scholarly journals The effects of acupuncture treatment on the right frontoparietal network in migraine without aura patients

2015 ◽  
Vol 16 (1) ◽  
Author(s):  
Kuangshi Li ◽  
Yong Zhang ◽  
Yanzhe Ning ◽  
Hua Zhang ◽  
Hongwei Liu ◽  
...  
Keyword(s):  
Migraine Without Aura ◽  
Acupuncture Treatment ◽  
Frontoparietal Network ◽  
The Right

scholarly journals The Cumulative Therapeutic Effect of Acupuncture Treatment in Patients With Migraine Without Aura: Evidence From Dynamic Alterations of Intrinsic Brain Activity and Effective Connectivity Analysis

2021 ◽  
Author(s):  
Yilei Chen ◽  
Yingjie Kang ◽  
Shilei Luo ◽  
Shanshan Liu ◽  
Bo Wang ◽  
...  
Keyword(s):  
Migraine Attack ◽  
Therapeutic Effect ◽  
Migraine Without Aura ◽  
Acupuncture Treatment ◽  
Brain Activity ◽  
Effective Connectivity ◽  
Life Questionnaire ◽  
Precentral Gyrus ◽  
The Right ◽  
Intrinsic Brain Activity

Abstract Background: The underlying neurological mechanism of acupuncture treatment in migraine without aura (MwoA) remains unclear. Therefore, we explored the dynamic alterations of intrinsic brain activity and effective connectivity in patients with MwoA after acupuncture treatment.Methods:The fMRI scans were separately obtained at baseline, after the first and after the 12th acupuncture sessions in 40 patients with MwoA. The acupuncture treatments were finished within 6 weeks as twice a week. 36 matched healthy controls (HCs) were recruited and performed once fMRI scan. The dynamic amplitude of low-frequency fluctuation (dALFF) and dynamic granger causality analysis(GCA) were used to analyze the difference of different time points in patients with MwoA. The correlation analyses were performed in dALFF variability, dynamic effective connectivity (DEC) variability with clinical variables in patients with MwoA.Results:Compared with HCs, Patients with MwoA at baseline showed decreased dALFF variability in regions within rostral ventromedial medulla (RVM), the superior lobe of left cerebellum (Cerebelum_Crus1_L), the right inferior frontal gyrus, triangular part (IFGtriang.R), the right median cingulate and paracingulate gyri (DCG.R), the right precuneus (PCUN.R), and the left inferior parietal, supramarginal and angular gyri (IPL.L), increased dALFF variability only in the left inferior occipital gyrus (IOG.L). After acupuncture treatment, the decreased dALFF variability of the RVM, Cerebelum_Crus1_L , and PCUN.R progressively recovered, the RVM revealed gradually increased DEC variability to the right middle frontal gyrus (MFG.R), the left insula (INS.L), the right precentral gyrus (PreCG.R), and the right supramarginal gyrus (SMG.R). And enhanced DEC variability from the right fusiform gyrus (FFG.R) to RVM. Furthermore, the increased DEC variability were found from Cerebelum_Crus1_L to the left middle occipital gyrus (MOG.L) and the left precentral gyrus (PreCG.L), from PCUN.R to the right thalamus (THA.R). These dALFF variabilities were significantly positive correlated with frequency of migraine attack and negative correlated with disease duration at baseline, dynamic GCA coefficients were significantly positive correlated with Migraine-Specific Quality of Life Questionnaire (MSQ) score, negative correlated with frequency of migraine attack and visual analog scale (VAS) score postacupuncture treatment.Conclusions:Our results provide insight into dynamic alterations from the perspective of dynamic local brain activity and effective connectivity for the understanding mechanisms of cumulative therapeutic effect of acupuncture in patients with MwoA.Trial registration: ChiCTR, ChiCTR1900023105. Registered 11 May 2019, http://www.chictr.org.cn/showproj.aspx?proj=36959.

