scholarly journals Agreement in breast lesion assessment and final BI-RADS classification between radial and meander-like breast ultrasound

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Pascale Brasier-Lutz ◽  
Claudia Jäggi-Wickes ◽  
Sabine Schaedelin ◽  
Rosemarie Burian ◽  
Cora-Ann Schoenenberger ◽  
...  
Keyword(s):  
Breast Lesion ◽  
Morphological Characteristics ◽  
Lesion Size ◽  
Breast Ultrasound ◽  
Architectural Distortion ◽  
Suitable Alternative ◽  
Lesion Location ◽  
High Degree ◽  
Face Localization

Abstract Background This study prospectively investigates the agreement between radial (r-US) and meander-like (m-US) breast ultrasound with regard to lesion location, lesion size, morphological characteristics and final BI-RADS classification of individual breast lesions. Methods Each patient of a consecutive, unselected, mixed collective received a dual ultrasound examination. Results The agreement between r-US and m-US for lesion location ranged from good (lesion to mammilla distance ICC 0.64; lesion to skin distance ICC 0.72) to substantial (clock-face localization κ 0.70). For lesion size the agreement was good (diameter ICC 0.72; volume ICC 0.69), for lesion margin and architectural distortion it was substantial (κ 0.68 and 0.70, respectively). Most importantly, there was a substantial agreement (κ 0.76) in the final BI-RADS classification between r-US and m-US. Conclusions Our recent comparison of radial and meander-like breast US revealed that the diagnostic accuracy of the two scanning methods was comparable. In this study, we observe a high degree of agreement between m-US and r-US for the lesion description (location, size, morphology) and final BI-RADS classification. These findings corroborate that r-US is a suitable alternative to m-US in daily clinical practice. Trial registration NCT02358837. Registered January 2015, retrospectively registered https://clinicaltrials.gov/ct2/results?cond=&term=NCT02358837&cntry=&state=&city=&dist=

Agreement in Breast Lesion Assessment and Final BI-RADS Classification Between Radial and Meander-Like Breast Ultrasound

2020 ◽  
Author(s):  
Pascale Brasier-Lutz ◽  
Claudia Jäggi-Wickes ◽  
Sabine Schaedelin ◽  
Rosemarie Burian ◽  
Cora-Ann Schoenenberger ◽  
...  
Keyword(s):  
Breast Lesion ◽  
Morphological Characteristics ◽  
Lesion Size ◽  
Breast Ultrasound ◽  
Architectural Distortion ◽  
Suitable Alternative ◽  
Lesion Location ◽  
High Degree ◽  
Face Localization

Abstract Background: This study prospectively investigates the agreement between radial (r-US) and meander-like (m-US) breast ultrasound with regard to lesion location, lesion size, morphological characteristics and final BI-RADS classification of individual breast lesions. Methods: Each patient of a consecutive, unselected, mixed collective received a dual ultrasound examination. Results: The agreement between r-US and m-US for lesion location ranged from good (lesion to mammilla distance ICC 0.64; lesion to skin distance ICC 0.72) to substantial (clock-face localization κ 0.70). For lesion size the agreement was good (diameter ICC 0.72; volume ICC 0.69), for lesion margin and architectural distortion it was substantial (κ 0.68 and 0.70, respectively). Most importantly, there was a substantial agreement (κ 0.76) in the final BI-RADS classification between r-US and m-US.Conclusions: Our recent comparison of radial and meander-like breast US revealed that the diagnostic accuracy of the two scanning methods was comparable. In this study, we observe a high degree of agreement between m-US and r-US for the lesion description (location, size, morphology) and final BI-RADS classification. These findings corroborate that r-US is a suitable alternative to m-US in daily clinical practice.Trial registration: NCT02358837. Registered January 2015, retrospectively registeredhttps://clinicaltrials.gov/ct2/results?cond=&term=NCT02358837&cntry=&state=&city=&dist=

scholarly journals Similar Diagnostic Accuracy and Reproducibility of BIRADS 4 and 5 Lesions in Radial and Meander-Like Breast Ultrasound

