scholarly journals Occupational exposure to pesticides and respiratory health

2015 ◽  
Vol 24 (136) ◽  
pp. 306-319 ◽  
Author(s):  
Ali Mamane ◽  
Isabelle Baldi ◽  
Jean-François Tessier ◽  
Chantal Raherison ◽  
Ghislaine Bouvier
Keyword(s):  
Occupational Exposure ◽  
Chronic Bronchitis ◽  
Respiratory Function ◽  
Respiratory Symptoms ◽  
Pesticide Exposure ◽  
Respiratory Health ◽  
Epidemiological Studies ◽  
Chronic Obstructive ◽  
Cross Sectional ◽  
Increased Risk

This article aims to review the available literature regarding the link between occupational exposure to pesticides and respiratory symptoms or diseases. Identification of epidemiological studies was performed using PubMed. 41 articles were included, 36 regarding agricultural workers and five regarding industry workers.Among the 15 cross-sectional studies focusing on respiratory symptoms and agricultural pesticide exposure, 12 found significant associations with chronic cough, wheeze, dyspnoea, breathlessness or chest tightness. All four studies on asthma found a relationship with occupational exposure, as did all three studies on chronic bronchitis. The four studies that performed spirometry reported impaired respiratory function linked to pesticide exposure, suggestive of either obstructive or restrictive syndrome according to the chemical class of pesticide.12 papers reported results from cohort studies. Three out of nine found a significant relationship with increased risk of wheeze, five out of nine with asthma and three out of three with chronic bronchitis. In workers employed in pesticide production, elevated risks of chronic obstructive pulmonary disease (two studies out of three) and impaired respiratory function suggestive of an obstructive syndrome (two studies out of two) were reported.In conclusion, this article suggests that occupational exposure to pesticides is associated with an increased risk of respiratory symptoms, asthma and chronic bronchitis, but the causal relationship is still under debate.

scholarly journals Increase in the Risk of Respiratory Disorders in Adults and Children Related to Crop-Growing in Niger

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Ali Mamane ◽  
Jean-François Tessier ◽  
Ghislaine Bouvier ◽  
Roger Salamon ◽  
Pierre Lebailly ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Environmental Factors ◽  
Respiratory Symptoms ◽  
Respiratory Health ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Face To Face ◽  
Increased Risk ◽  
Adults And Children ◽  
Agricultural Areas

Background and Objective. Environmental factors are an increasing concern for respiratory health in developing countries. The objective of this study was to investigate whether Nigerien people living in cultivated areas have more respiratory symptoms than those living in pastoral areas. Method. A cross-sectional study was conducted in 2013 in two populations during the rainy season when land is cultivated. Environmental factors including pesticide use and respiratory symptoms were collected in adults and children during face-to-face interviews. Multivariate analysis between exposures and symptoms was performed in children and in adults separately. Results. The study included 471 adults and 229 children. Overall, none of the households reported the use of pesticides for agricultural purposes. However, 87.2% reported the use of insecticides at home. Multivariate analysis showed that people living in agricultural areas compared to those in pastoral areas had an increased risk of respiratory symptoms in adults (wheezing, dyspnea, sudden shortness of breath, and cough without fever) and in children (cough without fever). The use of insecticides showed no effect on respiratory symptoms after adjustment. Conclusion. This first epidemiological study on the environment and respiratory health conducted in Niger demonstrates a significant relationship between respiratory manifestations and the agricultural characteristics of the living area. However only the effect of insecticides in the home on respiratory health was observed.

scholarly journals Allergic and Respiratory Symptoms in Employees of Indoor Cannabis Grow Facilities

2020 ◽  
Vol 64 (7) ◽  
pp. 754-764
Author(s):  
Coralynn Sack ◽  
Niloufar Ghodsian ◽  
Karen Jansen ◽  
Brynne Silvey ◽  
Christopher D Simpson
Keyword(s):  
Respiratory Symptoms ◽  
Respiratory Health ◽  
Skin Prick Testing ◽  
Airflow Obstruction ◽  
Allergic Diseases ◽  
Washington State ◽  
Cross Sectional ◽  
Health Symptoms ◽  
Work Related ◽  
Increased Risk