scholarly journals The Cumulative Therapeutic Effect of Acupuncture Treatment in Patients with Migraine without Aura: Evidence from Dynamic Alterations of Intrinsic Brain Activity and Effective Connectivity Analysis

2022 ◽  
Author(s):  
Yilei Chen ◽  
Yingjie Kang ◽  
Shilei Luo ◽  
Shanshan Liu ◽  
Bo Wang ◽  
...  
Keyword(s):  
Migraine Attack ◽  
Therapeutic Effect ◽  
Migraine Without Aura ◽  
Acupuncture Treatment ◽  
Brain Activity ◽  
Effective Connectivity ◽  
Life Questionnaire ◽  
Precentral Gyrus ◽  
The Right ◽  
Intrinsic Brain Activity

Abstract We explored the dynamic alterations of intrinsic brain activity and effective connectivity after acupuncture treatment to investigate the underlying neurological mechanism of acupuncture treatment in patients with migraine without aura (MwoA). The fMRI scans were separately obtained at baseline, after the first and after the 12th acupuncture sessions in 40 patients with MwoA. Compared with HCs, patients with MwoA showed mostly decreased dynamic amplitude of low-frequency fluctuation (dALFF) variability in regions with differences. After acupuncture treatment, the decreased dALFF variability of the rostral ventromedial medulla (RVM), the superior lobe of left cerebellum (Cerebelum_Crus1_L), and the right precuneus (PCUN.R) progressively recovered. The RVM revealed gradually increased dynamic effective connectivity (DEC) variability outflow to the right middle frontal gyrus, the left insula, the right precentral gyrus, and the right supramarginal gyrus, and enhanced DEC variability from the right fusiform gyrus inflow to RVM. Furthermore, the increased DEC variability were found from Cerebelum_Crus1_L outflow to the left middle occipital gyrus and the left precentral gyrus, from PCUN.R outflow to the right thalamus. These dALFF variabilities were positive correlated with frequency of migraine attack and negative correlated with disease duration, dynamic GCA coefficients were positive correlated with Migraine-Specific Quality of Life Questionnaire score, negative correlated with frequency of migraine attack and visual analog scale score postacupuncture treatment. Our results provide insight into dynamic alterations from the perspective of dynamic local brain activity and effective connectivity for the understanding mechanisms of cumulative therapeutic effect of acupuncture in patients with MwoA.

Effects of external trigeminal nerve stimulation (eTNS) on laser evoked cortical potentials (LEP): A pilot study in migraine patients and controls

Cephalalgia ◽  
2017 ◽  
Vol 38 (7) ◽  
pp. 1245-1256 ◽  
Author(s):  
Eleonora Vecchio ◽  
Eleonora Gentile ◽  
Giovanni Franco ◽  
Katia Ricci ◽  
Marina de Tommaso
Keyword(s):  
Pilot Study ◽  
Nerve Stimulation ◽  
Migraine Without Aura ◽  
Anterior Cingulate ◽  
Evoked Responses ◽  
The Real ◽  
Sham Stimulation ◽  
Primary Headache Disorders ◽  
Transcutaneous Nerve Stimulation ◽  
The Right

Background Transcutaneous external supraorbital nerve stimulation has emerged as a treatment option for primary headache disorders, though its action mechanism is still unclear. Study aim In this randomized, sham-controlled pilot study we aimed to test the effects of a single external transcutaneous nerve stimulation session on pain perception and cortical responses induced by painful laser stimuli delivered to the right forehead and the right hand in a cohort of migraine without aura patients and healthy controls. Methods Seventeen migraine without aura patients and 21 age- and sex-matched controls were selected and randomly assigned to a real or sham external transcutaneous nerve stimulation single stimulation session. The external transcutaneous nerve stimulation was delivered with a self-adhesive electrode placed on the forehead and generating a 60 Hz pulse at 16 mA intensity for 20 minutes. For sham stimulation, we used 2 mA intensity. Laser evoked responses were recorded from 21 scalp electrodes in basal condition (T0), during external transcutaneous nerve stimulation and sham stimulation (T1), and immediately after these (T2). The laser evoked responses were analyzed by LORETA software. Results The real external transcutaneous nerve stimulation reduced the trigeminal N2P2 amplitude in migraine and control groups significantly in respect to placebo. The real stimulation was associated with lower activity in the anterior cingulate cortex under trigeminal laser stimuli. The pattern of LEP-reduced habituation was reverted by real and sham transcutaneous stimulation in migraine patients. Conclusions The present results could suggest that the external transcutaneous nerve stimulation may interfere with the threshold and the extent of trigeminal system activation, with a mechanism of potential utility in the resolution and prevention of migraine attacks.

