scholarly journals Trunk-to-peripheral fat ratio predicts a subsequent blood pressure in normal-weight pubertal boys: a 3-year follow-up of the Kitakata Kids Health Study

2020 ◽  
Vol 25 (1) ◽  
Author(s):  
Katsuyasu Kouda ◽  
Masayuki Iki ◽  
Yuki Fujita ◽  
Harunobu Nakamura ◽  
Masami Hamada ◽  
...  
Circulation ◽  
2015 ◽  
Vol 131 (suppl_1) ◽  
Author(s):  
An Pan ◽  
Gim Gee Teng ◽  
Jian-Min Yuan ◽  
Woon-Puay Koh

Introduction: Although it has been hypothesized that the hypertension-gout relation is bidirectional, few studies have addressed this hypothesis in a prospective setting, particularly in the Asian populations. Methods: We analyzed data from the Singapore Chinese Health Study (SCHS), a cohort of 63,257 Chinese aged 45-74 years at recruitment from 1993-98. The information about self reports of physician-diagnosed hypertension and gout was enquired at follow-ups I (1999-2004) and II (2006-2010). We included participants with complete data for both follow-ups and who were free of heart disease, stroke and cancer at follow-up I. For the analysis of hypertension and risk of incident gout, participants with prevalent gout were further excluded and the final analysis included 31,694 participants. For the analysis of gout and risk of incident hypertension, participants with prevalent hypertension were further excluded and the final analysis included 20,490 participants. Cox proportional hazards models were used to estimate multivariable-adjusted relative risks (RRs) and 95% confidence intervals (CIs) with adjustment for age, sex, years of interview, dialect group, education, smoking status, alcohol intake, physical activity, body mass index (BMI) and history of diabetes. Results: The mean age of the participants at baseline was 60.1 (SD 7.3) years, and the average follow-up year was 6.8 (SD 1.4) years. In the analysis of hypertension and risk of gout, 836 incident cases were identified. Compared to normotensive participants, hypertensive patients had a 93% increased risk of developing gout (RR 1.93; 95% CI 1.66-2.24). The association was slightly stronger in women (RR 2.09; 95% CI 1.69-2.58) compared to men (RR 1.72; 95% CI 1.39-2.14; P for interaction=0.056). The association was also stronger in normal weight adults (BMI <24 kg/m2; RR 2.25; 95% CI 1.82-2.77) compared to overweight/obese individuals (BMI ≥24 kg/m2; RR 1.66; 95% CI 1.34-2.04; P for interaction=0.03). In the parallel analysis of gout and risk of hypertension, 5491 participants reported to have newly diagnosed hypertension during the follow-up. Compared to participants without gout, those with gout had a 17% increased risk of developing hypertension (RR 1.17; 95% CI 1.01-1.35). The association was evident in men (RR 1.29; 95% CI 1.07-1.55) but not in women (RR 0.94; 95% CI 0.73-1.20; P for interaction=0.03). The association was present in normal weight adults (RR 1.34; 95% CI 1.09-1.64) but not among overweight/obese individuals (RR 0.99; 95% CI 0.80-1.23; P for interaction=0.03). Conclusions: Our results provide compelling evidence that the hypertension-gout association is bidirectional in Chinese population. The potential interactions of the bidirectional association with sex and obesity deserve further investigations.


2019 ◽  
Vol 32 (10) ◽  
pp. 1013-1020 ◽  
Author(s):  
David M Tehrani ◽  
Wenjun Fan ◽  
Vijay Nambi ◽  
Julius Gardin ◽  
Calvin H Hirsch ◽  
...  

