scholarly journals Aqueous extract of Combretum molle boughs ameliorates hyperglycaemia and hyperlipidemia in sucrose-induced insulin resistant rats

2019 ◽  
Vol 8 (4) ◽  
pp. 328-332
Author(s):  
David Miaffo ◽  
Fidele Ntchapda ◽  
Sylvie Lea Wansi ◽  
Sylviane Laure Kamani Poualeu ◽  
Albert Kamanyi
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
Density Lipoprotein ◽  
Tolerance Test ◽  
The Body ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Standard Group ◽  
Insulin Resistant ◽  
Combretum Molle

Introduction: Combretum molle R.B/G.Don (Combretaceae) is distributed especially in tropical Africa and used in treatment various diseases including diabetes. The aim of the present study was to evaluate the effects of aqueous extract from C. molle boughs (CMAE) on hyperglycemia and dyslipidemia in insulin resistant rats. Methods: Animals were divided into 5 groups and treated for 30 days. Control group received distilled water, sucrose group received 30% sucrose, standard group received 30% sucrose plus metformin (40 mg/kg), and others groups received 30% sucrose plus CMAE (250 and 500 mg/kg). Body weight, food and water intake were evaluated each 10 days for 30 days. Glucose tolerance test was performed on the 30th day of the experiment. Later on, animals were sacrificed and blood was collected for the determination of the concentration of glucose, lipids and insulin. Results: The body weight and food intake of the rats receiving 500 mg/kg of extract decreased significantly on the 30th day of the experiment. CMAE caused a significant reduction of insulin, glucose, cholesterol, triglycerides and low-density lipoprotein cholesterol levels compared to the sucrose lot. However, the extract (250 and 500 mg/kg) showed a significant increase in high-density lipoprotein cholesterol. CMAE induced a significant decrease in postprandial glycaemia. Conclusion: CMAE improved postprandial hyperglycemia and hyperlipidemia in insulin resistant rats.Consequently, CMAE may be able to delay onset of insulin resistance, and reduce the risks and complications of type 2 diabetes.

scholarly journals The Hypolipidemic Effect of Aqueous Extract of Hibiscus sabdariffa on Paracetamol-induced Hepatotoxicity in Albino Wistar Rats

2020 ◽  
pp. 54-60
Author(s):  
E. B. Umoren ◽  
J. F. Ekpenyong ◽  
O. E. Oyama ◽  
A. O. Obembe
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Treated Group ◽  
The Body ◽  
Control Group ◽  
Hypolipidemic Effect ◽  
Low Density ◽  
Hibiscus Sabdariffa

Aim of the Study: This study was undertaken to ascertain if Hibiscus sabdariffa extract can affect the lipid profile (Total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL), very low density lipoprotein (VLDL), and low density lipoprotein (LDL)) levels in a paracetamol- induced hepatotoxicity using albino Wistar rat as a model. Materials and Methods: Thirty (30) rats used for this study were divided into three groups. Group A (n=10) served as control. Group B (n=10) was administered paracetamol only at a dose of 750 mg/kg body weight. Group C (n=10) was administered paracetamol (dose 750 mg/kg body weight) and aqueous extract of H. sabdariffa (dose 10 ml/kg body weight) of the animal for 3 weeks. All animals were allowed free access to clean drinking water and normal rat chow. Results: Results of the study revealed that TC was significantly lower (p<0.05) in the paracetamol + H. sabdariffa-treated group as compared to paracetamol-treated group and control respectively. Similar trend was observed with TG, VLDL-c, LDL-c and HDL-c. However, the decrease in HDL-c was not statistically significant when compared to control. Conclusion: The presence of bioactive constituents vis; anthocyanins, flavonoids, polyvenols and free radical scavenging properties in H. sabdariffa enabled a hypolipidemic effect on the animals by lowering the levels of serum TG, VLDL-c, LDL-c despite challenge on the liver. However, it was unable to produce significant effect on HDL concentration -very important cholesterol required in high level to maintain homeostasis inside the body. This may be due to the challenge on the liver as a result of the paracetamol abuse.

scholarly journals Effects of Apple Polyphenol on Fat Metabolism in Mice

2021 ◽  
Vol 267 ◽  
pp. 02025
Author(s):  
Ruimin Fu ◽  
Wei Tang ◽  
Hong Zhang ◽  
Huiping Chang ◽  
Wuling Chen
Keyword(s):  
Body Weight ◽  
Low Density Lipoprotein ◽  
Fat Metabolism ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
The Body ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Obese Mice ◽  
Total Triglyceride

