus of the animals. Overall, the alterations in the biochemical parameters by the various extracts of S. aculeastrum berries at these doses indicated that the normal functioning of these organs may be adversely affected. However, drying and boiling might reduce the toxic effect of the berries.

scholarly journals Anti-diabetic, Antioxidants, Anti-hepatorenaltoxicity Activities of Cyperus rotundus Rhizome Extract in Alloxan-induced Diabetic Rats

2021 ◽  
Author(s):  
Mohammed Al-Awar ◽  
Turki Alqabbani
Keyword(s):  
Elevated Serum ◽  
Density Lipoprotein ◽  
Diabetic Rats ◽  
Cyperus Rotundus ◽  
Lipoprotein Cholesterol ◽  
Male Rats ◽  
Diabetic Rat ◽  
Histological Structure ◽  
Amylase Level ◽  
Liver And Kidney

Objective: The hypoglycemic, hepatorenalprotective, and antioxidant Activities of Cyperus rotundus rhizomes extract in an alloxan-induced diabetic rat model were investigated in this work.Methods: 25 Male rats were divided into 5 groups: normal control, diabetic control, diabetic of C. rotundus (200 mg/kg b.w), diabetic of C. rotundus (400 mg/kg b.w), diabetic of glibenclamide (0.6mg/kg).Treatments were administered orally for 6 weeks.Results: A single injection of alloxan to rats (150mg/kg b.w) caused pathological alterations in all studied parameters and histological structure of the pancreas. On the other hand, results showed that oral administration of C. rotundus rhizomes extract in dose of 200 and 400 mg/kg caused significant reduction in glucose, HbA1C%, &alpha;-amylase level and plasma lactate together with significant elevation in serum insulin, serum pyruvate with an improvement in insulin resistance. In line with amelioration of the diabetic state, C. rotundus rhizomes extract improved of the liver and kidney functions, and oxidative marker levels. Moreover, the extract succeeded to reduce the elevated serum total cholesterol, triglyceride (TG) and low-density lipoprotein- cholesterol (LDL-C) levels and to elevate the reduced high-density lipoprotein- cholesterol (HDL-C) level of diabetic rats.Conclusion: The investigation data concluded that C. rotundus rhizomes extract could be used as alternative treatments as antidiabetic, antioxidant and antihyperlipidemic, and agent as well as in liver and kidney protective in alloxan induced-diabetic rats. This may be related to the presence of saponin glycosides, polyphenols, flavonoids, and terpenoids in the ethanolic extract of C. rotundus rhizomes, which was discovered by phytochemical screening in this study to be present in the plant.

Physiological and Histological Study to the Effects of Monosodium Glutamate in Laboratory male Rats and the protective role of vitamin E

2019 ◽  
Vol 10 (02) ◽  
Author(s):  
Genan Musheer Ghaib AL-Khatawi ◽  
Mohammed R S AL-Attabi ◽  
Ali Fayadh Bargooth
Keyword(s):  
Body Weight ◽  
Vitamin E ◽  
Low Density Lipoprotein ◽  
Monosodium Glutamate ◽  
Density Lipoprotein ◽  
Male Rats ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Liver And Kidney

