scholarly journals Lesion segmentation in breast ultrasound images using the optimized marked watershed method

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Xiaoyan Shen ◽  
He Ma ◽  
Ruibo Liu ◽  
Hong Li ◽  
Jiachuan He ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Rural Areas ◽  
Early Stage ◽  
Speckle Noise ◽  
Breast Ultrasound ◽  
Dice Similarity Coefficient ◽  
Ultrasound Images ◽  
Lesion Segmentation ◽  
Early Screening ◽  
Side Window

Abstract Background Breast cancer is one of the most serious diseases threatening women’s health. Early screening based on ultrasound can help to detect and treat tumours in the early stage. However, due to the lack of radiologists with professional skills, ultrasound-based breast cancer screening has not been widely used in rural areas. Computer-aided diagnosis (CAD) technology can effectively alleviate this problem. Since breast ultrasound (BUS) images have low resolution and speckle noise, lesion segmentation, which is an important step in CAD systems, is challenging. Results Two datasets were used for evaluation. Dataset A comprises 500 BUS images from local hospitals, while dataset B comprises 205 open-source BUS images. The experimental results show that the proposed method outperformed its related classic segmentation methods and the state-of-the-art deep learning model RDAU-NET. Its accuracy (Acc), Dice similarity coefficient (DSC) and Jaccard index (JI) reached 96.25%, 78.4% and 65.34% on dataset A, and its Acc, DSC and sensitivity reached 97.96%, 86.25% and 88.79% on dataset B, respectively. Conclusions We proposed an adaptive morphological snake based on marked watershed (AMSMW) algorithm for BUS image segmentation. It was proven to be robust, efficient and effective. In addition, it was found to be more sensitive to malignant lesions than benign lesions. Methods The proposed method consists of two steps. In the first step, contrast limited adaptive histogram equalization (CLAHE) and a side window filter (SWF) are used to preprocess BUS images. Lesion contours can be effectively highlighted, and the influence of noise can be eliminated to a great extent. In the second step, we propose adaptive morphological snake (AMS). It can adjust the working parameters adaptively according to the size of the lesion. Its segmentation results are combined with those of the morphological method. Then, we determine the marked area and obtain candidate contours with a marked watershed (MW). Finally, the best lesion contour is chosen by the maximum average radial derivative (ARD).

scholarly journals Lesion Segmentation in Breast Ultrasound Images using Optimized Marked Watershed Method

2021 ◽  
Author(s):  
Xiaoyan Shen ◽  
He Ma ◽  
Ruibo Liu ◽  
Hong Li ◽  
Jiachuan He ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Deep Learning ◽  
Early Stage ◽  
Speckle Noise ◽  
Histogram Equalization ◽  
Breast Ultrasound ◽  
Ultrasound Images ◽  
Lesion Segmentation ◽  
Early Screening ◽  
Side Window

Abstract Background: Breast cancer is one of the most serious diseases threatening women’s health. Early screening based on ultrasound can help to detect and treat tumors in early stage. However, due to the lack of radiologists with professional skills, ultrasound based breast cancer screening has not been widely used in rural area. Computer-aided diagnosis (CAD) technology can effectively alleviates this problem. Since Breast Ultrasound (BUS) images have low resolution and speckle noise, lesion segmentation, which is an important step in CAD system, is challenging.Results: Two datasets were used for evaluation. Dataset A comprises 500 BUS images from local hospitals, while dataset B comprises 205 BUS images from open source. The experimental results show that the proposed method outperformed its related classic segmentation methods and the state-of-the-art deep learning model, RDAU–NET. And its’ Accuracy(Acc), Dice efficient(DSC) and Jaccard Index(JI) reached 96.25%, 78.4% and 65.34% on dataset A, and ACC, DC and Sen reached 97.96%, 86.25% and 88.79% on dataset B.Conclusions: We proposed an adaptive morphology snake based on marked watershed(AMSMW) algorithm for BUS images segmentation. It was proven to be robust, efficient and effective. In addition, it was found to be more sensitive to malignant lesions than benign lesions. What’s more, since the Rectangular Region of Interest(RROI) in the proposed method is drawn manually, we will consider adding deep learning network to automatically identify RROI, and completely liberate the hands of radiologists.Methods: The proposed method consists of two main steps. In the first step, we used Contrast Limited Adaptive Histogram Equalization(CLAHE) and Side Window Filter(SWF) to preprocess BUS images. Therefore, lesion contours can be effectively highlighted and the influence of noise can be eliminated to a great extent. In the second step, we proposed adaptative morphology snake(AMS) as an embedded segmentation function of AMSMW. It can adjust working parameters adaptively, according to different lesions’ size. By combining segmentation results of AMS with marker region obtained by morphological method, we got the marker region of marked watershed (MW). Finally, we obtained candidate contours by MW. And the best lesion contour was chosen by maximum Average Radial Derivative(ARD).