Abstract Background While little is known about the occupational hazards associated with Cannabis cultivation, both historical research in the hemp industry and preliminary data from modern grow houses, suggest that Cannabis workers may be at increased risk of respiratory and allergic diseases. Objectives We sought to investigate the association between workplace exposures and health symptoms in an indoor Cannabis grow facility in Washington State, USA. Methods We performed a cross-sectional study with all consenting employees in an indoor Cannabis grow facility in Seattle, WA using a questionnaire. The questionnaire gathered data on respiratory, ocular, nasal, and dermal symptoms. A subset of employees with work-related symptoms underwent repeated cross-shift and cross-week measurement of spirometry, fractional exhaled nitrogen oxide (FeNO), and skin prick testing for Cannabis sensitization. Exposure to Cannabis dust was classified based on self-described tasks, expert opinion, and exposure monitoring of particulate matter. Multivariable logistic regression was undertaken to examine associations between exposure to Cannabis dust (classified as low, medium, and high) and health symptoms. Linear mixed effects models examined the relationship between cross-shift and cross-week changes in spirometry and FeNO. Results Ninety-seven percent (97%) of the employees (n = 31) surveyed were recreational cannabis users, with 81% (n = 25) smoking cannabis multiple times per day. Twenty-two (71%) employees reported one or more work-related symptoms: 65% respiratory, 39% ocular, 32% nasal, and 26% dermal symptoms. There was a trend toward increased likelihood of work-related symptoms with increasing exposure to Cannabis dust, although none of these results were statistically significant. Of the 10 employees with work-aggravated symptoms, 5 had borderline-high or high FeNO, 7 had abnormal spirometry, and 5 had evidence of Cannabis sensitization on skin prick testing. FeNO increased by 3.78 ppb (95% confidence interval 0.68–6.88 ppb) across the work-week and there was a trend toward cross-week and cross-shift reduced airflow. Conclusions We found a high prevalence of work-related allergic- and particularly respiratory symptoms in the employees of one indoor Cannabis grow facility in Washington State. A high proportion of employees with work-aggravated symptoms had findings consistent with probable work-related asthma based on high FeNO, airflow obstruction on spirometry, and Cannabis sensitization on skin prick testing. However, due to the high incidence of recreational cannabis use among these workers, the relative influence of occupational versus recreational exposure to Cannabis dust on the respiratory health and sensitization status of these workers could not be resolved in this study.

scholarly journals Respiratory Symptoms and Lung Function among Ethiopian Women in Relation to Household Fuel Use

2019 ◽  
Vol 17 (1) ◽  
pp. 41 ◽  
Author(s):  
Mulugeta Tamire ◽  
Adamu Addissie ◽  
Abera Kumie ◽  
Emma Husmark ◽  
Susann Skovbjerg ◽  
...  
Keyword(s):  
Lung Function ◽  
Rural Areas ◽  
Respiratory Symptoms ◽  
Respiratory Health ◽  
Forced Expiratory Volume ◽  
Solid Fuels ◽  
Chronic Obstructive ◽  
European Respiratory Society ◽  
Cross Sectional ◽  
Validated Questionnaire

Exposure to household air pollution has been linked to chronic obstructive pulmonary disease, respiratory symptoms and reduced lung function. This study aims to assess respiratory symptoms and lung function among Ethiopian women in relation to exposure to HAP. We conducted a cross-sectional study among non-smoking women responsible for household cooking. Data was collected on socio-demographic characteristics, respiratory symptoms and risk factors using a validated questionnaire. Spirometry with reversibility testing was performed according to American Thoracic Society/European Respiratory Society guidelines. We used independent t-test and multivariable logistic regression to compare the means and measure association respectively. A total of 545 women participated in the study out of which 231 (42.3%) performed spirometry with at least three acceptable manoeuvres. Everyone in the rural group and 43% of the urban group were exposed to HAP from solid fuels during cooking. The odds of developing at least one respiratory symptom when compared with those using cleaner fuels are twice as high for women cooking within the living house. We also found significantly lower forced expiratory volume in the first second (FEV1) (L) among solid fuels users compared with cleaner energy users. Given the larger population settlement in the rural areas and the use of solid fuel as the only energy source, there is a higher risk of developing chronic respiratory health problems for those women in Ethiopia.

scholarly journals Increased respiratory symptoms in COPD patients living in the vicinity of livestock farms

2015 ◽  
Vol 46 (6) ◽  
pp. 1605-1614 ◽  
Author(s):  
Floor Borlée ◽  
C. Joris Yzermans ◽  
Christel E. van Dijk ◽  
Dick Heederik ◽  
Lidwien A.M. Smit
Keyword(s):  
Respiratory Symptoms ◽  
Respiratory Health ◽  
Personal Characteristics ◽  
Chronic Obstructive ◽  
Livestock Farming ◽  
Obstructive Pulmonary Disease ◽  
Livestock Farm ◽  
Copd Patients ◽  
Increased Risk ◽  
Livestock Farms

