scholarly journals Application of a complete blood count to screening lethargic and anorectic cats for pancreatitis

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Magdalena Maria Krasztel ◽  
Michał Czopowicz ◽  
Olga Szaluś-Jordanow ◽  
Agata Moroz ◽  
Marcin Mickiewicz ◽  
...  
Keyword(s):  
Neutrophil Count ◽  
Blood Count ◽  
Complete Blood Count ◽  
Screening Method ◽  
High Sensitivity ◽  
Total Leukocyte Count ◽  
Crude Odds Ratio ◽  
Abdominal Ultrasonography ◽  
Diagnostic Potential ◽  
Increased Risk

Abstract Background Feline pancreatitis (FP) is an important health problem of cats. Its diagnostics is based on the combination of quantification of serum pancreatic lipase immunoreactivity (fPLI) and abdominal ultrasonography (AUS). These modalities allow for establishing highly specific diagnosis, however they are relatively expensive and time-consuming. On the other hand, a screening test of high sensitivity which would allow to rule out FP on the first visit without a considerable increase of costs would be clinically useful. To evaluate accuracy of nonspecific inflammatory biomarkers based on complete blood count (CBC) in diagnosing FP 73 client-owned cats with signs of lethargy and reduced appetite lasting for at least 2 days before presentation were enrolled in the cross-sectional study. They were examined with fPLI assay and AUS and classified as cats with very low risk of FP when fPLI ≤3.5 μg/L and AUS negative for FP, or as cats with increased risk of FP in the case of any other combination of results. Then, 7 various CBC measurements were measured in each cat and linked to the risk of FP using the multivariable logistic regression. Results Five CBC measurements turned out to be significantly associated with the risk of FP – total leukocyte count (WBC; crude odds ratio(ORcrude) = 12.2; CI 95%: 1.52, 98.5), total neutrophil count (ORcrude = 5.84; CI 95%: 1.22, 27.9), band neutrophil count (BNC; ORcrude = 6.67; CI 95%: 1.98, 22.4), neutrophil-to-lymphocyte ratio (ORcrude = 3.68; CI 95%: 1.25, 10.9), and eosinophil count (EC; ORcrude = 0.34; CI 95%: 0.12, 0.96). The model based on WBC, BNC, and EC proved to have at least fair diagnostic potential (area under ROC curve 82.7%; CI 95%: 72.8%, 92.5%). When WBC <  18 G/L, BNC <  0.27 G/L, and EC >  0.3 G/L was considered as a negative result, and any other combination as the positive result, the CBC model had high sensitivity (91.8%; CI 95%: 80.8%, 96.8%) at a relatively low specificity (58.3%; CI 95%: 38.8%, 75.5%). Conclusion The combination of three CBC measurements is an immediately available and fairly accurate screening method for identification of lethargic and anorectic cats with increased risk of FP.

scholarly journals CORRELATION OF TOTAL COUNT (WBC), NEUTROPHIL COUNT AND CRP TEST AMONG FEBRILE PATIENTS IN NAVIMUMBAI.

2019 ◽  
Vol 3 (9) ◽  
Author(s):  
Dr. Sarita Shrivatstva ◽  
Dr. Narayana Kamath ◽  
Mrs. Ashwini Panchmahalkar
Keyword(s):  
Neutrophil Count ◽  
Bacterial Infections ◽  
Blood Count ◽  
Complete Blood Count ◽  
Malarial Parasite ◽  
Differential Count ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Streptolysin O ◽  
Febrile Condition