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Brasier-Lutz P ◽  
◽  
Jäggi-Wickes C ◽  
Burian R ◽  
Schaedelin S ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Diagnostic Accuracy ◽  
Predictive Value ◽  
Breast Biopsy ◽  
Breast Ultrasound ◽  
Breast Lesions ◽  
Suitable Alternative ◽  
Malignancy Rate ◽  
Examination Time

Breast ultrasound is crucial in the diagnostics of breast cancer. While meander-like Ultrasound (m-US) is most commonly used, radial Ultrasound (r- US) is emerging as suitable alternative. Breast lesions category BI-RADS 4 and 5 are suspicious and highly suggestive of malignancy, respectively, and mandate breast biopsy. We compare m-US and r-US in real-time with regard to diagnostic accuracy, examination time and the agreement in location, size and final BIRADS classification of BI-RADS 4 and 5 lesions. Out of 1948 dual examinations (m-US and r-US), 57 lesions were classified as BI-RADS 4 or 5 either by r-US or m-US or by both scanning methods. For breast lesions category BI-RADS 4 or 5, sensitivity (both scan methods 94.1%), specificity (m-US 21.7%, r-US 39.1%), cancers missed rate (both 5.9%), accuracy (m-US 64.9%, r-US 71.9%), positive predictive value (m-US 64.0%, r-US 69.6%) and negative predictive value (both 100%) were similar. In m-US, the malignancy rate for category BI-RADS 5 was 93.8% versus for 50.0% for BI-RADS 4 whereas in r-US, malignancy rates were 88.2% and 58.6% for category BI-RADS 5 and 4, respectively. The examination was significantly shorter (p<0.01) for r-US (13.6 minutes) compared to m-US (27.8 minutes). Our results support radial ultrasound as an alternative to meander-like ultrasound in breast lesions category BI-RADS 4 and 5 where patients benefit from a significantly shorter examination time.

RHYNCHOLITES AND THE PROBLEM OF NARROW AND BROAD CONCEPTION OF TAXONS

2018 ◽  
pp. 12-17 ◽  
Author(s):  
I. R. Khuzina ◽  
V. N. Komarov
Keyword(s):  
Sexual Dimorphism ◽  
Morphological Characteristics ◽  
Mass Scale ◽  
Individual Variability ◽  
Point Of View ◽  
The Other ◽  
New Taxon ◽  
Artificial System ◽  
Broad Understanding

The paper considers a point of view, based on the conception of the broad understanding of taxons. According to this point of view, rhyncholites of the subgenus Dentatobeccus and Microbeccus are accepted to be synonymous with the genus Rhynchoteuthis, and subgenus Romanovichella is considered to be synonymous with the genus Palaeoteuthis. The criteria, exercising influence on the different approaches to the classification of rhyncholites, have been analyzed (such as age and individual variability, sexual dimorphism, pathological and teratological features, degree of disintegration of material), underestimation of which can lead to inaccuracy. Divestment of the subgenuses Dentatobeccus, Microbeccus and Romanovichella, possessing very bright morphological characteristics, to have an independent status and denomination to their synonyms, has been noted to be unjustified. An artificial system (any suggested variant) with all its minuses is a single probable system for rhyncholites. The main criteria, minimizing its negative sides and proving the separation of the new taxon, is an available mass-scale material. The narrow understanding of the genus, used in sensible limits, has been underlined to simplify the problem of the passing the view about the genus to the other investigators and recognition of rhyncholites for the practical tasks.

scholarly journals Morphological Characteristics, Classifications and Difficulties in the Use of Diagnostic Criteria for Serrated Lesions of the Large Intestine

