Mood instability, depression, and anxiety in pregnancy and adverse neonatal outcomes

Abstract Background Antenatal women experience an increased level of mood and anxiety symptoms, which have negative effects on mothers’ mental and physical health as well as the health of their newborns. The relation of maternal depression and anxiety in pregnancy with neonate outcomes is well-studied with inconsistent findings. However, the association between antenatal mood instability (MI) and neonatal outcomes has not been investigated even though antenatal women experience an elevated level of MI. We sought to address this gap and to contribute to the literature about pregnancy neonate outcomes by examining the relationship among antenatal MI, depression, and anxiety and neonatal outcomes. Methods A prospective cohort of women (n = 555) participated in this study at early pregnancy (T1, 17.4 ± 4.9 weeks) and late pregnancy (T2, 30.6 ± 2.7 weeks). The Edinburgh Postnatal Depression Scale (EPDS) was used to assess antenatal depressive symptoms, anxiety was measured by the EPDS anxiety subscale, and mood instability was measured by a visual analogue scale with five questions. These mood states together with stress, social support, as well as lifestyle were also examined in relation to neonatal outcomes using chi-square tests and logistic regression models. Results Mood instability, depression, and anxiety were unrelated to adverse neonatal outcomes. Only primiparous status was associated with small for gestational age after Bonferroni correction. Conclusions We report no associations between antenatal mood symptoms including MI, depression, and anxiety and neonatal outcomes. More studies are required to further explore the relationship between antenatal mood instability, depression, and anxiety and neonatal outcomes.

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Mood Symptoms and Other Maternal Factors in Pregnancy and Adverse Neonate Outcomes

10.21203/rs.3.rs-61702/v1 ◽

2020 ◽

Author(s):

Hua Li ◽

Angela Bowen ◽

Rudy Bowen ◽

Nazeem Muhajarine ◽

Lloyd Balbuena

Keyword(s):

Social Support ◽

Statistical Significance ◽

Depression Scale ◽

Neonatal Outcomes ◽

Maternal Factors ◽

Mood Instability ◽

Mood Symptoms ◽

Antenatal Depressive Symptoms ◽

Adverse Neonatal Outcomes ◽

In Pregnancy

Abstract Background Antenatal women experience a higher level of mood symptoms, which have negative effects on mothers’ mental and physical health and their newborns. The relation of maternal moods including depression and anxiety and other maternal factors in pregnancy and neonate outcomes are well-studied with inconsistent findings. Although antenatal women experience a higher level of mood instability (MI), the association between antenatal MI and neonatal outcomes has not been investigated. We aimed to address this gap and to contribute to the pregnancy-neonate outcomes literature by examining the relationship between antenatal mood symptoms and other maternal factors and neonatal outcomes.Methods A prospective cohort of women (n = 555) participated in this study at early pregnancy (T1, 17.4 ± 4.9 weeks) and late pregnancy (T2, 30.6 ± 2.7 weeks). The Edinburgh Postnatal Depression Scale (EPDS) was used to assess antenatal depressive symptoms, the EPDS anxiety subscale was utilized to measure anxiety symptoms, and mood instability was measured using a visual analogue scale. These mood states together with stress, social support, as well as healthy and unhealthy behaviours were also examined in relation to neonatal outcomes using chi-square tests and logistic regression models. Results Depression and MI were unrelated to adverse neonatal outcomes and anxiety was related to Apgar score with marginal statistical significance. Higher stress, lack of partner support, smoking, and primiparous status were associated with some adverse outcomes.Conclusions The current study identified no associations between antenatal mood symptoms and neonatal outcomes. Our findings further support and extend previous evidence on smoking abstinence or cessation, and the provision of resources for stress management and social support that could help prevent or alleviate adverse neonatal outcomes.

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A-121 Functional Outcomes in Bilingual Persons with Traumatic Brain: The Role of Mood

Archives of Clinical Neuropsychology ◽

10.1093/arclin/acab062.139 ◽

2021 ◽

Vol 36 (6) ◽

pp. 1171-1171

Author(s):

Winter Olmos ◽

Daniel W Lopez-Hernandez ◽

Isabel Munoz ◽

Laura Schierholz ◽

Rachel A Rugh-Fraser ◽

...