150 febrile patients included children (50), adult (50) and neonates (50) from outpatient departments and inpatients of private clinics and hospitals. Patients presented with fever and chills for more than 1 day to 3 days, throat infection, ear infection and cold and fever and only fever as the principal symptoms. After clinical examination all the patients were prescribed for Complete Blood Count (CBC) with differential count(DC) and C-reactive protein(CRP) tests, and in children below 14 years anti-Streptolysin O(ASO) tests ( 75) were prescribed. Patients treated with antibiotics previously two weeks before the study period were not included. Qualitative and quantitative tests were performed on all patients’ samples included in the study depending on the need/prescription by the physician or paediatrician. CBC, neutrophil count and CRP have been very useful indicators and significant in the diagnosis and treatment as well as follow-up of the febrile condition of the patients specially in patients suffering with bacterial infections. Even in patients with Dengue and malaria it gives a fair idea if there were leucocytosis or leukopenia, neutrophilia or neutropenia, thrombocytosis or thrombocytopenia. CBC: Complete blood count, DC: Differential count; MP: malarial parasite, CRP: C-reactive protein, ASO: Anti-Streptolysin O.

scholarly journals Evaluation Of Complete Blood Count Parameters To Predict Ovarian Torsion In Women With Adnexal Mass

2017 ◽  
pp. 1 ◽  
Author(s):  
Ahter T. Tayyar ◽  
Enis Özkaya ◽  
Çiğdem Abide Yayla ◽  
Mehmet Baki Şentürk ◽  
Selçuk Selçuk ◽  
...  
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Neutrophil Count ◽  
Ovarian Cyst ◽  
Blood Count ◽  
Complete Blood Count ◽  
Adnexal Mass ◽  
Ovarian Torsion ◽  
Adnexal Torsion ◽  
Neutrophil Lymphocyte Ratio

<p><strong>Objective:</strong> The aim of this study was to evaluate complete blood count parameters to predict ovarian torsion in cases presented with ovarian mass.</p><p><strong>Study Design:</strong> Pre-operative demographic data and complete blood count parameters of 72 patients, who were operated on preliminary adnexal torsion and diagnosed as adnexal torsion with a benign ovarian cyst (Study group) were retrospectively compared with those of 77 patients who were operated with an indication of persistent benign ovarian cysts without torsion (control group) at Zeynep Kamil Women and Children’s Health Training and Research Hospital and Department of Obstetrics &amp; Gynecology at Erciyes University Medical Faculty between 2011 and 2015. Complete blood count parameters were utilized to predict ovarian torsion cases.</p><p><strong>Result:</strong> Neutrophil (AUC=792, P=&lt;0.001), white blood cell (AUC=787, P=&lt;0.001) counts and neutrophil/lymphocyte ratio (AUC=770, P=&lt;0.001) were significant predictors for adnexal torsion. Optimal cut off value for white blood cell, neutrophil count and neutrophil/lymphocyte ratio were 8.3x103 (72% sensitivity, 73% specificity), 5.5x103 (73% sensitivity, 76% specificity), 2.9 (73% sensitivity, 79% specificity) respectively.</p><p><strong>Conclusion:</strong> Among all the parameters white blood cell count, neutrophil/lymphocyte and neutrophil count were the most powerful predictors for real adnexal torsion cases. Simple blood count parameters detailed evaluation may help clinicians to confirm or rule out adnexal torsion in cases presented with ovarian cyst and adnexal mass.</p>

scholarly journals Immunometabolic response in Egyptian water buffalo cows during the transition period

2021 ◽  
pp. 2678-2685
Author(s):  
Naglaa A. Gomaa ◽  
Samy A. Darwish ◽  
Mahmoud A. Aly
Keyword(s):  
Neutrophil Count ◽  
Water Buffalo ◽  
Transition Period ◽  
Complete Blood Count ◽  
Leukocyte Count ◽  
Density Lipoprotein ◽  
Physiological Adaptation ◽  
Total Leukocyte Count ◽  
Gamma Glutamyl Transferase ◽  
Glutamyl Transferase

