High Risk of Suicide in Behavioral Variant Frontotemporal Dementia

Aim: The purpose of the study was to determine the prevalence of suicidal ideation and attempts in patients with behavioral variant frontotemporal dementia (bvFTD), evaluating possible risk factors for suicidality. Methods: Risk of suicide was assessed using the Scale for Suicide Ideation (SSI) in 35 patients with bvFTD and 25 controls. Results: According to SSI, 40% of patients with bvFTD had suicidal ideation in comparison to 8% of controls ( P = .009). Four patients with bvFTD have attempted suicide versus none control ( P = .006). Patients with bvFTD with suicide risk showed higher levels of anxiety, depression, stress, and hopelessness than patients without suicide risk ( P < .001). Patients who attempted suicide were younger and had a longer disease duration than those with only suicide ideation. Intriguingly, 40% of patients with parkinsonism presented high level of suicide ideation. Conclusions: Our findings show that patients with bvFTD have a high risk of suicide. Additional studies in larger populations are needed to confirm our results.

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Low dose oral ketamine treatment in chronic suicidality: An open-label pilot study

Translational Psychiatry ◽

10.1038/s41398-021-01230-z ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Adem T. Can ◽

Daniel F. Hermens ◽

Megan Dutton ◽

Cyrana C. Gallay ◽

Emma Jensen ◽

...

Keyword(s):

Suicidal Ideation ◽

Low Dose ◽

Suicide Ideation ◽

Well Being ◽

Primary Outcome Measure ◽

Open Label ◽

Oral Ketamine ◽

High Level ◽

Chronic Suicidality

AbstractRecently, low-dose ketamine has been proposed as a rapid-acting treatment option for suicidality. The majority of studies to date have utilised intravenous (IV) ketamine, however, this route of administration has limitations. On the other hand, oral ketamine can be administered in a range of settings, which is important in treating suicidality, although studies as to safety and feasibility are lacking. n = 32 adults (aged 22–72 years; 53% female) with chronic suicidal thoughts participated in the Oral Ketamine Trial on Suicidality (OKTOS), an open-label trial of sub-anaesthetic doses of oral ketamine over 6 weeks. Participants commenced with 0.5 mg/kg of ketamine, which was titrated to a maximum 3.0 mg/kg. Follow-up assessments occurred at 4 weeks after the final dose. The primary outcome measure was the Beck Scale for Suicide Ideation (BSS) and secondary measures included scales for suicidality and depressive symptoms, and measures of functioning and well-being. Mean BSS scores significantly reduced from a high level of suicidal ideation at the pre-ketamine (week 0) timepoint to below the clinical threshold at the post-ketamine (week 6) timepoint. The proportion of participants that achieved clinical improvement within the first 6 weeks was 69%, whereas 50% achieved a significant improvement by the follow-up (week 10) timepoint. Six weeks of oral ketamine treatment in participants with chronic suicidality led to significant reduction in suicidal ideation. The response observed in this study is consistent with IV ketamine trials, suggesting that oral administration is a feasible and tolerable alternative treatment for chronic suicidality.

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Suicidal Ideation Profiles in Patients with Fibromyalgia Using Transdiagnostic Psychological and Fibromyalgia-Associated Variables

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18010209 ◽

2020 ◽

Vol 18 (1) ◽

pp. 209

Author(s):

Jorge L. Ordóñez-Carrasco ◽

María Sánchez-Castelló ◽

Elena P. Calandre ◽

Isabel Cuadrado-Guirado ◽

Antonio J. Rojas-Tejada

Keyword(s):