To study the regulation effect of apple polyphenol on fat metabolism in mice. The mice were randomly divided into 5 groups, except the basic control group, the other 4 groups were given high fat diet, body weight was measured once a week, and the obesity model was established. The basal control group and the obesity model group were intragastrically given normal saline (4.2mg/(kgbw.d), The three dose groups were gavaged separately with apple polyphenol 4.2, 8.4, 12.6 mg/(kg bw. d). After 4 consecutive weeks, the body weight of mice, the contents of total cholesterol (TC), total triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), malondialdehyde (MDA) in serum and the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), liver lipase (HL) and lipoprotein lipase (LPL) in serum. should be measured respectively. Apple polyphenol can significantly reduce the body weight, TG, LDL-C, TC and MDA contents, coupled with the atherosclerosis index (AI) of obese mice. It can increase the serum HDL-C content of obese mice, and effectively increase the activities of SOD, GSH-Px, HL and LPL in mice. Apple Polyphenol can reduce blood lipid and prevent atherosclerosis via regulating fat metabolism in mice.

scholarly journals Effect of Bitter Melon Extracts on Lipid Levels in Japanese Subjects: A Randomized Controlled Study

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Hiroki Kinoshita ◽  
Yasuyuki Ogata
Keyword(s):  
Body Weight ◽  
Lipid Metabolism ◽  
Systolic Pressure ◽  
Density Lipoprotein ◽  
The Body ◽  
Hot Water ◽  
Lipoprotein Cholesterol ◽  
Controlled Study ◽  
Control Group ◽  
Bitter Melon

Dyslipidemia is exemplified by high levels of low-density lipoprotein cholesterol (LDL-C) and represents a risk factor for cardiovascular diseases and requires therapeutic intervention. Several experimental studies suggest that bitter melon (Momordica charantia) improves lipid metabolism in animal models of dyslipidemia and diabetes. This study evaluated the effects of bitter melon extracts on lipid metabolism following a 30-day treatment period in Japanese adults. This randomized, double-blind, placebo-controlled trial included 43 adult volunteers who received either 100 mg of hot-water extracts of bitter melon (n = 23) or a placebo (n = 20) three times daily for 30 days. The body weight, blood pressure, and levels of LDL-C and other blood parameters of each subject were measured before and after the study period. The results showed that the intervention group exhibited significantly lower LDL-C levels (P = 0.02) as compared with the control group, and there were no significant changes in either group in terms of body weight, body mass index, systolic pressure, diastolic pressure, total cholesterol, high-density lipoprotein cholesterol, triglycerides, or blood glucose. These results suggested that bitter melon extracts might effectively lower LDL-C levels in humans and exhibit potential therapeutic value for the management of dyslipidemic conditions.

scholarly journals Duration of exposure dependent effect of carbamate treated net on serum lipid profile of Wistar rats

2021 ◽  
Vol 27 (1) ◽  
pp. 27-34
Author(s):  
R.U. Ukpanukpong ◽  
L.K. Eban ◽  
G.I. Ekpo ◽  
U.I. Aletan ◽  
D.D. Asuquo
Keyword(s):  
Body Weight ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Wistar Rats ◽  
Density Lipoprotein ◽  
The Body ◽  
Lipoprotein Cholesterol ◽  
Serum Lipid Profile ◽  
Control Group ◽  
Dependent Effect

The duration of exposure dependent effect of Carbamate treated net on serum lipid profile of female Wistar rats was investigated in this study. Eighteen (18) animals were randomly divided into three (3) study groups with six (6) rats each. Group 1 was designated as the control group while groups 2 and 3 constituted the experimental groups containing rats exposed to Carbamate treated net for 30 and 60 days respectively. The rats were exposed daily to Carbamate treated net by whole body and nose inhalation mode of exposure. The body weight of rats was measured at the commencement of the experiment and at the end of the experiment. The organ weight result obtained indicated that the body weight increased significantly in the rats of the experimental groups when compared to the rats in the control group at p<0.05. The result obtained indicated that the body weight increased significantly in the rats of the experimental groups when compared to the rats in the control group at p<0.05. The total cholesterol (TC), triacylglycerol (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) concentrations in the sera of the rats were determined at the end of the experiment. The result obtained showed that the TC, TG, HDL-C and LDL-C levels increased significantly in the rats of the experimental groups when compared to the rats in the control group at p<0.05. The observation from this study suggests that long-term exposure to Carbamate treated net in household setting may alter the level of the serum lipid profile of the experimental animals, thereby leading to various health complications.