Keyword(s):

Depressive Symptoms ◽

Functional Outcomes ◽

Depression Scale ◽

Anxiety And Depression ◽

Depression And Anxiety ◽

Hospital Anxiety ◽

Anxiety Levels ◽

The Relationship ◽

Pearson Correlations

Abstract Introduction We examined the relationship between depression and anxiety, language, and functional outcomes in persons with traumatic brain injury (TBI). Methods The sample consisted of 48 acute TBI (ATBI: 23 Spanish-English Bilinguals; 25 English monolinguals), 30 chronic TBI (CTBI: 17 Spanish English Bilinguals; 12 English monolinguals), and 47 healthy comparison (HC: 29 Spanish-English Bilinguals; 18 English monolinguals) participants. The Hospital Anxiety and Depression Scale was used to measure depression (HADS-D) and anxiety (HADS-A). The Mayo Portland Adaptability Inventory-4 (MPAI-4) was used to measure functional outcomes (ability, adjustment, participation). Results An ANCOVA, controlling for age, revealed the ATBI group reported lower anxiety levels compared to the CTBI group, p = 0.034 np2 = 0.06. HC participants demonstrated significantly higher functional ability compared to both TBI groups, p < 0.05, np2 = 0.08–0.19. The ATBI group demonstrated worse participation scores compared to the CTBI and HC groups, p = 0.001, np2 = 0.11. Pearson correlations revealed mood was related to functional status in ATBI monolinguals (HADS-A: r = 0.29–0.64; HADS-D, r = 0.49–0.62). Monolingual participants with ATBI demonstrated correlations between depressive symptoms and functional adjustment (r = 0.57, p = 0.005) and ability (r = 0.44, p = 0.034). For monolinguals with CTBI, HADS-A correlated with functional outcomes, r = 0.60–0.66, p < 0.05. For bilinguals with CTBI, functional outcomes correlated with HADS-A, r = 0.53–0.66, p < 0.05, and HADS-D, r = 0.54–0.66, p < 0.05. For HC monolinguals, functional outcomes correlated with HADS-A, r = 0.53–0.70, p < 0.05, and HADS-D, r = 0.50–0.72, p < 0.05. Finally, for HC bilinguals, functional outcomes correlated with HADS-A, r = 0.59–0.68, p < 0.05. Conclusion Our results suggest that a relationship between anxiety and depressive symptoms is related more to functional outcomes in monolingual TBI survivors compared to bilingual TBI survivors.

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Integrated Review of Cytokines in Maternal, Cord, and Newborn Blood: Part II— Associations With Early Infection and Increased Risk of Neurologic Damage in Preterm Infants

Biological Research For Nursing ◽

10.1177/1099800409344619 ◽

2009 ◽

Vol 11 (4) ◽

pp. 377-386 ◽

Cited By ~ 19

Author(s):

Rita Pickler ◽

Lisa Brown ◽

Jacqueline McGrath ◽

Debra Lyon ◽

Debra Rattican ◽

...

Keyword(s):

Preterm Infants ◽

Proinflammatory Cytokines ◽

Early Infection ◽

Neonatal Outcomes ◽

Mediators Of Inflammation ◽

Increased Risk ◽

Adverse Neonatal Outcomes ◽

Factor Α ◽

Relationship Of ◽

The Relationship

A growing body of literature supports the relationship of maternal inflammation with preterm birth and adverse neonatal outcomes, including infection and central nervous system (CNS) dysfunction. Mediators of inflammation, most notably proinflammatory cytokines, have been implicated as having an association with and perhaps playing a causal role in the pathogenesis, leading to adverse neonatal outcomes. Even though the association of cytokines with early adverse neonatal outcomes has been actively pursued as a line of research, there has been little integration of diverse findings across studies. Therefore, the purpose of this systematic review was to appraise and classify empirical evidence from human studies for the association of cytokine levels in blood (serum, plasma, or cells; maternal, cord, or neonatal) with two adverse early outcomes in preterm infants: early infection and increased risk of neurologic damage. The review revealed that the proinflammatory cytokines most frequently linked with sepsis are in the interleukin (IL) 1 family as well as tumor necrosis factor α (TNF-α) and IL-6. The proinflammatory cytokines most frequently linked to neurologic insult in the reviewed studies were IL-1β, IL-6, and IL-8. In all cases where IL-1β was studied, the levels were increased when there was neurologic insult. A better understanding of the relationship of these inflammatory substances with these adverse conditions is needed for the future development of maternal and neonatal biobehavioral nursing research.