Suicidal Ideation ◽

High Risk ◽

Suicide Risk ◽

Fibromyalgia Impact Questionnaire ◽

Cross Sectional Study ◽

Psychological Pain ◽

Cross Sectional ◽

Psychological Variables ◽

Interpersonal Needs Questionnaire ◽

High Degree

Several studies have emphasized the heterogeneity of fibromyalgia patients. Furthermore, fibromyalgia patients are considered a high-risk suicide group. The ideation-to-action framework proposes a set of transdiagnostic psychological factors involved in the development of suicidal ideation. The present study aims to explore the existence of different subgroups according to their vulnerability to suicidal ideation through these transdiagnostic psychological variables and a set of variables typically associated with fibromyalgia. In this cross-sectional study, 151 fibromyalgia patients were assessed through the Revised Fibromyalgia Impact Questionnaire, Beck Depression Inventory-II, Plutchik Suicide Risk Scale, Interpersonal Needs Questionnaire, Defeat Scale, Entrapment Scale, Psychache Scale, and Beck Hopelessness Scale. A K-means cluster analysis identified two clusters, one (45.70%) according to a low vulnerability, and a second (54.30%) with a high vulnerability to suicidal ideation. These clusters showed statistically significant differences in suicidal ideation and suicide risk. However, no differences were observed in most socio-demographic variables. In conclusion, fibromyalgia patients who present a clinical condition characterized by a moderate-high degree of physical dysfunction, overall disease impact and intensity of fibromyalgia-associated symptoms, along with a high degree of perceived burdensomeness, thwarted belongingness, defeat, entrapment, psychological pain and hopelessness, form a homogeneous group at high risk for suicidal ideation.

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Suicidal Ideation and Associated Factors among Adolescents in Northeastern Brazil

The Scientific World JOURNAL ◽

10.1155/2014/450943 ◽

2014 ◽

Vol 2014 ◽

pp. 1-8 ◽

Cited By ~ 6

Author(s):

Roberto Jerônimo dos Santos Silva ◽

Fabio Alexandre Lima dos Santos ◽

Nara Michelle Moura Soares ◽

Emerson Pardono

Keyword(s):

Suicidal Ideation ◽

Suicide Attempt ◽

Attempted Suicide ◽

Suicide Ideation ◽

Illicit Drug ◽

Violent Behavior ◽

Northeastern Brazil ◽

Significance Level ◽

Factors Associated ◽

Suicide Planning

This study aimed to identify the prevalence and factors associated with suicidal ideation among Brazilian adolescents. The instrument designed for the research was used considering three models with outcomes that identified the following: (a) adolescent had considered suicide, (b) adolescents have planned suicide, and (c) adolescents have attempted suicide. Logistic Regression was used in all models with significance level of 5%. An association between being female and suicidal ideation(OR=2.18, CI 95% 1.60 to 2.97), suicide planning(OR=1.80, CI 95% = 1.26–2.56), and suicide attempt(OR=2.91, CI 95% 1.79 to 4.75) was found. Violent behavior/involvement in fights was associated with thinking about suicide(OR=2.00, CI 95% = 1.43 to 2.81), suicide planning(OR=1.65, CI 95% = 1.10–2.46), and suicide attempt(OR=2.35, CI 95% = 1.49 to 3.70). For cigarette consumption, association was found with suicide ideation(OR=1.62, CI 95% 1.03 to 2.55), planning(OR=1.88, CI 95% = 1.15 to 3.08), and attempt(OR=2.35, CI 95% 1.37 to 4.03). For alcohol consumption, association was found with suicide ideation(OR=1.93, CI 95% 1.47 to 2.54), planning(OR=2.22, CI 95% 1.61 to 3.08), and attempt(OR=1.73, CI 95% 1.15 to 2.59). It was concluded that suicidal ideation was associated with female sex, involvement in fights, and illicit drug use.

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The effects of acceptance and commitment therapy on psychosocial impact and adherence of MDR-TB patients

Journal of Public Health Research ◽

10.4081/jphr.2021.2737 ◽

2021 ◽

Author(s):

Priyo Purnomo As’hab ◽

Budi Anna Keliat ◽

Ice Yulia Wardani

Keyword(s):

Suicidal Ideation ◽

Treatment Adherence ◽

Acceptance And Commitment Therapy ◽

Suicide Ideation ◽

Nursing Intervention ◽

Commitment Therapy ◽

Acceptance And Commitment ◽

Post Test ◽

Mdr Tb ◽

Anxiety Depression

Background: The Worldwide resistance prevalence of the first-line TB drug, rifampicin (RR-TB), in 2017 was 7.4 per 100,000 population, and 82% of them experienced multidrug-resistant tuberculosis (MDR-TB). Indonesia is the top 20 country with an MDR-TB burden, and its prevalence is 8.8 per 100,000 population. MDR-TB requires a long-time treatment and has accompanying side effects: biological and psychosocial effects. However, efforts to overcome the psychosocial impacts have not been conducted. This study aims to determine the effect of acceptance and commitment therapy (ACT) on anxiety, depression, suicidal ideation, and treatment adherence in MDR-TB patients.Design and methods: This research employed a quasi-experimental design with a pre-test three post-tests using total sampling. The pre-test was conducted before the standard nursing intervention, post-test 1 was after the standard nursing intervention, post-test 2 was after ACT session 1, and post-test 3 was after ACT session 2. Data were collected by the Hamilton Rating Scale for Anxiety (HAM-A), Beck Hopelessness Scale (BHS), a Scale for Suicide Ideation (SSI), and Morisky Medication Adherence Scale (MMAS).Results: The standard nursing action and ACT reduce anxiety (p = 0.002), reduced depression (p = 0.0001), reduced suicidal ideation (p = 0.008), and increased treatment adherence (p = 0.0001).Conclusions: The standard nursing action and ACT reduce anxiety, depression, and suicidal ideation. They increase treatment adherence recommended for use in MDR-TB patients.