Several studies have investigated the effect of livestock farm emissions on the respiratory health of local residents, but results are inconsistent. This study aims to explore associations between the presence of livestock farms and respiratory health in an area of high-density livestock farming in the Netherlands. We focused especially on associations between farm exposures and respiratory symptoms within subgroups of potentially susceptible patients with a pre-existing lung disease.In total, 14 875 adults (response rate 53.4%) completed a questionnaire concerning respiratory health, smoking habits and personal characteristics. Different indicators of livestock farm exposures relative to the home address were computed using a geographic information system.Prevalence of chronic obstructive pulmonary disease (COPD) and asthma was lower among residents living within 100 m of a farm (OR 0.47, 95% CI 0.24–0.91 and OR 0.65, 95% CI 0.45–0.93, respectively). However, >11 farms in 1000 m compared to fewer than four farms in 1000 m (fourth quartileversusfirst quartile) was associated with wheezing among COPD patients (OR 1.71, 95% CI 1.01–2.89). Using general practitioners' electronic medical records, we demonstrated that selection bias did not affect the observed associations.Our data suggest a protective effect of livestock farm emissions on the respiratory health of residents. Nonetheless, COPD patients living near livestock farms reported more respiratory symptoms, suggesting an increased risk of exacerbations.

scholarly journals Occupational exposures and incidence of chronic bronchitis and related symptoms over two decades: the European Community Respiratory Health Survey

2019 ◽  
pp. oemed-2018-105274 ◽  
Author(s):  
Theodore Lytras ◽  
Manolis Kogevinas ◽  
Hans Kromhout ◽  
Anne-Elie Carsin ◽  
Josep Maria Antó ◽  
...  
Keyword(s):  
Chronic Bronchitis ◽  
European Community ◽  
Health Survey ◽  
Mineral Dust ◽  
Respiratory Health ◽  
Occupational Exposures ◽  
Dust Exposure ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Increased Risk

ObjectivesChronic bronchitis (CB) is an important chronic obstructive pulmonary disease (COPD)-related phenotype, with distinct clinical features and prognostic implications. Occupational exposures have been previously associated with increased risk of CB but few studies have examined this association prospectively using objective exposure assessment. We examined the effect of occupational exposures on CB incidence in the European Community Respiratory Health Survey.MethodsPopulation samples aged 20–44 were randomly selected in 1991–1993, and followed up twice over 20 years. Participants without chronic cough or phlegm at baseline were analysed. Coded job histories during follow-up were linked to the ALOHA Job Exposure Matrix, generating occupational exposure estimates to 12 categories of chemical agents. Their association with CB incidence over both follow-ups was examined with Poisson models using generalised estimating equations.Results8794 participants fulfilled the inclusion criteria, contributing 13 185 observations. Only participants exposed to metals had a higher incidence of CB (relative risk (RR) 1.70, 95% CI 1.16 to 2.50) compared with non-exposed to metals. Mineral dust exposure increased the incidence of chronic phlegm (RR 1.72, 95% CI 1.43 to 2.06). Incidence of chronic phlegm was increased in men exposed to gases/fumes and to solvents and in women exposed to pesticides.ConclusionsOccupational exposures are associated with chronic phlegm and CB, and the evidence is strongest for metals and mineral dust exposure. The observed differences between men and women warrant further investigation.

scholarly journals Asthma and chronic bronchitis symptoms among adult population of Belgrade

2011 ◽  
Vol 139 (3-4) ◽  
pp. 149-154 ◽  
Author(s):  
Branislava Milenkovic ◽  
Marija Mitic-Milikic ◽  
Predrag Rebic ◽  
Miodrag Vukcevic ◽  
Aleksandra Dudvarski-Ilic ◽  
...  
Keyword(s):  
Chronic Bronchitis ◽  
Respiratory Symptoms ◽  
Respiratory Health ◽  
Adult Population ◽  
Chronic Obstructive ◽  
Sputum Production ◽  
Chronic Obstructive Pulmonary Diseases ◽  
High Prevalence ◽  
Smoking Addiction ◽  
Almost All

