Predictors of the physical impact of Multiple Sclerosis following community-based, exercise trial

2014 ◽  
Vol 21 (5) ◽  
pp. 590-598 ◽  
Author(s):  
M Kehoe ◽  
J Saunders ◽  
P Jakeman ◽  
S Coote
Keyword(s):  
Multiple Sclerosis ◽  
Exercise Intervention ◽  
Walking Distance ◽  
Intervention Period ◽  
Community Based ◽  
Large Variability ◽  
Exercise Interventions ◽  
Positive Effects ◽  
Lower Baseline ◽  
Physical Impact

Background: Studies evaluating exercise interventions in people with multiple sclerosis (PwMS) demonstrate small to medium positive effects and large variability on a number of outcome measures. No study to date has tried to explain this variability. Objective: This paper presents a novel exploration of data examining the predictors of outcome for PwMS with minimal gait impairment following a randomised, controlled trial evaluating community-based exercise interventions ( N = 242). Methods: The primary variable was the physical component of the Multiple Sclerosis Impact Scale-29, version 2 (MSIS-29, v2) after a 10-week, controlled intervention period. Predictors were identified a priori and were measured at baseline. Multiple linear regression was conducted. Results: Four models are presented lower MSIS-29, v2 scores after the intervention period were best predicted by a lower baseline MSIS-29,v2, a lower baseline Modified Fatigue Impact Score (physical subscale), randomisation to an exercise intervention, a longer baseline walking distance measured by the Six Minute Walk Test and female gender. This model explained 57.4% of the variance (F (5, 211) = 59.24, p < 0.01). Conclusion: These results suggest that fatigue and walking distance at baseline contribute significantly to predicting MSIS-29, v29 (physical component) after intervention, and thus should be the focus of intervention and assessment. Exercise is an important contributor to minimising the physical impact of MS, and gender-specific interventions may be warranted.

scholarly journals Perceptions of Participants in a Group, Community, Exercise Programme for People with Multiple Sclerosis

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Rosemary Clarke ◽  
Susan Coote
Keyword(s):  
Multiple Sclerosis ◽  
Exercise Programme ◽  
Psychological Benefits ◽  
Community Based ◽  
Main Trial ◽  
Exercise Interventions ◽  
Positive Effects ◽  
Evaluation Approach ◽  
The Impact

Purpose. The purpose of this study was to explore the perceptions of people with multiple sclerosis of a community based, group exercise programme.Method. A pragmatic programme evaluation approach using qualitative research design was adopted. Focus groups were used to gather data from 14 participants who had taken part in a RCT of community based exercise interventions for PwMS who used at most a stick to walk outdoors. Data were transcribed verbatim and thematic analysis was used to first identify categories and then to group them into themes.Results. Three themes emerged, psychological benefits, physical benefits, and knowledge gained. The psychological benefits included the role of the group as a social and motivational factor, empowerment, confidence, hope, sense of achievement, and pride. Physical benefits were improved energy and reduced fatigue and improved ability and participation. Knowledge gained caused a shift from thoughts that exercise might do harm, to sufficient knowledge that would give participants confidence to exercise themselves. The role of the group was a key element in the positive outcomes.Conclusions. The qualitative analysis supports the findings of the main trial confirming positive effects of community exercise interventions by reducing the impact of MS and fatigue and improving participation.

scholarly journals Interrelationship between Sleep and Exercise: A Systematic Review

2017 ◽  
Vol 2017 ◽  
pp. 1-14 ◽  
Author(s):  
Brett A. Dolezal ◽  
Eric V. Neufeld ◽  
David M. Boland ◽  
Jennifer L. Martin ◽  
Christopher B. Cooper
Keyword(s):  
Sports Medicine ◽  
Exercise Intervention ◽  
Negative Impact ◽  
Sleep Study ◽  
Exercise Interventions ◽  
Positive Effects ◽  
Study Results ◽  
Intensity Of Exercise ◽  
The Impact ◽  
The Relationship