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The Effects of Suicide Ideation Assessments on Urges to Self-Harm and Suicide

Crisis ◽

10.1027/0227-5910/a000233 ◽

2014 ◽

Vol 35 (2) ◽

pp. 123-131 ◽

Cited By ~ 12

Author(s):

Rahel Eynan ◽

Yvonne Bergmans ◽

Jesmin Antony ◽

John R. Cutcliffe ◽

Henry G. Harder ◽

...

Keyword(s):

Suicidal Ideation ◽

Suicide Risk ◽

Suicide Ideation ◽

Psychiatric Service ◽

Exclusion Criterion ◽

Primary Concern ◽

Assessment Protocol ◽

Self Harm ◽

Study Participants

Background: Participants’ safety is the primary concern when conducting research with suicidal or potentially suicidal participants. The presence of suicide risk is often an exclusion criterion for research participants. Subsequently, few studies have examined the effects of research assessments on study participants’ suicidality. Aims: The purpose of this research was to examine the patterns of postassessment changes in self-harm and suicide urges of study participants who were recently discharged from an inpatient psychiatric service. Method: Study participants (N = 120) were recruited from patients with a lifetime history of suicidal behavior admitted with current suicidal ideation or suicide attempt to an inpatient psychiatric service and/or a crisis stabilization unit. Participants were assessed for suicidal ideation with the Suicide Ideation Scale at 1, 3, and 6 months following their discharge from hospital. The risk assessment protocol was administered at the start and at the end of each of the study follow-up assessments. Results: Changes in self-harm and suicide urges following study assessments were small, infrequent, and were most likely to reflect a decrease in suicidality. Similarly, participants rarely reported worsening self-control over suicidal urges, and when they did, the effect was minimal. By the end of the 6-month follow-up period, increases in self-harm and suicidal urges postassessment were not seen. Conclusion: The inclusion of suicidal participants in research interviews rarely increased suicide risk. Research involving suicidal individuals is possible when study protocols are well planned and executed by trained assessors and clinicians who are able to identify participants at risk and provide intervention if necessary. The few participants that required intervention had high levels of suicide ideation and behavior at baseline and almost all reported symptoms of posttraumatic stress disorder. Further study is needed to better characterize this subgroup of participants.

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Differences in Suicide Risk Severity Among Suicidal Youth With Anxiety Disorders

Crisis ◽

10.1027/0227-5910/a000571 ◽

2019 ◽

Vol 40 (5) ◽

pp. 333-339 ◽

Cited By ~ 3

Author(s):

Joanna Herres ◽

Annie Shearer ◽

Tamar Kodish ◽

Barunie Kim ◽

Shirley B. Wang ◽

...

Keyword(s):

Anxiety Disorder ◽

Suicidal Ideation ◽

Social Anxiety ◽

Anxiety Disorders ◽

Suicide Risk ◽

Suicide Ideation ◽

Self Report ◽

Health Concern ◽

Future Research ◽

Major Depressive

Abstract. Background: Adolescent suicidality is a growing public health concern. Although evidence supports a link between anxiety and suicidality, little is known about risk associated with specific anxiety disorders. Aims: This study examined the prevalence of anxiety disorders in a sample of adolescents with depression and suicidal ideation and the associations between specific anxiety disorders and suicide ideation severity and attempt history. Method: The sample consisted of 115 adolescents ( Mage= 14.96 years; 55.8% African American) entering a clinical trial for suicidal ideation and depressive symptoms. Prior to treatment, adolescents completed self-report and interview measures. Results: In all, 48% of the sample met criteria for an anxiety disorder, 22% met criteria for social anxiety disorder (SAD), and 40% met criteria for major depressive disorder (MDD). SAD was uniquely associated with more severe suicidal ideation. Limitations: Findings may not generalize to all suicidal adolescents, and non-measured variables may account for the observed relationships. Conclusion: Future research should examine whether targeting social anxiety would improve treatment response for suicidal adolescents.