scholarly journals Comparison of Three Segmentation Methods for Breast Ultrasound Images based on Level Set and Morphological Operations

2017 ◽  
Vol 7 (1) ◽  
pp. 383
Author(s):  
Dewi Putrie Lestari ◽  
Sarifuddin Madenda ◽  
Ernastuti Ernastuti ◽  
Eri Prasetyo Wibowo
Keyword(s):  
Breast Cancer ◽  
Level Set ◽  
Active Contour ◽  
Level Set Methods ◽  
Breast Ultrasound ◽  
Medical Image Segmentation ◽  
Image Processing Technique ◽  
Dice Similarity Coefficient ◽  
Ultrasound Images ◽  
Morphological Operations

Breast cancer is one of the major causes of death among women all over the world. The most frequently used diagnosis tool to detect breast cancer is ultrasound. However, to segment the breast ultrasound images is a difficult thing. Some studies show that the active contour models have been proved to be the most successful methods for medical image segmentation. The level set method is a class of curve evolution methods based on the geometric active contour model. Morphological operation describes a range of image processing technique that deal with the shape of features in an image. Morphological operations are applied to remove imperfections that introduced during segmentation. In this paper, we have evaluated three level set methods that combined with morphological operations to segment the breast lesions. The level set methods that used in our research are the Chan Vese (C-V) model, the Selective Binary and Gaussian Filtering Regularized Level Set (SBGFRLS) model and the Distance Regularized Level Set Evolution (DRLSE) model. Furthermore, to evaluate the method, we compared the segmented breast lesion that obtained by each method with the lesion that obtained manually by radiologists. The evaluation is done by four metrics: Dice Similarity Coefficient (DSC), True-Positive Ratio (TPR), True-Negative Ratio (TNR), and Accuracy (ACC). Our experimental results with 30 breast ultrasound images showed that the C-V model that combined with morphological operations have better performance than the other two methods according to mean value of DSC metrics.

scholarly journals BGM-Net: Boundary-Guided Multiscale Network for Breast Lesion Segmentation in Ultrasound

2021 ◽  
Vol 8 ◽  
Author(s):  
Yunzhu Wu ◽  
Ruoxin Zhang ◽  
Lei Zhu ◽  
Weiming Wang ◽  
Shengwen Wang ◽  
...  
Keyword(s):  
Breast Lesion ◽  
Speckle Noise ◽  
Breast Ultrasound ◽  
Ultrasound Images ◽  
Lesion Segmentation ◽  
Low Contrast ◽  
Feature Enhancement ◽  
Boundary Map ◽  
Weak Boundaries ◽  
Feature Pyramid