Although a substantial body of literature has explored the relationship between sleep and exercise, comprehensive reviews and definitive conclusions about the impact of exercise interventions on sleep are lacking. Electronic databases were searched for articles published between January 2013 and March 2017. Studies were included if they possessed either objective or subjective measures of sleep and an exercise intervention that followed the guidelines recommended by the American College of Sports Medicine. Thirty-four studies met these inclusion criteria. Twenty-nine studies concluded that exercise improved sleep quality or duration; however, four found no difference and one reported a negative impact of exercise on sleep. Study results varied most significantly due to participants’ age, health status, and the mode and intensity of exercise intervention. Mixed findings were reported for children, adolescents, and young adults. Interventions conducted with middle-aged and elderly adults reported more robust results. In these cases, exercise promoted increased sleep efficiency and duration regardless of the mode and intensity of activity, especially in populations suffering from disease. Our review suggests that sleep and exercise exert substantial positive effects on one another; however, to reach a true consensus, the mechanisms behind these observations must first be elucidated.

VO2peak Response Heterogeneity in Persons with Multiple Sclerosis: To HIIT or Not to HIIT?

2021 ◽  
Author(s):  
Marit Lea Schlagheck ◽  
Anika Wucherer ◽  
Annette Rademacher ◽  
Niklas Joisten ◽  
Sebastian Proschinger ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cardiorespiratory Fitness ◽  
Exercise Intervention ◽  
Cycle Ergometer ◽  
Individual Variability ◽  
Peak Oxygen Consumption ◽  
Continuous Training ◽  
Novel Approach ◽  
Lower Baseline ◽  
High Intensity Interval

AbstractExercise is described to provoke enhancements of cardiorespiratory fitness in persons with Multiple Sclerosis (pwMS). However, a high inter-individual variability in training responses has been observed. This analysis investigates response heterogeneity in cardiorespiratory fitness following high intensity interval (HIIT) and moderate continuous training (MCT) and analyzes potential predictors of cardiorespiratory training effects in pwMS. 131 pwMS performed HIIT or MCT 3–5x/ week on a cycle ergometer for three weeks. Individual responses were classified. Finally, a multiple linear regression was conducted to examine potential associations between changes of absolute peak oxygen consumption (absolute ∆V̇O2peak/kg), training modality and participant’s characteristics. Results show a time and interaction effect for ∆V̇O2peak/kg. Absolute changes of cardiorespiratory responses were larger and the non-response proportions smaller in HIIT vs. MCT. The model accounting for 8.6% of the variance of ∆V̇O2peak/kg suggests that HIIT, younger age and lower baseline fitness predict a higher absolute ∆V̇O2peak/kg following an exercise intervention. Thus, this work implements a novel approach that investigates potential determinants of cardiorespiratory response heterogeneity within a clinical setting and analyzes a remarkable bigger sample. Further predictors need to be identified to increase the knowledge about response heterogeneity, thereby supporting the development of individualized training recommendations for pwMS.

Exercise interventions in multiple sclerosis rehabilitation need better reporting on comorbidities: a systematic scoping review

2017 ◽  
Vol 31 (10) ◽  
pp. 1305-1312 ◽  
Author(s):  
Etienne J Bisson ◽  
Afolasade Fakolade ◽  
Julie Pétrin ◽  
Julie Lamarre ◽  
Marcia Finlayson
Keyword(s):  
Multiple Sclerosis ◽  
English Language ◽  
Exercise Intervention ◽  
Gait Training ◽  
Exclusion Criterion ◽  
Positive Outcomes ◽  
Exercise Interventions ◽  
Cardiovascular Training ◽  
Randomized Control ◽  
Rehabilitation Need

Objective: To identify the extent to which exercise intervention studies in multiple sclerosis rehabilitation are addressing comorbidities and if researchers consider comorbidities as possible moderators or mediators of exercise outcomes. Methods: Five databases were searched from inception to January 8, 2016, for exercise-related terms in combination with multiple sclerosis. Studies were screened and limited to randomized control trials, full text, and English language. We assessed whether comorbidities were excluded or included, how they were reported and described, and if they were examined as possible moderators or mediators of exercise outcomes. Results: We reviewed 99 articles that included various exercise interventions, where the most common were general multi-faceted exercise training ( n=34), cardiovascular training ( n=18), progressive-resistance training ( n=12), and balance and gait training ( n=12). In total, 77 of 99 studies reported one or more comorbidities as an exclusion criterion. The most commonly excluded comorbidities were cardiovascular diseases, cognitive impairments or psychiatric disorders, and unspecified conditions or contraindications. Only nine studies reported details on excluded participants with comorbidities. Across studies that reported comorbidities of included participants ( n=8), none examined comorbidities as possible moderators or mediators of exercise outcomes. Conclusion: Although a variety of exercise interventions have positive outcomes, there is limited evidence that these interventions are generalizable to people with multiple sclerosis who have comorbid conditions.

