LSC - 2021 - The role of the systemic inflammation in bronchiectasis exacerbation frequency

Systemic inflammation is a common denominator to a variety of cardiovascular (CV) and non-CV diseases and relative risk factors, including hypertension and its control, metabolic diseases, rheumatic disorders, and those affecting the gastrointestinal tract. Besides medications, a non-pharmacological approach encompassing lifestyle changes and other complementary measures is mentioned in several updated guidelines on the management of these conditions. We performed an updated narrative review on the mechanisms behind the systemic impact of inflammation and the role of non-pharmacological, complementary measures centered on lowering systemic phlogosis for preserving or restoring a good global health. The central role of genetics in shaping the immune response is discussed in conjunction with that of the microbiome, highlighting the interdependence and mutual influences between the human genome and microbial integrity, diversity, and functions. Several plausible strategies to modulate inflammation and restore balanced crosstalk between the human genome and the microbiome are then recapitulated, including dietary measures, active lifestyle, and other potential approaches to manipulate the resident microbial community. To date, evidence from high-quality human studies is sparse to allow the unconditioned inclusion of understudied, though plausible solutions against inflammation into public health strategies for global wellness. This gap claims further focused, well-designed research targeted at unravelling the mechanisms behind future personalized medicine.

Download Full-text

Systemic inflammation and oxidative stress induced by inhaled paraquat in rat improved by carvacrol, possible role of PPARγ receptors

BioFactors ◽

10.1002/biof.1761 ◽

2021 ◽

Author(s):

Fatemeh Amin ◽

Arghavan Memarzia ◽

Hamideh Kazemi Rad ◽

Farzaneh Shakeri ◽

Mohammad Hossein Boskabady

Keyword(s):

Oxidative Stress ◽

Systemic Inflammation ◽

And Oxidative Stress

Download Full-text

Does the Interaction between Local and Systemic Inflammation Provide a Link from Psychology and Lifestyle to Tissue Health in Musculoskeletal Conditions?

International Journal of Molecular Sciences ◽

10.3390/ijms22147299 ◽

2021 ◽

Vol 22 (14) ◽

pp. 7299

Author(s):

David M. Klyne ◽

Mary F. Barbe ◽

Greg James ◽

Paul W. Hodges

Keyword(s):

Connective Tissue ◽

Systemic Inflammation ◽

Molecular Basis ◽

Tissue Level ◽

Lifestyle Factors ◽

Local Inflammation ◽

Musculoskeletal Conditions ◽

Tissue Biology ◽

Mind And Body

Musculoskeletal conditions are known to involve biological, psychological, social and, often, lifestyle elements. However, these domains are generally considered in isolation from each other. This siloed approach is unlikely to be adequate to understand the complexity of these conditions and likely explains a major component of the disappointing effects of treatment. This paper presents a hypothesis that aims to provide a foundation to understand the interaction and integration between these domains. We propose a hypothesis that provides a plausible link between psychology and lifestyle factors with tissue level effects (such as connective tissue dysregulation/accumulation) in musculoskeletal conditions that is founded on understanding the molecular basis for interaction between systemic and local inflammation. The hypothesis provides plausible and testable links between mind and body, for which empirical evidence can be found for many aspects. We present this hypothesis from the perspective of connective tissue biology and pathology (fibrosis), the role of inflammation locally (tissue level), and how this inflammation is shaped by systemic inflammation through bidirectional pathways, and various psychological and lifestyle factors via their influence on systemic inflammation. This hypothesis provides a foundation for new consideration of the development and refinement of personalized multidimensional treatments for individuals with musculoskeletal conditions.