2021 ◽  
Author(s):  
Cesar de Souza Bastos Junior ◽  
Vera Lucia Nunes Pannain ◽  
Adriana Caroli-Bottino
Keyword(s):  
Diagnostic Criteria ◽  
Morphological Characteristics ◽  
World Health ◽  
Diagnostic Tools ◽  
Serrated Adenoma ◽  
The Past ◽  
The World ◽  
Serrated Lesions ◽  
Health Organization

Abstract Introduction Colorectal carcinoma (CRC) is the most common gastrointestinal neoplasm in the world, accounting for 15% of cancer-related deaths. This condition is related to different molecular pathways, among them the recently described serrated pathway, whose characteristic entities, serrated lesions, have undergone important changes in their names and diagnostic criteria in the past thirty years. The multiplicity of denominations and criteria over the last years may be responsible for the low interobserver concordance (IOC) described in the literature. Objectives The present study aims to describe the evolution in classification of serrated lesions, based on the last three publications of the World Health Organization (WHO) and the reproducibility of these criteria by pathologists, based on the evaluation of the IOC. Methods A search was conducted in the PubMed, ResearchGate and Portal Capes databases, with the following terms: sessile serrated lesion; serrated lesions; serrated adenoma; interobserver concordance; and reproducibility. Articles published since 1990 were researched. Results and Discussion The classification of serrated lesions in the past thirty years showed different denominations and diagnostic criteria. The reproducibility and IOC of these criteria in the literature, based on the kappa coefficient, varied in most studies, from very poor to moderate. Conclusions Interobserver concordance and the reproducibility of microscopic criteria may represent a limitation for the diagnosis and appropriate management of these lesions. It is necessary to investigate diagnostic tools to improve the performance of the pathologist's evaluation, for better concordance, and, consequently, adequate diagnosis and treatment.

scholarly journals Identification of the degree of impact of dams on the hydrologic regime of semi-arid rivers: an evaluation of the DHRAM method

RBRH ◽  
2017 ◽  
Vol 22 (0) ◽  
Author(s):  
Naiah Caroline Rodrigues de Souza ◽  
◽  
Andrea Sousa Fontes ◽  
Lafayette Dantas da Luz ◽  
Sandra Maria Conceição Pinheiro ◽  
...  
Keyword(s):  
Hydrological Regime ◽  
Flow Regulation ◽  
Hydrologic Regime ◽  
Local Conditions ◽  
Operating Rules ◽  
Hydrologic Variability ◽  
High Degree ◽  
The Impact ◽  
Semi Arid

ABSTRACT The flow regulation that results from the implantation of dams causes consequences to the river ecosystems due to the modification on the characteristics of the hydrologic regime. The investigation of these changes become relevant, mainly in semi-arid regions where there is a great amount of these hydraulic structures and lack of such analyzes. Considering the above, this paper aims to evaluate the Dundee Hydrological Regime Alteration Method (DHRAM) through the classification of the degree of impact of dams located on rivers Itapicuru, Paraguaçu and their tributaries, verifying the adequacy of its use to represent the semi-arid hydrologic regime. Thereby, the DHRAM was applied in three versions: considering the thresholds that define the scores to classify the degree of impact in its original set (accordingly to Black et al. (2005)); with the adjustment of those thresholds to local conditions; and, with the regrouping of variables and adjustment of thresholds. The results showed that the method in its original set is applicable to semi-arid rivers, however it tends to be very restrictive against the high natural hydrologic variability characteristic of these rivers, and it ends up pointing to a high degree of alteration for dams that are known for not causing a very siginifcant flow regulation. The DHRAM with the regrouping of variables and the adjustment of thresholds presented the classification that approached the most to the known characteristics of the studied dams, being useful for the evaluation of the impact of dams still in project, and also to guide the adoption of operating rules that minimize the most significant hydrologic alterations that are identified.