scholarly journals Altered Connectivity of the Frontoparietal Network During Attention Processing in Prolactinomas

2021 ◽  
Vol 12 ◽  
Author(s):  
Chenglong Cao ◽  
Yu Wang ◽  
Jia Liu ◽  
Aobo Chen ◽  
Jinjiang Lu ◽  
...  
Keyword(s):  
Cognitive Functions ◽  
Healthy Controls ◽  
Frontoparietal Network ◽  
The Right

Prolactinomas have been reported for the failure of cognitive functions. However, the electrophysiological mechanisms of attention processing in prolactinomas remain unclear. In a visual mission, we monitored the scalp electroencephalography (EEG) of the participants. Compared with the healthy controls (HCs), larger frontoparietal theta and alpha coherence were found in the patients, especially in the right-lateralized hemisphere, which indicated a deficit in attention processing. Moreover, the frontoparietal coherence was positively correlated with altered prolactin (PRL) levels, implying the significance of PRL for adaptive brain compensation in prolactinomas. Taken together, this research showed the variations in attention processing between the HCs and prolactinomas. The coherence between frontal and parietal regions may be one of the possible electrophysiological biomarkers for detecting deficient attention processing in prolactinomas.

The digiti quinti sign in hemiplegic migraine

Cephalalgia ◽  
2010 ◽  
Vol 31 (1) ◽  
pp. 13-17 ◽  
Author(s):  
Maurice B Vincent ◽  
Fernanda ML Carvalho-e-Silva ◽  
Ronir R Luiz
Keyword(s):  
Sensitivity And Specificity ◽  
Migraine Without Aura ◽  
Clinical Indication ◽  
Motor Deficit ◽  
Optimal Cutoff ◽  
Hemiplegic Migraine ◽  
Optimal Cutoff Point ◽  
The Difference ◽  
The Right ◽  
Symptomatic Side

The digiti quinti sign (DQS), described originally as a clinical indication of subtle motor deficit, consists of a relatively greater abduction of the fifth finger on the affected side when both arms are extended forwards. This sign was previously observed interictally in three consecutive hemiplegic migraine (HM) patients. Patients and methods: To verify whether the DQS specifically discriminates HM from non-hemiplegic migraine (nHM), the angle between the fourth and fifth fingers (ANG) was measured interictally in 10 HM patients, 44 migraine with aura and migraine without aura patients, and 45 healthy controls. Results: The ANG was significantly wider at the symptomatic side in HM as compared with nHM and controls. The differences between the symptomatic and non-symptomatic (for HM) or between the right and left sides (absolute values for nHM and controls) were, respectively, 10.10° ± 9.58°, 4.15° ± 3.95° and 5.37° ± 4.74° ( p = .007). The optimal cutoff point for ANG was 15° at the symptomatic side (sensitivity and specificity of 80.0% and 72.2%, respectively), 10.5° at the non-symptomatic side (sensitivity and specificity of 60.0% and 52.3%), and 3° for the difference between sides (sensitivity and specificity of 90.0% and 79.5%). Conclusion: Data show that the DQS discriminates HM from nHM and controls.

scholarly journals Altered functional connectivity of the red nucleus and substantia nigra in migraine without aura