Background and Aim: The transition period is extremely critical for pregnant producing animals. However, there is very limited research on the metabolic and immunological changes in Egyptian water buffalo cows during the transition period. Therefore, this study was conducted to investigate the immunometabolic changes occurring during the transition period in Egyptian water buffalo cows. Materials and Methods: A total of 50 multiparous pregnant Egyptian water buffalo cows were subjected to weekly blood sampling 3 weeks before calving and 3 weeks after calving and on the day of parturition to determine the complete blood count, including red blood cell count, total leukocyte count (TLC), differential leukocyte count, hemoglobin level, and packed cell volume (PCV). Some selected serum biochemical and immunological parameters were analyzed, including serum glucose, beta-hydroxybutyric acid (BHBA), non-esterified fatty acids, triglycerides, high-density lipoprotein, low-density lipoprotein (LDL), very LDL (VLDL), cholesterol, total protein, albumin, globulin, creatinine, blood urea nitrogen (BUN), aspartate aminotransferase, alkaline phosphatase, alanine transaminase, gamma-glutamyl transferase, Haptoglobin, and C-reactive protein and the pro-inflammatory cytokines interleukin β1, interleukin 6 (IL-6), and tumor necrosis factor-alpha. All data were statistically analyzed using the IBM Statistical Package for the Social Sciences statistics software. Results: The neutrophil count showed a statistically significant increase at 2 weeks preparturition. There was also a significant increase in PCV, TLC, neutrophil count, and IL-6 and TNF-α level at the time of parturition and even at 2 weeks post parturition, except PCV that returned to normal levels in the 1st week post parturition. BHBA and BUN levels were increased significantly in the 2nd and 3rd weeks postcalving. Serum creatinine and VLDL levels were decreased significantly at the time of parturition, and VLDL levels showed a significant decrease even till the 3rd week postcalving, whereas creatinine levels gradually returned to the pre-calving levels in the 3rd week postcalving. Other parameters showed no significant changes. Conclusion: The most important immunometabolic changes occur in the first 2 weeks post parturition in Egyptian water buffalo cows, which exhibit a potent, remarkable physiological adaptation achieved by their functional liver, which can help the animal overcome the stressful conditions during the transition period.

scholarly journals Agranulocytosis Associated with Topiramate: A Case Report and Review of Published Cases

2018 ◽  
Vol 2018 ◽  
pp. 1-3
Author(s):  
Saroj Lohani ◽  
Niranjan Tachamo ◽  
Salik Nazir ◽  
Anthony Donato
Keyword(s):  
Absolute Neutrophil Count ◽  
Neutrophil Count ◽  
Blood Count ◽  
Complete Blood Count ◽  
Case Reports ◽  
Shortness Of Breath ◽  
Data Synthesis ◽  
Rare Side Effect ◽  
Dose Dependent ◽  
Dose Dependent Effect

A 41-year-old female presented to the hospital with sore throat and shortness of breath. She was hypoxic with an oxygen saturation of 87% in room air. Physical examination revealed swollen uvula with exudates. She had been started on topiramate for treatment of migraine few months ago. The dose of topiramate was increased to 100 mg twice daily 2 weeks ago. Complete blood count revealed an absolute neutrophil count (ANC) of 8 c/mm3. She was intubated and started on broad-spectrum antibiotics. She was transferred to our hospital on the fifth day of hospitalization. On arrival, her absolute neutrophil count was 10 c/mm3. Her agranulocytosis was attributed to topiramate after ruling out other possible causes. ANC improved after topiramate was stopped. ANC increased to 1000 after 5 days of stopping topiramate. We also reviewed published cases of topiramate-associated agranulocytosis. Agranulocytosis is a rare side effect of topiramate, and only 3 case reports have been published so far. In all cases, agranulocytosis developed after months of topiramate therapy and when dose was increased to 200 mg daily suggesting a dose-dependent effect. Next steps would be further research on the pathogenesis of agranulocytosis associated with topiramate and creation of registry for data synthesis.