The current study was conducted at the Department of Biology, College of Science, Wasit University to investigate physiological and histological effect monosodium glutamate in laboratory male rats, preventive role of vitamin E. This study was carried out in Laboratories of College of Science, Wasit University, AL- Shaheed Dr. Fairooz Hospitals, from November 2017 to April 2018.The study included twenty-four and divided into four groups (six rats per group). the first group severe as a control group orally dosed with distilled water, and treated the second group (100 mg/kg b.w. Monosodium glutamate for 30 days, and the third group were dosed orally 200 mg/kg of b.w. for 30 days, either The fourth group were dosed with a mixture of Monosodium glutamate 200mg/kg and vitamin E 100 mg/kg of body weight for 30 days. after the trial period has been sacrificing animals for testing and chemical standards physiological and histological. As are result of by exposure to Monosodium glutamate in blood serum are negatively biochemical whole height of the level of serum cholesterol, triglycerides, Low-density lipoprotein, very- low density lipoprotein, liver enzymes, AST, ALT, ALP, creatinine level, urea serum, further more we noticed a decrease in high density lipoprotein. The preventive treatment resulted in vitamin E 100mg/kg b.w. with Monosodium glutamate 200 mg/kg b.w. (p≤ 0.05) in body weight and relative weights of organs (liver and kidney). We noticed a higher moral when treatment with vitamin E with Monosodium glutamate 100 mg/kg in high- density lipoprotein, while serum cholesterol level decrease, triglycerides, Low-density lipoprotein, very- low density lipoprotein. And liver and kidney functions have improved by low Enzyme AST, ALT, ALP, creatinine and urea serum level. Histological examination revealed that the liver and kidneys, of rats exposed 100, 200 mg/kg of Monosodium glutamate has been adversely affected by exposure to Monosodium glutamate. Whereas, the histological of the liver of animals treated with vitamin E with Monosodium glutamate natural pictures showed improvement. These results demonstrate that MSG toxic effects on the liver and kidney tissue. The more toxic than salt rate too. The study recommends to avoid using MSG as food additives and food for animals because of the toxic effects of this salt.

scholarly journals Aqueous extract of Azadirachta indica leaves favorably alters the course of streptozotocin-induced diabetes in rats: A comparative prospective cohort study

2020 ◽  
Vol 7 (7) ◽  
pp. 3877-3889
Author(s):  
Obiajulu C. Ezeigwe ◽  
Francis C. Ezeonu ◽  
Chukwudi O. Okani ◽  
Daniel N. Onwusulu ◽  
Maryclare E. Onuegbu
Keyword(s):  
Aqueous Extract ◽  
Azadirachta Indica ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Organ System ◽  
Lipoprotein Cholesterol ◽  
Male Rats ◽  
Albino Rats ◽  
Low Density ◽  
The Mean

Introduction: Azadirachta indica (neem) is one of the plants commonly used in African traditional medicine for the treatment and management of diabetes mellitus. The present study was undertaken to evaluate the effect of aqueous extract of A. indica leaves on hematology, lipid profile and organ-system function of streptozotocin-induced diabetic male rats. Methods: Thirty albino rats of Wistar strain, weighing between 120 and 150 g, were randomly divided into 6 groups (A-F) and used for the study. Group A was used as a healthy normal control. Groups B-F were induced with diabetes using 50 mg/kg bodyweight (bw.) of streptozotocin. Group B was diabetic untreated; Group C was treated with 100 mg/kg bw. metformin; Groups D to F were treated with 100, 200 and 400 mg/kg bw. of the aqueous extract, respectively. The treatment was carried out daily for a period of 28 days. At the end of the experimental period, the hematological parameters were analyzed using auto haematology analyser. Lipid profiles and histopathological investigations were performed using standard methods. Results: The results obtained showed that aqueous extract of A. indica significantly (p < 0.05) increased the hemoglobin concentration, packed cell volume, red blood cell count, and platelet count of the streptozotocin-induced diabetic rats compared with those of the diabetic-untreated rats. The mean hemoglobin concentrations for groups A, B, C, D, E and F were 11.78, 8.200, 15.18, 13.88, 14.03 and 14.93, respectively. Treatment with the graded doses of the aqueous extract of A. indica significantly (p < 0.05) reduced the total cholesterol, low-density lipoprotein cholesterol, triglycerides and very-low-density lipoprotein, compared with those of the diabetic-untreated control. Treatment also significantly (p < 0.05) increased the high-density lipoprotein cholesterol (HDL-c), compared with that of the control. The mean HDL-c concentration for groups A, B, C, D, E and F were 49.58, 29.79, 40.89, 38.53, 40.40 and 46.54, respectively. The histopathological studies showed regeneration of the pancreas, liver, kidney, heart, brain and lungs for the groups treated with the extract, compared with the diabetic-untreated animals that revealed severe damage to the organ-system functions. Conclusion: These results suggest that the aqueous extract of A. indica can be considered as an excellent remedy for diabetes and a substitute for drugs to reduce complications associated with diabetic conditions.

