scholarly journals Recent developments in mesoporous polydopamine-derived nanoplatforms for cancer theranostics

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Menglu Zhu ◽  
Yi Shi ◽  
Yifan Shan ◽  
Junyan Guo ◽  
Xuelong Song ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Low Cost ◽  
Drug Loading ◽  
Delivery Systems ◽  
High Specific Surface Area ◽  
Preparation Methods ◽  
Nanodrug Delivery ◽  
Recent Developments ◽  
Marine Mussels ◽  
Cancer Theranostics

AbstractPolydopamine (PDA), which is derived from marine mussels, has excellent potential in early diagnosis of diseases and targeted drug delivery owing to its good biocompatibility, biodegradability, and photothermal conversion. However, when used as a solid nanoparticle, the application of traditional PDA is restricted because of the low drug-loading and encapsulation efficiencies of hydrophobic drugs. Nevertheless, the emergence of mesoporous materials broaden our horizon. Mesoporous polydopamine (MPDA) has the characteristics of a porous structure, simple preparation process, low cost, high specific surface area, high light-to-heat conversion efficiency, and excellent biocompatibility, and therefore has gained considerable interest. This review provides an overview of the preparation methods and the latest applications of MPDA-based nanodrug delivery systems (chemotherapy combined with radiotherapy, photothermal therapy combined with chemotherapy, photothermal therapy combined with immunotherapy, photothermal therapy combined with photodynamic/chemodynamic therapy, and cancer theranostics). This review is expected to shed light on the multi-strategy antitumor therapy applications of MPDA-based nanodrug delivery systems. Graphical Abstract

scholarly journals Diatoms Green Nanotechnology for Biosilica-Based Drug Delivery Systems

2018 ◽  
Author(s):  
Monica Terracciano ◽  
Luca De Stefano ◽  
Ilaria Rea
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Low Cost ◽  
Release Kinetics ◽  
Drug Carrier ◽  
Drug Loading ◽  
Porous Silica ◽  
Delivery Systems ◽  
High Specific Surface Area ◽  
Artificial Environment

Diatom microalgae are the most outstanding natural source of porous silica. Diatom cell is enclosed in 3-D ordered nanopatterned silica cell wall, called frustule. The unique properties of diatoms frustule, including high specific surface area, thermal stability, biocompatibility, tailorable surface chemistry, make them really promising for biomedical applications. Moreover, diatoms are easy to cultivate in artificial environment and there is a huge availability of diatom frustules as fossil material (diatomite) in several areas of the world. For all these reasons, diatoms are an intriguing alternative to synthetic materials for the development of low-cost drug delivery systems. This review article focuses on the possible use of diatoms derived silica as drug carrier systems. The functionalization strategies of diatom micro-/nanoparticles for improving their biophysical properties, such as cellular internalization and drug loading/release kinetics, are described. In addition, the realization of hybrid diatom-based devices with advanced properties for theranostics and targeted or augmented drug delivery applications, are also discussed.

scholarly journals Diatoms Green Nanotechnology for Biosilica-Based Drug Delivery Systems

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 242 ◽  
Author(s):  
Monica Terracciano ◽  
Luca De Stefano ◽  
Ilaria Rea
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Low Cost ◽  
Release Kinetics ◽  
Drug Carrier ◽  
Drug Loading ◽  
Three Dimensional ◽  
Delivery Systems ◽  
Diatom Frustule ◽  
Artificial Environment

Diatom microalgae are the most outstanding natural source of porous silica. The diatom cell is enclosed in a three-dimensional (3-D) ordered nanopatterned silica cell wall, called frustule. The unique properties of the diatom frustule, including high specific surface area, thermal stability, biocompatibility, and tailorable surface chemistry, make diatoms really promising for biomedical applications. Moreover, they are easy to cultivate in an artificial environment and there is a large availability of diatom frustules as fossil material (diatomite) in several areas of the world. For all these reasons, diatoms are an intriguing alternative to synthetic materials for the development of low-cost drug delivery systems. This review article focuses on the possible use of diatom-derived silica as drug carrier systems. The functionalization strategies of diatom micro/nanoparticles for improving their biophysical properties, such as cellular internalization and drug loading/release kinetics, are described. In addition, the realization of hybrid diatom-based devices with advanced properties for theranostics and targeted or augmented drug delivery applications is also discussed.

