Age-Differences in Verbal Recognition Memory Revealed by ERP

2005 ◽  
Vol 36 (3) ◽  
pp. 176-187 ◽  
Author(s):  
Anders M. Fjell ◽  
Kristine B. Walhovd ◽  
Ivar Reinvang

Seventy-four participants (aged 20–82 years) went through a continuous performance recognition memory task with multiple repetitions of words and non-words while ERPs were recorded from the scalp. The old/new ERP effect (the difference in activation to stimuli correctly recognized as old and stimuli correctly recognized as new) for words but not non-words declined with increasing age in a linear pattern, but the relationship between the old/new effect and age varied throughout the ERP time window. Differences in topography between age groups were manifested in a frontal shift in activation for older age groups. Further, the data point to differences in semantic versus non-semantic processing across the adult life span, and it is concluded that specific cognitive memory processes are differentially involved at different ages.

Viruses ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 619
Author(s):  
Lirong Cao ◽  
Shi Zhao ◽  
Jingzhi Lou ◽  
Hong Zheng ◽  
Renee W. Y. Chan ◽  
...  

Assessment of influenza vaccine effectiveness (VE) and identification of relevant influencing factors are the current priorities for optimizing vaccines to reduce the impacts of influenza. To date, how the difference between epidemic strains and vaccine strains at genetic scale affects age-specific vaccine performance remains ambiguous. This study investigated the association between genetic mismatch on hemagglutinin and neuraminidase genes and A(H1N1)pdm09 VE in different age groups with a novel computational approach. We found significant linear relationships between VE and genetic mismatch in children, young adults, and middle-aged adults. In the children’s group, each 3-key amino acid mutation was associated with an average of 10% decrease in vaccine effectiveness in a given epidemic season, and genetic mismatch exerted no influence on VE for the elderly group. We demonstrated that present vaccines were most effective for children, while protection for the elderly was reduced and indifferent to vaccine component updates. Modeling such relationships is practical to inform timely evaluation of VE in different groups of populations during mass vaccination and may inform age-specific vaccination regimens.


2020 ◽  
Vol 101 (3) ◽  
pp. 1751-1776
Author(s):  
Didier Sornette ◽  
Euan Mearns ◽  
Michael Schatz ◽  
Ke Wu ◽  
Didier Darcet

Abstract We present results on the mortality statistics of the COVID-19 epidemic in a number of countries. Our data analysis suggests classifying countries in five groups, (1) Western countries, (2) East Block, (3) developed Southeast Asian countries, (4) Northern Hemisphere developing countries and (5) Southern Hemisphere countries. Comparing the number of deaths per million inhabitants, a pattern emerges in which the Western countries exhibit the largest mortality rate. Furthermore, comparing the running cumulative death tolls as the same level of outbreak progress in different countries reveals several subgroups within the Western countries and further emphasises the difference between the five groups. Analysing the relationship between deaths per million and life expectancy in different countries, taken as a proxy of the preponderance of elderly people in the population, a main reason behind the relatively more severe COVID-19 epidemic in the Western countries is found to be their larger population of elderly people, with exceptions such as Norway and Japan, for which other factors seem to dominate. Our comparison between countries at the same level of outbreak progress allows us to identify and quantify a measure of efficiency of the level of stringency of confinement measures. We find that increasing the stringency from 20 to 60 decreases the death count by about 50 lives per million in a time window of 20  days. Finally, we perform logistic equation analyses of deaths as a means of tracking the dynamics of outbreaks in the “first wave” and estimating the associated ultimate mortality, using four different models to identify model error and robustness of results. This quantitative analysis allows us to assess the outbreak progress in different countries, differentiating between those that are at a quite advanced stage and close to the end of the epidemic from those that are still in the middle of it. This raises many questions in terms of organisation, preparedness, governance structure and so on.


2000 ◽  
Vol 30 (1) ◽  
pp. 11-22 ◽  
Author(s):  
A. F. JORM

Background. There is considerable disagreement about what happens to the risk of anxiety and depression disorders and symptoms as people get older.Methods. A search was made for studies that examine the occurrence of anxiety, depression or general distress across the adult life span. To be included, a study had to involve a general population sample ranging in age from at least the 30s to 65 and over and use the same assessment method at each age.Results. There was no consistent pattern across studies for age differences in the occurrence of anxiety, depression or distress. The most common trend found was for an initial rise across age groups, followed by a drop. Two major factors producing this variability in results were age biases in assessment of anxiety and depression and the masking effect of other risk factors that vary with age. When other risk factors were statistically controlled, a more consistent pattern emerged, with most studies finding a decrease in anxiety, depression and distress across age groups. This decrease cannot be accounted for by exclusion of elderly people in institutional care from epidemiological surveys or by selective mortality of people with anxiety or depression.Conclusion. There is some evidence that ageing is associated with an intrinsic reduction in susceptibility to anxiety and depression. However, longitudinal studies covering the adult life span are needed to distinguish ageing from cohort effects. More attention needs to be given to understanding the mechanism behind any ageing-related reduction in risk for anxiety and depression with age. Possible factors are decreased emotional responsiveness with age, increased emotional control and psychological immunization to stressful experiences.


