Recent Trends in the Prescribing of ADHD Medications in Canadian Primary Care

2017 ◽  
Vol 24 (2) ◽  
pp. 301-308 ◽  
Author(s):  
Rachael Morkem ◽  
Scott Patten ◽  
John Queenan ◽  
David Barber
Keyword(s):  
Primary Care ◽  
Age Groups ◽  
Fold Increase ◽  
Population Based ◽  
Adhd Medication ◽  
Fourfold Increase ◽  
School Aged Children ◽  
Medication Prescribing ◽  
And Gender ◽  
Adhd Medications

Objective: The aim of this study was to describe the prevalence and incidence of ADHD medication prescribing, by age and gender, from 2005 to 2015 in Canadian primary care. Method: A population-based retrospective cohort study was conducted to evaluate the prescribing of ADHD medications between 2005 and 2015 using electronic medical record data. Yearly prevalence and incidence of ADHD medication prescribing were calculated for preschoolers (up to 5 years old), school-aged children (6-17 years old), and adults (18-65 years old) along with a description of the types of ADHD medications prescribed between 2005 and 2015. Results: Between 2005 and 2015, there was a 2.6-fold increase in the prevalence of ADHD medication prescribing to preschoolers, a 2.5-fold increase in school-aged children, and a fourfold increase in adults. There was a corresponding rise in incidence of prescribing although this rise was moderate and estimates were much lower compared with prevalence. The most commonly prescribed medication was Methylphenidate (65.0% of all ADHD medications prescribed). Conclusion: Although the prevalence of ADHD has remained stable over time, this study found an increase in the prescribing of ADHD medications in all age groups between 2005 and 2015. Incidence of new prescriptions was small relative to prevalence, suggesting that longer term treatments are being adopted.

scholarly journals Late-life suicidal behaviours among new users of antidepressants: a prospective population-based study of sociodemographic and gender factors in those aged 75 and above

BMJ Open ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. e022703 ◽  
Author(s):  
Khedidja Hedna ◽  
Karolina Andersson Sundell ◽  
Gunnel Hensing ◽  
Ingmar Skoog ◽  
Sara Gustavsson ◽  
...  
Keyword(s):  
Suicide Attempts ◽  
Nordic Country ◽  
Age Groups ◽  
Antidepressant Medication ◽  
Late Life ◽  
Sociodemographic Factors ◽  
Population Based ◽  
Entire Cohort ◽  
Hazard Ratios ◽  
And Gender

ObjectiveTo investigate sociodemographic and gender factors associated with suicide and suicide attempts among new users of antidepressants aged 75 and above.DesignRegister-based cohort study.SettingNational population-based cohort of Swedish residents aged ≥75 years.Participants185 225 patients who initiated antidepressant medication between 1 January 2007 and 31 December 2013 were followed until 31 December 2014.Main outcome measuresSuicide and suicide attempts. Fine and Gray regression models were used to analyse the sociodemographic factors (age, country of birth, marital status, education level, last occupation, income and social allowance) associated with suicidal behaviours in the entire cohort and by gender.ResultsDuring follow-up, 295 suicides and 654 suicide attempts occurred. Adjusted sub-hazard ratios (aSHRs) for suicide were lower among older age groups (aSHR 0.73, 95% CI 0.53 to 0.99 for those 85–89 years; and aSHR 0.53, 95% CI 0.33 to 0.86 for those ≥90 years). A similar pattern was observed for suicide attempts. Suicide attempts were more common among those born in foreign countries (aSHR 1.58, 95% CI 1.16 to 2.15 for those born in another Nordic country; and aSHR 1.43, 95% CI 1.06 to 1.93 for those born in non-Nordic countries). In the gender-stratified analyses, being single or divorced, and born in another Nordic country was associated with a higher risk of suicide among men. Educational and occupational history and being born in a non-Nordic country influenced risk of suicidal behaviours in women.ConclusionSuicidal behaviours occurred more commonly among new users who were ‘younger’ old adults and those with foreign background, suggesting that those groups might require greater support when initiating antidepressant therapy. Our findings suggest the need for gender-specific, multifaceted approaches to the prevention of suicidal behaviours in late life.