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Az alacsony szérumkoleszterin-szint mint lehetséges öngyilkossági rizikótényező

Orvosi Hetilap ◽

10.1556/650.2021.32225 ◽

2021 ◽

Vol 162 (43) ◽

pp. 1732-1739

Author(s):

Edina Dimény ◽

Erika Bán ◽

László Gyula Fekete ◽

Attila Brassai

Keyword(s):

Suicidal Ideation ◽

Total Cholesterol ◽

Suicide Risk ◽

Suicide Ideation ◽

Psychiatric Patients ◽

Total Cholesterol Level ◽

Risk Category ◽

Moderate Risk ◽

Cholesterol Levels ◽

Hospital Referral

Összefoglaló. Bevezetés: A koleszterinszint a köztudatban elsősorban mint cardiovascularis rizikófaktor van jelen. Nem mellékes azonban, hogy akár a magas, akár az alacsony koleszterinszint direkt összefüggésbe hozható számos pszichiátriai kórképpel. Célkitűzés: A jelen tanulmány célja felhívni a figyelmet a holisztikus nézőpont kialakítására, hisz a hypercholesterinaemia korai cardiovascularis elhalálozáshoz vezethet, viszont alacsony koleszterinszint esetén megnövekedhet a hangulatzavarra és főleg az öngyilkosságra való hajlam. Módszer: Kutatásunkban 200 olyan pszichiátriai beteg összkoleszterinszintjét vizsgáltuk meg, akik öngyilkossági gondolatokkal küszködtek. Az öngyilkossági veszélyt a Modified Scale for Suicide Ideation (Miller és mtsai) segítségével mértük. Eredmények: Az elért pontszámok alapján 3 kategóriába soroltuk a betegeket: 52 minimális suicid késztetésű, 49 középsúlyos és 99 súlyos rizikójú beteg. A legsúlyosabb kategóriába tartozó betegek nagy többségének (83 páciens, 84%) összkoleszterinje 4,5 mmol/l alatti volt. A másik két kategóriában ezen arány jelentősen kisebbnek bizonyult: a minimális suicid késztetésű kategóriában ez az érték csak 3 betegre (6%) volt vonatkoztatható, és a középsúlyosak esetén is csak 13 betegre (29%). Megbeszélés: Ezen tanulmányunk hátrányát képezheti a relatíve kis betegszám és a longitudinális utánkövetés megvalósításának hiánya. Következtetés: Jelen eredményeink alapján jogosan vetődhet fel a koleszterinszint mérésének rutinszerű bevezetése mint hatásos, szűrésre alkalmas öngyilkossági rizikófaktor biomarker. Orv Hetil. 2021; 162(43): 1732–1739. Summary. Introduction: High cholesterol levels are widely recognized as cardiovascular risk factors. However, lower or higher cholesterol levels can be in a solid relationship with several mental disorders, too. Objective: Our study aims to raise awareness about the fact that hypocholesterolemia is involved in various mood disorders and even suicidal behavior looks to be much more frequent. Method: Our current study implicates 200 psychiatric patients. These subjects had suicidal ideation upon hospital referral. In the first 24 hours, their total cholesterol levels were measured and the severity of self-harm intentions was evaluated with the Modified Scale for Suicide Ideation by Miller et al. Results: By the obtained evaluation score we differentiated 3 groups: 52 patients with low suicide risk, 49 with moderate risk and 99 with high suicide risk. In this last group, 83 patients had their serum total cholesterol level under 4,5 mmol/L (84%). By comparison, in the low-risk category only 3 patients (6%) and in the moderate-risk 13 patients (29%) were with such levels. Discussion: Clear conclusion cannot be drawn due to the reduced number of our patients, due to the absence of long-term consequent monitorization, and due to the heterogeneity of the studied population. Conclusion: Considering these data, a possible usefulness of total cholesterol levels in psychiatric patients may be suggested as a screening tool for the severity of suicidal ideation. Orv Hetil. 2021; 162(43): 1732–1739.

