Dietary intake of vitamin A, lung function, and incident asthma in childhood

Longitudinal epidemiological data are scarce on the relation between dietary intake of vitamin A and respiratory outcomes in childhood. We investigated whether a higher intake of preformed vitamin A or provitamin β-carotene in mid-childhood is associated with higher lung function and with asthma risk in adolescence.In the Avon Longitudinal Study of Parents and Children, dietary intakes of preformed vitamin A and β-carotene equivalents were estimated by food frequency questionnaire at 7 years of age. Post- bronchodilator forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), and forced expiratory flow at 25–75% of FVC (FEF25–75) were measured at 15.5 years and transformed to z scores. Incident asthma was defined by new cases of doctor-diagnosed asthma at age 11 or 14 years.In multivariable adjusted models, a higher intake of preformed vitamin A was associated with higher lung function and a lower risk of incident asthma: comparing top versus bottom quartiles of intake, regression coefficients (95% confidence intervals) for FEV1 and FEF25–75 were, respectively, 0.21 (0.05–0.38; P-trend 0.008) and 0.18 (0.03–0.32; P-trend 0.02); odds ratios (95% confidence intervals) for FEV1/FVC ratio below the lower limit of normal and incident asthma were, respectively, 0.49 (0.27–0.90, P-trend 0.04) and 0.68 (0.47, 0.99; P-trend 0.07). In contrast, there was no evidence for association with β-carotene. We also found some evidence for modification of the associations between preformed vitamin A intake and lung function by BCMO1, NCOR2 and CC16 gene polymorphisms.A higher intake of preformed vitamin A, but not β-carotene, in mid-childhood is associated with higher subsequent lung function and lower risk of fixed airflow limitation and incident asthma.

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Dietary β-Cryptoxanthin and α-Carotene Have Greater Apparent Bioavailability Than β-Carotene in Subjects from Countries with Different Dietary Patterns

Nutrients ◽

10.3390/nu12092639 ◽

2020 ◽

Vol 12 (9) ◽

pp. 2639

Author(s):

Begoña Olmedilla-Alonso ◽

Elena Rodríguez-Rodríguez ◽

Beatriz Beltrán-de-Miguel ◽

Rocío Estévez-Santiago

Keyword(s):

Vitamin A ◽

Dietary Intake ◽

Dietary Patterns ◽

Dietary Intakes ◽

Serum Concentrations ◽

Human Diet ◽

The World ◽

Apparent Bioavailability ◽

Β Carotene ◽

Retinol Equivalents

β-carotene, α-carotene and β-cryptoxanthin are greater contributors to vitamin A intake than retinol in the human diet for most people around the world. Their contribution depends on several factors, including bioavailability and capacity of conversion into retinol. There is an increasing body of research showing that the use of retinol activity equivalents or retinol equivalents could lead to the underestimation of the contribution of β-cryptoxanthin and of α-carotene. The aim is to assess their apparent bioavailability by comparing concentrations in blood to their dietary intakes and identifying the major food contributors to their dietary intake. Dietary intake (3-day 24-h records) and serum concentrations (by HPLC) were calculated in normolipemic subjects with adequate retinol status (≥1.1 µmol/L) from our studies (n = 633) and apparent bioavailability calculated from 22 other studies (n = 29,700). Apparent bioavailability was calculated as the ratio of concentration in the blood to carotenoid intake. Apparent bioavailabilities for α-carotene and β-cryptoxanthin were compared to those for β-carotene. Eating comparable amounts of α-carotene, β-cryptoxanthin and β-carotene foods resulted in 55% greater α-carotene (95% CI 35, 90) and 686% higher β-cryptoxanthin (95% CI 556, 1016) concentrations than β-carotene in blood. This suggests differences in the apparent bioavailability of α-carotene and β-cryptoxanthin and even larger differences with β-cryptoxanthin, greater than that of β-carotene. Four fruits (tomato, orange, tangerine, red pepper) and two vegetables (carrot, spinach) are the main contributors to their dietary intake (>50%) in Europeans.

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Dietary Intake of Anti-Oxidant Vitamins A, C, and E Is Inversely Associated with Adverse Cardiovascular Outcomes in Chinese—A 22-Years Population-Based Prospective Study

Nutrients ◽

10.3390/nu10111664 ◽

2018 ◽

Vol 10 (11) ◽

pp. 1664 ◽

Cited By ~ 14

Author(s):

Chi-Ho Lee ◽

Ruth Chan ◽

Helen Wan ◽

Yu-Cho Woo ◽

Chloe Cheung ◽

...