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Xiaobin Huang ◽  
Di Zhang ◽  
Yuchen Chen ◽  
Peng Wang ◽  
Cunnan Mao ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Substantia Nigra ◽  
Resting State ◽  
Migraine Without Aura ◽  
Parietal Lobe ◽  
Red Nucleus ◽  
Correlation Method ◽  
Postcentral Gyrus ◽  
And Performance ◽  
The Right

Abstract Background Functional connectivity (FC) has been used to investigate the pathophysiology of migraine. Accumulating evidence is pointing toward malfunctioning of brainstem structures, i.e., the red nucleus (RN) and substantia nigra (SN), as an important factor in migraine without aura (MwoA). We aimed to identify atypical FC between the RN and SN and other brain areas in patients with MwoA and to explore the association between RN and SN connectivity changes and performance on neuropsychological tests in these patients. Methods Resting-state functional magnetic resonance imaging (fMRI) data were obtained from 30 patients with MwoA and 22 age-, sex-, and years of education-matched healthy controls (HC). The FC of the brainstem structures was analyzed using a standard seed-based whole-brain correlation method. The results of the brainstem structure FC were assessed for correlations with other clinical features. Results Patients with MwoA exhibited reduced left RN-based FC with the left middle frontal gyrus, reduced right RN-based FC with the ipsilateral superior parietal lobe, and increased FC with the ipsilateral cerebellum. Additionally, patients with MwoA demonstrated significantly decreased right SN-based FC with the right postcentral gyrus, left parietal lobule, and left superior frontal gyrus. Hypo-connectivity between the right SN and right postcentral gyrus was negatively correlated with disease duration (r = − 0.506, P = 0.004). Additionally, increased connectivity of the right RN to the ipsilateral cerebellar lobes was positively correlated with the Headache Impact Test-6 scores (r = 0.437, P = 0.016). Conclusions The present study suggested that patients with MwoA have disruption in their RN and SN resting-state networks, which are associated with specific clinical characteristics. The changes focus on the regions associated with cognitive evaluation, multisensory integration, and modulation of perception and pain, which may be associated with migraine production, feedback, and development. Taken together, these results may improve our understanding of the neuropathological mechanism of migraine.

scholarly journals Characteristics of executive control network function based on a lateralized version of the ANT-R test in athletes from open skill sports: An fNIRS study

2019 ◽  
Author(s):  
Miao Yu ◽  
Yi B. Liu ◽  
Guang Yang
Keyword(s):  
Executive Control ◽  
Near Infrared ◽  
Inferior Frontal Gyrus ◽  
Control Network ◽  
Functional Near Infrared Spectroscopy ◽  
Executive Control Network ◽  
Network Function ◽  
Frontoparietal Network ◽  
The Right ◽  
Flanker Interference

AbstractThe purpose of the study was to investigate the executive control network function characteristics of interceptive and strategic sports athletes from open skill sports. In order to do so, we used a revised lateralized attention network task to measure executive control efficiency and activation related to flanker interference changes on the right frontoparietal network using functional near-infrared spectroscopy in athletes from different sport sub-categories. Strategic athletes had higher accuracy and lower flanker conflict effects on accuracy, as well as longer reaction time and stronger conflict effects under the valid cue and invalid cue conditions. This was accompanied by higher activity in the right inferior frontal gyrus. These results extend the evidence suggesting that differences among interceptive sports and strategic sports athletes are due to the former using higher velocities to solve conflicts, and the latter using higher accuracy in the same tasks. These effects are attributed to differences in the right frontoparietal network.

scholarly journals White-Matter Hyperintensity Load and Differences in Resting-State Network Connectivity Based on Mild Cognitive Impairment Subtype

2021 ◽  
Vol 13 ◽  
Author(s):  
Martina Vettore ◽  
Matteo De Marco ◽  
Claudia Pallucca ◽  
Matteo Bendini ◽  
Maurizio Gallucci ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Resting State ◽  
Large Scale ◽  
Network Connectivity ◽  
Functional Networks ◽  
Frontoparietal Network ◽  
Definition Of ◽  
The Right