Antidiabetic Effects of Ethanolic Extract of Ficus glomerata (L.) Roots

2020 ◽  
Vol 16 (1) ◽  
pp. 33-41
Author(s):  
Mohini C. Upadhye ◽  
Uday Deokate ◽  
Rohini Pujari ◽  
Vishnu Thakare
Keyword(s):  
Body Weight ◽  
Glucose Tolerance ◽  
Density Lipoprotein ◽  
Ethanolic Extract ◽  
Tolerance Test ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Oral Glucose ◽  
Ficus Glomerata

Background: Ficus glomerata (F. glomerata) Linn. Family Moraceace is a large tree found all over India including outer Himalayan ranges, Punjab, Chota Nagpur, Bihar, Orissa, West Bengal, Rajasthan, Deccan and also as a common plant in South India. It is planted around the home and temples. It is cultivated throughout the year, distributed in evergreen forests and moist localities. Objective: The Ethanolic Extract of roots of F. Glomerata (EEFG) belonging to the family Moraceace, was investigated for its antidiabetic activity using alloxan induced diabetic rats. Methods: Thirty rats were divided into 5 groups having 6 rats in each group. The alloxan was administered to the rats of all groups except normal control group through intraperitoneal route at a concentration of 140mg/kg body weight. A dose of 100mg/kg and 200 mg/kg body weight of EEFG was administered to alloxan induced diabetic rats. The administration of the extract was lasted for 11 days. Effectiveness of the extract on glucose, cholesterol, triglycerides, and high density lipoprotein and protein concentrations was analyzed. Results: Significant (p<0.05) reduction in the levels of glucose, cholesterol, triglyceride of the diabetic rats was observed after treatment with ethanolic extract. After subjecting to oral glucose tolerance test EEFG also showed significant improvement in glucose tolerance. Conclusion: F. glomerata root ethanolic extract showed that it possesses antidiabetic effect and can be found useful for the management of diabetes mellitus.

scholarly journals EVALUATION OF ANTI-OBESITY EFFECT OF AQUEOUS EXTRACT OF MUCUNA PRURIENS SEEDS ON RATS

2017 ◽  
Vol 9 (3) ◽  
pp. 111
Author(s):  
Javid Mansuri ◽  
Archana Paranjape
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Aqueous Extract ◽  
Density Lipoprotein ◽  
Mucuna Pruriens ◽  
Control Group ◽  
Dopamine Level ◽  
Sprague Dawley ◽  
Brain Dopamine ◽  
Standard Drug

Objective: Evaluation of the anti-obesity effect of aqueous extract of Mucuna pruriens seeds on rats.Methods: Male Sprague-Dawley (SD) rats were subjected to high-fat diet (HFD) for 12 wk. L-DOPA (12.5 mg/kg, p. o.) as standard drug and aqueous extract of Mucuna pruriens (AEMP) seeds (200 mg/kg, p. o. and 400 mg/kg, p. o.) as test drugs were administered in last 4 wk along with HFD. Body weight, food intake, body mass index (BMI), serum total cholesterol (TC), triglyceride (TG) and high-density lipoprotein (HDL) levels were measured at the end of fourth, eighth and twelfth wk, while white adipose tissue (WAT) mass and brain dopamine levels were measured at the end of the twelfth wk.Results: AEMP (200 mg/kg, p. o.) and (400 mg/kg, p. o.) treated groups showed a significant decrease in food intake and weight gain without altering BMI. Moreover, TG levels were lower in treated groups as compared to the HFD group, but no significant changes were observed in TC and HDL levels. L-DOPA-treated group showed a significant decrease in body weight, food intake, BMI and WAT. Both AEMP and L-DOPA-treated groups showed an increase in brain dopamine levels as compared to disease control group (p<0.05).Conclusion: L-DOPA and AEMP showed anti-obesity activity by reducing body weight gains, food intake and WAT weights; modulating TG with increased brain dopamine level which correlates to the inhibitory action of dopamine on reward mechanism. 

scholarly journals Effect of intermittent versus continuous calorie restriction on body weight and cardiometabolic risk markers in subjects with overweight or obesity and mild-to-moderate hypertriglyceridemia: a randomized trial

