Comparison of the effects of open vs. closed skill exercise on the acute and chronic BDNF, IGF-1 and IL-6 response in older healthy adults

Abstract Background Accumulating evidence shows that physical exercise has a positive effect on the release of neurotrophic factors and myokines. However, evidence regarding the optimal type of physical exercise for these release is still lacking. The aim of this study was to assess the acute and chronic effects of open-skill exercise (OSE) compared to closed-skill exercise (CSE) on serum and plasma levels of brain derived neurotrophic factor (BDNFS, BDNFP), and serum levels of insulin like growth factor 1 (IGF-1), and interleukin 6 (IL-6) in healthy older adults. Methods To investigate acute effects, thirty-eight participants were randomly assigned to either an intervention (badminton (aOSE) and bicycling (aCSE), n = 24, 65.83 ± 5.98 years) or control group (reading (CG), n = 14, 67.07 ± 2.37 years). Blood samples were taken immediately before and 5 min after each condition. During each condition, heart rate was monitored. The mean heart rate of aOSE and aCSE were equivalent (65 ± 5% of heart rate reserve). In a subsequent 12-week training-intervention, twenty-two participants were randomly assigned to either a sport-games (cOSE, n = 6, 64.50 ± 6.32) or a strength-endurance training (cCSE, n = 9, 64.89 ± 3.51) group to assess for chronic effects. Training intensity for both groups was adjusted to a subjective perceived exertion using the CR-10 scale (value 7). Blood samples were taken within one day after the training-intervention. Results BDNFS, BDNFP, IGF-1, and IL-6 levels increased after a single exercise session of 30 min. After 12 weeks of training BDNFS and IL-6 levels were elevated, whereas IGF-1 levels were reduced in both groups. However, only in the cOSE group these changes were significant. We could not find any significant differences between the exercise types. Conclusion Our results indicate that both exercise types are efficient to acutely increase BDNFS, BDNFP, IGF-1 and IL-6 serum levels in healthy older adults. Additionally, our results tend to support that OSE is more effective for improving basal BDNFS levels after 12 weeks of training.

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Lack of Correlation between Accelerometers and Heart-Rate Monitorization during Exercise Session in Older Adults

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17155518 ◽

2020 ◽

Vol 17 (15) ◽

pp. 5518

Author(s):

Laura Carbonell-Hernández ◽

Diego Pastor ◽

Alejandro Jiménez-Loaisa ◽

Juan Arturo Ballester-Ferrer ◽

Carlos Montero-Carretero ◽

...

Keyword(s):

Older Adults ◽

Heart Rate ◽

Physical Exercise ◽

Older People ◽

The Other ◽

Exercise Session ◽

Active Aging ◽

Low Intensity ◽

Indispensable Tool ◽

Highly Correlated

Aging is increasing worldwide; hence, aging-related health is also more relevant. Well-programmed physical exercise is now an indispensable tool to achieve active aging and preserve older people’s health. Such “well-programmed” exercise requires efficient and useful tools to measure the activity. The objective of this study is to evaluate the effectiveness of accelerometers to estimate two different intensities of physical exercise in older people. Thirty-eight subjects (64.5 ± 5.3 years) were measured during two different sessions of physical exercise: one moderate in intensity, the other of low intensity. Heart rate and accelerometry were recorded and analyzed. The results showed that the two variables in the physical exercise sessions were not highly correlated, and that accelerometry did not seem useful to assess low-intensity sessions not based on walking.

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iRest Meditation for Older Adults with Depression Symptoms: A Pilot Study

International Journal of Yoga Therapy ◽

10.17761/2019-00036 ◽

2019 ◽

Vol 29 (1) ◽

pp. 9-17 ◽

Cited By ~ 2

Author(s):

Helané Wahbeh ◽

Melissa Nelson

Keyword(s):

Older Adults ◽

Heart Rate ◽

Pilot Study ◽

Perceived Stress ◽

The United States ◽

Control Group ◽

Depression Symptoms ◽

Home Practice ◽

Healthy Older Adults ◽

Growing Population

Abstract Older adults, a rapidly growing population in the United States, have fewer physiological reserves and are more likely to be affected by stress, making them especially susceptible to depression symptoms. Meditation offers promising potential as an effective treatment; however, few studies have evaluated meditation interventions for this demographic. The objectives of this pilot study were to evaluate the feasibility and acceptability of an iRest meditation program in older adults with depression symptoms and to collect preliminary data on its effect on depression and depression-related symptoms compared to a vacation control. The study occurred at the Institute of Noetic Sciences EarthRise Retreat Center and participants' homes. Thirty generally healthy older adults, aged 55–90, with depression symptoms were recruited. Participants were randomly assigned to a 2-day retreat of either iRest meditation training or vacation. After the retreat, participants were asked to complete 20 minutes of home practice per day for 6 weeks; this consisted of either guided meditations (iRest) or music (vacation). Data were collected pre- and post-retreat and then 6 weeks later. Measures included depression-related variables (expectancy, depression symptoms, perceived stress, resilience, pain, sleep quality, and spirituality) and biomarkers (voice stress analysis, heart rate, heart rate variability). We found the iRest intervention for older adults with depression symptoms to be feasible and acceptable. Preliminary results at 6 weeks demonstrated improvements in sleep impairment in older adults compared to the control group and promising trends in improvements in depression symptoms and pain severity.