P5309Age and gender distributions of coronary artery calcium in the Dutch adult population: preliminary results of the ImaLife study

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
C Xia ◽  
M Rook ◽  
G J Pelgrim ◽  
J N Van Bolhuis ◽  
P M A Van Ooijen ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Reference Values ◽  
Coronary Artery Calcium ◽  
Adult Population ◽  
Age Groups ◽  
Population Based ◽  
Imaging Biomarkers ◽  
Dutch Population ◽  
Age And Gender ◽  
And Gender

Abstract Background Coronary artery calcium (CAC) scoring is a promising tool for cardiovascular risk classification. Population-based reference values are important for the clinical interpretation of CAC scores. Purpose To establish standards of CAC distributions by age and gender in an unselected Dutch population, which can be used to determine reference values. Methods ImaLife (Imaging in Lifelines) is a computed tomography (CT) based substudy of the Lifelines cohort, with a primary aim to establish reference values of imaging biomarkers for early stages of coronary artery disease in adults (above 45 years old). In total, 12,000 participants will be enrolled from an unselected adult population in the northern Netherlands for CAC scoring with third generation dual-source CT. CAC is quantified with dedicated commercial software using the Agatston method. Results Included so far were 3,702 participants (57.5% females, mean age 54 years, range 45–82 years). CAC was present in 39.2% of participants, with a higher prevalence of CAC in men (55.3%) than in women (27.3%). CAC scores increased with increasing age in both genders. The percentiles of CAC scores by age and gender groups are summarized in the table. Agatston CAC score percentiles by age and gender Percentiles Women – Age, years Men – Age, years 45–49 50–54 55–59 60–64 65∼ 45–49 50–54 55–59 60–64 65∼ N 505 634 719 260 10 355 473 543 185 18 25th 0 0 0 0 0 0 0 0 1 75 50th 0 0 0 0 4 0 1 6 22 556 75th 0 0 6 33 386 6 21 72 129 751 90th 4 26 77 120 1037 49 154 242 500 1803 Conclusion This preliminary result presents CAC distribution by age and gender in a middle-aged unselected Dutch population. Compared with the Heinz Nixdorf Recall study, CAC scores in our cohort for both genders were lower in the 5-year age groups between 45 and 64 years. Based on the overall data, expected within 2 years, reference values of CAC for the Dutch population can be established.

scholarly journals Characterization of enterotoxigenic Escherichia coli strains isolated from Nicaraguan children in hospital, primary care and community settings

2014 ◽  
Vol 63 (5) ◽  
pp. 729-734 ◽  
Author(s):  
Samuel Vilchez ◽  
Sylvia Becker-Dreps ◽  
Erick Amaya ◽  
Claudia Perez ◽  
Margarita Paniagua ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Primary Care ◽  
Age Groups ◽  
Community Setting ◽  
Population Based ◽  
Enterotoxigenic Escherichia Coli ◽  
Full Spectrum ◽  
Exact Test ◽  
Primary Care Clinics

Enterotoxigenic Escherichia coli (ETEC) is one of the most common causes of diarrhoea among young children in developing countries. ETEC vaccines offer promise in reducing the burden of ETEC disease, but the development of these vaccines relies on the characterization of ETEC isolates from a variety of settings. To best reflect the full spectrum of ETEC disease in León, Nicaragua, the aim of this study was to characterize ETEC strains isolated from children with diarrhoea attending different settings (hospital, primary care clinics and in the community) and children from different age groups. We characterized ETEC isolates in terms of their colonization factors (CFs) and enterotoxins, and determined whether these factors varied with setting and age group. Diarrhoeal stool samples were obtained from children under the age of 60 months from: (1) the regional public hospital, (2) four public primary care clinics, and (3) a population-based cohort. In total, 58 ETEC-positive isolates were analysed by multiplex-PCR assays for the identification of CFs (CS1, CS2, CS3, CS4, CS5, CS6, CS7, CS8, CS12, CS13, CS14, CS15, CS17, CS18, CS19, CS20, CS21, CS22 and CFA/I), and enterotoxins [heat-labile toxin (LT) and heat-stable variants STh and STp]. The frequency of CFs and enterotoxins was compared among the three settings and for different age groups, using Fisher’s exact test or a χ2 test. At least one CF was detected among one-half of samples; CS19 was detected among all strains in which a CF was identified, either alone or in combination with another CF. Among all CFs detected, 91.7 % were identified as members of the class 5 fimbrial family. CFs were detected more commonly among samples from infants captured in the health facility setting compared with the community setting. Overall, LT was detected among 67.2 % of samples, STh was detected among 20.7 % and both enterotoxins were detected among 12.1 %. The enterotoxin STh was detected more commonly among cases in the community, whilst a combination of STh and LT was detected more commonly among cases treated in health facilities. Our results suggest that, to protect against diarrhoeal cases associated with this E. coli pathotype in León, Nicaragua, an ETEC vaccine that effectively targets the archeotype CFA/I of the class 5 fimbrial family would be the most effective in this setting.