The lesion detection efficacy of deep learning on automatic breast ultrasound and factors affecting its efficacy: a pilot study

2021 ◽  
Author(s):  
Xiao Luo PhD ◽  
Min Xu ◽  
Guoxue Tang ◽  
Yi Wang PhD ◽  
Na Wang ◽  
...  
Keyword(s):  
Deep Learning ◽  
Breast Tissue ◽  
Test Group ◽  
Lesion Size ◽  
Breast Ultrasound ◽  
Lesion Detection ◽  
Detection Sensitivity ◽  
Control Group ◽  
Factors Affecting ◽  
Handheld Ultrasound

Objectives: The aim of this study was to investigate the detection efficacy of deep learning (DL) for automatic breast ultrasound (ABUS) and factors affecting its efficacy. Methods: Women who underwent ABUS and handheld ultrasound from May 2016 to June 2017 (N = 397) were enrolled and divided into training (n = 163 patients with breast cancer and 33 with benign lesions), test (n = 57) and control (n = 144) groups. A convolutional neural network was optimised to detect lesions in ABUS. The sensitivity and false positives (FPs) were evaluated and compared for different breast tissue compositions, lesion sizes, morphologies and echo patterns. Results: In the training set, with 688 lesion regions (LRs), the network achieved sensitivities of 93.8%, 97.2 and 100%, based on volume, lesion and patient, respectively, with 1.9 FPs per volume. In the test group with 247 LRs, the sensitivities were 92.7%, 94.5 and 96.5%, respectively, with 2.4 FPs per volume. The control group, with 900 volumes, showed 0.24 FPs per volume. The sensitivity was 98% for lesions > 1 cm3, but 87% for those ≤1 cm3 (p < 0.05). Similar sensitivities and FPs were observed for different breast tissue compositions (homogeneous, 97.5%, 2.1; heterogeneous, 93.6%, 2.1), lesion morphologies (mass, 96.3%, 2.1; non-mass, 95.8%, 2.0) and echo patterns (homogeneous, 96.1%, 2.1; heterogeneous 96.8%, 2.1). Conclusions: DL had high detection sensitivity with a low FP but was affected by lesion size. Advances in knowledge: DL is technically feasible for the automatic detection of lesions in ABUS.

scholarly journals Can Cut-Off-Values for Tumor Size or Patient Age in Breast Ultrasound Reduce Unnecessary Biopsies or is it all About Bi-rads?– A Retrospective Analysis of 763 Biopsied T1-Sized Lesions

2017 ◽  
Vol 03 (03) ◽  
pp. E94-E98 ◽  
Author(s):  
Laura Holzer-Fruehwald ◽  
Matthias Meissnitzer ◽  
Michael Weber ◽  
Stephan Holzer ◽  
Klaus Hergan ◽  
...  
Keyword(s):  
Regression Models ◽  
Breast Lesion ◽  
Binary Logistic Regression ◽  
Lesion Size ◽  
Breast Lesions ◽  
Predictive Values ◽  
Logistic Regression Models ◽  
Independent Variables ◽  
Oval Shape ◽  
Histological Result

Abstract Aims and Objectives To assess whether it is possible to establish a size cut-off-value for sonographically visible breast lesions in a screening situation, under which it is justifiable to obviate a biopsy and to evaluate the grayscale characteristics of the identified lesions. Materials and Methods Images of sonographically visible and biopsied breast lesions of 684 patients were retrospectively reviewed and assessed for the following parameters: size, shape, margin, lesion boundary, vascularity, patient’s age, side of breast, histological result, and initial BI-RADS category. Statistical analyses (t-test for independent variables, ROC analyses, binary logistic regression models, cross-tabulations, positive/negative predictive values) were performed using IBM SPSS (Version 21.0). Results Of all 763 biopsied lesions, 223 (29.2%) showed a malignant histologic result, while 540 (70.8%) were benign. Although we did find a statistically significant correlation of malignancy and lesion size (p=0.031), it was not possible to define a cut-off value, under which it would be justifiable to obviate a biopsy in terms of sensitivity and specificity (AUC: 0.558) at any age. Lesions showing the characteristics of a round or oval shape, a sharp delineation and no echogenic rim (n=112) were benign with an NPV of 99.1%. Conclusion It is not possible to define a cut-off value for size or age, under which a biopsy of a sonographically visible breast lesion can be obviated in the screening situation. The combination of the 3 grayscale characteristics, shape (round or oval), margin (circumscribed) and no echogenic-rim sign, showed an NPV of 99.1%. Therefore, it seems appropriate to classify such lesions as BI-RADS 2.