Keyword(s):

Hong Kong ◽

Cardiovascular Risk ◽

Vitamin A ◽

Dietary Intake ◽

Cox Regression ◽

Population Based ◽

Cardiovascular Outcomes ◽

Hong Kong Chinese ◽

Dietary Intakes ◽

Anti Oxidant

Background: Conflicting and population-dependent findings have been reported from epidemiological studies on the associations of dietary intake of anti-oxidant vitamins with cardiovascular events. We investigated the prospective relationship between dietary intake of anti-oxidant vitamins and incident adverse cardiovascular outcomes amongst Hong Kong Chinese. Methods: In this prospective population-based study, baseline dietary intake of anti-oxidant vitamins (A, C, and E) were assessed using a food frequency questionnaire in 875 Chinese participants from the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS) in 1995–1996. The adjusted hazard ratio (HR) of incident adverse cardiovascular outcomes, defined as the first recorded diagnosis of cardiovascular deaths, non-fatal myocardial infarction or non-fatal stroke, and coronary or other arterial revascularizations, was calculated per unit intake of each vitamin using multivariable Cox regression. Results: Over a median follow-up of 22 years, 85 participants (9.7%) developed adverse cardiovascular outcomes. Dietary intakes of vitamin A, C, and E were independently and inversely associated with incident adverse cardiovascular outcomes (HR 0.68, 95%CI 0.53–0.88, p = 0.003 for vitamin A; HR 0.66, 95%CI 0.52–0.85, p = 0.001 for vitamin C; and HR 0.57, 95%CI 0.38–0.86, p = 0.017 for vitamin E) after adjustments for conventional cardiovascular risk factors at baseline. Conclusions: Dietary intakes of anti-oxidant vitamins A, C, and E reduced the risk of adverse cardiovascular outcomes in Hong Kong Chinese.

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Predictive Modelling of Lung Function using Emphysematous Density Distribution

Scientific Reports ◽

10.1038/s41598-019-56351-9 ◽

2019 ◽

Vol 9 (1) ◽

Author(s):

Kuo-Lung Lor ◽

Cheng-Pei Liu ◽

Yeun-Chung Chang ◽

Chong-Jen Yu ◽

Cheng-Yi Wang ◽

...

Keyword(s):

Lung Function ◽

Predictive Model ◽

Lung Volume ◽

Model Fitting ◽

Chronic Obstructive Lung Disease ◽

Correlation Study ◽

Forced Expiratory Volume ◽

Airflow Limitation ◽

Normal Lung ◽

Chronic Obstructive

AbstractTarget lung tissue selection remains a challenging task to perform for treating severe emphysema with lung volume reduction (LVR). In order to target the treatment candidate, the percentage of low attenuation volume (LAV%) representing the proportion of emphysema volume to whole lung volume is measured using computed tomography (CT) images. Although LAV% have shown to have a correlation with lung function in patients with chronic obstructive pulmonary disease (COPD), similar measurements of LAV% in whole lung or lobes may have large variations in lung function due to emphysema heterogeneity. The functional information of regional emphysema destruction is required for supporting the choice of optimal target. The purpose of this study is to develop an emphysema heterogeneity descriptor for the three-dimensional emphysematous bullae according to the size variations of emphysematous density (ED) and their spatial distribution. The second purpose is to derive a predictive model of airflow limitation based on the regional emphysema heterogeneity. Deriving the bullous representation and grouping them into four scales in the upper and lower lobes, a predictive model is computed using the linear model fitting to estimate the severity of lung function. A total of 99 subjects, 87 patients with mild to very severe COPD (Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage I~IV) and 12 control participants with normal lung functions (forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) > 0.7) were evaluated. The final model was trained with stratified cross-validation on randomly selected 75% of the dataset (n = 76) and tested on the remaining dataset (n = 23). The dispersed cases of LAV% inconsistent with their lung function outcome were evaluated, and the correlation study suggests that comparing to LAV of larger bullae, the widely spread smaller bullae with equivalent LAV has a larger impact on lung function. The testing dataset has the correlation of r = −0.76 (p < 0.01) between the whole lung LAV% and FEV1/FVC, whereas using two ED % of scales and location-dependent variables to predict the emphysema-associated FEV1/FVC, the results shows their correlation of 0.82 (p < 0.001) with clinical FEV1/FVC.

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Trends in dietary intakes of vitamins A, C and E among Japanese men and women from 1974 to 2001

Public Health Nutrition ◽

10.1017/s1368980008003960 ◽

2009 ◽

Vol 12 (9) ◽

pp. 1343-1350 ◽

Cited By ~ 5

Author(s):

Yoshimi Kato ◽

Satoyo Ikehara ◽

Koutatsu Maruyama ◽

Mieko Inagawa ◽

Miyuki Oshima ◽

...