Community-Based Exercise Intervention for Gait and Functional Fitness Improvement in an Older Population: Study Protocol

2017 ◽  
Vol 25 (1) ◽  
pp. 84-93 ◽  
Author(s):  
Fátima Ramalho ◽  
Filomena Carnide ◽  
Rita Santos-Rocha ◽  
Helô-Isa André ◽  
Vera Moniz-Pereira ◽  
...  
Keyword(s):  
Exercise Intervention ◽  
Survival Rates ◽  
Secondary Outcome ◽  
Functional Fitness ◽  
Exercise Programs ◽  
Community Based ◽  
Older Population ◽  
Exercise Interventions ◽  
Gait Parameters ◽  
And Control

Functional fitness (FF) and gait ability in older populations have been associated with increased survival rates, fall prevention, and quality of life. One possible intervention for the improvement of FF is well-structured exercise programs. However, there are inconsistent findings regarding the effects of exercise interventions in the maintenance of gait parameters. The aim of this protocol is to develop a community-based exercise intervention targeting an older population. The intervention aim is the improvement of gait parameters and FF. A control trial with follow-up will be performed. The primary outcome variables will be plantar pressure gait parameters. The secondary outcome variables will be aerobic endurance, lower limb strength, agility, and balance. These variables will be recorded at baseline and after 12, 24, and 36 weeks, in the intervention and control groups. If effective, this protocol can be used by exercise professionals in improving community exercise programs.

scholarly journals Effective recruitment strategies in an exercise trial for patients with fibromyalgia

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Michelle Park ◽  
Raveendhara R. Bannuru ◽  
Lori Lyn Price ◽  
William F. Harvey ◽  
Jeffrey B. Driban ◽  
...  
Keyword(s):  
Exercise Intervention ◽  
Controlled Trial ◽  
Urban Setting ◽  
Phone Call ◽  
Recruitment Strategies ◽  
Racially Diverse ◽  
Community Based ◽  
Exercise Interventions ◽  
Recruitment Methods ◽  
The Cost

Abstract Background Recruitment of fibromyalgia populations into long-term clinical trials involving exercise interventions is a challenge. We evaluated the cost and randomization yields of various recruitment methods used for a fibromyalgia trial in an urban setting. We also investigated differences in participant characteristics and exercise intervention adherence based on recruitment source. Methods We recruited individuals with fibromyalgia in the greater Boston area to a randomized controlled trial (RCT) using six recruitment strategies: newspaper advertisements, web advertisements, flyers, clinic referrals, direct mailing to patients in a clinic database, and word of mouth. We used the American College of Rheumatology 1990 and 2010 diagnostic criteria to screen and enroll participants. During an initial phone call to an interested participant, the study staff asked how they heard about the study. In this study, we compared the cost and yield of the six recruitment strategies as well as baseline characteristics, adherence, and attendance rates of participants across strategies. Results Our recruitment resulted in 651 prescreens, 272 screening visits, and 226 randomized participants. Advertisements in a local commuter newspaper were most effective, providing 113 of 226 randomizations, albeit high cost ($212 per randomized participant). Low-cost recruitment strategies included clinical referrals and web advertisements, but they only provided 32 and 16 randomizations. Community-based strategies including advertisement and flyers recruited a more racially diverse participant sample than clinic referrals and mailing or calling patients. There was no evidence of difference in adherence among participants recruited from various strategies. Conclusions Newspaper advertisement was the most effective and most expensive method per randomized participant for recruiting large numbers of individuals with fibromyalgia in an urban setting. Community-based strategies recruited a more racially diverse cohort than clinic-based strategies. Trial registration ClinicalTrials.gov NCT01420640. Registered on 19 August 2011.

scholarly journals Caregivers’ perception about their participation in a community-based exercise intervention - Body & Brain Project