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Mahsa Maroofi ◽  
Javad Nasrollahzadeh
Keyword(s):  
Body Weight ◽  
Calorie Restriction ◽  
Density Lipoprotein ◽  
The Body ◽  
Trial Registration ◽  
Lipoprotein Cholesterol ◽  
Short Term ◽  
Significant Difference ◽  
The Impact ◽  
Overweight Or Obesity

Abstract Background Intermittent calorie restriction (ICR) is a novel method of dietary restriction for body weight control with the potential to improve obesity-related cardiometabolic markers, but the impact of this diet on subjects with hypertriglyceridemia (HTG) remains unknown. Methods Eighty-eight subjects with overweight or obesity and mild-to-moderate HTG were randomized to the continuous calorie restriction (CCR) group, or ICR group (a very low-calorie diet during 3 days of the week) for 8 weeks (44 patients in each group). Body composition, plasma lipids, glucose, insulin, adiponectin, and liver enzymes were measured at baseline and after 8 weeks. An intention-to-treat analysis was performed. Results The body weight decreased in both groups (4.07 ± 1.83 kg in the CCR group and 4.57 ± 2.21 kg in the ICR group) with no significant difference between the groups. There was no significant difference between the two groups in the reduced amount of fat mass, fat-free mass, and waist circumference. Both groups achieved a significant reduction in plasma triglycerides after 8 weeks (by 15.6 and 6.3% in ICR and CCR groups, respectively) with no difference between treatment groups. HOMA-IR improved significantly in ICR compared to the CCR group (P = 0.03). Plasma glucose, insulin, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, liver enzyme, and adiponectin were not different between the two groups. Conclusions The results of this short-term study suggest that three-days a week of the ICR is comparable to a CCR diet for the reduction of triglycerides level in patients with HTG and in the short-term it appears to be more effective than continuous dieting in improving insulin resistance. However, longer-term studies are needed to confirm these findings. Trial registration Trial registration number:NCT04143971.

scholarly journals Antihyperglycemic and Antihyperlipidemic of Karala (Momordica charantia) Fruits in Streptozotocin Induced Diabetic Rats

2012 ◽  
Vol 5 (1) ◽  
pp. 29-37 ◽  
Author(s):  
MA Hossain ◽  
M Mostofa ◽  
D Debnath ◽  
AKMR Alam ◽  
Z Yasmin ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Body Weight ◽  
Total Cholesterol ◽  
Aqueous Extract ◽  
Diabetic Rats ◽  
Momordica Charantia ◽  
The Body ◽  
Control Group ◽  
Albino Rats ◽  
Higher Doses

To investigate the antihyperglycemic and antihyperlipidemic effect of Momordica charantia (Karala), the aqueous extract of the Karala fruit was tested on streptozotocin (STZ)-induced diabetic rats. Thirty six albino rats were used in the experiment, 30 diabetic and the remaining six as negative control (T1). Diabetes was induced by administering (injecting) STZ at dose of 55mg/kg body weight. Thirty diabetic animals were randomly divided into five groups such as diabetic control group (T2) without any application of treatment, and groups T3,T4,T5 and T6 were treated with aqueous extract of Karala fruits daily at the doses of 250,    500 and 750mg/kg and glibenclamide (at a dose of 5mg/kg body weight) respectively. The body weight was taken and blood samples were collected from individual animal to determine glucose levels at 15 day interval up to 90 days. In addition, Asparate  Transaminenase(AST), Alanine Transaminenase(ALT), Alkaline Phosphatase(ALP), Total cholesterol (TCh) and Triglyceride (TGA) were determined at day 15 and at the end of the experiment. All three doses of Karala extracts reduced diabetic induced blood sugar and the reduction is comparable with standard glibenclamide (GLM) dose particularly with higher doses Karala extracts (500 and 750mg). Karala also prevented body weight loss due to induced diabetes as did by GLM treatment.. The treatment also resulted in a significant reduction of Asparate Transaminenase(AST), Alanine Transaminenase(ALT), Alkaline Phosphatase(ALP), Total cholesterol (TCh) and Triglyceride (TGA) activities of treated rats when compared to the STZ induced  diabetic rats. Higher doses of Karala (500 and 750mg/kg) are as effective as standard GLM dose on measured variables. This study demonstrated that Karala has hyperglycemia and antihyperlipidemic effect against STZ induced diabetic rats. These findings open the possibility of using Karala extract to treat diabetic animal and human patients although further research is warranted. DOI: http://dx.doi.org/10.3329/jesnr.v5i1.11550 J. Environ. Sci. & Natural Resources, 5(1): 29 - 37, 2012  

scholarly journals ERDOSTEINE: AN EFFECTIVE ANTIOXIDANT FOR PROTECTING COMPLETE FREUND’S ADJUVANT INDUCED ARTHRITIS IN RATS