Inequitable distribution of implantable cardioverter defibrillators in Ontario

2007 ◽  
Vol 23 (3) ◽  
pp. 354-361 ◽  
Author(s):  
Jacob A. Udell ◽  
David N. Juurlink ◽  
Alexander Kopp ◽  
Douglas S. Lee ◽  
Jack V. Tu ◽  
...  
Keyword(s):  
Heart Failure ◽  
Fold Increase ◽  
Population Based ◽  
Implantable Cardioverter Defibrillators ◽  
Icd Implantation ◽  
Coronary Syndrome ◽  
Patients With Heart Failure ◽  
History Of ◽  
And Gender ◽  
Cardioverter Defibrillators

Objectives:Implantable cardioverter defibrillator (ICD) therapy reduces the risk of sudden death in patients with ischemic cardiomyopathy, but their novelty and cost may represent barriers to utilization. The objective of this study was to examine the influence of age, gender, place of residence, and socioeconomic status on rates of ICD implantation for the primary prevention of death.Methods:We conducted a population-based retrospective cohort study involving the entire province of Ontario, Canada. Patients were eligible if they had survived following hospitalization for heart failure from 1 January 1993, to 31 March 2004, and previously sustained an acute coronary syndrome within 5 years. Patients with an existing ICD or a documented history of cardiac arrest were excluded, as were patients who died in the hospital. Primary outcome was ICD implantation.Results:We identified 48,426 patients hospitalized for heart failure who survived to hospital discharge. Of these, 440 received an ICD, with a gradual 30-fold increase in implantation rates over the study period (.12–3.9 percent). ICD recipients were more likely to be men (odds ratio [OR] = 4.14; 95 percent confidence interval [CI], 3.24–5.30), younger than 75 years of age (OR = 3.19; 95 percent CI, 2.57–3.96), reside in a metropolitan area (OR = 1.42; 95 percent CI, 1.04–1.9), and live in a higher socioeconomic neighborhood (OR = 1.32; 95 percent CI, 1.08–1.61).Conclusions:Among patients with heart failure and a previous myocardial infarction, ICD use is increasing in Ontario. However, the application of this technology is characterized by major sociodemographic inequities. The causes and consequences of the pronounced age and gender discrepancies, in particular, warrant further investigation.

NORMATIVE VALUES OF BILATERAL SHOULDER ROTATION FLEXIBILITY FOR NIGERIANS USING SHOULDER ROTATION TEST

2019 ◽  
Vol 22 (01n02) ◽  
pp. 1950004
Author(s):  
Babatunde Olusola Adeleke Adegoke ◽  
Adeniyi Ademola Fowowe
Keyword(s):  
Survey Methods ◽  
Age Groups ◽  
Sampling Technique ◽  
Population Based ◽  
Normative Values ◽  
Steady Increase ◽  
Cross Sectional ◽  
Rotation Test ◽  
And Gender ◽  
Descriptive Survey

