scholarly journals A mechanistic investigation of thrombotic microangiopathy associated with IV abuse of Opana ER

Blood ◽  
2017 ◽  
Vol 129 (7) ◽  
pp. 896-905 ◽  
Author(s):  
Ryan Hunt ◽  
Ayla Yalamanoglu ◽  
James Tumlin ◽  
Tal Schiller ◽  
Jin Hyen Baek ◽  
...  
Keyword(s):  
Thrombotic Microangiopathy ◽  
Key Points ◽  
Mechanistic Investigation ◽  
Inert Ingredients ◽  
The Impact

Key PointsThe inert ingredients in Opana ER tablets can elicit TMA in the setting of IV abuse and stems from the impact of HMW PEO.

The impact of cultural factors on attachment dynamics: a view from Irish society

2019 ◽  
Vol 13 (2) ◽  
pp. 207-223
Author(s):  
Michael O’Toole
Keyword(s):  
Significant Role ◽  
Emotional Development ◽  
Cultural Factors ◽  
Seamus Heaney ◽  
Irish Society ◽  
Irish Context ◽  
Key Points ◽  
The Many ◽  
The Impact ◽  
The Relationship

In this article I examine aspects of the relationship between mothers and sons from an attachment perspective in an Irish context. Through the works of Irish writers such as Seamus Heaney, John McGahern, and Colm Tóibín, I focus on particular aspects of this relationship, which fails to support the developmental processes of separation and individuation in the many men who come to me for psychotherapy. I illustrate key points concerning this attachment dynamic through the use of clinical examples of my work with two men from my practice. While acknowledging that many other cultural factors play a significant role in the emotional development of children, integrating the work of our poets, novelists, and scholars with an attachment perspective

scholarly journals Decreased Medical Care During the COVID-19 Pandemic – A Comprehensive Analysis of Radiological Examinations

2021 ◽  
Author(s):  
Annette Aigner ◽  
Bernd Hamm ◽  
Florian Nima Fleckenstein ◽  
Tazio Maleitzke ◽  
Georg Böning ◽  
...  
Keyword(s):  
Medical Care ◽  
Control Period ◽  
Surrogate Marker ◽  
Medical Specialty ◽  
Case Volume ◽  
Medical Specialties ◽  
Key Points ◽  
Depth Analysis ◽  
The Impact ◽  
Radiological Examinations

Objectives As a cross-section discipline within the hospital infrastructure, radiological departments might be able to provide important information regarding the impact of the COVID-19 pandemic on healthcare. The goal of this study was to quantify changes in medical care during the first wave of the pandemic using radiological examinations as a comprehensive surrogate marker and to determine potential future workload. Methods A retrospective analysis of all radiological examinations during the first wave of the pandemic was performed. The number of examinations was compared to time-matched control periods. Furthermore, an in-depth analysis of radiological examinations attributed to various medical specialties was conducted and postponed examinations were extrapolated to calculate additional workload in the near future. Results A total of 596,760 examinations were analyzed. Overall case volumes decreased by an average of 41 % during the shutdown compared to the control period. The most affected radiological modalities were sonography (–54 %), X-ray (–47 %) followed by MRI (–42 %). The most affected medical specialty was trauma and orthopedics (–60 % case volume) followed by general surgery (–49 %). Examination numbers increased during the post-shutdown period leading to a predicted additional workload of up to 22 %. Conclusion This study shows a marked decrease in radiological examinations in total and among several core medical specialties, indicating a significant reduction in medical care during the first COVID-19 shutdown. Key Points: Citation Format

scholarly journals The Epidemiological Characteristics of the COVID-19 Pandemic in Europe: Focus on Italy

2021 ◽  
Vol 18 (6) ◽  
pp. 2942
Author(s):  
Giovanni Gabutti ◽  
Erica d’Anchera ◽  
Francesco De Motoli ◽  
Marta Savio ◽  
Armando Stefanati
Keyword(s):  
Social Structures ◽  
World Population ◽  
European Continent ◽  
Key Points ◽  
Reporting Systems ◽  
The World ◽  
Definition Of ◽  
Epidemiological Characteristics ◽  
The Impact ◽  
Epidemiological Situation

