scholarly journals Association between acute critical life events and the speed of onset of depressive episodes in male and female depressed patients

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Maria Strauss ◽  
Roland Mergl ◽  
Nora Gürke ◽  
Kerstin Kleinert ◽  
Christian Sander ◽  
...  
2019 ◽  
Vol 7 (1) ◽  
Author(s):  
Maximilian Pilhatsch ◽  
Thomas J Stamm ◽  
Petra Stahl ◽  
Ute Lewitzka ◽  
Anne Berghöfer ◽  
...  

Abstract Background Symptoms of anxiety co-occur in a variety of disorders including in depressive episodes of bipolar disorder and in patients with thyrotoxicosis. Treatment of refractory bipolar disorder with supraphysiologic doses of levothyroxine (L-T4) has been shown to improve the phenotypic expression of the disorder and is associated with an increase of circulating thyroid hormones. However, it might be associated with somatic and mental adverse effects. Here we report the investigation of the influence of treatment with supraphysiologic doses of L-T4 on symptoms of anxiety in patients with refractory bipolar depression. Methods Post-hoc analysis from a 6-week, multi-center, randomized, double-blind, placebo-controlled study of the effects of supraphysiologic L-T4 treatment on anxiety symptoms in bipolar depression. Anxiety symptoms were measured weekly with the Hamilton anxiety/somatization factor (HASF) score of the Hamilton Depression Rating Scale (HAMD) and the State- and Trait Anxiety Inventory (STAI). Results Treatment of both groups was associated with a significant reduction in anxiety symptoms (p < 0.001) with no statistical difference between groups (LT-4: from 5.9 (SD = 2.0) at baseline to 3.7 (SD = 2.4) at study end; placebo: from 6.1 (SD = 2.4) at baseline to 4.4 (SD = 2.8) at study end; p = 0.717). Severity of anxiety at baseline did not show a statistically significant correlation to the antidepressive effect of treatment with supraphysiologic doses of L-T4 (p = 0.811). Gender did not show an influence on the reduction of anxiety symptoms (females: from 5.6 (SD = 1.7) at baseline to 3.5 (SD = 2.4) at study end; males: from 6.1 (SD = 2.3) at baseline to 4.0 (SD = 2.4) at study end; p = 0.877). Conclusions This study failed to detect a difference in change of anxiety between bipolar depressed patients treated with supraphysiologic doses of L-T4 or placebo. Comorbid anxiety symptoms should not be considered a limitation for the administration of supraphysiologic doses of L-T4 refractory bipolar depressed patients. Trial registration ClinicalTrials, ClinicalTrials.gov identifier: NCT01528839. Registered 2 June 2012—Retrospectively registered, https://clinicaltrials.gov/ct2/show/study/NCT01528839


2000 ◽  
Vol 87 (3) ◽  
pp. 750-752 ◽  
Author(s):  
J. E. Hovens ◽  
I. Bramsen ◽  
H. M. van der Ploeg ◽  
I. E. W. Reuling

Three groups of first-year male and female medical students (total N = 90) completed the Trauma and Life Events Self-report Inventory twice. Test-retest reliability for the three different time periods was .82, .89, and .75, respectively.


Out in Time ◽  
2019 ◽  
pp. 67-90
Author(s):  
Perry N. Halkitis

Gay men experience the process of coming out to various groups of individuals, in myriad contexts, and throughout the course of their lives. For many gay men, telling one’s parents and families represents the most significant act of disclosure. Methods used for coming out to parents, circumstances by which the men came out, and reactions of their families in both the short and long term are explored. A variety of different approaches are evidenced in the life stories. The impact of these critical life events is considered in relation to the well-being and health of each of the men. Coming out to parents and family is challenging in every generation, but the circumstances related to coming out are influenced and shaped by both the sociopolitical contexts of the time and the crisis of each generation.