Mode of cellular toxicity of aqueous extract of Fadogia agrestis (Schweinf. Ex Hiern) stem in male rat liver and kidney

2009 ◽  
Vol 28 (8) ◽  
pp. 469-478 ◽  
Author(s):  
MT Yakubu ◽  
AT Oladiji ◽  
MA Akanji
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
Plasma Membranes ◽  
Experimental Period ◽  
Male Rats ◽  
Male Rat ◽  
Gamma Glutamyl Transferase ◽  
Cellular Toxicity ◽  
Liver And Kidney ◽  
Glutamyl Transferase

The mode of cellular toxicity of aqueous extract of Fadogia agrestis stem in male rats was investigated. Rats were grouped into four: A, B, C and D where A (the control) received orally 1 mL of distilled water; B, C and D (test groups) received orally 18, 50 and 100 mg/kg body weight of the extract, respectively, for 28 days. Infrared spectroscopy indicated the presence of hydroxyl (OH) and primary amine (CONH). Clinical toxicity symptoms such as respiratory distress, epistasis, salivation, hypo- and hyperactivity were not observed at any period of the experiment. No mortality was also recorded. Extract administration significantly reduced (p < .05) the activities of alkaline phosphatase, lactate dehydrogenase and gamma glutamyl transferase in the liver and kidney with corresponding increases in the serum. Serum malondialdehyde also increased significantly in all the extract-treated groups. The liver and kidney body weight ratios of the extract-treated animals compared well (P > .05) with their controls throughout the experimental period. The extract did not cause any swelling, atrophy or hypertrophy of the organs. The other evidence in this study suggests disruption of the ordered lipid bilayer of the plasma membranes of the hepatocytes and nephrons. This might have resulted from peroxidation of the polyunsaturated fatty acids on the membranes of the hepatocytes and nephrons made possible by the functional groups or the product of metabolism of the extract. This may be responsible for the compromise of the integrity of the plasma membranes of the hepatocytes and nephrons.

scholarly journals Aqueous extract of Combretum molle boughs ameliorates hyperglycaemia and hyperlipidemia in sucrose-induced insulin resistant rats

2019 ◽  
Vol 8 (4) ◽  
pp. 328-332
Author(s):  
David Miaffo ◽  
Fidele Ntchapda ◽  
Sylvie Lea Wansi ◽  
Sylviane Laure Kamani Poualeu ◽  
Albert Kamanyi
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
Density Lipoprotein ◽  
Tolerance Test ◽  
The Body ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Standard Group ◽  
Insulin Resistant ◽  
Combretum Molle

Introduction: Combretum molle R.B/G.Don (Combretaceae) is distributed especially in tropical Africa and used in treatment various diseases including diabetes. The aim of the present study was to evaluate the effects of aqueous extract from C. molle boughs (CMAE) on hyperglycemia and dyslipidemia in insulin resistant rats. Methods: Animals were divided into 5 groups and treated for 30 days. Control group received distilled water, sucrose group received 30% sucrose, standard group received 30% sucrose plus metformin (40 mg/kg), and others groups received 30% sucrose plus CMAE (250 and 500 mg/kg). Body weight, food and water intake were evaluated each 10 days for 30 days. Glucose tolerance test was performed on the 30th day of the experiment. Later on, animals were sacrificed and blood was collected for the determination of the concentration of glucose, lipids and insulin. Results: The body weight and food intake of the rats receiving 500 mg/kg of extract decreased significantly on the 30th day of the experiment. CMAE caused a significant reduction of insulin, glucose, cholesterol, triglycerides and low-density lipoprotein cholesterol levels compared to the sucrose lot. However, the extract (250 and 500 mg/kg) showed a significant increase in high-density lipoprotein cholesterol. CMAE induced a significant decrease in postprandial glycaemia. Conclusion: CMAE improved postprandial hyperglycemia and hyperlipidemia in insulin resistant rats.Consequently, CMAE may be able to delay onset of insulin resistance, and reduce the risks and complications of type 2 diabetes.

scholarly journals Evaluation of the fertility activity of the aqueous leaves extract of Zanthoxylum macrophylla (Rutaceae) on male rats