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Determining fetal sex in pregnancy with reference to pregnant women behavior in late pregnancy

Polish Journal of Public Health ◽

10.1515/pjph-2015-0030 ◽

2015 ◽

Vol 125 (2) ◽

pp. 87-89

Author(s):

Dorota Robak-Chołubek ◽

Gustaw Chołubek ◽

Ewa Piróg

Keyword(s):

Sex Determination ◽

Pregnant Women ◽

Late Pregnancy ◽

Unborn Child ◽

Fetal Sex ◽

Factors Influencing ◽

The Relationship ◽

Emotional Level ◽

In Pregnancy

Abstract Introduction. Pregnant women often create their own image of a child. The ultrasound is able to model and modify this picture. The image of the unborn child develops along with the process of creating the space for the baby on the psychological and emotional level and is continued after the delivery. Aim. The authors of the study made an attempt to evaluate the influence of fetal sex determination during ultrasound in pregnancy on emotional and ‘practical’ experiencing late pregnancy - after the 28th week of its duration. Material and methods. The study included 200 pregnant women. Qualification criteria for the research was the declared awareness of fetal sex confirmed by ultrasound. Among others, factors influencing decision to determine fetal sex, emotional bond with the unborn child after identifying the sex, as well as preparation for birth regarding prognosticated sex were assessed. Results. Nearly all pregnant women wanted to find out the fetal sex, usually claiming that they did so out of curiosity. After they did it, about 2/3 of them stated that the emotional bond with the baby increased and the vast majority of women started preparing layettes for their future babies. Conclusions. Determination of fetal sex during ultrasound improves the relationship between the mother and her future baby. It also enables the woman to prepare for childbirth considering its sex by the purchase of clothes, pram and preparation of layette or baby’s room

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The Mediational Effect of Weight Self-Stigma in the Relationship between Blatant and Subtle Discrimination and Depression and Anxiety

The Spanish Journal of Psychology ◽

10.1017/sjp.2017.1 ◽

2017 ◽

Vol 20 ◽

Cited By ~ 9

Author(s):

Alejandro Magallares ◽

Patricia Bolaños-Rios ◽

Inmaculada Ruiz-Prieto ◽

Pilar Benito de Valle ◽

Jose Antonio Irles ◽

...

Keyword(s):

Social Stigma ◽

Depression Scale ◽

Anxiety And Depression ◽

Depression And Anxiety ◽

Hospital Anxiety ◽

Obesity Stigma ◽

Subtle Discrimination ◽

Dependent Variables ◽

Similar Weight ◽

The Relationship

AbstractObesity may be considered a social stigma. In addition, people with obesity are frequently aware of stigma directed at others who have a similar weight and come to think stigmatized thoughts about themselves. Our study focused specifically on how blatant and subtle discrimination and weight self-stigma are related to depression and anxiety in people with obesity. The sample comprised 170 participants from the Clinical Nutrition Unit of the “Hospital de Valme” (Seville, Spain). The Weight Self-Stigma Questionnaire, the Multidimensional Perceived Discrimination Scale, and the Hospital Anxiety and Depression Scale were used. It was found that blatant and subtle discrimination and weight self-stigma were positively related to depression (.31, .38, and .45 respectively) and anxiety (.30, .36, and .49 respectively; all ps < .01). The path analysis conducted showed that there was a mediational effect of weight self-stigma between blatant (β = .36) and subtle discrimination (β = .40) and depression (β = .24) and anxiety (β = .49; all ps < .01). According to these results, it can be said that weight self-stigma was a full mediator in the model found because the relationships between the independent and the dependent variables were non-significant. Finally, results are discussed in the frame of the obesity stigma literature, and some clinical implications of the results of the study are suggested.