Keyword(s):

Vitamin E ◽

Vitamin A ◽

Vitamin C ◽

Dairy Products ◽

Public Health Issue ◽

Dietary Intakes ◽

Adequate Intake ◽

Japanese Men ◽

Men And Women ◽

Β Carotene

AbstractObjectiveTo investigate long-term trends in dietary intakes of vitamins A, C and E in Japanese adults.DesignTime series by community-based nutrition survey.SettingTwo rural communities (Ikawa and Kyowa) between 1974 and 2001 in Japan.SubjectsA total of 3713 men and 3726 women aged 40–69 years.MethodsDietary intake data were collected by the 24 h dietary recall.ResultsIn Ikawa, mean intake of vitamin A (β-carotene and retinol) increased by 13–40 %; vitamins C and E increased by approximately 23–33 % among men and women from 1974–1977 to 1998–2000. In Kyowa, mean intake of vitamin A, primarily retinol, increased by 13–21 % among men and women; vitamin C from fruits decreased by 16 % among men; and vitamin E increased by 29 % among women from 1982–1986 to 1998–2001. Mean intake of vitamin E in the latest survey period was lower than the Adequate Intake among men and women in both communities. Generally, there were increased intakes of β-carotene and vitamin C from green/yellow and other vegetables; increased retinol intake from fish/shellfish, eggs, milk/dairy products and fats/oils; and increased vitamin E intake from green/yellow and other vegetables, fish/shellfish, eggs, milk/dairy products and fats/oils.ConclusionsMean intakes of the antioxidant vitamins A, C and E increased among middle-aged Japanese men and women between the 1970s and the 1990s except for decreased vitamin C among Kyowa men. The lower mean intake of vitamin E than the Adequate Intake should be considered a potential public health issue for the prevention of CVD.

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Carotenoid Intake and Serum Concentration in Young Finnish Children and Their Relation with Fruit and Vegetable Consumption

Nutrients ◽

10.3390/nu10101533 ◽

2018 ◽

Vol 10 (10) ◽

pp. 1533 ◽

Cited By ~ 4

Author(s):

Marianne Prasad ◽

Hanna-Mari Takkinen ◽

Liisa Uusitalo ◽

Heli Tapanainen ◽

Marja-Leena Ovaskainen ◽

...

Keyword(s):

Serum Concentration ◽

Dietary Intake ◽

Vegetable Consumption ◽

Age Groups ◽

Dietary Intakes ◽

Serum Concentrations ◽

Fruit And Vegetable ◽

Prediction And Prevention ◽

Cross Classification ◽

Β Carotene

Fruit and vegetable intake has been associated with a reduced risk of many chronic diseases. These foods are the main dietary source of carotenoids. The aim of the present study was to evaluate the associations between dietary intake and serum concentrations of α- and β-carotene in a sample of young Finnish children from the population-based birth cohort of the Type 1 Diabetes Prediction and Prevention (DIPP) Study. The current analysis comprised 3-day food records and serum samples from 207 children aged 1, 2 and 3 years. Spearman and partial correlations, as well as a cross-classification analyses, were used to assess the relationship between dietary intake and the corresponding biomarkers. Serum concentrations of α- and β-carotene were significantly higher among the 1-year-old compared to the 3-year-old children. Dietary intakes of α- and β-carotene correlated significantly with their respective serum concentrations in all age groups, the association being highest at the age of 1 year (α-carotene r = 0.48; p < 0.001 and β-carotene r = 0.47; p < 0.001), and lowest at the age of 3 years (α-carotene r = 0.44; p < 0.001 and β-carotene r = 0.30; p < 0.001). A cross-classification showed that 72–81% of the participants were correctly classified to the same or adjacent quartile, when comparing the reported dietary intakes and the concentrations of the corresponding carotenoid in serum. The 3-day food record seems to be reasonably valid in the assessment of root vegetable consumption among young Finnish children. Root vegetables were the main dietary source of both carotenoids in all age groups. The high consumption of commercial baby foods among the 1-year-old children was reflected in the relatively high dietary intake and serum concentration of both carotenoids.