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 900-900
Author(s):  
Oscar Ribeiro ◽  
Pedro Marques ◽  
Duarte Barros ◽  
Paula Silva ◽  
Joana Carvalho ◽  
...  
Keyword(s):  
Exercise Intervention ◽  
Decisive Role ◽  
Structured Interview ◽  
Training Intervention ◽  
Community Based ◽  
Exercise Interventions ◽  
Care Recipients ◽  
And Performance ◽  
Time And Being ◽  
Age Range

Abstract Evidence is scarce on caregivers’ perception regarding their participation in exercise interventions targeting individuals with neurocognitive disorder (NCD). This study aims to investigate the views of family caregivers of people with NCD about taking part in a community-based physical exercise intervention with their care-recipients. Twenty caregivers (N Male: 13; 66.5 ± 14.39 years old; age range: 36-88) answered to a semi-structured interview conducted by telephone about their perception on participating or not as class members of a 6-month multicomponent training intervention. Transcribed data from the interview were analyzed through thematic analysis. Main themes regard their perceived key-role in the care recipients’ participation, which included knowing their limitations, making them feel accompanied and motivated, and the possibility of providing comfort and tranquility throughout the intervention. Caregivers also mentioned the possibility of fulfilling own needs for physical activity and being engaged in new experiences. Disturbing the care recipients’ involvement and performance, the opportunity for respite during the sessions’ time, and being enrolled in the program only in specific moments or by telephone were also mentioned. Findings highlight the inclusive perspective of caregivers to take part of exercise programs designed for people with NCD, not only due to their decisive role on care-recipients engagement but also due to the associated (in-/)direct personal benefits. This data may be useful for planning and prescribing future community-based exercise interventions for NCD caregiving dyads. Trial registration: ClinicalTrials.gov - NCT04095962. Supported by FCT: “Body and Brain” (POCI-01-0145-FEDER-031808), CIAFEL (FCT/UIDB/00617/2020), and Ph.D. Grants (SFRH/BD/136635/2018) to FM (2020.05911.BD) to DB.

scholarly journals The effect of exercise therapy on fatigue in multiple sclerosis

2011 ◽  
Vol 17 (9) ◽  
pp. 1041-1054 ◽  
Author(s):  
AK Andreasen ◽  
E Stenager ◽  
U Dalgas
Keyword(s):  
Multiple Sclerosis ◽  
Exercise Therapy ◽  
Primary Outcome ◽  
Therapeutic Option ◽  
Primary Outcome Measure ◽  
Exercise Interventions ◽  
Future Studies ◽  
Positive Effects ◽  
Study Population ◽  
Positive Effect

Background: Fatigue occurs in the majority of patients with multiple sclerosis (MS) and therapeutic possibilities are few. Exercise therapy is a therapeutic option but no studies have systematically reviewed the existing literature evaluating the effect of exercise therapy on MS fatigue. Objective: To determine the effect of exercise therapy on MS fatigue by systematically reviewing the literature. Methods: A comprehensive literature search (PubMed, SweMed +, Embase, Cochrane, CINAHL, PEDro, Sport Discuss and Bibliotek.dk) was conducted. Results: Studies evaluating the effect of exercise therapy on MS fatigue show heterogeneous results and only few studies have evaluated MS fatigue as the primary outcome. The heterogeneous findings seem to be related to the selected study population, which in many studies are non-fatigued. Most studies that have included fatigued patients with MS show positive effects, although it is not clear whether any exercise modalities are superior to others because there are no comparative studies regarding different exercise interventions. Conclusion: Exercise therapy has the potential to induce a positive effect on MS fatigue, but findings are heterogeneous probably because many studies have applied non-fatigued study populations. Furthermore, only few studies have evaluated MS fatigue as the primary outcome measure, emphasizing the need for future studies within this field.

scholarly journals Exercise as an Alternative Approach for Treating Smartphone Addiction: A Systematic Review and Meta-Analysis of Random Controlled Trials

2019 ◽  
Vol 16 (20) ◽  
pp. 3912 ◽  
Author(s):  
Shijie Liu ◽  
Tao Xiao ◽  
Lin Yang ◽  
Paul D. Loprinzi
Keyword(s):  
Systematic Review ◽  
Motor Skills ◽  
Exercise Intervention ◽  
Meta Analysis ◽  
Cost Effective ◽  
Public Health Issue ◽  
Smartphone Addiction ◽  
Controlled Trials ◽  
Exercise Interventions ◽  
Positive Effects