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Suicide Attempt History, Self-Esteem, and Suicide Risk in a Sample of 116 Depressed Voluntary Inpatients

Psychological Reports ◽

10.2466/pr0.95.3f.1092-1094 ◽

2004 ◽

Vol 95 (3_suppl) ◽

pp. 1092-1094 ◽

Cited By ~ 11

Author(s):

Charles James Palmer

Keyword(s):

Suicidal Ideation ◽

Suicide Attempt ◽

Suicide Risk ◽

Suicide Ideation ◽

Self Esteem ◽

Significant Difference ◽

History Of ◽

Group 3 ◽

Group 2 ◽

Group 1

116 consecutively admitted depressed inpatients were divided into three groups based on self-reported history of suicidal ideation and history of suicide attempt. Participants in Group 1 ( M age 34.0, SD = 14.0), 13 men and 24 women, reported no history of suicidal ideation or history of suicide attempt. Group 2 ( M age 34.0, SD = 8.6), 14 men and 25 women, reported having a history of suicidal ideation but no history of suicide attempt. Group 3 ( M age 34.0 yr., SD = 6.3), 14 men and 26 women, reported a history of suicidal ideation and at least one suicide attempt. Each participant completed the Suicide Risk Scale and the Self-esteem Scale. Analysis of variance with Tukey post hoc comparisons yielded a significant difference between Groups 1 and 2, between Groups 1 and 3, and between Groups 2 and 3 on the Suicide Risk Scale. There was a significant difference between Group 1 and Group 2 and between Group 1 and Group 3 on the Self-esteem Scale. These data indicated that suicide ideation and suicide attempt history significantly elevated suicide risk. Self-esteem was significantly decreased by suicide ideation and suicide attempt history.

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Alexithymia and Suicide Risk among Patients with Obsessive-compulsive Disorder

European Psychiatry ◽

10.1016/s0924-9338(09)71263-5 ◽

2009 ◽

Vol 24 (S1) ◽

pp. 1-1

Author(s):

D. De Berardis ◽

N. Serroni ◽

A.M. Pizzorno ◽

F.S. Moschetta ◽

G. Sepede ◽

...

Keyword(s):

Suicidal Ideation ◽

Obsessive Compulsive Disorder ◽

Suicide Risk ◽

Rating Scales ◽

Suicide Ideation ◽

Rating Scale ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

Chronic Course ◽

Tas 20

Objective:The aim of our study was to evaluate relationships between alexithymia and suicidal ideation a sample of adult outpatients with obsessive-compulsive disorder (OCD).Methods:A sample of 86 adult outpatients with OCD (44 females and 42 males), was evaluated with a series of rating scales such as the Yale-Brown Obsessive Compulsive Scale (Y-BOCS), the Toronto Alexithymia Scale (TAS-20), the Scale for Suicide Ideation (SSI) and Montgomery-Åsberg Depression Rating Scale (MADRS). the score of item #11 on the Y-BOCS was considered as a measure of insight.Results:Alexithymics showed a more early onset, a longer duration of illness and were more suitable to have a chronic course than nonalexithymics; they also reported higher MADRS and SSI scores. Alexithymics without insight (n=21) reported higher SSI scores than alexithymics with insight, nonalexythimics without insight and nonalexithymics with insight. A linear regression showed that chronic OCD course together with DIF dimension of TAS-20 and higher MADRS scores were significantly associated with higher suicide risk.Conclusions:Alexithymia and depressive symptoms were highly correlated in OCD patients and were significantly associated with higher suicide risk. DIF dimension of TAS-20 seems to be significantly associated with presence of suicidal ideation as well as chronic course of disorder. However, further longitudinal studies on larger samples are needed to definitely clarify this topic.

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Suicide clusters among young Kenyan men

Journal of Health Psychology ◽

10.1177/1359105317743803 ◽

2017 ◽

Vol 25 (7) ◽

pp. 1004-1013 ◽

Cited By ~ 1

Author(s):

Michael L Goodman ◽

Eve S Puffer ◽

Philip H Keiser ◽

Stanley Gitari

Keyword(s):

Meaning In Life ◽

Suicide Risk ◽

Attempted Suicide ◽

Suicide Ideation ◽

Self Esteem ◽

Peer Networks ◽

Collective Self ◽

Suicide Clusters ◽

Peer Suicide ◽

Collective Self Esteem

Suicide is a leading cause of global mortality. Suicide clusters have recently been identified among peer networks in high-income countries. This study investigates dynamics of suicide clustering within social networks of young Kenya men ( n = 532; 18–34 years). We found a strong, statistically significant association between reported number of friends who previously attempted suicide and present suicide ideation (odds ratio = 1.9; 95% confidence interval (1.42, 2.54); p < 0.001). This association was mediated by lower collective self-esteem (23% of total effect). Meaning in life further mediated the association between collective self-esteem and suicide ideation. Survivors of peer suicide should be evaluated for suicide risk.

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