AbstractBackgroundHigh-sensitivity cardiac troponin T (hs-cTnT) is individually associated with incident hypertension (HTN) and cardiovascular disease (CVD) events. We hypothesize that the increases in hs-cTnT with increases in blood pressure will be related to higher incidence of CVD.METHODSThe Cardiovascular Health Study is a longitudinal cohort of older adults. Those with hs-cTnT data and CVD risk factors at baseline and follow-up (2–3 years later) were stratified based on systolic blood pressure (SBP; optimal: <120 mm Hg, intermediate: 120–139 mm Hg, elevated: ≥140 mm Hg) and hs-cTnT (undetectable: <5 ng/l, detectable: 5–13 ng/l, elevated: ≥14 ng/l) categories. SBP and hs-cTnT were classified as increased or decreased if they changed categories between exams, and stable if they did not. Cox regression evaluated incident CVD events over an average 9-year follow-up.RESULTSAmong 2,219 adults, 510 (23.0 %) had decreased hs-cTnT, 1,279 (57.6 %) had stable hs-cTnT, and 430 (19.4 %) had increased hs-cTnT. Those with increased hs-cTnT had a higher CVD risk with stable SBP (hazard ratio [HR]: 1.28 [1.04–1.57], P = 0.02) or decreased SBP (HR: 1.57 [1.08–2.28], P = 0.02) compared to those within the same SBP group but a stable hs-cTnT. In those with lower SBP at follow-up, there was an inverse relation between diastolic blood pressure (DBP) and risk of CVD events in those with increased hs-cTnT (HR: 0.44 per 10 mm Hg increase, P < 0.01).CONCLUSIONAn increase in hs-cTnT over time is associated with a higher risk of CVD even when the blood pressure is stable or decreases over time.


Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Martha Tamez ◽  
Eric Rimm ◽  
Bernard Rosner ◽  
Daniela Sotres-Alvarez ◽  
Martha L Daviglus ◽  
...  

Introduction: Little is known about whether prevailing diet quality scores apply to Hispanics/Latinos when assessing hypertension risk or if a diet score applied to a traditional diet would be more relevant. Objective: To compare a traditional Mexican diet score (tMexS) against three prevailing diet quality scores (Mediterranean Diet Score [MeDS], Alternate Healthy Eating Index-2010 [AHEI-2010], and Dietary Approaches to Stop Hypertension [DASH]) in association with risk of hypertension and change in systolic and diastolic blood pressure (BP) in adults of Mexican heritage in the U.S. Methods: Data were analyzed from 3,542 U.S. adults of Mexican heritage in the multicenter population-based Hispanic Community Health Study/Study of Latinos (HCHS/SOL) cohort with baseline (2008-2011) and follow-up (2014-2017) visits, and without CVD and hypertension at baseline. Diet quality scores were calculated from the average of two 24-h recalls. Higher scores of MeDS, AHEI-2010, and DASH indicate a healthier diet, while a higher tMexS indicates a more traditional Mexican diet. Hypertension was defined as an average of ≥140 systolic or ≥90 mmHg diastolic BP from triplicate measurements, or self-reported use of antihypertensive medications. Logistic regression models tested the association of four dietary scores with incident hypertension, and linear regression models tested the association of dietary scores and changes in systolic and diastolic BP by hypertension status. Multivariable models with complex survey procedures were adjusted for confounders, and the final model included all dietary scores simultaneously. Results: After an average 6y of follow-up, there were 553 incident cases of hypertension. Mean (±SE) total score was 5.8 ± 0.05 for tMexS (range: 0-12), 5.3 ± 0.04 for MeDS (range: 0-9), 51.4 ± 0.19 for AHEI-2010 (range: 0-110), and 48.5 ± 0.22 for DASH (range: 0-90). The tMexS, MeDS, and DASH were not associated with risk of hypertension. A 10-unit increase in the AHEI-2010 was associated with a lower risk of hypertension (OR: 0.77; 95% CI: 0.60, 0.98). Among normotensive adults, diastolic BP decreased by 0.24 ± 0.11 mmHg per one-unit increase in tMexS (p-value=0.02). No significant changes were noted for systolic BP nor among adults with hypertension. Conclusions: In this prospective cohort, the AHEI-2010, but not DASH, MeDS, or tMexS, was associated with lower hypertension risk among U.S. adults of Mexican heritage, while the tMexS reduced diastolic BP among normotensive adults. To decrease hypertension risk, adults of Mexican heritage should adhere to AHEI-2010 dietary recommendations, while consuming traditional Mexican foods for modest benefits on blood pressure.


2021 ◽  
Vol 28 (05) ◽  
pp. 697-701
Author(s):  
Ahmed Murtaz Khalid ◽  
Iffat Naiyar ◽  
Rizwan Masud ◽  
Aiman Farogh Anjum ◽  
Fatima Kamran ◽  
...  