Context: Dearth of normative data for bilateral shoulder rotation flexibility (BSRF) for Nigerians is currently a limitation in screening of athletes and patient management. Aims: This study was designed to generate normative values for BSRF among healthy Nigerians of different age groups using the shoulder rotation test (SRT). Settings and Design: A four-stage sampling technique was used in recruiting 4000 (male [Formula: see text] 2048; female [Formula: see text] 1952) participants into this cross-sectional descriptive survey. Methods and Material: Participants aged between 5 and 64 years were grouped into 12 age strata. Participants' BSRF was measured using the Acuflex III flexibility tester. Data were analyzed using descriptive statistics of mean, standard deviation and percentiles. Results: Participants' mean age was 24.22 [Formula: see text] 14.65 years. Participants’ BSRF increased with age thus indicating reduced flexibility with age. In the twelve age groups of 5–9, 10–14, 15–19, 20–24, 25–29, 30–34, 35–39, 40–44, 45–49, 50–54, 55–59 and 60–64, the BSRF for the male participants were 26.29 [Formula: see text] 12.64cm, 37.95 [Formula: see text] 16.15cm, 54.33 [Formula: see text] 21.08cm, 58.21 [Formula: see text] 23.01cm, 65.50 [Formula: see text] 22.67cm, 74.75 [Formula: see text] 17.06cm, 74.42 [Formula: see text] 17.06cm, 77.97 [Formula: see text] 16.38cm, 81.26 [Formula: see text] 14.88cm, 82.77 [Formula: see text] 14.42cm, 86.00 [Formula: see text] 14.82cm and 93.25 [Formula: see text] 12.73cm respectively. Those for female participants were 25.34 [Formula: see text] 12.28cm, 41.12 [Formula: see text] 15.48cm, 50.46 [Formula: see text] 18.60cm, 49.19 [Formula: see text] 19.75cm, 58.26 [Formula: see text] 17.16cm, 62.40 [Formula: see text] 16.72cm, 67.32 [Formula: see text] 18.50cm, 69.37 [Formula: see text] 17.14cm, 71.80 [Formula: see text] 15.18cm, 75.21 [Formula: see text] 15.57cm, 73.55 [Formula: see text] 14.09cm and 81.21 [Formula: see text] 10.89cm respectively. Males generally had higher scores (lesser flexibility) than females across the twelve age groups except for the 10–14 year age. The percentiles of the BSRF scores for the participants showed a steady increase in BSRF scores from age 5–9years to 60–64years. Conclusion: This study generated population-based normative values according to age and gender for BSRF using the SRT for healthy Nigerians.

scholarly journals Temporal trends in use of tests in UK primary care, 2000-15: retrospective analysis of 250 million tests

BMJ ◽  
2018 ◽  
pp. k4666 ◽  
Author(s):  
Jack W O’Sullivan ◽  
Sarah Stevens ◽  
F D Richard Hobbs ◽  
Chris Salisbury ◽  
Paul Little ◽  
...  
Keyword(s):  
Primary Care ◽  
Temporal Trends ◽  
Age Groups ◽  
Fold Increase ◽  
Practice Research ◽  
Clinical Practice Research Datalink ◽  
Test Use ◽  
Over Time ◽  
Age And Sex ◽  
Total Test

Abstract Objectives To assess the temporal change in test use in UK primary care and to identify tests with the greatest increase in use. Design Retrospective cohort study. Setting UK primary care. Participants All patients registered to UK General Practices in the Clinical Practice Research Datalink, 2000/1 to 2015/16. Main outcome measures Temporal trends in test use, and crude and age and sex standardised rates of total test use and of 44 specific tests. Results 262 974 099 tests were analysed over 71 436 331 person years. Age and sex adjusted use increased by 8.5% annually (95% confidence interval 7.6% to 9.4%); from 14 869 tests per 10 000 person years in 2000/1 to 49 267 in 2015/16, a 3.3-fold increase. Patients in 2015/16 had on average five tests per year, compared with 1.5 in 2000/1. Test use also increased statistically significantly across all age groups, in both sexes, across all test types (laboratory, imaging, and miscellaneous), and 40 of the 44 tests that were studied specifically. Conclusion Total test use has increased markedly over time, in both sexes, and across all age groups, test types (laboratory, imaging, and miscellaneous) and for 40 of 44 tests specifically studied. Of the patients who underwent at least one test annually, the proportion who had more than one test increased significantly over time.

scholarly journals Incidence of Type 1 Diabetes May Be Underestimated in the Chinese Population: Evidence From 21.7 Million People Between 2007 and 2017

2021 ◽  
Author(s):  
Chang Liu ◽  
Ying-Chao Yuan ◽  
Mo-Ning Guo ◽  
Zhong Xin ◽  
Guan-Jie Chen ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Chinese Population ◽  
Age Groups ◽  
Population Based ◽  
Annual Incidence ◽  
Age Group ◽  
And Gender ◽  
Population Based Registry ◽  
Design And Methods