Author(s):  
Tesya Imanisa Setiadi ◽  
Wening Udasmoro ◽  
Hayatul Cholsy

Abstract. Suicide is one of the causes of death that occurs in a global scope but always causes divisive perspectives in various circles of society. For most people, suicide is a taboo topic, but not for other groups. The film Monsieur Lazhar (2011) is a film that shows the different perspectives between different age groups, namely the adult age group and the young age group, on a suicide that occurred at an elementary school in Montreal, Canada. This study aims at determining the different perspectives of the two different parties on suicide and the reasons for these differences in views. Pierre Bourdieu’s Champ de Force theory is the lens used in this research. The difference in perspective is influenced by the disposition system which Bourdieu calls the habitus. Habitus operates in a realm (champ). In the film, the domain in question is school. Meanwhile, Durkheim’s theory of suicide was chosen to determine the relationship of social problems to suicide. The method used in this research is content analysis. The data used are the chronological text of the scenes and the transcript of the conversations from the film. From the research, it was found that the school, which is the adult age group, has a counter and stigmatic view of suicide, reinforced by perceptions of psychological problems and social taboos. Meanwhile, students, who are in the young age group, tend to view suicide as a problem related to personal aspects and personal experiences so that they do not have a judgmental attitude like the school. Keywords : Suicide, Contestation, Realm, Perspective, Habitus


Author(s):  
Mariana Ing Malelak ◽  
Nathania Mirabel Halim

This study aims to examine spending patterns in the millennial generation in Surabaya. Respondents of this study were the millennial generation who were divided into two age groups, namely 21-28 years old, who were referred to as junior millennials, and those aged 29-36 years who were referred to as senior millennials. The analysis technique used is a crosstab to examine the relationship between age and spending pattern of the millennial generation and an independent-sample t-test to test the difference between the spending pattern of the junior millennials and senior millennials. This study showed a significant relationship between age and spending pattern on the millennial generation, and there is a significant difference between the spending pattern of the junior millennials and senior millennials.


2019 ◽  
Author(s):  
Elham Alshammari

Building pharmacokinetics and pharmacodynamics models that describe the relationship between drug concentration and its clinical response in different disease conditions and age groups should be emphasized. This review aims to explore modelling in case of bone marrow transplantation staring from bone marrow and immune system, transplantation process, immune reconstitution and graft versus host disease, the difference in case of children, to handling of data that arise from patients.


Author(s):  
Omar E. Staben ◽  
Molly J. Gardner ◽  
Frank J. Infurna ◽  
Suniya S. Luthar ◽  
Kevin J. Grimm

This chapter discusses conceptual and methodological considerations for studying post-traumatic growth across adulthood and into old age. Conceptual considerations that the authors focus on include examining character strengths and virtues longitudinally across multiple age groups and also the stability of these strengths and virtues across the life span. Methodological considerations elaborated are the use of convenience sampling in scale development and the importance of measurement invariance when examining character strengths in the context of post-traumatic growth. The authors provide examples from previous research on post-traumatic growth and discuss methods of measurement that could be utilized to enhance the validity of current measures. The chapter highlights the importance of character strengths and virtues and aims to solidify their role in the scientific community. Additionally, it highlights the need for more rigorous lines of scientific inquiry in this area due to its potential to impact healthy aging outcomes for persons across the adult life span.


2008 ◽  
Vol 20 (10) ◽  
pp. 1762-1776 ◽  
Author(s):  
Anja Soldan ◽  
Yunglin Gazes ◽  
H. John Hilton ◽  
Yaakov Stern

This study examined how aging affects the spatial patterns of repetition effects associated with perceptual priming of unfamiliar visual objects. Healthy young (n = 14) and elderly adults (n = 13) viewed four repetitions of structurally possible and impossible figures while being scanned with blood oxygenation level-dependent functional magnetic resonance imaging. Although explicit recognition memory for the figures was reduced in the elder subjects, repetition priming did not differ across the two age groups. Using multivariate linear modeling, we found that the spatial networks of regions that demonstrated repetition-related increases and decreases in activity were identical in both age groups, although there was a trend for smaller magnitude repetition effects in these networks in the elder adults for objects that had been repeated thrice. Furthermore, repetition-related reductions in activity in the left inferior frontal cortex for possible objects correlated with repetition-related facilitation in reaction time across both young and elder subjects. Repetition-related increases of an initially negative response were observed for both object types in both age groups in parts of the default network, suggesting that less attention was required for processing repeated stimuli. These findings extend prior studies using verbal and semantic picture priming tasks and support the view that perceptual repetition priming remains intact in later adulthood because the same spatial networks of regions continue to show repetition-related neural plasticity across the adult life span.


1992 ◽  
Vol 47 (3) ◽  
pp. P138-P141 ◽  
Author(s):  
T. H. Crook ◽  
G. J. Larrabee

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Peter Panfilov ◽  
Dmitry Zaytsev ◽  
Olga V. Antonova ◽  
Victoria Alpatova ◽  
Larissa P. Kiselnikova

Objective. The cause of considerable elasticity and plasticity of human dentin is discussed in the relationship with its microstructure.Methods. Structural state of teenage and mature human dentin is examined by using XRD and TEM techniques, and their deformation behavior under compression is studied as well.Result. XRD study has shown that crystallographic type of calcium hydroxyapatite in human dentin (calcium hydrogen phosphate hydroxide Ca9HPO4(PO4)5OH; Space Group P63/m (176);a= 9,441 A;c= 6,881 A;c/a= 0,729; Crystallite (Scherrer) 200 A) is the same for these age groups. In both cases, dentin matrix is X-ray amorphous. According to TEM examination, there are amorphous and ultrafine grain phases in teenage and mature dentin. Mature dentin is stronger on about 20% than teenage dentin, while teenage dentin is more elastic on about 20% but is less plastic on about 15% than mature dentin.Conclusion. The amorphous phase is dominant in teenage dentin, whereas the ultrafine grain phase becomes dominant in mature dentin. Mechanical properties of human dentin under compression depend on its structural state, too.


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