2017 ◽  
Vol 6 (5) ◽  
pp. 277-281
Author(s):  
Ngandjui Alphonse ◽  
◽  
Ngaha Njila Marie ◽  
Kenmogne Hubert ◽  
Koloko Brice Landry ◽  
...  
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
Serum Testosterone ◽  
Daily Basis ◽  
The Body ◽  
Male Rats ◽  
Serum Testosterone Level ◽  
Structural Abnormalities ◽  
Reproductive Activities ◽  
Daily Sperm Production

Zanthoxylum macrophylla, one of the useful medicinal plants in Cameroon, was scientifically conducted to find its aqueous extract leaves effect in some fertility parameters of male rats. 24 rats were randomly divided into 4 groups: Control, A, B and C group of six animals each. They received respectively 0, 100, 200 and 400 mg/kg body weight of aqueous extract of Z. macrophylla leaves on daily basis for 14 days. There were no significant changes on the body weight of treated animals. However, the weight of testis and the Daily Sperm Production respectively increased at dose of 200 mg/kg (P< 0.05 and P< 0.001) and 400 mg/kg (P< 0.01 and P< 0.001) while the weight of seminal vesicle and prostate also increased respectively at dose of 200 mg/kg (P< 0.05) and 400 mg/kg (P< 0.01) when compared to the control. The serum testosterone level significantly increased at the dose of 200 mg/kg (P< 0.01) and 400 mg/kg (P< 0.001) while the total cholesterol decreased at dose of 400 mg/kg (P< 0.05) when compared to the control. The serum protein decreased respectively at dose of 200 mg/kg (P< 0.01) and 400 mg/kg (P< 0.01) when compared to the control. The histological sections of the testis did not show any structural abnormalities in all treated animals. These results indicate that Zanthoxylum macrophylla could improve male reproductive activities.

Unwanted road to anaemia in transthyretin familial amyloid polyneuropathy may continue irrespective of tafamidis treatment

2018 ◽  
Vol 55 (5) ◽  
pp. 571-575
Author(s):  
Tokunori Ikeda ◽  
Teruaki Masuda ◽  
Mitsuharu Ueda ◽  
Taro Yamashita ◽  
Yohei Misumi ◽  
...  
Keyword(s):  
Density Lipoprotein ◽  
Familial Amyloid Polyneuropathy ◽  
Lipoprotein Cholesterol ◽  
Corpuscular Haemoglobin ◽  
Longitudinal Changes ◽  
Amyloid A ◽  
Amyloid Polyneuropathy ◽  
Mean Corpuscular Haemoglobin ◽  
Transthyretin Familial Amyloid Polyneuropathy ◽  
Blood Data

Background This retrospective longitudinal study was performed to determine whether tafamidis treatment leads to improvements in commonly used blood data for transthyretin familial amyloid polyneuropathy (TTR-FAP). Methods Commonly used blood data (complete blood count [including a haemogram], total protein, albumin, blood urea nitrogen, creatinine, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, γ-glutamyl transpeptidase, total bilirubin [T-Bil], creatine kinase, choline esterase, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, estimated glomerular filtration rate [eGFR], serum amyloid A protein, TTR, haemoglobin A1c, free triiodothyronine [FT3] and free thyroxine [FT4]) were investigated in 33 TTR-FAP patients. These values included longitudinal data at three time points: six months before or after tafamidis treatment and one year after tafamidis treatment. Longitudinal changes in each blood item were examined using a linear mixed model, adjusting for age at starting tafamidis, sex, TTR-FAP stage and value before tafamidis treatment. Results Our results show elevated TTR concentrations after tafamidis treatment. In contrast, haemoglobin, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, mean platelet volume, platelet distribution width, T-Bil, eGFR, FT3 and FT4, gradually decreased through a reference range. There were no characteristic observations in any other items. TTR binds to thyroid hormone; therefore, FT3 and FT4 decreased in inverse proportion to increased TTR concentrations. Conclusion Unfortunately, progression to anaemia may occur regardless of tafamidis treatment. Because anaemia is sometimes present in TTR-FAP, attention should be paid to longitudinal changes in commonly used blood data, irrespective of tafamidis treatment.