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Effect of exercise training on heart rate variability in healthy older adults

American Heart Journal ◽

10.1016/s0002-8703(99)70162-6 ◽

1999 ◽

Vol 138 (3) ◽

pp. 567-576 ◽

Cited By ~ 84

Author(s):

Phyllis K. Stein ◽

Ali A. Ehsani ◽

Peter P. Domitrovich ◽

Robert E. Kleiger ◽

Jeffrey N. Rottman

Keyword(s):

Older Adults ◽

Heart Rate ◽

Heart Rate Variability ◽

Exercise Training ◽

Healthy Older Adults

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Processing gender stereotypes in dementia patients and older healthy adults: a self-paced reading study

Linguistics Vanguard ◽

10.1515/lingvan-2018-0029 ◽

2019 ◽

Vol 5 (s2) ◽

Cited By ~ 1

Author(s):

Daniel Müller-Feldmeth ◽

Katharina Ahnefeld ◽

Adriana Hanulíková

Keyword(s):

Older Adults ◽

Young Adults ◽

Sentence Processing ◽

Gender Stereotypes ◽

Time Course ◽

Healthy Adults ◽

Control Group ◽

Healthy Older Adults ◽

Dementia Patients ◽

Age Related

AbstractWe used self-paced reading to examine whether stereotypical associations of verbs with women or men as prototypical agents (e.g. the craftsman knits a sweater) are activated during sentence processing in dementia patients and healthy older adults. Effects of stereotypical knowledge on language processing have frequently been observed in young adults, but little is known about age-related changes in the activation and integration of stereotypical information. While syntactic processing may remain intact, semantic capacities are often affected in dementia. Since inferences based on gender stereotypes draw on social and world knowledge, access to stereotype information may also be affected in dementia patients. Results from dementia patients (n = 9, average age 86.6) and healthy older adults (n = 14, average age 79.5) showed slower reading times and less accuracy in comprehension scores for dementia patients compared to the control group. While activation of stereotypical associations of verbs was visible in both groups, they differed with respect to the time-course of processing. The effect of stereotypes on comprehension accuracy was visible for healthy adults only. The evidence from reading times suggests that older adults with and without dementia engage stereotypical inferences during reading, which is in line with research on young adults.

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Seasonal Variation in Vitamin D in Association with Age, Inflammatory Cytokines, Anthropometric Parameters, and Lifestyle Factors in Older Adults

Mediators of Inflammation ◽

10.1155/2017/5719461 ◽

2017 ◽

Vol 2017 ◽

pp. 1-14 ◽

Cited By ~ 16

Author(s):

Leticia Elizondo-Montemayor ◽

Elena C. Castillo ◽

Carlos Rodríguez-López ◽

José R. Villarreal-Calderón ◽

Merit Gómez-Carmona ◽

...

Keyword(s):

Older Adults ◽

Vitamin D ◽

Seasonal Variation ◽

Vitamin D Deficiency ◽

High Probability ◽

Sun Exposure ◽

Serum Levels ◽

Lifestyle Factors ◽

Anthropometric Parameters ◽

Healthy Older Adults

Vitamin D deficiency is present even in sunny regions. Ageing decreases pre-vitamin D production in the skin and is associated with altered cytokine profile. We performed a multivariate analysis considering lifestyle factors, anthropometric, and inflammatory markers according to seasonal variation in Mexican healthy older adults. The same cohort was followed during 12 months. Vitamin D deficiency/insufficiency was found in 91.3% of the subjects despite living in appropriate latitude (25°40′0″N). 25(OH)D levels remained below <30 ng/mL through all seasons. Vitamin D deficiency did not correlate to sun exposure or dietary intake. Gender was the strongest associated factor, explaining a variance of 20%. Waist circumference (WC) greater than 88 cm was a risk factor for vitamin D deficiency. Age (>74 years) combined with WC (>88 cm) and BMI (>32.7) showed a high probability (90%) of vitamin D deficiency. Remarkably, an increase in one centimeter in WC decreased 25(OH)D by 0.176 ng/mL, while an increase in one point BMI decreased 25(OH)D by 0.534 ng/mL. A cutoff point of 74 years of age determined probability of vitamin D hipovitaminosis. Vitamin D deficiency was correlated with TNF-αserum levels, possibly increasing the susceptibility of older adults to a proinflammatory state and its related diseases.