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The Effects of Physical Activity on Arterial Stiffness during Pregnancy: An Observational Study

Applied Physiology Nutrition and Metabolism ◽

10.1139/apnm-2021-0121 ◽

2021 ◽

Author(s):

Brittany A Matenchuk ◽

Katelyn Donna Fujii ◽

Rachel J Skow ◽

Frances M Sobierajski ◽

Christina MacKay ◽

...

Keyword(s):

Physical Activity ◽

Arterial Stiffness ◽

Vigorous Physical Activity ◽

Late Pregnancy ◽

Physical Activity Guidelines ◽

Peripheral Pulse ◽

Curvilinear Relationships ◽

The Relationship ◽

Carotid Artery Compliance ◽

In Pregnancy

The objective of the present study was to investigate the relationship between moderate-to-vigorous physical activity (MVPA) and arterial stiffness in pregnancy. Thirty-nine women participated in this study resulting in 68 measurements in non-pregnant (NP; n=21), first (TM1; n=8), second (TM2; n=20), and third trimesters (TM3; n=19). Compliance, distensibility, elasticity, β-stiffness, and carotid to femoral (central) and carotid to finger (peripheral) pulse wave velocity (PWV) were assessed. MVPA was measured using accelerometry. Multilevel linear regressions adjusted for multiple tests per participant using random effects to generate β coefficients and 95% confidence intervals (CI) were performed. Distensibility, elasticity, β-stiffness, central- and peripheral-PWV did not differ between pregnant and non-pregnant assessments. Carotid artery compliance was higher in TM2 compared to NP. Central PWV (β Coef: -0.14, 95% CI: -0.27, -0.02) decreased from early to mid-pregnancy and increased in late pregnancy. Meeting the MVPA guidelines was significantly associated with central-PWV (Adj. β Coef: -0.34, 95% CI: -0.62, -0.06, p=0.016), peripheral-PWV (Adj. β Coef: -0.54, 95% CI: -0.91, -0.16, p=0.005), and distensibility (Adj. β Coef: -0.001, 95% CI: -0.002, -0.0001, p=0.018), in pregnancy. These results suggest that MVPA may be associated with improved (i.e. reduced) arterial stiffness in pregnancy. Novelty Bullets • Central PWV, distensibility, compliance, elasticity, and ß-stiffness, but not peripheral PWV, exhibited curvilinear relationships with gestational age • Central and peripheral PWV were lower in pregnant women who met the physical activity guidelines of 150 minutes of moderate-to-vigorous physical activity per week

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The pregnancy intention to have a second child and antenatal depressive symptoms in Chinese women under the new two-child-per-couple policy

10.21203/rs.2.15650/v1 ◽

2019 ◽

Author(s):

Meili Xiao ◽

Bing Fu ◽

Chunmei Mi ◽

Chen Pan ◽

Shujuan Zhu ◽

...

Keyword(s):