OBJECTIVE─ Previous reports of the annual incidence of type 1 diabetes (T1D) in China were conducted using retrospective hospital cases, which may not reflect the reality. This longitudinal study estimated T1D incidence in a 21.7-million Chinese population during 2007-2017. <p>RESEARCH DESIGN AND METHODS─ A population-based registry of T1D was performed by the Beijing Municipal Health Commission Information Center. Annual incidence and 95% confidence intervals (CI) were calculated by age group and gender. The association of gender with T1D incidence and predicted new T1D cases were assessed using Poisson regression models. Annual percentage change and average annual percentage of change were assessed using Joinpoint regression. </p> <p>RESULTS─ Overall, there were 6,875 individuals who developed T1D from 2007 to 2017 in this population. T1D incidence [95% CI] (/100,000 persons) significantly increased from 2.72 [2.51, 2.93] in 2007 to 3.60 [3.38, 3.78] in 2017 (p<0.001). The T1D onset peak was in the 10-14 age group. While no significant trend was found in the 0-14 and 15-29 age groups, T1D incidence markedly increased from 1.87 to 3.52 in ≥30 age group (p<0.05). The prevalence of diabetic ketoacidosis at diagnosis was highest in 0-4 age group. We predicted T1D new cases will increase to 1.57-fold over the next decade. </p> CONCLUSIONS─ T1D incidence in this large Chinese population is higher than has been reported previously. During 2007-2017, although the incidence peak was in the 10-14 age group, the T1D incidence increased sharply in adults but not in youth.

Abstract 145: Is the Rate of Ischemic Stroke Incidence Changing Differentially Over Time for Women and Men?

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
Jane C Khoury ◽  
Brett Kissela ◽  
Heidi Sucharew ◽  
Kathleen Alwell ◽  
Charles Moomaw ◽  
...  
Keyword(s):  
Age Groups ◽  
Population Based ◽  
Incidence Rates ◽  
Age And Gender ◽  
Stroke Incidence ◽  
Men And Women ◽  
Stroke Prevalence ◽  
And Gender ◽  
Gender Specific ◽  
Over Time

Background: A surge of midlife (age 55-64 years) stroke in women, and not in men, has previously been reported using prevalence data from NHANES. However it is not clear if this same finding would be seen within age- and gender-specific incidence rates of stroke. We sought to examine the incidence of ischemic (IS) stroke and the gender-specific trends over time in a population-based study of stroke epidemiology. Methods: Data from the population-based Greater Cincinnati and Northern Kentucky epidemiology of stroke study for adults (≥ 20 years) was used from three collection periods; 7/1993 to 6/1994, 1999, and 2005. We compared the IS stroke incidence rates in women versus men between the three study periods, in particular for the ages 35 to 65 years. Sex specific age, and race adjusted incidence rates and race adjusted, age and gender specific incidence rates were estimated and adjusted to the 2000 US population. Results: A total of 5166 incident IS strokes were identified: 1709 from 7/1993 to 6/1994, 1778 from 1999, and 1679 from 2005. These were 56% female, 18% black; mean age was 71.4 (13.7) years. Overall, IS stroke incidence declined in both women and men in 2005 compared to the previous time periods (p<0.01). However, there was a significant increase over time in stroke incidence seen in both men and women in the younger age groups in 2005, compared with 1993/94 (p<0.05). Conclusions: We found that stroke incidence is not changing differently over time for men and women. There has been an increase in IS stroke incidence in the young, but this is found in both men and women. The previously reported “surge” in middle-aged stroke prevalence may be related in part to increased rates of stroke in the young, with survival to middle-age, but our incidence findings do not explain the reported difference in prevalence found between women and men in the NHANES cohort.

Medication Use for ADHD and the Risk of Driving Citations and Crashes Among Teenage Drivers: A Population-Based Cohort Study

2020 ◽  
pp. 108705472091576
Author(s):  
Almut G. Winterstein ◽  
Yan Li ◽  
Tobias Gerhard ◽  
Stephan Linden ◽  
Jonathan J. Shuster
Keyword(s):  
Medication Use ◽  
Population Based ◽  
Motor Vehicles ◽  
Adhd Medication ◽  
Cox Models ◽  
Hazard Ratios ◽  
Driver's License ◽  
Teenage Drivers ◽  
Driving Outcomes ◽  
Adhd Medications

Objectives: To evaluate the real-world effectiveness of ADHD medications on adverse driving outcomes in teenage drivers with ADHD. Method: We retrospectively followed 15- to 20-year-old ADHD patients with valid driver’s license to compare the risk for crashes and citations between periods with and without ADHD medication use, using Florida Medicaid records linked to Department of Motor Vehicles data from 1999 to 2004. Patient-level demographic, clinical, and driver licensing characteristics as well as county-level crash and traffic statistics were adjusted in Cox models. Results: A total of 2,049 patients had 67 crashes and 319 citations. Adjusted hazard ratios comparing ADHD medication use versus no use were 1.22 (95% confidence interval [CI] = [0.66, 1.90]) and 0.89 (95% CI = [0.69, 1.13]) for crashes and citations, respectively. Conclusion: Our study showed no evidence that ADHD medication use was associated with a reduced risk of adverse driving outcomes among teenage drivers enrolled in Medicaid programs. Limitations in interpreting this finding are presented.