Evaluational Reactions to Erotic Literature

1965 ◽  
Vol 16 (3) ◽  
pp. 985-994 ◽  
Author(s):  
Leon A. Jakobovits
Keyword(s):  
Short Stories ◽  
Hard Core ◽  
Cumulative Effect ◽  
Sampling Bias ◽  
Male And Female ◽  
Warm Up ◽  
Erotic Literature ◽  
High Degree ◽  
Very High

On the basis of analysis of a variety of erotic literature Kronhausen and Kronhausen (1959) have suggested that there seem to be two general types: erotic realism ( ER) and hard-core obscenity ( O). Using three of the distinguishing criteria which were identified (context, exaggeration, and anti-eroticism), 20 short stories were specifically written in such a way that 10 had the characteristics of ER and the others had the characteristics of O. Study I showed a very high degree of agreement between judges in their classification of these stories as either ER or O. Study II revealed that male and female readers react differentially to the two types of stories. Females consistently rate O as more interesting and sexually stimulating than males do, the latter finding ER as more arousing than O. Other evaluational reactions are also described. A “warm-up” cumulative effect with successive reading was found with both sexes. The possibility of sampling bias affecting the data was noted.

scholarly journals Early Iron Age Sword from the Territory of the Middle Yenisei

2021 ◽  
Vol 20 (7) ◽  
pp. 135-143
Author(s):  
Oleg A. Mitko ◽  
Sergey G. Skobelev
Keyword(s):  
Iron Age ◽  
Low Carbon Steel ◽  
Morphological Characteristics ◽  
Early Iron Age ◽  
Low Carbon ◽  
North Caucasus ◽  
Group Iii ◽  
The North ◽  
Minusinsk Basin

Purpose. The article is devoted to the characteristics of a double-edged iron sword, which can be attributed to the unique phenomena of the early Iron Age of the Minusinsk Basin. Results. According to its morphological characteristics, the sword is an increased technological modification of the traditional Tagar dagger. The total length of the sword is 59.5 cm; the width of the lenticular blade in cross-section is about 7 cm. The handle with a volute-like pommel is separated from the blade by a narrow butterfly-shaped crosshair. The length of the hilt is 8 cm, which corresponds to the size of the hilts of most Scythian swords. This is a very small size, since in men the average palm width is about 12 cm. Probably, the rounded outlines of the pommel and narrow crosshairs allow, due to their shape, to hold the short handle of a heavy sword more tightly. Conclusion. According to the classification of O. I. Kura, Scythian swords with a narrow butterfly-shaped crosshair and volute-like pommel are included in Group III, Type II A2 dating from the end of the 5th – 4th centuries BC, which corresponds to the boundary between the Podgorny and Saragashen stages of the Tagar culture. The earliest form of sword hilts with typologically similar forms of crosshairs (kidney-shaped, heart-shaped, butterfly-shaped) with bar-shaped pommels appeared in the North Caucasus in the first half of the 7th century BC. On the territory of the Minusinsk Basin, most morphologically similar daggers are usually dated to the 6th – 4th centuries BC. Before the discovery of the Krasnoyarsk sword, long-bladed iron weapons were not known there. At the same time, swords of the Scythian time were found in the nearest regions of Altai and Kazakhstan. The later appearance of the technology for processing iron in the Minusinsk Basin makes it possible to consider the Krasnoyarsk sword an import item. According to another hypothesis, it belongs to the period of the late 3rd – 2nd centuries BC, when local craftsmen mastered the processing of iron and began to make massive quantities of weapons and tools from low-carbon steel. In doing so, they copied traditional archaic forms.

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