Automatic and accurate segmentation of breast lesion regions from ultrasonography is an essential step for ultrasound-guided diagnosis and treatment. However, developing a desirable segmentation method is very difficult due to strong imaging artifacts e.g., speckle noise, low contrast and intensity inhomogeneity, in breast ultrasound images. To solve this problem, this paper proposes a novel boundary-guided multiscale network (BGM-Net) to boost the performance of breast lesion segmentation from ultrasound images based on the feature pyramid network (FPN). First, we develop a boundary-guided feature enhancement (BGFE) module to enhance the feature map for each FPN layer by learning a boundary map of breast lesion regions. The BGFE module improves the boundary detection capability of the FPN framework so that weak boundaries in ambiguous regions can be correctly identified. Second, we design a multiscale scheme to leverage the information from different image scales in order to tackle ultrasound artifacts. Specifically, we downsample each testing image into a coarse counterpart, and both the testing image and its coarse counterpart are input into BGM-Net to predict a fine and a coarse segmentation maps, respectively. The segmentation result is then produced by fusing the fine and the coarse segmentation maps so that breast lesion regions are accurately segmented from ultrasound images and false detections are effectively removed attributing to boundary feature enhancement and multiscale image information. We validate the performance of the proposed approach on two challenging breast ultrasound datasets, and experimental results demonstrate that our approach outperforms state-of-the-art methods.

scholarly journals Perbandingan Teknik Reduksi Derau Speckle Pada Citra Ultrasonograpi Payudara

2018 ◽  
Vol 4 (2) ◽  
pp. 27-36
Author(s):  
Yuli Triyani
Keyword(s):  
Breast Cancer ◽  
Ultrasound Image ◽  
Speckle Noise ◽  
Breast Ultrasound ◽  
Ultrasound Images ◽  
Reduction Techniques ◽  
Noise Filter ◽  
Incidence And Mortality ◽  
Structural Content ◽  
Aided Diagnosis

Breast cancer is the most commonly diagnosed cancer with the highest prevalence, incidence, and mortality rate for females in Indonesia and worldwide. Ultrasonography is a recommended modality for breast cancer, because it is comfortable, radiation free and it can be widely used. However, ultrasound images often occur in quality degradation caused by speckle noise that appears during image acquisition. It causes difficulty for radiologists or Computer Aided Diagnosis (CAD) systems to diagnose these images. Some techniques are proposed for reducing the speckle noise. This journal aims to compare the performance of 14 noise reduction techniques in breast ultrasound images. Quantitative testing was carried out on 58 breast ultrasound images and 3 artificial breast ultrasound image. The quantitative parameters are used include texture analysis (Mean, Variant, skewness, kurtosis, contrast and entropy) and evaluation of image quality (MSE, RMSE, SNR, SSIM, Structural content and Maximum Difference). The qualitative testing was also carried out with the assessment of 3 radiology specialists on 3 samples of each reduction technique. Based on test results, the 3 best performance filters are DsFsrad, DsFamedian dan DsFhmedian. Keywords: Ultrasound, speckle noise, filter

scholarly journals Lesion Segmentation in Breast Ultrasound Images using Optimized Marked Watershed Method

2020 ◽  
Author(s):  
Xiaoyan Shen ◽  
He Ma ◽  
Ruibo Liu ◽  
Hong Li ◽  
Jiachuan He ◽  
...  
Keyword(s):  
Malignant Tumors ◽  
Classical Method ◽  
Ultrasound Image ◽  
Breast Ultrasound ◽  
Experimental Result ◽  
Benign Tumors ◽  
Ultrasound Images ◽  
Lesion Segmentation ◽  
Obvious Effect ◽  
Side Window