Depressive Symptoms ◽

Pregnant Women ◽

Edinburgh Postnatal Depression Scale ◽

Chinese Women ◽

Depression Scale ◽

Pregnancy Intention ◽

Key Words Pregnancy ◽

Second Child ◽

Logistic Regression Models ◽

Antenatal Depressive Symptoms

Abstract Background: Few studies investigated the association between the pregnancy intention to have a second child and antenatal depressive symptoms.The aim of this study was to explore the association between the pregnancy intention to have a second child by pregnant women’s own desires, pregnant women’s husband own desires, parents who want to grandchild desires, couple’s concordance desires and antenatal depressive symptoms. Methods: A total of 306 participants who completed questionnaire were included in our analysis. Antenatal depressive symptom was assessed using the Chinese version of Edinburgh Postnatal Depression Scale. Logistic regression models were used to estimate the association between the pregnancy intention to have a second child by pregnant women’s own desires, pregnant women’s husband own desires, parents who want to grandchild desires and antenatal depressive symptoms. Results: the prevalence of antenatal depressive symptoms was 36.3% among the second child pregnant women. Of the 306 participants, the proportion of the pregnancy intention to have a second child by pregnant women’s own desires, pregnant women’s husband desires, parents who want to grandchild desires and couple’s concordance desires was 8.5%, 8.5%, 10.8% and 72.2% respectively. Compared with the pregnancy intention by couple’s concordance desires, pregnant women’s own desires to have a second child had higher risk of antenatal depressive symptoms after adjustment for potential confounders (OR=4.560, 95%CI: 1.603,12.973). No association was found between the pregnancy intention to have a second child by pregnant women’s husband own desires, parents who want to grandchild desires and antenatal depressive symptoms after adjustment for confounders (OR=1.996, 95%CI:0.781,5.105; OR=0.744, 95%CI: 0.306,1.811, respectively). Conclusion: These findings suggest the pregnancy intention to have a second child by pregnant women own’s desires may be a risk factors for antenatal depressive symptoms among two-child pregnant women. A qualitative study should be carried out to investigate the real reason for the intention by pregnant women’s own desires and antenatal depressive symptoms in the future, because of this study was a quantitative study. Key words: pregnancy intention; antenatal depressive symptoms; second child

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0474 A NATIONAL COHORT STUDY OF OBSTRUCTIVE SLEEP APNEA IN PREGNANCY AND ADVERSE NEONATAL OUTCOMES

SLEEP ◽

10.1093/sleepj/zsx050.473 ◽

2017 ◽

Vol 40 (suppl_1) ◽

pp. A177-A177 ◽

Cited By ~ 1

Author(s):

G Bourjeily ◽

V Danilack ◽

M Bublitz ◽

H Lipkind ◽

D Caldwell ◽

...

Keyword(s):

Obstructive Sleep Apnea ◽

Cohort Study ◽

Sleep Apnea ◽

Neonatal Outcomes ◽

Obstructive Sleep ◽

Adverse Neonatal Outcomes ◽

National Cohort ◽

In Pregnancy

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Does Vitamin D Prophylaxis in Pregnancy Decrease the Risk of Adverse Neonatal Outcomes? [33N]

Obstetrics and Gynecology ◽

10.1097/01.aog.0000533129.31245.69 ◽

2018 ◽

Vol 131 ◽

pp. 160S-161S

Author(s):

Malini D. Persad ◽

Victoria Ly ◽

Kimberly Herrera ◽

Michael Demishev ◽

J. Gerald Quirk ◽

...

Keyword(s):

Vitamin D ◽

Neonatal Outcomes ◽

Adverse Neonatal Outcomes ◽

In Pregnancy

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The relationship between depression and anxiety: construction of a prototypical anxiety and depression scale

Psychological Medicine ◽

10.1017/s0033291700038058 ◽

1992 ◽

Vol 22 (3) ◽

pp. 597-606 ◽

Cited By ~ 6

Author(s):

Maarten W. J. Koeter ◽

Wim Van Den Brink

Keyword(s):

Discriminant Validity ◽

Depression Scale ◽

Reliability And Validity ◽

Anxiety And Depression ◽

Depression And Anxiety ◽

Good Reliability ◽

Clinical Pictures ◽

Screening Device ◽

Depression Scales ◽

The Relationship

SynopsisThe question of the relationship between anxiety and depression remains to be solved. The fact that clinical pictures show substantial overlap makes it difficult, using conventional instruments, to distinguish between the co-occurrence of anxiety and depression and overlap in definitions and measurement of the two syndromes. This calls for the construction of scales which exclude symptoms common to both syndromes and incorporate symptoms specific only to anxiety or only to depression; i.e. scales with maximum discriminant validity. This article describes the construction of two such scales based on PSE symptoms; a prototypical anxiety scale and a prototypical depression scale. In a sample of 134 non-psychotic psychiatric out-patients these scales show good reliability and validity, both as a measure of severity and as a screening device. Compared to the Hamilton anxiety and depression scales (HARS and HRSD), the correlation between the prototypical anxiety and depression scales is low.

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