Accuracy of Urologic Conditions Portrayed on Grey’s Anatomy

2021 ◽  
pp. 109019812199039
Author(s):  
Hanson Zhao ◽  
Jennifer T. Anger
Keyword(s):  
Male Genitalia ◽  
General Public ◽  
Television Series ◽  
Urologic Diseases ◽  
The Common ◽  
Insight Into

Despite the common prevalence of urologic diseases, studies have demonstrated that the general public often has little knowledge or insight into the field of urology or the role of an urologist. In this study, we investigated the context, frequency, and accuracy of urologic conditions on the television series Grey’s Anatomy. We reviewed episodes from the first 15 seasons. Episodes with urologic references were then screened and the urologic conditions, outcomes, and treatments were recorded. We identified a total of only 21 urologic events across 15 seasons and 342 episodes of Grey’s Anatomy. A total of 52% (11/21) of the conditions were related to external male genitalia. The portrayal of these conditions and the associated treatments were considered to be medically accurate within reason 62% (13/21) of the time. There is significant room for improvement to increase the portrayal of common urologic conditions and malignancies to improve the public’s awareness and perception of our specialty.

scholarly journals MicroRNAs: a complex regulatory network drives the acquisition of malignant cell phenotype

2010 ◽  
Vol 17 (1) ◽  
pp. F51-F75 ◽  
Author(s):  
Libero Santarpia ◽  
Milena Nicoloso ◽  
George A Calin
Keyword(s):  
Cancer Biology ◽  
Malignant Cell ◽  
Cell Phenotype ◽  
Endocrine Tumors ◽  
Functional Capabilities ◽  
Self Sufficiency ◽  
Multistep Process ◽  
The Common ◽  
Insight Into

Several lines of evidence indicate that tumorigenesis is a complex multistep process, and that most, if not all, cancers acquire the same set of functional capabilities during development and progression, albeit through various mechanistic strategies. Increasing data show an important role of microRNAs (miRNAs or miRs) in regulating various aspects of cancer biology. This review describes the role of microRNAs during the multiple steps that drive the progressive transformation of normal cells into highly malignant derivatives, outlining the role of microRNAs in regulating the common hallmarks of tumorigenesis: self-sufficiency in growth signals, insensitivity to antigrowth signals, abnormal apoptosis, limitless replicative potential, induction and sustained angiogenesis, and tissue invasion and metastasis. Recent evidence suggests an important role of microRNAs in the regulation of the expression of most genes regulating and coordinating a wide variety of processes in endocrine glands. We will highlight microRNAs of potential relevance to endocrine tumors and hormone-dependent cancers. Through this overview of how microRNAs regulate multiple targets and entire pathways, we will provide insight into the potential to develop new molecular microRNA-targeted therapies for endocrine tumors.

scholarly journals The Return to Ethiopia of the Twelve Tribes of Israel

2016 ◽  
Vol 90 (1-2) ◽  
pp. 1-27
Author(s):  
Giulia Bonacci
Keyword(s):  
International Expansion ◽  
Internal Dynamics ◽  
New West ◽  
Long Time ◽  
History Of ◽  
The Common ◽  
Seminal Article ◽  
Relationship Of ◽  
Insight Into

Twenty-eight years ago, F.J. van Dijk published in the New West Indian Guide what remained for a long time the only scholarly paper on the Twelve Tribes of Israel. Undoubtedly the largest Rastafari organization both in terms of membership and international expansion, the Twelve Tribes of Israel remains little known in public and academic circles. This article fills two major but closely related gaps in Van Dijk’s seminal article. The first is information on the formation and history of the Twelve Tribes, and the second is how the organization mobilized the return of members to Africa, a cornerstone of Rastafari belief. This article argues that the issue of return to the continent determined the very genesis of the organization and subsequently the development of its eighteen international branches. In its turn, this focus on return to Africa offers another perspective on the internal dynamics of the Rastafari movement, namely the structuring role of Rastafari organizations, a role which challenges the common image of Rastafari as an “acephalous” movement. Exploring the tangible relationship of Rastafari with Ethiopia, through the return to Ethiopia of members of the Twelve Tribes of Israel, offers new insight into the history of the Rastafari movement.

scholarly journals Language, Media and Ideology: CDA of an Animation, “The Donkey King”

2020 ◽  
Vol 10 (5) ◽  
pp. 366
Author(s):  
Afshan Quyyum ◽  
Sikandar Ali ◽  
Junaid Akash
Keyword(s):  
Critical Thinking ◽  
Qualitative Method ◽  
Three Dimensional ◽  
False Consciousness ◽  
Reality Construction ◽  
The Common ◽  
The Masses ◽  
Random Sampling Approach ◽  
Insight Into