Abstract Background: Ultrasound is the most popular tool for early detection of breast cancer because of its non radiation and low cost. However, breast ultrasound(BUS) images have low resolution and speckle noise, which make lesion segmentation become a challenge. Most of deep learning(DL) models applied on images segmentation don't have good generalization ability for BUS images. Therefore, it is time to go back to the classical method and consider combining it with DL to achieve more accurate and efficient effect in a semi-automatic way.Methods: This paper mainly proposed an effective and efficient semi-automatic BUS images segmentation method, Adaptive morphological snake and marked watershed( AMSMW). It includes two parts: preprocessing and segmentation. In the first part, we combine contrast limited adaptive histogram equalization(CLAHE) and side window filtering(SWF) methods for the first time. In the second part, We use the proposed adaptive morphological snake algorithm (AMS) to provide a mark for marked watershed(MW) method. Results: we tested on 500 BUS images, whose ratio of benign and malignant is 1:1. After quantitative and qualitative analysis, AMSMW is proven to outperform existing classical methods on the effectiveness and efficiency. Furthermore, we compared with Zhuang’s RDAU-NET on both our dataset and theirs. Experimental result showes AMSMW achieved better performance on most of indicators, including loss, accuracy, sensitivity, dice and F1-score. Conlusions: The new image preprocessing method proposed by us has obvious effect on segmentation of breast ultrasound image. In addition, the proposed adaptive morphology snake method and optimized marked watershed turn out to be more efficient and effective than some relative classical method and the advanced DL method at present. Moreover, by studying on the algorithm’s sensitivity in segmenting benign and malignant tumors, we found that AMSMW is more sensitivity to malignant tumors, and more stable to benign tumors, which is significant for further research of precision medicine.

Use of breast-conserving surgery for treatment of stage I and stage II breast cancer.

1998 ◽  
Vol 16 (1) ◽  
pp. 101-106 ◽  
Author(s):  
E Guadagnoli ◽  
J C Weeks ◽  
C L Shapiro ◽  
J H Gurwitz ◽  
C Borbas ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cohort Study ◽  
Surgical Treatment ◽  
Rural Areas ◽  
Medical Records ◽  
Retrospective Cohort ◽  
Early Stage ◽  
Breast Conserving Surgery ◽  
Teaching Hospitals ◽  
Type Of Surgery

PURPOSE To assess the use of breast-conserving surgery in two states reported to differ with respect to surgical treatment of breast cancer. METHODS A retrospective cohort study based on data collected from medical records and patients was performed among 1,514 patients diagnosed with early-stage breast cancer in Massachusetts and 1,061 patients in Minnesota. Patients were identified at 18 randomly selected hospitals in Massachusetts and at 30 hospitals in Minnesota. The rate of breast-conserving surgery in both states and the correlates of breast-conserving surgery among women eligible for the procedure were determined. RESULTS The rate of breast-conserving surgery in both states was much higher than previously reported. Among those eligible for the procedure, nearly 75% underwent breast-conserving surgery in Massachusetts and nearly half did so in Minnesota. Significantly (P < .003) more women who underwent mastectomy in Minnesota (27%) than in Massachusetts (15%) reported that their surgeon did not discuss breast-conserving surgery with them. Among women who underwent mastectomy and who reported being informed of both surgical alternatives, more women (P < .001) in Minnesota (74%) than in Massachusetts (62%) said they ultimately chose mastectomy because their surgeon recommended it. In Massachusetts, women treated at teaching hospitals were twice as likely as other women to undergo breast-conserving surgery. In Minnesota, women over age 70 and those who lived in rural areas were less likely than other women to undergo breast-conserving surgery. CONCLUSION Although the rate of breast-conserving surgery in each state was higher than expected based on earlier reports, the rates differed considerably between states. Additional studies are needed to determine whether variation in practice between geographic areas is due to differences in patients' preferences and values or to surgeons' propensity for one type of surgery based on where they practice.

scholarly journals A Fast, Fully Automated Prostate Boundary Segmentation Using Probabilistic Approaches In Ultrasound Images

2021 ◽  
Author(s):  
Rasa Vafaie
Keyword(s):  
Em Algorithm ◽  
Signal To Noise Ratio ◽  
Transrectal Ultrasound ◽  
Speckle Noise ◽  
Computational Time ◽  
Dice Similarity Coefficient ◽  
Ultrasound Images ◽  
Segmentation Method ◽  
Initial Model ◽  
Hybrid Segmentation