Objective: To know the association between different anthropometric parameters for overweight and obese individuals to prevalence of prehypertension. Study Design: Correlational study. Setting: Vicinity of Kharian and at Outpatient Department, CMH Kharian Cantt. Period: February 2019 and January 2020. Material & Methods: Correlational study carried out in the vicinity of Kharian by employing different anthropometric measurements in accordance with guidelines to look at how blood pressure figure behaves in overweight, obese and morbidly obese population and further is there a difference in overall outcome if we use waist circumference rather than BMI and its significance in targeting preventive strategies. Results: Our results show a staircase pattern of increase in blood pressure, initially lying in different phases of prehypertension among normal weight (BMI 23±1.65; waist circumference (WC): 86.45±8.78; Systolic BP:127±11.99; Diastolic BP:80.44 ±9.45), overweight (BMI 27.35 ±1.23; WC:100±5.32; Systolic BP:128.72 ±11.29; Diastolic BP:80.05 ±6.66) and obese individuals (BMI 31.97 ±1.45; WC:112.12±9.22; Systolic BP:138.06 ±21.61; Diastolic BP:87.56 ±9.78), while this trend shifted to full blown hypertension among morbidly obese individuals (BMI 39.88 ±4.30; WC:120.38±12.84; Systolic BP:145 ±17.64; Diastolic BP:89.23 ±10.95) Conclusion: We conclude that prehypertension is already prevalent among normal weight and overweight individuals, and intensive follow up and lifestyle intervention strategy should be employed earlier at this level and waist circumference is a better predictor of cardiovascular disease than BMI and should be routinely done in local primary health care set up to prevent the onset of complications associated with this silent killer.


Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Lisa Rafalson ◽  
Richard P Donahue ◽  
Saverio Stranges

Background: Prehypertension is an increasingly highly prevalent condition in the general population, and is associated with an increased risk for coronary heart disease and stroke. However, evidence from population-based studies of the risk factors for prehypertension is scant. We sought to examine the predictors of progression from normotension to prehypertension in a community-based population from Western New York. Methods: We conducted a longitudinal analysis, over six years of follow-up, among 569 men and women (51.8 years, 96% White, 70% female) who were free of prehypertension, hypertension, cardiovascular disease and type 2 diabetes at the baseline examination, in the Western New York Health Study (WNYHS). Incident prehypertension at follow-up was defined as systolic blood pressure of 120-139 mmHg and/or diastolic blood pressure of 80-89 mmHg. Results: In bivariate analyses, there were several correlates of incident prehypertension, including age, BMI and waist circumference, impaired fasting glucose (IFG), uric acid, and baseline blood pressure levels. After multivariate adjustment, IFG at baseline odds ratio (OR):1.69, 95%CI:1.06-2.67) and weight gain since age 25 (OR: 1.28, 1.11-1.58 per 10 lb. increase) were the strongest significant predictors of prehypertension at follow-up. Neither waist circumference nor current BMI were predictor variables in models when they were substituted for weight gain. Conclusions: Results from this study suggest early dysregulation of glucose metabolism and weight gain over the lifespan are likely to represent important risk factors for prehypertension in the general population.


Circulation ◽  
2015 ◽  
Vol 131 (suppl_1) ◽  
Author(s):  
Lynn L Moore ◽  
M. Loring Bradlee ◽  
Martha R Singer ◽  
Stephen R Daniels

Cardiometabolic risk (CMR) factor clustering has its roots in childhood and the presence of multiple cardiovascular risk factors in younger populations has been linked with early vascular dysfunction. A DASH-style eating pattern has been shown to reduce blood pressure and other selected cardiometabolic outcomes, primarily in adults, but its role in the development of CMR clustering during adolescence has not been studied. Data from the National Heart, Lung, and Blood Institute’s Growth and Health Study (NGHS) will be used to evaluate the relation between early-to-mid adolescent dietary intake and CMR clustering at the end of adolescence. The NGHS began in 1987-1988 with the enrollment of 2,379 adolescent girls (with approximately equal numbers of blacks and whites), ages 9-10 years. Diet was assessed using 3-day diet records during eight of 10 years of follow up. A total of 1,369 girls had complete data on diet, all potential confounding variables, and follow-up over 10 years for all CMR factors of interest. Risk factor clustering scores were created by summing individual CMR outcomes defined as follows: waist circumference ≥88 cm, systolic and/or diastolic blood pressure ≥90th percentile for age, sex and height, LDL ≥110 mg/dL, HDL <50 mg/dL, serum TG ≥110mg/dl, and HOMA-IR ≥4. Multiple logistic regression analyses were used to estimate the impact of a DASH-style pattern on the relative risk (odds ratio) of CMR clustering at the end of adolescence, defined as having ≥ 2 or ≥ 3 of the above risk factors at 18-20 years of age. The proportion of white and black girls with CMR clustering was very similar. However, the types of risk factors differed by race with blacks being nearly twice as likely to have an increased waist size, elevated BP, or insulin resistance and white girls being much more likely to have abnormal lipid levels, particularly elevated triglyceride levels. By the end of adolescence, only 30.1% of girls had no abnormal CMR factors and 34.9% had a single risk factor; 16.6% of girls had two risk factors and 18.4% had between 3-6 prevalent risk factors. Higher intakes of fruit and non-starchy vegetables, dairy, and grains were independently associated with less CMR clustering. After adjusting for age, race, socio-economic status, height, physical activity, and television watching, girls with a DASH-style eating pattern during early-to-mid adolescence were nearly 50% less likely to have three or more CMR factors (O.R.=0.52; 95% CI: 0.30, 0.89) by late adolescence (at 18-20 years of age). These results suggest a DASH-style eating pattern during adolescence, characterized by higher intakes of fruit, non-starchy vegetables, and dairy, may lower risk for the development of subsequent cardiometabolic disorders.


Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Lu Wang ◽  
JoAnn E Manson ◽  
Susanne Rautiainen ◽  
J. Michael Gaziano ◽  
Julie E Buring ◽  
...  

Background: Laboratory studies suggest that ω3 and ω6 polyunsaturated fatty acids (PUFA) may have divergent effects on the development of obesity. Epidemiologic studies comparing the associations for ω3 and ω6 PUFA are limited. Objective: We prospectively examined whether the baseline proportions of ω3 and ω6 PUFAs on erythrocyte membranes were associated with the risk of becoming overweight and changes in body weight in the Women’s Health Study (WHS). Methods: We identified WHS participants in a previous nested case-control study of hypertension who reported a body mass index (BMI) <25 kg/m 2 at baseline. Baseline fatty acid (FA) composition of erythrocyte membranes was measured as biomarkers of dietary FA intake using gas chromatography. Women who subsequently reported a BMI ≥25 kg/m 2 during follow-up were defined as becoming overweight. Body weight change was calculated as the difference in reported body weight from baseline to annual follow-up questionnaires. Results: Among 534 women with baseline BMI <25 kg/m 2 , 186 became overweight during an average of 10 years of follow-up. After initial adjustment for age, race, randomized treatment, the hazard ratios (HR) and 95% confidence interval (95% CI) for becoming overweight across increasing quartiles of erythrocyte PUFA were 1.00, 0.77 (0.49-1.21), 1.12 (0.75-1.67), and 1.19 (0.79-1.77) for cis ω6 PUFA (p, trend: 0.31), 1.00, 0.90 (0.61-1.31), 0.76 (0.51-1.13), 0.71 (0.45-1.10) for cis ω3 PUFA (p, trend: 0.09), and 1.00, 1.37 (0.84-2.22), 1.57 (1.01-2.43), and 1.58 (1.01-2.46) for ω6 to ω3 PUFA ratio (p, trend: 0.046). Additional adjustment for lifestyle and dietary factors did not substantially attenuate these associations, with HR (95% CI) of 1.00, 1.26 (0.76-2.08), 1.44 (0.91-2.28), and 1.56 (0.97-2.51) across increasing quartiles of ω6 to ω3 PUFA ratio (p, trend: 0.064). Analysis of longitudinal change in body weight showed similar associations. After multivariable adjustment, the mean±standard error of weight gain over an average of 10 years of follow-up across increasing quartiles of erythrocyte PUFA were 2.34±0.49, 1.92±0.53, 2.86±0.54, and 3.10±0.53 kg for cis ω6 PUFA (p, trend: 0.04), 2.97±0.52, 2.60±0.53, 2.74±0.53, 2.16±0.51 kg for cis ω3 PUFA (p, trend: 0.095), and 2.13±0.51, 2.65±0.54, 2.77±0.53, 2.98±0.52 kg for ω6 to ω3 PUFA ratio (p, trend: 0.05). trans PUFA 18:2 was not associated with the risk of becoming overweight or longitudinal weight gain. Analyses of joint categories of ω3 and ω6 PUFA did not show significant interaction . Conclusion: In this prospective study, we found suggestive evidence that the proportion of cis ω6 PUFA on erythrocyte membrane was positively associated, and cis ω3 PUFA inversely associated, with the risk of becoming overweight and weight gain in initially normal-weight women.


Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Tali Elfassy ◽  
Neil Schneiderman ◽  
Tatjana Rundek ◽  
Leopoldo Raij ◽  
Asmi Panigrahi ◽  
...  

Introduction: Among US Hispanics/Latinos, greater acculturation to US society is associated with higher blood pressure. However, the extent to which this relationship varies across diverse Hispanic/Latino groups is unclear. Objectives: To determine whether acculturation is differentially associated with six-year change in systolic blood pressure (SBP) across Hispanic/Latino groups. Methods: The Hispanic Community Health Study/Study of Latinos is a prospective population-based study of diverse Hispanics/Latinos aged 18-74 years from four US communities. Acculturation at baseline (2008-2011) was defined by the Short Acculturation Scale for Hispanics (SASH) social and language scales (low, medium, or high acculturation) and nativity/duration of US residence (foreign-born with < 10 or ≥ 10 years of US residence, or US born-not including Puerto Rico). The average of three seated SBP measurements was used; difference in SBP from baseline to follow-up (2014-2017) was calculated in 7,836 adults free from hypertension at baseline (SBP < 140 mmHg; diastolic blood pressure < 90 mmHg; and not taking hypertension medication). Using linear regression models accounting for the complex survey design and adjusted for baseline age, sex, education, income, body mass index, years of follow-up, and hypertension medication at follow-up, we estimated the association of each measure of acculturation with change in SBP. Significant interactions between Hispanic/Latino group and measures of acculturation led to stratified models (SASH interaction p=0.01 for social; p=0.28 for language; and nativity/duration of US residence US interaction, p=0.05). Results: Mean baseline age was 36.7 years (SE: 0.23) and 51.7% were women (SE: 0.77). After an average follow-up of 6.2 years (SE: 0.02), mean change in SBP was 2.01 mmHg (SE: 0.20). Among individuals of Central American background, high vs. low SASH language was associated with +3.21 mmHg SBP increase (95% CI: 0.19, 6.24) and being US born vs. foreign-born < 10 years in US was associated with +5.31 mmHg SBP increase (95% CI: 2.10, 8.53). Among individuals of Puerto Rican background, those with ≥ 10 vs. < 10 years in the US 50 states had a 5.67 mmHg lower increase in SBP (95% CI: -9.85, -1.50). Associations between measures of acculturation and changes in SBP were not significant in other groups (i.e. Cubans, Dominicans, and South Americans), but did suggest a greater SBP increase with greater acculturation among Mexican background individuals (e.g. high vs. low SASH social β=1.67, 95% CI: -0.19, 3.52, p=0.08). Conclusions: Greater acculturation was associated with a greater SBP increase among those of Central American background but a lower SBP increase among individuals of Puerto Rican background. These findings show that consideration of Hispanic/Latino group is warranted when assessing potential health effects of acculturation.


Nutrients ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 691 ◽  
Author(s):  
Celine Heskey ◽  
Keiji Oda ◽  
Joan Sabaté

Avocados contain nutrients and bioactive compounds that may help reduce the risk of becoming overweight/obese. We prospectively examined the effect of habitual avocado intake on changes in weight and body mass index (BMI). In the Adventist Health Study (AHS-2), a longitudinal cohort (~55,407; mean age ~56 years; U.S. and Canada), avocado intake (standard serving size 32 g/day) was assessed by a food frequency questionnaire (FFQ). Self-reported height and weight were collected at baseline. Self-reported follow-up weight was collected with follow-up questionnaires between four and 11 years after baseline. Using the generalized least squares (GLS) approach, we analyzed repeated measures of weight in relation to avocado intake. Marginal logistic regression analyses were used to calculate the odds of becoming overweight/obese, comparing low (>0 to <32 g/day) and high (≥32 g/day) avocado intake to non-consumers (reference). Avocado consumers who were normal weight at baseline, gained significantly less weight than non-consumers. The odds (OR (95% CI)) of becoming overweight/obese between baseline and follow-up was 0.93 (0.85, 1.01), and 0.85 (0.60, 1.19) for low and high avocado consumers, respectively. Habitual consumption of avocados may reduce adult weight gain, but odds of overweight/obesity are attenuated by differences in initial BMI values.


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