scholarly journals POS0053 RHEUMATOID ARTHRITIS AND THE RISK OF COVID-19 DIAGNOSIS, HOSPITALISATION AND DEATH: A POPULATION-BASED MULTI-STATE COHORT ANALYSIS INCLUDING 5,586,565 PEOPLE IN CATALONIA, SPAIN

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 232.1-232
Author(s):  
A. Vivekanantham ◽  
E. Burn ◽  
S. Fernandez-Bertolin ◽  
M. Aragon ◽  
T. Duarte-Salles ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Primary Care ◽  
General Population ◽  
Cohort Analysis ◽  
Population Based ◽  
Survival Models ◽  
Hazard Ratios ◽  
Increased Risk ◽  
And Gender ◽  
Training Programmes

Background:The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is of particular concern for people with rheumatoid arthritis (RA), with concerns that these people may be at higher risk and have poorer outcomes. However, at present the implications of COVID-19 for people with RA remain poorly understood.Objectives:To investigate the associations between rheumatoid arthritis and the risk of COVID-19 diagnosis, hospitalisation with COVID-19 and COVID-19-related death.Methods:A population-based cohort study including all individuals registered in the Information System for Research in Primary Care (SIDIAP). SIDIAP includes primary care records covering over 80% of the population of Catalonia, Spain, and was linked to region-wide SARS-CoV-2 PCR testing, hospital and mortality records. Outpatient diagnoses of COVID-19, hospitalisations with COVID-19 and deaths with COVID-19 were identified as study outcomes between 1st March and 6th May 2020. A multi-state model was used, with cause-specific Cox survival models estimated for each transition, adjusted for age and sex.Results:A total of 5,586,565 individuals were identified in SIDIAP as of the 1st March 2020, of which 16,344 had RA. RA patients were median (IQR) 63 years (52.0, 74.0) and the majority (n=11,727, 71.8%) were female. Having RA was positively associated with being diagnosed with COVID-19 (adjusted HR 1.14 (1.03 to 1.28)), with hospitalisation with COVID-19 (HR 1.66 (1.35 to 2.04)). However, we did not find an association between RA status and the risk of worsening from outpatient diagnosis to hospitalization or death, or from hospitalization to death (see Table 1).Table 1.Estimated hazard ratios, adjusted for age and gender, for individuals with rheumatoid arthritisTransitionStudy population (RA), nTotal events (RA), nHazard Ratios(95% Confidence Intervals)From general population to diagnosed with COVID-195,586,565 (16,344)88,396 (324)1.14 (1.03 to 1.28)From general population to hospitalised with COVID-195,586,565 (16,344)10,143 (90)1.66 (1.35 to 2.04)From diagnosed with COVID-19 to hospitalised with COVID-1988,396 (324)5,946 (30)0.95 (0.66 to 1.36)From diagnosed with COVID-19 to death88,396 (324)2,295 (16)0.96 (0.58 to 1.56)From hospitalised with COVID-19 to death16,089 (120)2,602 (27)1.13 (0.77 to 1.64)Conclusion:To our knowledge, this is the largest study performed to date looking at COVID-19 outcomes in RA patients. Individuals with RA were found to have an increased risk of COVID-19 diagnosis and hospitalisation with COVID-19, compared to the general population. Further research is needed to address factors associated with this including the presence of other co-morbidities, underlying RA disease activity and the use of immunosuppressive medications.Disclosure of Interests:Arani Vivekanantham: None declared, Edward Burn: None declared, Sergio Fernandez-Bertolin: None declared, Maria Aragon: None declared, Talita Duarte-Salles: None declared, Daniel Prieto-Alhambra Grant/research support from: Dr. Prieto-Alhambra reports grants and other from AMGEN, grants, non-financial support and other from UCB Biopharma, grants from Les Laboratoires Servier, outside the submitted work; and Janssen, on behalf of IMI-funded EHDEN and EMIF consortiums, and Synapse Management Partners have supported training programmes organised by DPA’s department and open for external participants.

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