Segmentation of prostate boundaries in transrectal ultrasound (TRUS) images plays a great role in prostate cancer diagnosis. Due to the low signal to noise ratio and existence of the speckle noise in TRUS images, prostate image segmentation has proven to be an extremely difficult task. In this thesis report, a fast fully automated hybrid segmentation method based on probabilistic approaches is presented. First, the position of the initial model is automatically estimated using prostate boundary representative patterns. Next, the Expectation Maximization (EM) algorithm and Markov Random Field (MRF) theory are utilized in the deformation strategy to optimally fit the initial model on the prostate boundaries. A less computationally EM algorithm and a new surface smoothing technique are proposed to decrease the segmentation time. Successful experimental results with the average Dice Similarity Coefficient (DSC) value 93.9±2.7% and computational time around 9 seconds validate the algorithm.

scholarly journals M2 FILTER FOR SPECKLE NOISE SUPPRESSION IN BREAST ULTRASOUND IMAGES

2015 ◽  
Vol 06 (02) ◽  
pp. 1137-1144 ◽  
Author(s):  
Samundeeswari E.S. ◽  
◽  
Saranya P.K. ◽  
Manavalan R. ◽  
◽  
...  
Keyword(s):  
Noise Suppression ◽  
Speckle Noise ◽  
Breast Ultrasound ◽  
Ultrasound Images

scholarly journals Evaluating the Accuracy of Breast Cancer and Molecular Subtype Diagnosis by Ultrasound Image Deep Learning Model

2021 ◽  
Vol 11 ◽  
Author(s):  
Xianyu Zhang ◽  
Hui Li ◽  
Chaoyun Wang ◽  
Wen Cheng ◽  
Yuntao Zhu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Deep Learning ◽  
Sensitivity And Specificity ◽  
Molecular Subtypes ◽  
Learning Model ◽  
Breast Ultrasound ◽  
Ultrasound Images ◽  
Test Set ◽  
External Test ◽  
Deep Learning Model

Background: Breast ultrasound is the first choice for breast tumor diagnosis in China, but the Breast Imaging Reporting and Data System (BI-RADS) categorization routinely used in the clinic often leads to unnecessary biopsy. Radiologists have no ability to predict molecular subtypes with important pathological information that can guide clinical treatment.Materials and Methods: This retrospective study collected breast ultrasound images from two hospitals and formed training, test and external test sets after strict selection, which included 2,822, 707, and 210 ultrasound images, respectively. An optimized deep learning model (DLM) was constructed with the training set, and the performance was verified in both the test set and the external test set. Diagnostic results were compared with the BI-RADS categorization determined by radiologists. We divided breast cancer into different molecular subtypes according to hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) expression. The ability to predict molecular subtypes using the DLM was confirmed in the test set.Results: In the test set, with pathological results as the gold standard, the accuracy, sensitivity and specificity were 85.6, 98.7, and 63.1%, respectively, according to the BI-RADS categorization. The same set achieved an accuracy, sensitivity, and specificity of 89.7, 91.3, and 86.9%, respectively, when using the DLM. For the test set, the area under the curve (AUC) was 0.96. For the external test set, the AUC was 0.90. The diagnostic accuracy was 92.86% with the DLM in BI-RADS 4a patients. Approximately 70.76% of the cases were judged as benign tumors. Unnecessary biopsy was theoretically reduced by 67.86%. However, the false negative rate was 10.4%. A good prediction effect was shown for the molecular subtypes of breast cancer with the DLM. The AUC were 0.864, 0.811, and 0.837 for the triple-negative subtype, HER2 (+) subtype and HR (+) subtype predictions, respectively.Conclusion: This study showed that the DLM was highly accurate in recognizing breast tumors from ultrasound images. Thus, the DLM can greatly reduce the incidence of unnecessary biopsy, especially for patients with BI-RADS 4a. In addition, the predictive ability of this model for molecular subtypes was satisfactory,which has specific clinical application value.

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