scholarly journals Gold Nanorods for Light-Based Lung Cancer Theranostics

2018 ◽  
Vol 19 (11) ◽  
pp. 3318 ◽  
Author(s):  
Oscar Knights ◽  
James McLaughlan
Keyword(s):  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Continuous Wave ◽  
Low Cost ◽  
Laser System ◽  
Controlled Synthesis ◽  
Surface Plasmon Resonances ◽  
Plasmon Resonances ◽  
Theranostic Applications ◽  
Cancer Theranostics

Gold nanorods (AuNRs) have the potential to be used in photoacoustic (PA) imaging and plasmonic photothermal therapy (PPTT) due to their unique optical properties, biocompatibility, controlled synthesis, and tuneable surface plasmon resonances (SPRs). Conventionally, continuous-wave (CW) lasers are used in PPTT partly due to their small size and low cost. However, if pulsed-wave (PW) lasers could be used to destroy tissue then combined theranostic applications, such as PA-guided PPTT, would be possible using the same laser system and AuNRs. In this study, we present the effects of AuNR size on PA response, PW-PPTT efficacy, and PA imaging in a tissue-mimicking phantom, as a necessary step in the development of AuNRs towards clinical use. At equivalent NP/mL, the PA signal intensity scaled with AuNR size, indicating that overall mass has an effect on PA response, and reinforcing the importance of efficient tumour targeting. Under PW illumination, all AuNRs showed toxicity at a laser fluence below the maximum permissible exposure to skin, with a maximum of 80% cell-death exhibited by the smallest AuNRs, strengthening the feasibility of PW-PPTT. The theranostic potential of PW lasers combined with AuNRs has been demonstrated for application in the lung.

Recent Advances on Cellulose-Based Nano-Drug Delivery Systems: Design of Prodrugs and Nanoparticles

2019 ◽  
Vol 26 (14) ◽  
pp. 2410-2429 ◽  
Author(s):  
Lin Dai ◽  
Chuanling Si
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Low Cost ◽  
Drug Loading ◽  
Scale Up ◽  
Physicochemical Characterization ◽  
Systems Design ◽  
Delivery Systems ◽  
Recent Advances ◽  
Nano Drug Delivery

Background:Cellulose being the first abundant biopolymers in nature has many fascinating properties, including low-cost, good biodegradability, and excellent biocompatibility, which made cellulose a real potential material to create nano-drug delivery systems (nano-DDS). This review aims to present and discuss some remarkable recent advances on the drug delivery applications of cellulosebased prodrugs and nanoparticles.Methods:By searching the research literatures over last decade, a variety featured studies on cellulosebased nano-DDS were summarized and divided into prodrugs, prodrug nanoparticles, solid or derivative nanopartilces, amphiphilic copolymer nanoparticles, and polyelectrolyte complex nanoparticles. Various methods employed for the functionalization, pharmacodynamic actions and applications were described and discussed.Results:Many types of cellulose-based nano-DDS can ensure efficient encapsulation of various drugs and then overcome the free drug molecule shortcomings. Among all the method described, cellulosebased amphiphilic nanoparticles are most frequently used. These formulations have the higher drug loading capability, a simple and flexible way to achieve multi-functional. Apart from hydrophilic or hydrophobic modification, cellulose or its derivatives can form nanoparticles with different small molecules and macromolecules, leading to a large spectrum of cellulose-based nano-DDS and providing some unexpected advantages.Conclusion:Thorough physicochemical characterization and profound understanding of interactions of the cellulose-based nano-DDS with cells and tissues is indispensable. Moreover, studies toward technics parameter optimization and scale up from the laboratory to production level should be undertaken. The development of intravenous and orally applicable cellulose-based nano-DDS will be an important research area, and these systems will have more commercial status in the market.