A simple screening method for the diagnosis of chronic myeloid leukemia using the parameters of a complete blood count and differentials

2019 ◽  
Vol 489 ◽  
pp. 249-253 ◽  
Author(s):  
Atsushi Ogasawara ◽  
Hiromichi Matsushita ◽  
Yumiko Tanaka ◽  
Yukari Shirasugi ◽  
Kiyoshi Ando ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Blood Count ◽  
Complete Blood Count ◽  
Screening Method ◽  
Simple Screening

scholarly journals Performance of Neutrophil-to-Lymphocyte Ratio (NLR) in Differentiating Vaso-Occlusive Crisis from Infection in Patients Presenting with Sickle Cell Crisis

Blood ◽  
2021 ◽  
Vol 138 (Supplement 1) ◽  
pp. 4187-4187
Author(s):  
Satish Maharaj ◽  
Simone M Chang ◽  
Ruobing Xue ◽  
Kamila I. Cisak ◽  
Vivek R. Sharma
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Blood Count ◽  
Complete Blood Count ◽  
Neutrophil To Lymphocyte Ratio ◽  
Cell Disease ◽  
Lymphocyte Ratio ◽  
Presenting Symptoms ◽  
Increased Risk ◽  
The Absolute

Abstract Background: Patients with sickle cell disease (SCD) are at increased risk of developing serious infections as a result of functional asplenia and altered humoral immunity. Nevertheless, presenting symptoms of sepsis such as fever and arthralgias are common in SCD and can occur with many sickle cell related conditions, including vaso-occlussive crises (VOC) and may not correlate with true infections. The neutrophil-to-lymphocyte ratio (NLR) is calculated as the absolute neutrophil count divided by the absolute lymphocyte count and represents an easily accessible value that has been found to correlate with inflammation and prognosis in several conditions. Few studies have evaluated NLR as a biomarker in sickle cell disease, and its utility in differentiating infection vs. VOC in patients presenting to the emergency room remains unknown. Method: We conducted a retrospective review of 143 patients with SCD who presented to the emergency department with fever and painful crises. The patients were divided into two categories based on discharge diagnoses - patients with VOC only (n=92) and patients with proven/possible infection (n=51). Inclusion criteria for both groups were patients with SCD, 17 years and older and complete blood count with differential on presentation; patients who had received antibiotics prior to presentation were excluded. Data collected on presentation included genotype, age, gender, complete blood count, hydroxyurea use. Data was analyzed between the two groups using descriptive statistics and receiver-operating characteristic (ROC) curve analysis. Results: Demographics and clinical characteristics are summarized in the Table. The sample included primarily young adult males with 61% on hydroxyurea. Genotype HbSS (73%) was most prevalent followed by HbSC (23%) and HbSβ (4%). The mean Hb was around 8 g/dL. The VOC group had a lower mean white blood cell (WBC) count of 13.6, compare to 17.2 for patients with proven/possible infection. ROC analysis showed that NLR did correlate with infection, with a modest AUC 0.7 [95% CI (0.59-0.77)] that was significant (p=0.0002) when compared to the AUC=0.5 model. Maximum specificity and sensitivity in this sample was achieved with NLR = 4.5 (Specificity 75% and Sensitivity 59%). Conclusion: In this sample, NLR on presentation significantly but only modestly correlated with infection as opposed to VOC. Optimal performance at NLR=4.5 achieved Specificity 75% and Sensitivity 59%. Despite modest performance, given the widespread availability and cost-effectiveness of NLR testing, further study in a larger sample may derive other variables that can combine with NLR to formulate a predictive model to improve care for these patients. Figure 1 Figure 1. Disclosures No relevant conflicts of interest to declare.

scholarly journals Markers for Increased Thrombotic Risk within the Complete Blood Count

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 1429-1429
Author(s):  
Sæmundur Rögnvaldsson ◽  
Sigrún H. Lund ◽  
Malin Hultcrantz ◽  
Signý Vala Sveinsdóttir ◽  
Guðný Eiríksdóttir ◽  
...  
Keyword(s):  
General Population ◽  
Venous Thrombosis ◽  
Arterial Thrombosis ◽  
Blood Count ◽  
Complete Blood Count ◽  
Low Grade ◽  
Thrombotic Risk ◽  
Elderly Individuals ◽  
Increased Risk ◽  
Dose Dependent