2021 ◽  
pp. 71-75
Author(s):  
BANYLLA SYNMON ◽  
SANHATIDUTTA ROY ◽  
SUTAPA BISWAS MAJEE ◽  
MEGHNA PAUL ◽  
SANDIPAN DASGUPTA
Keyword(s):  
Body Weight ◽  
Test Group ◽  
The Body ◽  
Complete Freund’S Adjuvant ◽  
Control Group ◽  
Albino Rats ◽  
Standard Group ◽  
Freund’S Adjuvant ◽  
Complete Freund's Adjuvant ◽  
Freund's Adjuvant

Objective: The objective of this study was to evaluate the protective effect of Erdosteine on complete freund’s adjuvant (CFA) induced arthritic rats. Methods: Wistar Albino rats of 100–250 g were divided into five groups (n=6) and administered with 0.1 ml of CFA subcutaneously into the left hind paw except the negative control group. The standard group received methotrexate (MTX) 0.075 mg/kg body weight orally. Besides, the test groups received Erdosteine orally at a dose 10 mg/kg and 20 mg/kg bodyweight for 12 days. The changes in body weight, paw volume, hematological parameters, radiographical, and histological findings were the indicators to evaluate the efficacy of the test product. Discussion: Significant change in the body weight, paw volume, radiographical, hematological, and histological parameters were observed which supports the remarkable reduction of the arthritic development in the standard and test groups compared to the untreated group. However, the test group (Erdosteine) with the dose 20 mg/kg shows to be more potent than the test group (Erdosteine) with a dose 10 mg/kg and the standard group (MTX) to reduce the arthritic effect. Results: The test group with 20 mg/kg Erdosteine showed much better outcome than the standard group at significant (p<0.05). Therefore, Erdosteine acting as an anti-inflammatory and anti-oxidant is effective at a dose 20 mg/kg in treating the progression of rheumatoid arthritis in rats.

scholarly journals Anti-diabetic activity of rhizome extracts of Imperata cylindrical against alloxan-induced Diabetes Mellitus in rats

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 2704-2709
Author(s):  
Ranjana Kohli ◽  
Madan L Kaushik ◽  
Jai Parkash Kadian ◽  
Bhupendra Chauhan
Keyword(s):  
Body Weight ◽  
Glucose Level ◽  
Aqueous Extract ◽  
Ethanolic Extract ◽  
Treated Group ◽  
The Body ◽  
Control Group ◽  
Appreciable Effect ◽  
Aqueous Extracts ◽  
Study Results

The anti-diabetic effect of ethanolic and aqueous extracts of Imperata cylindrical  rhizomes was investigated in alloxan-induced diabeties in rats. Diabetes was induced by a single 150 mg/kg intraperitoneal dose of alloxan. Rats were divided into five groups with six rats in each group i.e. the normal control group, diabetic control group, standard group (glibenclamide, 10mg/kg, p.o.), Test-I group (200 mg/kg ethanolic extract) and Test-II group (200 mg/kg aqueous extract). The above concerned groups were inoculated on 21st day. On the last day of the experiment, fasted rats were killed by cervical dislocation. The body weight was measured at the initial day and final day. The blood samples were collected for estimation of glucose. The loss of body weight in control group, but recovery was observed in drug treated group. The serum glucose level was significant increased in diabetic rats. However, significant improvement was observed in treated group. The biochemical parameters such as HDL and proteins level were decreased in the control group but maintained in drug treated group. LDL, cholesterol, triglyceride creatinine and urea were significant increase in control group however, reduced level in drug treated group. The present study concluded that ethanolic and aqueous extracts of I. cylindrical  rhizome showed an appreciable effect in reducing the hyperglycemia and the complications associated with diabetes. However, aqueous extract is found more significant in decreasing blood glucose level in comparison to the ethanolic extract. The study results justify the traditional use of the plant as anti-diabetic.

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