Introduction. Over the last three decades the prevalence of respiratory diseases has been increasing worldwide thus increasing economic burden on the healthcare system. Recent studies have shown that the prevalence of asthma in West European countries ranges from 6-9%, while of chronic obstructive pulmonary diseases (COPD) is 8.0% worlwide. Objective. The aim of the study was to estimate the prevalence of respiratory symptoms and smoking habits, and to assess the prevalence of asthma and chronic bronchitis among adults in Belgrade, Serbia. Methods. To collect data we used a questionnaire based on the European Community Respiratory Health Survey (ECRHS) protocol, which was mailed to 10,208 randomly selected subjects. Results. There were 58.3% of responders to our questionnaire. We noted a higher prevalence of respiratory symptoms in subjects who responded promptly. The majority of the respondents were current or former smokers (37.5% and 17.5% respectively) and 79.9% of them reported respiratory symptoms. The most frequent symptoms were longstanding cough (32.2%), sputum production (30.4%) and wheezing (30.3%). Asthma attacks were reported in 4.4% of cases and 5.6% of subjects were using asthma medications. The prevalence of respiratory symptoms increased with age. Women reported coughing, attacks of breathlessness and coughing, chest tightness by night, allergic rhinitis and chronic coughing, more frequently than men. Productive cough was more frequent in men. The prevalence of almost all symptoms was higher in smokers compared to nonsmokers. Conclusion. In Serbia there is a high prevalence of respiratory symptoms, asthma and chronic bronchitis smoking addiction.

scholarly journals Lung function and respiratory diseases in people with psychosis: Population-based study

2015 ◽  
Vol 207 (1) ◽  
pp. 37-45 ◽  
Author(s):  
Krista Partti ◽  
Tuula Vasankari ◽  
Merja Kanervisto ◽  
Jonna Perälä ◽  
Samuli I. Saarni ◽  
...  
Keyword(s):  
Lung Function ◽  
General Population ◽  
Chronic Bronchitis ◽  
Respiratory Diseases ◽  
Psychotic Disorders ◽  
Respiratory Health ◽  
Population Based ◽  
Chronic Obstructive ◽  
Serum Cotinine ◽  
Increased Risk

BackgroundThere is little information on lung function and respiratory diseases in people with psychosis.AimsTo compare the respiratory health of people with psychosis with that of the general population.MethodIn a nationally representative sample of 8028 adult Finns, lung function was measured by spirometry. Information on respiratory diseases and symptoms was collected. Smoking was quantified with serum cotinine levels. Psychotic disorders were diagnosed utilising the Structured Clinical Interview for DSM-IV (SCID-I) and medical records.ResultsParticipants with schizophrenia and other non-affective psychoses had significantly lower lung function values compared with the general population, and the association remained significant for schizophrenia after adjustment for smoking and other potential confounders. Schizophrenia was associated with increased odds of pneumonia (odds ratio (OR) = 4.9), chronic obstructive pulmonary disease (COPD, OR = 4.2) and chronic bronchitis (OR = 3.8); and with high cotinine levels.ConclusionsSchizophrenia is associated with impaired lung function and increased risk for pneumonia, COPD and chronic bronchitis.

scholarly journals Chronic respiratory disease in adult outpatients in three African countries: a cross-sectional study

2022 ◽  
Vol 26 (1) ◽  
pp. 18-25
Author(s):  
A. B. Binegdie ◽  
H. Meme ◽  
A. El Sony ◽  
T. Haile ◽  
R. Osman ◽  
...  
Keyword(s):  
Chronic Bronchitis ◽  
Respiratory Disease ◽  
Respiratory Symptoms ◽  
Chronic Respiratory Disease ◽  
Cross Sectional Study ◽  
Chronic Obstructive ◽  
Sectional Study ◽  
African Countries ◽  
Cross Sectional ◽  
Hospital Outpatient

BACKGROUND: The greatest burden of chronic respiratory disease is in low- and middle-income countries, with recent population-based studies reporting substantial levels of obstructive and restrictive lung function.OBJECTIVE: To characterise the common chronic respiratory diseases encountered in hospital outpatient clinics in three African countries.METHODS This was a cross-sectional study of consecutive adult patients with chronic respiratory symptoms (>8 weeks) attending hospital outpatient departments in Ethiopia, Kenya and Sudan. Patients were assessed using a respiratory questionnaire, spirometry and chest radiography. The diagnoses of the reviewing clinicians were ascertained.RESULT: A total of 519 patients (209 Kenya, 170 Ethiopia, 140 Sudan) participated; the mean age was 45.2 years (SD 16.2); 53% were women, 83% had never smoked. Reviewing clinicians considered that 36% (95% CI 32–40) of patients had asthma, 25% (95% CI 21–29) had chronic bronchitis, 8% (95% CI 6–11) chronic obstructive pulmonary disease (COPD), 5% (95% CI 4–8) bronchiectasis and 4% (95% CI 3–6) post-TB lung disease. Spirometry consistent with COPD was present in 35% (95% CI 30–39). Restriction was evident in 38% (95% CI 33–43). There was evidence of sub-optimal diagnosis of asthma and COPD.CONCLUSION: In Ethiopia, Kenya and Sudan, asthma, COPD and chronic bronchitis account for the majority of diagnoses in non-TB patients with chronic respiratory symptoms. The suboptimal diagnosis of these conditions will require the widespread use of spirometry.