Abstract Introduction The complete blood count is one of the most frequently ordered patient blood test. It provides the most basic hematological measurements including hematocrit (Hct), white blood cell count (WBC), and platelet count (PLT). An increase in some of these markers have been shown to be associated an increased thrombotic risk. Most notablyHctfor patients with polycythemiaveraand WBC and PLT in cancer patients. Some population studies have shown an increased propensity of thrombosis among healthy individuals with elevatedHct. However these studies have not included sufficient clinical data to account for potential confounders. The aim of this study is to assess whether elevation of these hematological markers are risk factors for thrombosis in the general population. Methods Complete blood count and baseline characteristics were obtained from participants in the Reykjavik-AGES study at enrollment in 2002. The Reykjavik-AGES study, a nationwide screening study of 5755 elderly individuals, includes thorough medical history, physical examination, and blood measurements. Lifetime incidents of thrombotic events were recorded up to 2015 in the Icelandic National Health Service and cross-linked to the participants of the study through the National Registry of the total Population. Primary outcomes of arterial and venous thrombosis were considered separately 10 years before and after enrollment. Hct, WBC, and PLT were used to determine exposure and stratified into five quintiles in four respective analyses. The second quintile was used as a reference group. Cox proportional hazard regression was used to determine hazard ratios and confidence intervals. We then adjusted for age, gender, body mass index, diabetes mellitus, cigarette smoking (in pack years), hypertension and statin use. For arterial thrombosis we also adjusted for family history of arterial thrombosis and for venous thrombosis we censored at diagnosis of malignant neoplasm. In the analysis of WBC we also adjusted for C-reactive protein, an acute phase protein. Individuals with abnormal values of these parameters were excluded from the study (PLT < 150x109/L, WBC > 13x109/L or < 2.0,Hct < 35% were excluded) Results Crude analyses ofHctrevealed a dose dependent increased risk of arterial (hazard ratio (HR) 1.2, 95% confidence interval (CI) 1.08-1.33, p<0.001) and venous (HR 1.2, 95% CI 1.80-1.34, p=0.001) thrombosis with increasing values. However, after adjusting for confounders there was no association (Table). There was no association between higher levels of PLT and increased risk of thrombosis (Table). Analysis of WBC showed a dose dependent increase in risk for arterial thrombosis (HR 1.31, 95% CI 1.18-1.45, p<0.001) after adjusting for confounders. A similar but weaker effect was found for venous thrombosis (HR 1.16, 95% CI1.02-1.32, p=0.027). Conclusion In this large population-based prospective cohort study including detailed clinical information on 5755 elderly individuals, we observed no association of elevatedHctor PLT with risk of arterial or venous thrombosis after adjusting for confounders. However, we found a clear increase in the thrombotic risk associated with higher WBC, especially for arterial thrombosis. We speculate this may be due to a higher baseline of leukocyte activation and a low-grade inflammatory state. These factors have been shown to play a part in thrombotic pathways. We therefore conclude WBC to be a marker for thrombotic risk within the general population. Table Table. Disclosures No relevant conflicts of interest to declare.

Association of neutrophil count with overall survival in localized prostate cancer.

2015 ◽  
Vol 33 (7_suppl) ◽  
pp. 121-121
Author(s):  
Daniel Taussky ◽  
Houda Bahig ◽  
Guila Delouya ◽  
Paule Bodson-Clermont ◽  
Denis Soulieres
Keyword(s):  
Prostate Cancer ◽  
Overall Survival ◽  
Neutrophil Count ◽  
Biochemical Recurrence ◽  
Blood Count ◽  
Complete Blood Count ◽  
Univariate Analysis ◽  
Multivariate Model ◽  
Localized Prostate Cancer ◽  
Overall Mortality