Download Full-text

The role of systemic inflammation in heart failure

Kazan medical journal ◽

10.17816/kmj2021-510 ◽

2021 ◽

Vol 102 (4) ◽

pp. 510-517

Author(s):

E V Khazova ◽

O V Bulashova

Keyword(s):

Heart Failure ◽

Cardiovascular Diseases ◽

Systemic Inflammation ◽

Left Ventricular ◽

Left Ventricular Ejection ◽

C Reactive Protein ◽

Ventricular Ejection Fraction ◽

Reactive Protein ◽

Highly Sensitive

The discussion continues about the role of systemic inflammation in the pathogenesis of cardiovascular diseases of ischemic etiology. This article reviews the information on the role of C-reactive protein in patients with atherosclerosis and heart failure in risk stratification for adverse cardiovascular events, including assessment of factors affecting the basal level of highly sensitive C-reactive protein. Research data (MRFIT, MONICA) have demonstrated a relationship between an increased level of C-reactive protein and the development of coronary heart disease. An increase in the serum level of highly sensitive C-reactive protein is observed in arterial hypertension, dyslipidemia, type 2 diabetes mellitus and insulin resistance, which indicates the involvement of systemic inflammation in these disorders. Currently, the assessment of highly sensitive C-reactive protein is used to determine the risk of developing myocardial infarction and stroke. It has been proven that heart failure patients have a high level of highly sensitive C-reactive protein compared with patients without heart failure. The level of C-reactive protein is referred to as modifiable risk factors for cardiovascular diseases of ischemic origin, since lifestyle changes or taking drugs such as statins, non-steroidal anti-inflammatory drugs, glucocorticoids, etc. reduce the level of highly sensitive C-reactive protein. In patients with heart failure with different left ventricular ejection fraction values, it was found that the regression of the inflammatory response is accompanied by an improvement in prognosis, which confirms the hypothesis of inflammation as a response to stress, which has negative consequences for the cardiovascular system.

Download Full-text

THIOZOLIDINEDIONES IN THE TREATMENT OF PATIENTS WITH EXTENSIVE PSORIASIS AND CONCOMITANT ALIMENTARY OBESITY

Актуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії ◽

10.31718/2077-1096.20.4.30 ◽

2020 ◽

Vol 20 (4) ◽

pp. 30-34

Author(s):

Ya.O. Yemchenko ◽

K.Ye. Ishcheikin ◽

I.P. Kaidashev

Keyword(s):

Systemic Inflammation ◽

Molecular Mechanisms ◽

Current Data ◽

The Body ◽

Internal Organs ◽

Single View ◽

Multifactorial Diseases ◽

Alimentary Obesity ◽

Inflammatory Processes

Psoriasis is one of the most common chronic recurrent systemic autoimmune multifactorial diseases, affected the skin, joints, internal organs and systems of the body. Despite the significant prevalence of psoriasis and a large number of studies devoted this problem there is still no single view on the pathogenesis of this dermatosis. To clear up the pathogenesis of psoriasis, it seems to be reasonable to focus on the common comorbidities or multimorbidities, which may occur in the course of psoriasis, as this issue is still insufficiently studied. Recent reports have proven the evidences of indisputable link between psoriasis and obesity. The scientific literature extensively covers the issues of identical pathogenetic mechanisms of inflammatory processes in psoriasis and obesity. Given the current data on the role of systemic inflammation underlying the development of both psoriasis and obesity, the study of molecular mechanisms of its development and in particularly the role of proinflammatory nuclear transcription factors, thiazolidinediones have been found out as pathogenetically justified medicine of choice for the therapy of these diseases. In this study, we determined the effectiveness of using 30 mg of pioglitazone daily for 6 months in the course of treatment for patients with extensive psoriasis vulgaris of moderate severity, who were also diagnosed as having concomitant grade І-ІІ alimentary obesity that was supported by clinical and immunological findings evidenced of systemic inflammation. Analyzing the results obtained, we have found out the prolonged therapy with pioglitazone leads to a decrease in systemic inflammation and contributes to a milder recurrent course of psoriasis.