COPD, airflow limitation and chronic bronchitis in farmers: a systematic review and meta-analysis

2018 ◽  
Vol 76 (1) ◽  
pp. 58-68 ◽  
Author(s):  
Alicia Guillien ◽  
Thibaud Soumagne ◽  
Jean-Charles Dalphin ◽  
Bruno Degano
Keyword(s):  
Chronic Bronchitis ◽  
Meta Analysis ◽  
Airflow Limitation ◽  
Control Group ◽  
Chronic Obstructive ◽  
Cross Sectional ◽  
Agricultural Work ◽  
Current Definition ◽  
Increased Risk ◽  
Definition Of

IntroductionThe current definition of chronic obstructive pulmonary disease (COPD) associates persistent airflow limitation and chronic respiratory symptoms. Agricultural work has been associated with an increased risk of developing COPD, but the prevalence and definition of the disease vary greatly between studies. This meta-analysis aimed to assess the association between agricultural work and COPD using the most widely used definitions of the disease.MethodsInclusion criteria were: (1) design: cross-sectional or longitudinal, (2) groups: at least one group of farmers and a control group of non-farmers, (3) outcome: prevalence or unadjusted OR of COPD, airflow limitation and/or chronic bronchitis, (4) study subjects: groups of exposed subjects comprising ≥30 individuals and with a mean age ≥40 years and (5) language: English and French language, full-length, original publications in peer-reviewed journals.ResultsIn total, 22 manuscripts were included in the meta-analysis. Eight studies assessed only the prevalence of airflow limitation, nine assessed only the prevalence of chronic bronchitis and four assessed the prevalence of both these parameters. Only one assessed the prevalence of COPD according to its current definition, and this study also provided the prevalence of airflow limitation. Ten studies showed a positive association between farming exposure and airflow limitation or chronic bronchitis, and 12 showed no association (OR (95% CI)=1.77 (1.50 to 2.08), p<0.001). Cattle, swine, poultry and crop farming were associated with either airflow limitation or chronic bronchitis.ConclusionAlthough some features of COPD are associated with some agricultural work, well-designed studies with appropriate diagnostic criteria should be conducted to draw strong conclusions about the relationship between COPD and farming.

scholarly journals Comparative Proteomic Analysis of Carbonylated Proteins from the Striatum and Cortex of Pesticide-Treated Mice

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Christina Coughlan ◽  
Douglas I. Walker ◽  
Kelly M. Lohr ◽  
Jason R. Richardson ◽  
Laura M. Saba ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pesticide Exposure ◽  
Epidemiological Studies ◽  
Cytoskeletal Proteins ◽  
Synaptic Function ◽  
Behavioral Alterations ◽  
Mechanisms Of Toxicity ◽  
Kegg Pathways ◽  
Increased Risk ◽  
Proteomic Analyses

Epidemiological studies indicate exposures to the herbicide paraquat (PQ) and fungicide maneb (MB) are associated with increased risk of Parkinson’s disease (PD). Oxidative stress appears to be a premier mechanism that underlies damage to the nigrostriatal dopamine system in PD and pesticide exposure. Enhanced oxidative stress leads to lipid peroxidation and production of reactive aldehydes; therefore, we conducted proteomic analyses to identify carbonylated proteins in the striatum and cortex of pesticide-treated mice in order to elucidate possible mechanisms of toxicity. Male C57BL/6J mice were treated biweekly for 6 weeks with saline, PQ (10 mg/kg), MB (30 mg/kg), or the combination of PQ and MB (PQMB). Treatments resulted in significant behavioral alterations in all treated mice and depleted striatal dopamine in PQMB mice. Distinct differences in 4-hydroxynonenal-modified proteins were observed in the striatum and cortex. Proteomic analyses identified carbonylated proteins and peptides from the cortex and striatum, and pathway analyses revealed significant enrichment in a variety of KEGG pathways. Further analysis showed enrichment in proteins of the actin cytoskeleton in treated samples, but not in saline controls. These data indicate that treatment-related effects on cytoskeletal proteins could alter proper synaptic function, thereby resulting in impaired neuronal function and even neurodegeneration.

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