The present study has looked into the hidden realities and ideologies in an animation “The Donkey King” released on 13th October 2018, by using the English subtitles. This animation seems to be a reminiscent of the Orwellian plot and is a phenomenal depiction of the contemporary political scenario in Pakistan. Realities can be constructed, ideologies can be created and false consciousness can be spread among the common masses by unknown and unseen powers of the society. The research has explicated the hidden realities and ideologies through CDA three-dimensional framework proposed by Norman Fairclough (1989, 1992a, 1993, 1995). Qualitative method with convenient random sampling approach in chronological order has been utilized to carry out the research. CDA is a combination of politics and language use and the study provides a deep insight into the role of cinema, in reality construction. The study concludes that cinema is a powerful tool capable enough to create realities and ideologies among the masses. The study also contains message for all ages that the real king is the savior of the nation no matter which creed or cast he belongs to. The study is significant to bring changes in the society and recommends some practical and useful suggestions to the readers, leaders, viewers of cinema and for the upcoming researchers who can bring a positive change in the society. The main significance of the study lies in creating awareness in the masses for the welfare of a free and open society. Additionally, the current study suggests that critical thinking is crucial for viewers and readers; critical thinking would help them not to easily get triggered by the issues intended by the powerful institutions, in which ideology and power keep important influences. This study filled many gaps and persisted with numerous gaps for upcoming researchers. It is expected that the current study is going to serve a useful reference resource for the researchers in understanding the study about ideology and power in media discourse.

scholarly journals GATHERING BY DIVESTITURE AND EXTREMISM IN DISSEMINATION IN INDIA: ROLE OF THE STATE

2021 ◽  
Vol 02 (05) ◽  
pp. 54-58
Author(s):  
Frank N.L. ◽  
Keyword(s):  
General Public ◽  
The State ◽  
Standard Material ◽  
Critical Part ◽  
The Poor ◽  
Role Of The State ◽  
Big Picture ◽  
The Common

Divestiture and constrained partition of a segment of individuals from the methods for creation are inseparably connected with state-drove financial turn of events. In an acquired post-frontier improvement worldview, a 'big picture perspective' continued in India barred individuals living at the lower part of the financial stepping stool as equivalent accomplices who regarding rising 'standard' material assumptions experience 'divestiture' by removal. Extremism dependent on this ground reality, an outcome of lopsided improvement across friendly and monetary classes and across locales, turns into a result that worries both the state and the common society. Maybe than pulling out from the framework that advanced and got broken over the long haul, the paper thinks, the state needs to assume a critical part being developed the start and base of which must be to take into certainty the minimized areas of the general public like the ancestral individuals, the discouraged, and the poor as noble and equivalent accomplices.

scholarly journals Drosophila Rab39 Attenuates Lysosomal Degradation

2021 ◽  
Vol 22 (19) ◽  
pp. 10635
Author(s):  
Zsolt Lakatos ◽  
Péter Benkő ◽  
Gábor Juhász ◽  
Péter Lőrincz
Keyword(s):  
De Novo ◽  
Fat Body ◽  
Small Gtpases ◽  
Negative Regulator ◽  
Valuable Insight ◽  
Biological Mechanisms ◽  
Lysosomal Degradation ◽  
The Common ◽  
Insight Into

Lysosomal degradation, the common destination of autophagy and endocytosis, is one of the most important elements of eukaryotic metabolism. The small GTPases Rab39A and B are potential new effectors of this pathway, as their malfunction is implicated in severe human diseases like cancer and neurodegeneration. In this study, the lysosomal regulatory role of the single Drosophila Rab39 ortholog was characterized, providing valuable insight into the potential cell biological mechanisms mediated by these proteins. Using a de novo CRISPR-generated rab39 mutant, we found no failure in the early steps of endocytosis and autophagy. On the contrary, we found that Rab39 mutant nephrocytes internalize and degrade endocytic cargo at a higher rate compared to control cells. In addition, Rab39 mutant fat body cells contain small yet functional autolysosomes without lysosomal fusion defect. Our data identify Drosophila Rab39 as a negative regulator of lysosomal clearance during both endocytosis and autophagy.

scholarly journals Promotion of exercise in the management of cystic fibrosis - summary of national meetings

2018 ◽  
Vol 6 (2) ◽  
pp. 196 ◽  
Author(s):  
Owen William Tomlinson ◽  
James Shelley ◽  
Sarah Denford ◽  
Alan R Barker ◽  
Patrick J Oades ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cystic Fibrosis ◽  
Roles And Responsibilities ◽  
Health And Wellbeing ◽  
Wide Range ◽  
The Common ◽  
Insight Into ◽  
Multi Disciplinary Team ◽  
Current Provision