“Mild cognitive impairment” (MCI) is a diagnosis characterised by deficits in episodic memory (aMCI) or in other non-memory domains (naMCI). Although the definition of subtypes is helpful in clinical classification, it provides little insight on the variability of neurofunctional mechanisms (i.e., resting-state brain networks) at the basis of symptoms. In particular, it is unknown whether the presence of a high load of white-matter hyperintensities (WMHs) has a comparable effect on these functional networks in aMCI and naMCI patients. This question was addressed in a cohort of 123 MCI patients who had completed an MRI protocol inclusive of T1-weighted, fluid-attenuated inversion recovery (FLAIR) and resting-state fMRI sequences. T1-weighted and FLAIR images were processed with the Lesion Segmentation Toolbox to quantify whole-brain WMH volumes. The CONN toolbox was used to preprocess all fMRI images and to run an independent component analysis for the identification of four large-scale haemodynamic networks of cognitive relevance (i.e., default-mode, salience, left frontoparietal, and right frontoparietal networks) and one control network (i.e., visual network). Patients were classified based on MCI subtype (i.e., aMCI vs. naMCI) and WMH burden (i.e., low vs. high). Maps of large-scale networks were then modelled as a function of the MCI subtype-by-WMH burden interaction. Beyond the main effects of MCI subtype and WMH burden, a significant interaction was found in the salience and left frontoparietal networks. Having a low WMH burden was significantly more associated with stronger salience-network connectivity in aMCI (than in naMCI) in the right insula, and with stronger left frontoparietal-network connectivity in the right frontoinsular cortex. Vice versa, having a low WMH burden was significantly more associated with left-frontoparietal network connectivity in naMCI (than in aMCI) in the left mediotemporal lobe. The association between WMH burden and strength of connectivity of resting-state functional networks differs between aMCI and naMCI patients. Although exploratory in nature, these findings indicate that clinical profiles reflect mechanistic interactions that may play a central role in the definition of diagnostic and prognostic statuses.

scholarly journals The Simon Effect Based on Allocentric and Egocentric Reference Frame: Common and Specific Neural Correlates

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Hui Li ◽  
Nan Liu ◽  
You Li ◽  
Ralph Weidner ◽  
Gereon R. Fink ◽  
...  
Keyword(s):  
Reference Frame ◽  
Simon Effect ◽  
Neural Mechanisms ◽  
Precentral Gyrus ◽  
Egocentric Reference Frame ◽  
Frontoparietal Network ◽  
Object Locations ◽  
Allocentric Reference Frame ◽  
The Right ◽  
Task Irrelevant

Abstract An object’s location can be represented either relative to an observer’s body effectors (egocentric reference frame) or relative to another external object (allocentric reference frame). In non-spatial tasks, an object’s task-irrelevant egocentric position conflicts with the side of a task-relevant manual response, which defines the classical Simon effect. Growing evidence suggests that the Simon effect occurs not only based on conflicting positions within the egocentric but also within the allocentric reference frame. Although neural mechanisms underlying the egocentric Simon effect have been extensively researched, neural mechanisms underlying the allocentric Simon effect and their potential interaction with those underlying its egocentric variant remain to be explored. In this fMRI study, spatial congruency between the task-irrelevant egocentric and allocentric target positions and the task-relevant response hand was orthogonally manipulated. Behaviorally, a significant Simon effect was observed for both reference frames. Neurally, three sub-regions in the frontoparietal network were involved in different aspects of the Simon effect, depending on the source of the task-irrelevant object locations. The right precentral gyrus, extending to the right SMA, was generally activated by Simon conflicts, irrespective of the spatial reference frame involved, and showed no additive activity to Simon conflicts. In contrast, the right postcentral gyrus was specifically involved in Simon conflicts induced by task-irrelevant allocentric, rather than egocentric, representations. Furthermore, a right lateral frontoparietal network showed increased neural activity whenever the egocentric and allocentric target locations were incongruent, indicating its functional role as a mismatch detector that monitors the discrepancy concerning allocentric and egocentric object locations.

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