scholarly journals Effects of 1:1 Mixture of Anogeissus leiocarpus and Terminalia avicennioides Root Bark Extracts on Haematological Parameters, Liver and Kidney Function Indices of Male Rats

2018 ◽  
Vol 12 (5) ◽  
pp. 41-45
Author(s):  
Amadu Kayode Salau ◽  
◽  
Musa Toyin Yakubu ◽  
Adenike Temidayo Oladiji ◽  
◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Body Weight ◽  
Kidney Function ◽  
Blood Cells ◽  
Male Rats ◽  
Haematological Parameters ◽  
Root Bark ◽  
Liver And Kidney ◽  
Glutamyl Transferase ◽  
Anogeissus Leiocarpus

Background: This study evaluated the effects of 1:1 mixture of aqueous root bark extracts of Anogeissus leiocarpus (DC) Guill & Perr (Combretaceae) and Terminalia avicennioides Guill & Perr (Combretaceae) in male rats. Methods: Male rats were orally administered a 1:1 mixture of both extracts (250, 500 and 1000 mg/kg body weight) for seven days. Liver and kidney function indices, haematological parameters and the levels of malondialdehyde were evaluated in the animals at 7 days post-administration of the mixture of the extracts. Results: Administration of mixture of the extract significantly (p<0.05) increased the activities of liver and kidney alkaline phosphatase and reduced the serum alkaline phosphatase, liver and serum aspartate aminotransferase, alanine aminotransferase and gamma glutamyl transferase activities. The mixture also decreased the levels of serum chloride ions, liver and kidney malondialdehyde. Furthermore mixture significantly (p<0.05) increased the serum total protein concentrations whereas the levels of serum albumin, creatinine, urea, potassium, sodium and bicarbonate ions, red blood cells, white blood cells and their related indices were not significantly (p>0.05) altered. Conclusions: The present study revealed that the mixture caused functional toxicity of the liver and kidney of male rats without any evidence of haematotoxicity. The consumption of the 1:1 mixture of the plant extracts at 250, 500 and 1000 mg/kg body weight has some toxic implications in male rats.

scholarly journals Extract of Icacina trichanta Improves lipid Profile and CCl4- Induced Histological Changes in Wistar Rats

2019 ◽  
pp. 1-11
Author(s):  
O. D. Abu ◽  
B. M. Aleogho ◽  
F. O. Omoregie
Keyword(s):  
Lipid Profile ◽  
Normal Control ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Male Rats ◽  
Histological Changes ◽  
Aqueous Leaf Extract

Aim: This study was undertaken to investigate the effect of aqueous leaf extract of Icacina trichanta on lipid profile and CCl4- induced histological changes in Wistar rats. Study Design: Liver damage was induced with CCl4 and the rats were treated with aqueous extract of Icacina trichanta. Place and Duration of Study: This study was undertaken at the Department of Biochemistry, Faculty of Life Sciences, University of Benin, Benin City, Nigeria, between January to March 2014. Methodology: Phytochemical screening, lipid profile analysis and histopathological studies were carried out. Thirty-five male rats were divided into seven groups of five rats each. Groups I (normal control) and III rats were not induced. Groups II (negative control), IV, V, VI and VII were induced with 1.0 ml CCl4/kg body weight. Group II rats were not administered the extract, while those in group IV received 100 mg/kg bw of silymarin. Varied concentrations of the extract ranging from 200 to 400 mg/kg bw was administered to the test rats. Results: Phytochemical analyses revealed the presence of alkaloids, saponins, tannins and polyphenols. The concentration of triacylglycerol (TG) in the CCl4 control was significantly increased when compared with the normal control group (p<0.05). Concentrations of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) of the CCl4 control were significantly reduced relative to the normal control and the test rats (p<0.05). There was no significant difference in the concentration of high-density lipoprotein cholesterol (HDL-C) among the groups (p > 0.05). Results of histopathological examinations showed an ameliorative effect of aqueous leaf extract of Icacina trichanta on hepatorenal toxicity. Conclusion: Aqueous extract of I. trichanta leaf improves lipid profile and CCl4-induced histological changes in Wistar rats.

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