Background: With the emergence of electronic products, smartphones have become an indispensable tool in our daily life. On the other hand, smartphone addiction has become a public health issue. To help reduce smartphone addiction, cost-effective interventions such as exercise are encouraged. Purpose: We therefore performed a systematic review and meta-analysis evaluating existing literature on the rehabilitative effects of exercise interventions for individuals with a smartphone addiction. Methods: We searched PubMed, Web of Science, Scopus, CNKI, and Wanfang from inception to September 2019. Nine eligible randomized controlled trials (RCT) were finally included for meta-analysis (SMD represents the magnitude of effect of exercise) and their methodological quality were assessed using the PEDro scale. Results: We found significant positive effects of exercise interventions (Taichi, basketball, badminton, dance, run, and bicycle) on reducing the total score (SMD = −1.30, 95% CI −1.53 to −1.07, p < 0.005, I2 = 62%) of smartphone addiction level and its four subscales (withdrawal symptom: SMD = −1.40, 95% CI −1.73 to −1.07, p < 0.001, I2 = 81%; highlight behavior: SMD = −1.95, 95% CI −2.99 to −1.66, p < 0.001, I2 = 79%; social comfort: SMD = −0.99, 95% CI −1.18 to −0.81, p = 0.27, I2 = 21%; mood change: SMD = −0.50, 95% CI 0.31 to 0.69, p = 0.25, I2 = 25%). Furthermore, we found that individuals with severe addiction level (SMD = −1.19, I2 = 0%, 95%CI:−1.19 to −0.98) benefited more from exercise engagement, as compared to those with mild to moderate addiction levels (SMD = − 0.98, I2 = 50%, 95%CI:−1.31 to −0.66); individuals with smartphone addiction who participated in exercise programs of 12 weeks and above showed significantly greater reduction on the total score (SMD = −1.70, I2 = 31.2%, 95% CI −2.04 to −1.36, p = 0.03), as compared to those who participated in less than 12 weeks of exercise intervention (SMD = −1.18, I2 = 0%, 95% CI−1.35 to −1.02, p < 0.00001). In addition, individuals with smartphone addiction who participated in exercise of closed motor skills showed significantly greater reduction on the total score (SMD = −1.22, I2 = 0 %, 95% CI −1.41 to −1.02, p = 0.56), as compared to those who participated in exercise of open motor skills (SMD = −1.17, I2 = 44%, 95% CI−1.47 to −0.0.87, p = 0.03). Conclusions: Exercise interventions may have positive effects on treating smartphone addiction and longer intervention durations may produce greater intervention effects.

scholarly journals Multicomponent Physical Exercise in Older Adults after Hospitalization: A Randomized Controlled Trial Comparing Short- vs. Long-Term Group-Based Interventions

2020 ◽  
Vol 17 (2) ◽  
pp. 666 ◽  
Author(s):  
Iñaki Echeverria ◽  
Maria Amasene ◽  
Miriam Urquiza ◽  
Idoia Labayen ◽  
Pilar Anaut ◽  
...  
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Physical Exercise ◽  
Nutritional Status ◽  
Physical Function ◽  
Mixed Model ◽  
Exercise Intervention ◽  
Exercise Interventions ◽  
Positive Effects

Multicomponent physical exercise is effective in curbing the effect of hospitalization in older adults. However, it is not well established which characteristics of the exercise interventions would optimize intervention sustainability and efficacy. This study compared the effects of two group-based multicomponent exercise interventions of different lengths in older adults after hospitalization. Fifty-five participants were randomly assigned to a short-term group-based branch (SGB, n = 27) or to a long-term group-based branch (LGB, n = 28). The SGB participated in a six-week multicomponent group-based exercise-training program followed by 18 weeks of home-based exercise. The LGB completed 12 weeks of each phase. Physical function, physical activity, quality of life, anthropometrics, and nutritional status were assessed at baseline, after 12 weeks, and after 24 weeks of intervention. Both groups improved physical function and nutritional status and increased physical activity after 12 weeks of intervention (paired student’s t-test, p < 0.01), and maintained the positive effects during the following 12 weeks. No group-by-time interaction was observed in any of the studied variables using mixed-model ANOVA. Based on these findings, we determined that 6 weeks of a group-based exercise intervention caused similar functional and nutritional benefits to a longer group-based intervention of 12 weeks when both are continued at home until 24 weeks.

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