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One-Year Follow-Up of Healthy Older Adults with Electroencephalographic Risk for Neurocognitive Disorder After Neurofeedback Training

Journal of Alzheimer s Disease ◽

10.3233/jad-215538 ◽

2021 ◽

pp. 1-15

Author(s):

Graciela C. Alatorre-Cruz ◽

Thalía Fernández ◽

Susana A. Castro-Chavira ◽

Mauricio González-López ◽

Sergio M. Sánchez-Moguel ◽

...

Keyword(s):

Older Adults ◽

Theta Activity ◽

Control Group ◽

Global Changes ◽

Healthy Population ◽

Healthy Older Adults ◽

Cognitive Improvement ◽

One Year ◽

Experimental Group

Background: In healthy older adults, excess theta activity is an electroencephalographic (EEG) predictor of cognitive impairment. In a previous study, neurofeedback (NFB) treatment reinforcing reductions theta activity resulted in EEG reorganization and cognitive improvement. Objective: To explore the clinical applicability of this NFB treatment, the present study performed a 1-year follow-up to determine its lasting effects. Methods: Twenty seniors with excessive theta activity in their EEG were randomly assigned to the experimental or control group. The experimental group received an auditory reward when the theta absolute power (AP) was reduced. The control group received the reward randomly. Results: Both groups showed a significant decrease in theta activity at the training electrode. However, the EEG results showed that only the experimental group underwent global changes after treatment. These changes consisted of delta and theta decreases and beta increases. Although no changes were found in any group during the period between the posttreatment evaluation and follow-up, more pronounced theta decreases and beta increases were observed in the experimental group when the follow-up and pretreatment measures were compared. Executive functions showed a tendency to improve two months after treatment which became significant one year later. Conclusion: These results suggest that the EEG and behavioral benefits of this NFB treatment persist for at least one year, which adds up to the available evidence contributing to identifying factors that increase its efficacy level. The relevance of this study lies in its prophylactic features of addressing a clinically healthy population with EEG risk of cognitive decline.

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Effect of hypoxic conditioning on functional fitness, balance and fear of falling in healthy older adults: a randomized controlled trial

European Review of Aging and Physical Activity ◽

10.1186/s11556-021-00279-5 ◽

2021 ◽

Vol 18 (1) ◽

Author(s):

Rafael Timon ◽

Marta Camacho-Cardeñosa ◽

Adrián González-Custodio ◽

Guillermo Olcina ◽

Narcis Gusi ◽

...

Keyword(s):

Older Adults ◽

Fear Of Falling ◽

Controlled Trial ◽

Training Group ◽

Training Programme ◽

Control Group ◽

Functional Fitness ◽

Healthy Older Adults ◽

Hypoxia Exposure ◽

Hypoxic Conditions

Abstract Background Hypoxic conditioning has been proposed as a new tool to mitigate the sarcopenia and enhance health-related function, but decrements in standing balance have been observed during hypoxia exposure. The aim of the study was to evaluate the effect of a hypoxic conditioning training on functional fitness, balance and fear of falling in healthy older adults. Methods A total of 54 healthy older adults (aged 65–75 years), who voluntarily participated in the study, were randomly divided into three groups: the control group (CON), the normoxia training group (NT) that performed strength training in normoxia, and the hypoxia training group (HT) that trained under moderate hypoxic conditions at a simulated altitude of 2500 m asl. The training programme that was performed during 24 weeks was similar in both experimental groups and consisted of a full-body workout with elastic bands and kettlebells (three sets × 12–15 reps). The Senior Fitness Test (SFT), the Single Leg Stance test (SLS) and the Short Falls Efficacy Scale-International (FES-I) were assessed before and after the intervention. Results Results showed that after training, either in normoxia or in hypoxia, the participants increased upper and lower body strength, and the aerobic endurance, and decreased the fear of falling. Conclusions The moderate hypoxic conditioning seems to be a useful tool to increase the functional capacity in healthy older adults without observing a decline in balance. Trial registration ClinicalTrials.gov NCT04281264. Registered February 9, 2019-Retrospectively registered.