Starting from December 2019, SARS-CoV-2 has forcefully entered our lives and profoundly changed all the habits of the world population. The COVID-19 pandemic has violently impacted the European continent, first involving only some European countries, Italy in particular, and then spreading to all member states, albeit in different ways and times. The ways SARS-CoV-2 spreads are still partly unknown; to quantify and adequately respond to the pandemic, various parameters and reporting systems have been introduced at national and European levels to promptly recognize the most alarming epidemiological situations and therefore limit the impact of the virus on the health of the population. The relevant key points to implement adequate measures to face the epidemic include identifying the population groups most involved in terms of morbidity and mortality, identifying the events mostly related to the spreading of the virus and recognizing the various viral mutations. The main objective of this work is to summarize the epidemiological situation of the COVID-19 pandemic in Europe and Italy almost a year after the first reported case in our continent. The secondary objectives include the definition of the epidemiological parameters used to monitor the epidemic, the explanation of superspreading events and the description of how the epidemic has impacted on health and social structures, with a particular focus on Italy.

scholarly journals Sustainable Site System

2021 ◽  
Author(s):  
Jorden J. S. Lefler
Keyword(s):  
Urban Area ◽  
Urban Areas ◽  
Architectural Design ◽  
Heat Island ◽  
Rating Systems ◽  
Island Effect ◽  
Key Points ◽  
Site Design ◽  
The Impact ◽  
The City

This thesis discusses a method of analysing the input of interventions in a building's site design, all of which affect the heat island effect, bio-diversity and hydrology of urban areas. Existing standards from Toronto, Vancouver and Berlin have been researched and analysed. This paper presents an evolution of a method called biotope area factor used in Berlin, Germany. A synthesis of the approach of all three systems was considered and distilled into the key points which were then incorporated into the proposed method. In addition to the impact of an individual building, it also includes the impact from the adjacent street area. The final components of this thesis are the application of the method developed to an urban area in the city of Toronto and results showing the impacts on architectural design from site rating systems.

scholarly journals Development of a daily gridded precipitation data set for the Middle East

2008 ◽  
Vol 12 ◽  
pp. 165-170 ◽  
Author(s):  
A. Yatagai ◽  
P. Xie ◽  
P. Alpert
Keyword(s):  
Middle East ◽  
Climate Models ◽  
Daily Precipitation ◽  
Rain Gauge ◽  
Monthly Precipitation ◽  
Data Set ◽  
Key Points ◽  
Fertile Crescent ◽  
Precipitation Analysis ◽  
The Impact

Abstract. We show an algorithm to construct a rain-gauge-based analysis of daily precipitation for the Middle East. One of the key points of our algorithm is to construct an accurate distribution of climatology. One possible advantage of this product is to validate high-resolution climate models and/or to diagnose the impact of climate changes on local hydrological resources. Many users are familiar with a monthly precipitation dataset (New et al., 1999) and a satellite-based daily precipitation dataset (Huffman et al., 2001), yet our data set, unlike theirs, clearly shows the effect of orography on daily precipitation and other extreme events, especially over the Fertile Crescent region. Currently the Middle-East precipitation analysis product is consisting of a 25-year data set for 1979–2003 based on more than 1300 stations.

scholarly journals Surging virtual reference services: COVID-19 a game changer

2021 ◽  
Vol 82 (3) ◽  
pp. 106
Author(s):  
Marie L. Radford ◽  
Laura Costello ◽  
Kaitlin Montague
Keyword(s):  
Academic Library ◽  
The United States ◽  
User Interactions ◽  
Virtual Reference ◽  
Longitudinal Surveys ◽  
Reference Services ◽  
Key Points ◽  
Academic Librarian ◽  
Two Phases ◽  
The Impact

In March 2020, academic libraries across the United States closed and sent everyone home, some destined to not reopen for months. University offices closed. Classes were moved online. Suddenly, librarians and staff pivoted to working from home and to all remote services, without time for planning logistics or training. To study the impact of this extraordinary and sweeping transition on virtual reference services (VRS), we conducted a major study of academic library responses to the pandemic that focused on librarian perceptions of how services and relationships with users morphed during this COVID-19 year.Academic librarians rallied to our call, and we collected a total of 300 responses to two longitudinal surveys launched at key points during the pandemic. Data collection focused on two phases in 2020: 1) shutdown and immediate aftermath (mid-March to July), and 2) fall ramp up and into the semester (August to December). Via Zoom, we also interviewed 28 academic librarian leaders (e.g., heads of reference and/or VRS, associate directors for User Services) from September to November. Surveys and interviews centered on adaptations and innovations to reference services, especially VRS and perceptions of changes in user interactions.