Download Full-text

ROLE OF MACROPHAGES IN IMMUNOPATHOGENESIS OF PSORIASIS AND OBESITY

Актуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії ◽

10.31718/2077-1096.18.4.122 ◽

2018 ◽

Vol 18 (4) ◽

pp. 122-127 ◽

Cited By ~ 1

Author(s):

Ya. Yemchenko

Keyword(s):

Weight Loss ◽

Systemic Inflammation ◽

Genetic Factor ◽

Skin Diseases ◽

Inflammatory Reactions ◽

Multifactorial Diseases ◽

Psoriatic Disease ◽

Close Relationship ◽

Unified View

Psoriasis is one of the most common chronic recurrent multifactorial diseases of the skin with a predominance of genetic factor. The disease is characterized by hyperproliferation of epidermal cells, impairment in the keratinisation process against inflammatory reactions in the dermis, and by lesions on the nails, joints and scalp. According to the results of clinical and epidemiological research, about 3-4% of the population of our planet has psoriasis, regardless of gender, age and ethnic group, while the share of this pathology in the overall structure of skin diseases reaches from 1% - to 40% [4, 5], according to various data. However, despite the widespread of psoriasis and the large number of works on this problem, there is still no unified view on the pathogenesis of this dermatosis. To clear up the pathogenesis of psoriasis, it is necessary to take into account the insufficiently studied comorbidities typically associated with this pathology. Recently, there has been a tendency towards the growth of psoriatic disease and obesity in the pathogenesis of which a significant role is assigned to systemic inflammation and macrophages. According to the results of this research, it has been found out that obesity and psoriasis has a common link of the pathogenesis, systemic inflammation, which manifests itself in the increased number of macrophages producing a large number of proinflammatory cytokines. Thus, obesity and inflammation causes a vicious circle of cause-and-effect relationships. Obesity provokes inflammation, and inflammation, in turn, increases obesity and prevents weight loss. The close relationship between psoriasis and obesity is extremely important in selecting patient-centred therapy. Therefore, the goal of further research is to carry out detailed study of the psoriatic comorbidities that will contribute into revealing new targets for the treatment of this dermatosis.

Download Full-text

Role of Circulating Microparticles in Type 2 Diabetes Mellitus: Implications for Pathological Clotting

Seminars in Thrombosis and Hemostasis ◽

10.1055/s-0041-1740150 ◽

2021 ◽

Author(s):

Siphosethu Cassandra Maphumulo ◽

Etheresia Pretorius

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Systemic Inflammation ◽

Blood Cells ◽

Low Grade ◽

Chronic Hyperglycemia ◽

Increased Risk

AbstractType 2 diabetes mellitus (T2DM) is a multifactorial chronic metabolic disease characterized by chronic hyperglycemia due to insulin resistance and a deficiency in insulin secretion. The global diabetes pandemic relates primarily to T2DM, which is the most prevalent form of diabetes, accounting for over 90% of all cases. Chronic low-grade inflammation, triggered by numerous risk factors, and the chronic activation of the immune system are prominent features of T2DM. Here we highlight the role of blood cells (platelets, and red and white blood cells) and vascular endothelial cells as drivers of systemic inflammation in T2DM. In addition, we discuss the role of microparticles (MPs) in systemic inflammation and hypercoagulation. Although once seen as inert by-products of cell activation or destruction, MPs are now considered to be a disseminated storage pool of bioactive effectors of thrombosis, inflammation, and vascular function. They have been identified to circulate at elevated levels in the bloodstream of individuals with increased risk of atherothrombosis or cardiovascular disease, two significant hallmark conditions of T2DM. There is also general evidence that MPs activate blood cells, express proinflammatory and coagulant effects, interact directly with cell receptors, and transfer biological material. MPs are considered major players in the pathogenesis of many systemic inflammatory diseases and may be potentially useful biomarkers of disease activity and may not only be of prognostic value but may act as novel therapeutic targets.

Download Full-text