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Longitudinal impact and effects of booster sessions in a cognitive training program for healthy elderly

10.31234/osf.io/uqgdw ◽

2020 ◽

Author(s):

Lucas Matias Felix ◽

Marcela Mansur Alves ◽

Mariana Teles ◽

Laura Jamison ◽

Hudson Golino

Keyword(s):

Older Adults ◽

Cognitive Training ◽

Passive Control ◽

Control Group ◽

Longitudinal Impact ◽

Healthy Older Adults ◽

Booster Sessions ◽

Experimental Group

This paper reports the results from a three-years follow-up study to access the long-term efficacy of a cognitive training for healthy older adults and investigates the effects of booster sessions on the cognitive performance of the participants using an innovative analytical approach from information theory. Design: semi-randomized quasi-experimental controlled design. Participants: 50 healthy older adults, (M = 73.3, SD = 7.77) were assigned into an experimental (N = 25; Mean age = 73.9; SD = 8.62) and a passive control group (N = 25; mean age = 72.9; SD = 6.97). Instruments: six subtests of WAIS and two episodic memory tasks. Procedures: the participants were assessed in four occasions: after the end of the original intervention, pre-booster sessions (three years after the original intervention), immediately after the booster sessions and three months after the booster sessions. Results: the repeated measures ANOVA showed that two gains reported in the original intervention were identified in the follow-up: Coding (F(1, 44) = 11.79, MSE = 0.77, p = .001, ηˆG2 = .084) and Picture Completion (F(1, 47) = 10.01, MSE = 0.73, p = .003, ηˆG2 = .060). After the booster sessions, all variables presented a significant interaction between group and time favorable to the experimental group (moderate to high effect sizes). To compare the level of cohesion of the cognitive variables between the groups, an entropy-based metric was used. The experimental group presented a lower level of cohesion in three of the four measurement occasions, suggesting a differential impact of the intervention with immediate and short-term effects, but without long-term effects.

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Effects of Cognitive Training on Cognitive Performance of Healthy Older Adults

The Spanish Journal of Psychology ◽

10.1017/sjp.2017.38 ◽

2017 ◽

Vol 20 ◽

Cited By ~ 5

Author(s):

Mariana Teles Santos Golino ◽

Carmen Flores Mendoza ◽

Hudson Fernandes Golino

Keyword(s):

Older Adults ◽

Cognitive Training ◽

Repeated Measures ◽

Digit Span ◽

Intervention Group ◽

Control Group ◽

Digit Symbol ◽

Transfer Effects ◽

Healthy Older Adults ◽

Picture Completion

AbstractThe purpose of this study was to determine the immediate effects of cognitive training on healthy older adults and verify the transfer effects of targeted and non-targeted abilities. The design consisted of a semi-randomized clinical controlled trial. The final sample was composed of 80 volunteers recruited from a Brazilian community (mean age = 69.69; SD = 7.44), which were separated into an intervention group (N = 47; mean age = 69.66, SD = 7.51) and a control group (N = 33; mean age = 69.73, SD = 7.45). Intervention was characterized by adaptive cognitive training with 12 individual training sessions of 60 to 90 minutes (once a week). Eight instruments were used to assess effects of cognitive training. Five were used to assess trained abilities (near effects), including: Memorization Tests (List and History), Picture Completion, Digit Span, Digit Symbol-Coding, and Symbol Search (the last four from WAIS-III). Two instruments assessed untrained abilities (far effects): Arithmetic and Matrix Reasoning (WAIS-III). The non-parametric repeated measures ANOVA test revealed a significant interaction between group by time interaction for Picture Completion [F(74) = 14.88, p = .0002, d = 0.90, CLES = 73.69%], Digit Symbol-Coding [F(74) = 5.66, p = .019, d = 0.55, CLES = 65.21%] and Digit Span [F(74) = 5.38, p = .02, d = 0.54, CLES = 64.85%], suggesting an interventional impact on these performance tasks. The results supported near transfer effects, but did not demonstrate a far transfer effects.

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Mood Alterations in Older Adults following Acute Exercise

Perceptual and Motor Skills ◽

10.2466/pms.1994.79.1.191 ◽

1994 ◽

Vol 79 (1) ◽

pp. 191-194 ◽

Cited By ~ 24

Author(s):

Edgar F. Pierce ◽

Donald W. Pate

Keyword(s):

Older Adults ◽

Repeated Measures ◽

Acute Exercise ◽

Mood States ◽

Exercise Session ◽

Control Group ◽

Older Individuals ◽

Significant Difference ◽

Single Bout ◽

Affective Change

Limited research indicates positive affective change following acute bouts of exercise, but whether this improved affect among younger subjects may be generalized to older individuals is not known. The present study, then, examined the effects of a single bout of physical activity among older participants. 16 trained women ( Moge = 64.5 ± 7.6 yr.) completed an abbreviated Profile of Mood States prior to and immediately following a 75-min. session of aerobic line dancing. A series of one-way analyses of variance with repeated measures were used to examine differences between pre- and posttest subscores on mood states. Significant decreases following exercise in scores on Tension, Depression, Fatigue, and Anger and a significant increase in scores on Vigor relative to preexercise (control) scores were found. Global mood was significantly improved after the exercise session. No significant difference was found between pre- and postexercise measures of Confusion. Previous findings of significant improvements in affect immediately after an acute bout of exercise may be generalized to older adults. Repetition with a nonexercised control group is desirable.

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