21. Applications: prisoners’ rights

2021 ◽  
pp. 433-447
Author(s):  
Howard Davis
Keyword(s):  
Human Rights ◽  
The State ◽  
European Convention ◽  
Legal Knowledge ◽  
Key Points ◽  
Self Test ◽  
The Uk ◽  
Article 5 ◽  
The Impact ◽  
Domestic Law

Without assuming prior legal knowledge, books in the Directions series introduce and guide readers through key points of law and legal debate. It discusses European Convention law and relates it to domestic law under the HRA. Questions, discussion points, and thinking points help readers to engage fully with each subject and check their understanding as they progress and knowledge can be tested by self-test questions and exam questions at the chapter end. This chapter considers the application of Convention rights in the field of prisoners’ rights; the impact of Convention rights on prisoners in the UK is considered. Prisoners remain within the protection of the European Convention on Human Rights, though the application of these rights will take their position into account. Prisoners’ rights include not only rights to the non-arbitrary loss of liberty (Article 5) and rights to fair procedures (Articles 5 and 6), but also not to be disproportionately denied the rights and freedoms in Articles 8–11. Imprisonment deprives individuals of their liberty and, therefore, is a public function for which the state is responsible under the Convention. The controversy over prisoners’ right to vote is discussed in Chapter 25.

14. Investment

2019 ◽  
pp. 320-343
Author(s):  
Gary Watt
Keyword(s):  
Portfolio Theory ◽  
Capital Gains ◽  
Investment Policy ◽  
Legal Knowledge ◽  
Modern Portfolio Theory ◽  
General Law ◽  
Appropriate Care ◽  
Key Points ◽  
Investment Returns ◽  
The Impact

Without assuming prior legal knowledge, books in the Directions series introduce and guide readers through key points of law and legal debate. Questions, diagrams and exercises help readers to engage fully with each subject and check their understanding as they progress. Part II of the Trustee Act 2000 gives every trustee the power to make any kind of investment as long as he is absolutely entitled to the assets of the trust, a power that permits trustees to hold investments jointly or in common with other persons. There are no unauthorised types of investment, but it is important to know whether the type of investment chosen was appropriate to the trust on the basis of the ‘standard investment criteria’. This chapter examines the types of investment permitted by the general law, a breach of the duty to invest with appropriate care, the significance of modern portfolio theory to trustee investments and the impact of the Trustee Act 2000 upon trustee investments. It also looks at the historical need for income production and discusses capital gains as investment returns, the standard investment criteria, the need for trustees to obtain and consider proper advice about investments, particular types of investment and investment policy.

scholarly journals A Bibliometrics Review of Water Footprint Research in China: 2003–2018

2019 ◽  
Vol 11 (18) ◽  
pp. 5082 ◽  
Author(s):  
Zhu ◽  
Jiang ◽  
Han ◽  
Gao ◽  
He ◽  
...  
Keyword(s):  
Water Resource ◽  
Water Resource Management ◽  
Water Footprint ◽  
Supply And Demand ◽  
Water Security ◽  
China National Knowledge Infrastructure ◽  
Knowledge Infrastructure ◽  
Key Points ◽  
Bibliometric Review ◽  
The Impact

As water security becomes an increasingly important issue, the analysis of the conflict between water supply and demand has gained significance in China. This paper details a bibliometric review of papers published between 2003 and 2018 on the water footprint in China, one of the global hotspots of water resource research. The tendencies and key points of water footprint research were systematically analyzed based on 1564 articles, comprising 1170 original publications in Chinese from the China National Knowledge Infrastructure database and 394 publications in English from the Web of Science database. The results show that the literature associated with water footprint research has expanded significantly. The number of papers published increased from 104 in 2003–2006 to 735 in 2015–2018. Water footprint research has been applied to agricultural, industrial, and regional water resource management to quantify the impact of human activities on water resources and the environment. Water footprint metrics were extracted for regional comparisons. There are obvious regional characteristics of the water footprint in China, but the uncertainty of results makes further investigation necessary. Further water footprint modeling and field experimental research is needed to explore the water–ecological environment under complex systems.

scholarly journals A homozygous telomerase T-motif variant resulting in markedly reduced repeat addition processivity in siblings with Hoyeraal Hreidarsson syndrome

Blood ◽  
2013 ◽  
Vol 121 (18) ◽  
pp. 3586-3593 ◽  
Author(s):  
Maria M. Gramatges ◽  
Xiaodong Qi ◽  
Ghadir S. Sasa ◽  
Julian J.-L. Chen ◽  
Alison A. Bertuch
Keyword(s):  
Protein Function ◽  
Severe Disease ◽  
Computational Algorithms ◽  
Key Points ◽  
The Impact ◽  
Motif Variant ◽  
Limited Sensitivity

Key Points Biallelic inheritance of a telomerase T-motif mutation selectively impairs repeat addition processivity and results in severe disease. Computational algorithms commonly used to predict the impact of variants on protein function have limited sensitivity with regard to hTERT.

Sign in / Sign up

Export Citation Format

Share Document