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β-Cryptoxanthin- and α-carotene-rich foods have greater apparent bioavailability than β-carotene-rich foods in Western diets

British Journal Of Nutrition ◽

10.1017/s0007114510003260 ◽

2010 ◽

Vol 105 (2) ◽

pp. 212-219 ◽

Cited By ~ 46

Author(s):

Betty J. Burri ◽

Jasmine S. T. Chang ◽

Terry R. Neidlinger

Keyword(s):

Vitamin A ◽

Reversed Phase ◽

The Body ◽

Provitamin A ◽

Food Sources ◽

Dietary Intakes ◽

Reversed Phase Hplc ◽

Food Record ◽

Apparent Bioavailability ◽

Β Carotene

β-Carotene (BC), β-cryptoxanthin (CX) and α-carotene (AC) are common carotenoids that form retinol. The amount of retinol (vitamin A) formed from carotenoid-rich foods should depend chiefly on the bioavailability (absorption and circulation time in the body) of carotenoids from their major food sources and the selectivity and reactivity of carotene cleavage enzymes towards them. The objective of the present study was to estimate the apparent bioavailability of the major sources of provitamin A (AC, BC and CX) from the diet by comparing the concentrations of these carotenoids in blood to their dietary intakes. Dietary intakes were estimated by FFQ (three studies in this laboratory, n 86; apparent bioavailability calculated for six other studies, n 5738) or by food record (two studies in our laboratory, n 59; apparent bioavailability calculated for two other studies, n 54). Carotenoid concentrations were measured by reversed-phase HPLC. Apparent bioavailability was calculated as the ratio of concentration in the blood to carotenoid intake. Then apparent bioavailabilities for AC and CX were compared to BC. Eating comparable amounts of AC-, CX- and BC-rich foods resulted in 53 % greater AC (99 % CI 23, 83) and 725 % greater CX (99 % CI 535, 915) concentrations in the blood. This suggests that the apparent bioavailability of CX from typical diets is greater than that of BC. Thus, CX-rich foods might be better sources of vitamin A than expected.

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The Relationship Between Serum β-Carotene Concentrations and Reported Dietary β-Carotene Intakes Is Moderated by BMI in U.S. Adults

Current Developments in Nutrition ◽

10.1093/cdn/nzab034_006 ◽

2021 ◽

Vol 5 (Supplement_2) ◽

pp. 72-72

Author(s):

Ambria Crusan ◽

Ryan Demmer ◽

Marla Reicks ◽

Susan Raatz

Keyword(s):

Dietary Intake ◽

The United States ◽

Primary Objective ◽

Dietary Intakes ◽

Class Iii ◽

Fat Percentage ◽

Obesity Class ◽

The Relationship ◽

Β Carotene

Abstract Objectives Serum β-carotene (BC) concentrations are not reflective of dietary BC status as serum concentrations can vary as a result of intake, lifestyle factors, adiposity, and physiological factors related to digestion and absorption. Longitudinal studies have shown a positive relationship between serum carotenoids and dietary BC intake, but the role of body mass index (BMI), as a surrogate for adiposity, in predicting serum BC concentrations is not well understood. The primary objective was to determine the role of BMI in the association between reported dietary BC intakes and serum BC concentrations. Methods Relationships between serum BC and reported dietary intake of BC were estimated using data from National Health and Nutrition Examination Surveys (NHANES)/What We Eat in America (WWEIA) survey 2003–2006 for 2580 male and non-pregnant female participants aged 20–85 years in the United States (US). The distributions of reported dietary and serum BC concentrations were skewed, therefore natural log (ln) was used to transform the data. Multivariable linear regression estimated serum BC concentrations based on reported dietary intake of BC adjusted for age, sex, race/ethnicity. Additional models were run by BMI category (normal, overweight, obesity class I, obesity class II, and obesity class III). Results Mean serum BC concentrations were 14.59 ± 0.1 μg/dL, BMI was 27.80 ± 0.1 kg/m2, and reported dietary intakes of BC were 828.82 ± 0.06 μg. A moderate association was present between serum BC and reported dietary BC intake, r = 0.30, P < 0.0001. When assessed according to BMI categories, the multivariable linear model shows attenuation of the β coefficient from 0.21 to 0.16, 0.12, 0.12, and 0.13 for the respective BMI categories. Conclusions In a representative sample of U.S. adults, there was a moderate association present between reported dietary BC intakes and serum BC concentrations. Additionally, the relationship between serum BC concentrations and reported dietary BC intakes was moderated by BMI, suggesting individuals with an increased BMI and/or body fat percentage may have a greater risk of low serum BC concentrations despite dietary BC intake. Funding Sources N/A.

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Plasma concentrations of carotenoids and vitamin C are better correlated with dietary intake in normal weight than overweight and obese elderly subjects

British Journal Of Nutrition ◽

10.1017/s0007114507659017 ◽

2007 ◽

Vol 97 (5) ◽

pp. 977-986 ◽

Cited By ~ 92

Author(s):

Jesús Vioque ◽

Tanja Weinbrenner ◽

Laura Asensio ◽

Adela Castelló ◽

Ian S. Young ◽

...