121 Background: Systemic inflammation has been linked to worse outcome in metastatic prostate cancer. This study analyzes the influence of complete blood count (CBC) on outcome after curative radiotherapy for localized prostate cancer. Methods: We reviewed our institutional database of patients with localized prostate cancer treated with either definitive external beam radiotherapy (EBRT) or brachytherapy from September 2001- June 2014. Data on pre-treatment CBC such as hemoglobin (Hgb), mean corpuscular volume(MCV) and platelet count (PLT) were available in 1,021 pts, neutrophil/lymphocyte ratio (NLR) in 1,015 pts. Univariate and multivariate cox proportional hazards models were used to analyze the influence of complete blood count parameters on overall and recurrence free survival (PSA nadir + 2 ng/mL). A p<0.05 was considered statistically significant. Results: Median follow-up was 44 months. 55 patients had biochemical recurrence and 68 patients died.On univariate analysis, increasing risk of biochemical recurrence was associated with a combination of all known risk factors as defined by the Cancer of the Prostate Risk Assessment (CAPRA) score, but not by age. When adjusting for age (p=0.009), CAPRA remained significant (p=0.0003) but no comorbidity or CBC. On univariate analysis for overall survival, CAPRA (p=0.0001) and neutrophil count (p=0.04, HR1.16, 1.01-1.34) as well as a cardiac history (p=0.009) were associated with increased risk of overall mortality. The first multivariate model was adjusted for age and included the CAPRA, comorbidity and CBC variables: age (p=0.006) and CAPRA (p=0.008) were prognostic, neutrophil count was borderline significant (p=0.056, HR 1.17, 0.99-1.37). In a second multivariate model without adjusting for age, neutrophil count was a significant prognostic factor for overall survival (p=0.032, HR 1.18, 1.01-1.38) as well as the CAPRA (p=0.005, HR 1.18, 1.05-1.33). Conclusions: In this testing cohort, neutrophil count was an independent risk factor for increased overall mortality in patients with localized prostate cancer. The influence of age on this prognostic factor will be further studied. A validation cohort is needed to corroborate these results.

A combination of both testosterone and white blood count as predictive factors of overall survival in localized prostate cancer.

2017 ◽  
Vol 35 (6_suppl) ◽  
pp. 129-129
Author(s):  
Daniel Taussky ◽  
Denis Soulieres ◽  
Laurent Azoulay ◽  
Hui Yin ◽  
Houda Bahig ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Overall Survival ◽  
Biochemical Recurrence ◽  
Blood Count ◽  
Complete Blood Count ◽  
Large Population ◽  
Cox Proportional Hazards ◽  
Localized Prostate Cancer ◽  
White Blood Count ◽  
Increased Risk

129 Background: Low testosterone is generally associated with a higher overall mortality rate. We previously published that an increase in neutrophils is associated with lower overall survival in a large population of patients with localized prostate cancer. In this study, we tested a combination of both testosterone and neutrophils to predict for overall survival in a prospective cohort of patients treated with radiotherapy for localized prostate cancer. Methods: 414 patients from our institutional database were enrolled prospectively in phase 2 or 3 studies. To be included in this present analysis, patients had to have a baseline testosterone and complete blood count before enrollment in their respective study. Thirty-three patients were excluded for missing data for a total of 381 (92%) patients were included for analysis. Multivariate cox proportional hazards models were used to analyze the influence of white blood count (WBC = neutrophils + lymphocytes) and testosterone level on biochemical recurrence (Phoenix definition) and overall survival (OS). A cutoff level for testosterone of 10.4 nmol/l ( = 300ng/dL) was used as an indicator of hypogonadism and a WBC cutoff of 6.2 (109/L) representing the median value of this study population. Results were adjusted for cancer characteristics, comorbidities and androgen deprivation therapy. Results: Median age (range) was 71 (52-82) years. The median follow-up for biochemical recurrence and OS analysis were 72 and 78 months, respectively. WBC and testosterone were not predictive of biochemical recurrence, but CAPRA score 6-10 vs. ≤ 2 was (HR 5.39, 95% CI 1.19-24.45). WBC ≥ 6.2 alone was not associated with OS (HR 0.66, 95% CI 0.30-1.46), but when combined with a testosterone > 10.3 nmol/l, it was associated with a HR of 2.96 (95%CI 1.45-6.06) when compared to a WBC < 6.2, P-interaction = 0.01. Conclusions: A combination of high WBC and normal testosterone levels seem to be associated with increased mortality in patients with localized prostate cancer. Validation in larger samples is needed and could help to identify patients with increased risk of mortality within the first 6-7 years post treatment.

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