The effects of telmisartan treatment on the abdominal fat depot in patients with metabolic syndrome and essential hypertension: Abdominal fat Depot Intervention Program of Okayama (ADIPO)

Background: Elevated circulating plasma levels of both lipopolysaccharide-binding protein (LBP) and chemerin are reported in patients with obesity, but few studies are available on lifestyle intervention programs. We investigated the association of both LBP and chemerin plasma levels with metabolic syndrome (MetS) outcomes in a lifestyle intervention in children and adolescents with abdominal obesity Methods: Twenty-nine patients enrolled in a randomized controlled trial were selected. The lifestyle intervention with a 2-month intensive phase and a subsequent 10-month follow-up consisted of a moderate calorie-restricted diet, recommendations to increase physical activity levels, and nutritional education. Results: Weight loss was accompanied by a significant reduction in MetS prevalence (−43%; p = 0.009). Chemerin (p = 0.029) and LBP (p = 0.033) plasma levels were significantly reduced at 2 months and 12 months, respectively. At the end of intervention, MetS components were associated with both LBP (p = 0.017) and chemerin (p < 0.001) plasma levels. Conclusions: We describe for the first time a reduction in both LBP and chemerin plasma levels and its association with MetS risk factors after a lifestyle intervention program in children and adolescents with abdominal obesity. Therefore, LBP and chemerin plasma levels could be used as biomarkers for the progression of cardiovascular risk in pediatric populations.

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Android Fat Depot Is More Closely Associated with Metabolic Syndrome than Abdominal Visceral Fat in Elderly People

PLoS ONE ◽

10.1371/journal.pone.0027694 ◽

2011 ◽

Vol 6 (11) ◽

pp. e27694 ◽

Cited By ~ 91

Author(s):

Seon Mee Kang ◽

Ji Won Yoon ◽

Hwa Young Ahn ◽

So Yeon Kim ◽

Kyoung Ho Lee ◽

...

Keyword(s):

Metabolic Syndrome ◽

Elderly People ◽

Visceral Fat ◽

Android Fat ◽

Abdominal Visceral Fat ◽

Fat Depot

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Abstract P033: Relationship Between Adiponectin Level and Metabolic Syndrome after Weight Loss in Patients with Abdominal Obesity

Circulation ◽

10.1161/circ.127.suppl_12.ap033 ◽

2013 ◽

Vol 127 (suppl_12) ◽

Author(s):

Aelita Berezina ◽

Olga Belyaeva ◽

Olga Berkovich ◽

Elena Baranova ◽

Tatyina Karonova

Keyword(s):

Metabolic Syndrome ◽

Weight Loss ◽

Abdominal Obesity ◽

Metabolic Disorders ◽

Intervention Program ◽

Adiponectin Level ◽

The Metabolic Syndrome ◽

Outpatient Intervention ◽

Before And After ◽

The Relationship

Objective: to investigate the relationship between adiponectin level and metabolic syndrome (MS) after weight loss in patients with abdominal obesity (AO). Method: A 3-year randomized lifestyle intervention trial performed in 153 patients with AO, age 43,2±0,8 yrs, BMI 32,1±1,9 kg/m 2 . 74 patients keep hypocaloric diet (gr.1), 79 patients keep diet and performed aerobic exercise (gr.2). Adiponectin concentration, body mass (BM), waist circumference (WC), body fat (BF), BMI, the levels of BP, glucose, insulin, HOMA-IR, TC, HDL-C, LDL-C, TG, CRP were measured before and after a 3-years outpatient intervention program. Results. 100% patients with AO had some metabolic disorders and 38% had MS before the treatment. The adiponectin levels and others parameters didn’t differ between the groups before intervention (p>0,05). In 3 years 53 (71,6%) and 58 (73,4%) patients from 1 and 2 groups reduced weight. The rate of improving BM, BMI, BF, WC, HDL-C, TG and insulin was grater in patients gr.2 (p<0,05). The favorable dynamics of MS (MS didn’t appeared at the end of study or didn’t registered in patients who had it before) didn’t differ between the groups 1 and 2 (81,1% and 91,4%, p>0,05). The increasing of adiponectin level occurred more often in patients gr.2, than gr.1 (93,1% and 58,5%, p=0,001, respectively). Adiponectin level increased only in patients gr.2 (18,0±1,1mcg/ml and 23,8±1,3 mcg/ml, p= [[Unable to Display Character: р]]=0,0001), didn’t changed in gr.1 (p>0,05). It was established that in patients with combination of weight loss and increasing of adiponectin level favorable dynamics of MS occurred more often than in patients who lost weight without increasing of adiponectin level (91,7% and 69,2%, p=0,0001). In patients with favorable dynamics of MS increasing of adiponectin level had met more often, than in patients with unfavorable dynamics of MS (MS continued or appeared) (88,6% and 11,4%, p=0,0001). Increasing of adiponectin level associated with positive dynamics of the MS - OR=9,1 (4,0-20,6). Conclusion. Combination of weight loss and increasing of adiponectin level associated with favorable dynamics of the metabolic syndrome.