Author(s):  
Carlos Blanco ◽  
John C. Markowitz ◽  
Myrna M. Weissman

Interpersonal psychotherapy (IPT) is a time-limited, diagnosis-focused therapy. IPT was defined in a manual. Research has established its efficacy as an acute and chronic treatment for patients with major depressive disorder (MDD) of all ages, as an acute treatment for bulimia nervosa, and as adjunct maintenance treatment for bipolar disorder. The research findings have led to its inclusion in treatment guidelines and increasing dissemination into clinical practice. Demonstration of efficacy in research trials for patients with major depressive episodes (MDEs) has led to its adaptation and testing for other mood and non-mood disorders. This has included modification for adolescent and geriatric depressed patients patients with bipolar and dysthymic disorders; depressed HIV-positive and depressed pregnant and postpartum patients; depressed primary care patients; and as a maintenance treatment to prevent relapse of the depression. Most of the modifications have been relatively minor and have retained the general principles and techniques of IPT for major depression. Non-mood targets have included anorexia, bulimia, substance abuse, borderline personality disorder, and several anxiety disorders. In general, outcome studies of IPT have suggested its promise for most psychiatric diagnoses in which it has been studied, with the exceptions of anorexia, dysthymic disorder, and substance use disorders. IPT has two complementary basic premises. First, depression is a medical illness, which is treatable and not the patient's fault. Second, depression does not occur in a vacuum, but rather is influenced by and itself affects the patient's psychosocial environment. Changes in relationships or other life events may precipitate depressive episodes; conversely, depressive episodes strain relationships and may lead to negative life events. The goal of treatment is to help the patient solve a crisis in his or her role functioning or social environment. Achieving this helps the patient to gain a sense of mastery over his or her functioning and relieves depressive symptoms. Begun as a research intervention, IPT has only lately started to be disseminated among clinicians and in residency training programmes. The publication of efficacy data, the promulgation of practice guidelines that embrace IPT among antidepressant treatments, and economic pressures on length of treatment have led to increasing interest in IPT. This chapter describes the concepts and techniques of IPT and its current status of adaptation, efficacy data, and training. The chapter provides a guide to developments and a reference list, but not a comprehensive review.


2019 ◽  
Vol 41 (3) ◽  
pp. 412-426
Author(s):  
Reyna Rodriguez ◽  
Izbieta Rocha ◽  
Alinne Z. Barrera

Research on depression among Latinx populations is increasing; however, a focus on what triggers depression among this community is lacking. This study aims to identify perceived triggers for depression through a secondary analysis of 28 adolescent girls who self-identified as Latinx (mean age = 17.07 years, SD = 0.77). Sixty-one percent of the girls reported being first generation (born in Mexico), having lived in Mexico an average of 8.95 years and the primary language at home being Spanish (63%). Of these, the associated triggers of 20 major depression episodes (MDE) and eight minor depressive episodes (i.e., two to four MDE criteria endorsed) were examined. Seventy-five triggers were identified with a majority reflecting family/parent relationships, romance/friendship issues, and self and others’ expectations/pressures. These findings suggest that certain life events and stressors precede depressive symptoms among Latinx adolescent girls.


2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S308-S308
Author(s):  
Charikleia Lampraki ◽  
Dario Spini ◽  
Daniela Jopp

Abstract Self-continuity is an identity mechanism that inter-connects past and present experiences with future expectations, creating a coherent whole. However, research is limited regarding inter-individual differences and life course determinants of change in self-continuity. Using a life-course perspective on vulnerability, we investigate how the accumulation of resources (e.g., social, hopeful attitude) and the occurrence of critical life events (e.g., childhood adversity, divorce) across the life course may affect changes in self-continuity. Data derived from the LIVES Intimate Partner Loss Study conducted in Switzerland from 2012 to 2016 (3 waves). The sample consisted of individuals having experienced divorce (N = 403, Mage = 55.43) or bereavement (N = 295, Mage = 69.91) in the second half of life, using a continuously married group as a reference (N = 535, Mage = 65.60). Multilevel hierarchical models were used. Results indicated that as individuals grew older they experienced more self-continuity. More childhood adversity was negatively associated with inter-individual differences in self-continuity for all groups. Divorcees with more childhood adverse events felt significantly less self-continuity as they grew older than divorcees with less childhood adversity. In the bereaved group, more childhood adversity and less hope was linked to lower levels of self-continuity. More hopeful married individuals felt more self-continuity as they grew older than less hopeful ones. In sum, findings demonstrate that self-continuity changes as a function of age, but also differs with regard to the critical life events experienced across the life course and the availability of resources.


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