Rationale, aims and objectives: Physical activity (PA) and exercise are important in maintaining and improving health and wellbeing in people with cystic fibrosis (CF) and measures of exercise capacity are useful outcomes in monitoring disease progression. The roles and responsibilities of CF multi-disciplinary team (MDT) members in supporting PA and exercise have yet to be fully defined. This communication reports on national meetings of CF MDT staff whose interest is to improve and standardise person-centered exercise provision and testing as part of routine CF care. We also introduce the role of the physiotherapy technician in supporting PA interventions.Meetings: The two meetings covered a range of presentations, discussions and workshops, focusing on the role of exercise and PA in CF management. Forty people from 15 NHS Hospital Trusts and 3 universities were asked to provide feedback via a questionnaire.Results: The common roles and responsibilities of clinical staff involved in exercise testing and prescription are described, with a wide range of duties identified. In addition, physiotherapists were reported as the main MDT member responsible for exercise provision. The majority of teams reported discussing exercise at every clinical visit (57%) and felt confident in discussing exercise with patients (67%).Conclusions: While this report highlights the current provision of exercise in CF MDTs, it also provides insight into the resources MDTs may require in order to enhance the profile of exercise within CF services, including enhanced training, guidelines and standardised clinical roles.

Regional SME and Development Agencies

2020 ◽  
pp. 35-67
Keyword(s):  
Economic Development ◽  
Regional Development ◽  
Social Economic ◽  
New Method ◽  
Development Interventions ◽  
The Common ◽  
Development Agencies ◽  
Social Economic Development ◽  
Insight Into

In Chapter 2, the author shared research evidence on the role of regional SME and development agencies, which are profiled as factors of SME support, regional development, and improvement of competitiveness. The author inquires whether it is possible to experiment with new institutional concepts with a basic role given to the agencies as facilitators of social-economic development reaching out locally, regionally, globally, and in particular, rurally. Such institutions have as their substance a series of development interventions that flow and merge into each other without sharp divisions that might inhibit entrepreneurship and, as will be seen later, rural development. What is proposed here is not a new institution as such but, rather, a new fashion of using the existing development infrastructure. The author develops this approach as experimentation with institutions, which is meant mainly to provide an insight into the fragmentary function of the common social-economic development rather than to propose a totally new method of developing an economy at the local and rural level.

scholarly journals The Role of Vesicle Trafficking Defects in the Pathogenesis of Prion and Prion-Like Disorders

2020 ◽  
Vol 21 (19) ◽  
pp. 7016
Author(s):  
Pearl Cherry ◽  
Sabine Gilch
Keyword(s):  
Neurodegenerative Diseases ◽  
Prion Diseases ◽  
Primary Component ◽  
Vesicular Trafficking ◽  
Polyglutamine Diseases ◽  
Amyloid Aggregates ◽  
The Common ◽  
Trafficking Defects ◽  
Insight Into

Prion diseases are fatal and transmissible neurodegenerative diseases in which the cellular form of the prion protein ‘PrPc’, misfolds into an infectious and aggregation prone isoform termed PrPSc, which is the primary component of prions. Many neurodegenerative diseases, like Alzheimer’s disease, Parkinson’s disease, and polyglutamine diseases, such as Huntington’s disease, are considered prion-like disorders because of the common characteristics in the propagation and spreading of misfolded proteins that they share with the prion diseases. Unlike prion diseases, these are non-infectious outside experimental settings. Many vesicular trafficking impairments, which are observed in prion and prion-like disorders, favor the accumulation of the pathogenic amyloid aggregates. In addition, many of the vesicular trafficking impairments that arise in these diseases, turn out to be further aggravating factors. This review offers an insight into the currently known vesicular trafficking defects in these neurodegenerative diseases and their implications on disease progression. These findings suggest that these impaired trafficking pathways may represent similar therapeutic targets in these classes of neurodegenerative disorders.

scholarly journals Essence of the common cold (Arch. f. klin. Med., Bd. 117, H. 6: Bd. 119, H. 3.)

2021 ◽  
Vol 18 (1) ◽  
pp. 150-151
Author(s):  
V. G.
Keyword(s):  
Common Cold ◽  
General Public ◽  
Modern Medicine ◽  
Pathogenic Role ◽  
Secondary Importance ◽  
Clinical Observations ◽  
The Common ◽  
The Moment

With the development of infectious pathology, the paramount importance that the ancient doctors so willingly attached to colds in the occurrence of various diseases, especially of an inflammatory nature, almost disappeared: in modern medicine, for a cold, only the secondary importance of the moment predisposing to certain diseases is recognized, although in the general public Until now, a view has been preserved on the important role of the common cold in the occurrence of various diseases, and clinical observations indicate that, perhaps, the pathogenic role of this factor is not so small.

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