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Metabolic Syndrome in Italian Obese Children and Adolescents: Stronger Association with Central Fat Depot than with Insulin Sensitivity and Birth Weight

International Journal of Hypertension ◽

10.4061/2011/257168 ◽

2011 ◽

Vol 2011 ◽

pp. 1-6 ◽

Cited By ~ 10

Author(s):

Claudia Brufani ◽

Danilo Fintini ◽

Ugo Giordano ◽

Alberto Enrico Tozzi ◽

Fabrizio Barbetti ◽

...

Keyword(s):

Metabolic Syndrome ◽

Birth Weight ◽

Insulin Sensitivity ◽

Low Birth Weight ◽

Children And Adolescents ◽

Central Obesity ◽

Obese Children ◽

Obesity Index ◽

Central Fat ◽

Fat Depot

Aim. To evaluate whether body fat distribution, birth weight, and family history for diabetes (FHD) were associated with metabolic syndrome (MetS) in children and adolescents.Methods. A total of 439 Italian obese children and adolescents (5–18 years) were enrolled. Subjects were divided into 2 groups: prepubertal and pubertal. MetS was diagnosed according to the adapted National Cholesterol Education Program criteria. Birth weight percentile, central obesity index (measured by dual-energy X-ray absorptiometry), insulin sensitivity (ISI), and disposition index were evaluated. Multivariate logistic regression models were used to determine variables associated with MetS.Results. The prevalence of MetS was 17%, with higher percentage in adolescents than in children (21 versus 12%). In the overall population, central obesity index was a stronger predictor of MetS than insulin sensitivity and low birth weight. When the two groups were considered, central fat depot remained the strongest predictor of MetS, with ISI similarly influencing the probability of MetS in the two groups and birth weight being negatively associated to MetS only in pubertal individuals. Neither FHD nor degree of fatness was a significant predictor of MetS.Conclusion. Simple clinical parameters like increased abdominal adiposity and low birth weight could be useful tools to identify European obese adolescents at risk for metabolic complications.

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Effects of a long-term lifestyle intervention program with Mediterranean diet and exercise for the management of patients with metabolic syndrome in a primary care setting

European Journal of Internal Medicine ◽

10.1016/j.ejim.2015.04.007 ◽

2015 ◽

Vol 26 (5) ◽

pp. 317-323 ◽

Cited By ~ 24

Author(s):

R. Gomez-Huelgas ◽

S. Jansen-Chaparro ◽

A.J. Baca-Osorio ◽

J. Mancera-Romero ◽

F.J. Tinahones ◽

...

Keyword(s):

Primary Care ◽

Metabolic Syndrome ◽

Mediterranean Diet ◽

Lifestyle Intervention ◽

Intervention Program ◽

Care Setting ◽

Primary Care Setting ◽

Diet And Exercise ◽

Lifestyle Intervention Program

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Metabolic syndrome and abdominal fat are associated with inflammation, but not with clinical outcomes, in peritoneal dialysis patients

Cardiovascular Diabetology ◽

10.1186/1475-2840-12-86 ◽

2013 ◽

Vol 12 (1) ◽

pp. 86 ◽

Cited By ~ 7

Author(s):

Jenq-Wen Huang ◽

Chung-Yi Yang ◽

Hon-Yen Wu ◽

Kao-Lang Liu ◽

Chi-Ting Su ◽

...