Keyword(s):

Plasma Concentration ◽

Vitamin C ◽

Dietary Intake ◽

Plasma Concentrations ◽

Normal Weight ◽

Elderly Subjects ◽

Plasma Vitamin ◽

Dietary Intakes ◽

Cross Sectional ◽

Β Carotene

Carotenoid and vitamin C intakes, assessed by FFQ, have been positively associated with plasma concentrations in different populations. However, the influence of BMI on these associations has not been explored in detail. We explored in a cross-sectional study the relation between dietary carotenoid and vitamin C intakes, using a 135-item FFQ, with their plasma concentrations by BMI categories in 252 men and 293 women, 65 years and older. For men and women combined, significant (P < 0·05) Pearson correlations were observed between energy-adjusted dietary intakes and plasma concentrations (carotenoids adjusted for cholesterol) for: α-carotene 0·21, β-carotene 0·19, lycopene 0·18, β-cryptoxanthin 0·20 and vitamin C 0·36. Multiple linear regression analyses showed that the intake of carotenoids and vitamin C were significant predictors of their respective plasma concentration (P < 0·01), and that BMI was inversely associated with plasma concentration of carotenoids (P ≤ 0·01) but not with plasma vitamin C. In addition, we observed significant interactions between BMI and the intakes of α-carotene and lutein + zeaxanthin, and to a lower extent β-carotene, suggesting that these intakes in subjects with high BMI were not good predictors of their plasma concentration. The present data suggest that plasma carotenoids and vitamin C may be good markers of dietary intake in elderly subjects, but not so for α-carotene, β-carotene and lutein + zeaxanthin in obese subjects.

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Carotenoids, vitamin A, vitamin C, vitamin E, and folate and risk of self-reported hearing loss in women

American Journal of Clinical Nutrition ◽

10.3945/ajcn.115.109314 ◽

2015 ◽

Vol 102 (5) ◽

pp. 1167-1175 ◽

Cited By ~ 23

Author(s):

Sharon G Curhan ◽

Konstantina M Stankovic ◽

Roland D Eavey ◽

Molin Wang ◽

Meir J Stampfer ◽

...

Keyword(s):

Hearing Loss ◽

Vitamin E ◽

Vitamin A ◽

Vitamin C ◽

Lower Risk ◽

Proportional Hazards ◽

Cox Proportional Hazards ◽

Folate Intake ◽

Health Study ◽

Β Carotene

ABSTRACT Background: Higher intake of certain vitamins may protect against cochlear damage from vascular compromise and oxidative stress, thereby reducing risk of acquired hearing loss, but data are limited. Objective: We prospectively examined the relation between carotenoids, vitamin A, vitamin C, vitamin E, and folate intake and risk of self-reported hearing loss in women. Design: This prospective cohort study followed 65,521 women in the Nurses’ Health Study II from 1991 to 2009. Baseline and updated information obtained from validated biennial questionnaires was used in Cox proportional hazards regression models to examine independent associations between nutrient intake and self-reported hearing loss. Results: After 1,084,598 person-years of follow-up, 12,789 cases of incident hearing loss were reported. After multivariable adjustment, we observed modest but statistically significant inverse associations between higher intake of β-carotene and β-cryptoxanthin and risk of hearing loss. In comparison with women in the lowest quintile of intake, the multivariable-adjusted RR of hearing loss among women in the highest quintile was 0.88 (95% CI: 0.81, 0.94; P-trend < 0.001) for β-carotene and 0.90 (95% CI: 0.84, 0.96; P-trend < 0.001) for β-cryptoxanthin. In comparison with women with folate intake 200–399 μg/d, very low folate intake (<200 μg/d) was associated with higher risk (RR: 1.19; 95% CI: 1.01, 1.41), and higher intake tended to be associated with lower risk (P-trend = 0.04). No significant associations were observed for intakes of other carotenoids or vitamin A. Higher vitamin C intake was associated with higher risk; in comparison with women with intake <75 mg/d, the RR among women with vitamin C intake ≥1000 mg/d (mainly supplemental) was 1.22 (95% CI: 1.06, 1.42; P-trend = 0.02). There was no significant trend between intake of vitamin E intake and risk. Conclusion: Higher intakes of β-carotene, β-cryptoxanthin, and folate, whether total or from diet, are associated with lower risk of hearing loss, whereas higher vitamin C intake is associated with higher risk.

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