Keyword(s):

Metabolic Syndrome ◽

Peritoneal Dialysis ◽

Clinical Outcomes ◽

Abdominal Fat ◽

Dialysis Patients

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Physical Fitness and the Metabolic Syndrome in Adults From the Quebec Family Study

Canadian Journal of Applied Physiology ◽

10.1139/h05-111 ◽

2005 ◽

Vol 30 (2) ◽

pp. 140-156 ◽

Cited By ~ 21

Author(s):

Normand G. Boulé ◽

Claude Bouchard ◽

Angelo Tremblay

Keyword(s):

Metabolic Syndrome ◽

Physical Fitness ◽

Hdl Cholesterol ◽

Work Capacity ◽

Abdominal Fat ◽

Fat Free Mass ◽

Physical Work ◽

Physical Work Capacity ◽

Abdominal Adiposity ◽

The Metabolic Syndrome

Physically fit individuals have a lower risk of cardiovascular disease and type 2 diabetes. However, it is unknown whether the associations between physical fitness and the metabolic syndrome are independent of total and abdominal adiposity. Physical fitness was defined as the physical work capacity on a cycle ergometer at heart rate of 150 bpm (PWC 150) in a sample of 158 men and 198 women 20-60 years of age. PWC 150 was adjusted for fat-free mass prior to the analyses. Percent body fat was estimated by hydrostatic weighing. Visceral and subcutaneous abdominal fat were measured by computed tomography. The prevalence of the metabolic syndrome was based on two definitions. The metabolic syndrome decreased with increasing fitness in men (approx. 6 times higher in less fit vs. most fit fertile, p < 0.05) and in women (approx. 4 times higher in less fit vs. most fit tertile, p < 0.05). Fitness was negatively associated with most individual components of the metabolic syndrome, except HDL-cholesterol for which the correlation was positive. However, in men and in women, the effects of physical fitness on the individual components of the metabolic syndrome were attenuated after considering total and abdominal adiposity. Key words: aerobic capacity, adiposity, abdominal fat, insulin resistance syndrome

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Intra-abdominal fat accumulation is an important predictor of metabolic syndrome in young adults

Medicine ◽

10.1097/md.0000000000022202 ◽

2020 ◽

Vol 99 (37) ◽

pp. e22202

Author(s):

Masakazu Kobayashi ◽

Sayaka Ogawa ◽

Jun Tayama ◽

Ikuko Sagara ◽

Atsushi Takeoka ◽

...

Keyword(s):

Metabolic Syndrome ◽

Young Adults ◽

Abdominal Fat ◽

Important Predictor ◽

Fat Accumulation

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Impact of Recreational Sports Activities on Metabolic Syndrome Components in Adolescents

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17010143 ◽

2019 ◽

Vol 17 (1) ◽

pp. 143 ◽

Cited By ~ 1

Author(s):

Fernanda Faria ◽

Cheryl Howe ◽

Ricardo Faria ◽

Alynne Andaki ◽

João Carlos Marins ◽

...

Keyword(s):

Metabolic Syndrome ◽

Intervention Program ◽

Vigorous Physical Activity ◽

Low Density Lipoprotein ◽

Intervention Group ◽

Density Lipoprotein ◽

Recreational Sports ◽

Fat Percentage ◽

The Impact ◽

Sports Activities

We investigated the impact of a sports activities program on metabolic syndrome (MetS) components and pre-MetS among adolescents. Blood samples, blood pressure, weight, height, body mass index, waist circumference, body fat percentage, frequency of food consumption, daily time in moderate-to-vigorous physical activity (MVPA), and sedentary behavior (SB) of 92 male adolescents aged 14–18 years (16.07 ± 0.93) were evaluated. From this initial sample, 36 participants (39.1%) were diagnosed with pre-MetS or MetS and were invited to participate in the intervention program. Twelve individuals diagnosed with pre-MetS or MetS agreed to participate in a recreational sports activities program lasting 14 weeks. The pre- and post-sport program comparison showed a reduction in total cholesterol, low-density lipoprotein, and non-high-density lipoprotein (HDL), and an increase in HDL and MVPA time in the intervention group. Sports activities accounted for 42% of the MVPA daily recommendation, and at the end of the intervention period, only seven subjects maintained a positive diagnosis for pre-MetS or MetS. This study showed that recreational sports activities had a significant impact on the lipid profile.

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