Study on the Preparation Technology and Regeneration Technology of Activated Carbon

2019 ◽  
Vol 807 ◽  
pp. 159-164
Author(s):  
Yuan Ze Ma ◽  
Xiu Xia Zhang ◽  
Rong Fan
Keyword(s):  
Activated Carbon ◽  
Raw Materials ◽  
Low Cost ◽  
Chemical Properties ◽  
High Specific Surface Area ◽  
Green Economy ◽  
Utilization Rate ◽  
Preparation Methods ◽  
Advantages And Disadvantages ◽  
Physical And Chemical

Due to the developed pore structure ,high specific surface area, low cost, accessible raw materials and stable physical and chemical properties, activated carbon has caused high attention of society. Nowadays activated carbon has been widely used in capacitor electrode production, water pollution treatment, medicine and other fields. We review the various preparation methods of activated carbon and analyze the advantages and disadvantages of them in this paper. The characteristics of activated carbon regeneration technology are also discussed from the perspective of improving the utilization rate of activated carbon. With the development of China's green economy and the increasing awareness of people's environmental protection, the research on the preparation and regeneration of activated carbon will surely have a broader development prospect.

scholarly journals Protein nanoparticles directed cancer imaging and therapy

2022 ◽  
Vol 9 (1) ◽  
Author(s):  
Yao Miao ◽  
Tao Yang ◽  
Shuxu Yang ◽  
Mingying Yang ◽  
Chuanbin Mao
Keyword(s):  
Cancer Imaging ◽  
Drug Loading ◽  
Inorganic Nanoparticles ◽  
Surface Groups ◽  
Preparation Methods ◽  
Albumin Nanoparticles ◽  
Protein Nanoparticles ◽  
The Common ◽  
Cancer Theranostics ◽  
Representative Protein

AbstractCancer has been a serious threat to human health. Among drug delivery carriers, protein nanoparticles are unique because of their mild and environmentally friendly preparation methods. They also inherit desired characteristics from natural proteins, such as biocompatibility and biodegradability. Therefore, they have solved some problems inherent to inorganic nanocarriers such as poor biocompatibility. Also, the surface groups and cavity of protein nanoparticles allow for easy surface modification and drug loading. Besides, protein nanoparticles can be combined with inorganic nanoparticles or contrast agents to form multifunctional theranostic platforms. This review introduces representative protein nanoparticles applicable in cancer theranostics, including virus-like particles, albumin nanoparticles, silk protein nanoparticles, and ferritin nanoparticles. It also describes the common methods for preparing them. It then critically analyzes the use of a variety of protein nanoparticles in improved cancer imaging and therapy.

Recent Developments on Noble Metal Based Microparticles for Their Applications in Organic Catalysis

2020 ◽  
Vol 24 (8) ◽  
pp. 855-869
Author(s):  
Jian-Long Liu ◽  
Bo Jiang ◽  
Guo-Zhi Han
Keyword(s):  
Noble Metal ◽  
Noble Metals ◽  
High Selectivity ◽  
Low Cost ◽  
Organic Chemical ◽  
Preparation Methods ◽  
Practical Applications ◽  
Organic Catalysis ◽  
Recent Developments ◽  
Catalytic Applications

Noble metal microparticles have been employed as desired catalysts for a number of classical organic chemical reactions due to their unique physicochemical properties. Currently, in order to obtain more benefits for practical applications such as low cost, easy separation and high selectivity, many efforts of scientists are devoted to constructing composite microparticles in which noble metals are coupled with other materials. In this paper, we summarize some recent research developments on noble metal based microparticles for their catalytic applications in organic synthesis. Among them, application of the gold and silver based microparticles is the focus of this paper for their relatively low cost and the diversity of preparation methods. Furthermore, the challenges and prospects of noble metal based microparticles for their applications in organic catalysis are also discussed.

scholarly journals Using Supercritical Fluid Technology as a Green Alternative During the Preparation of Drug Delivery Systems

Pharmaceutics ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 629 ◽  
Author(s):  
Paroma Chakravarty ◽  
Amin Famili ◽  
Karthik Nagapudi ◽  
Mohammad A. Al-Sayah
Keyword(s):  
Drug Delivery ◽  
Supercritical Fluid ◽  
Drug Delivery Systems ◽  
Drug Carrier ◽  
Drug Loading ◽  
Size Control ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Preparation Methods ◽  
Residual Solvent

Micro- and nano-carrier formulations have been developed as drug delivery systems for active pharmaceutical ingredients (APIs) that suffer from poor physico-chemical, pharmacokinetic, and pharmacodynamic properties. Encapsulating the APIs in such systems can help improve their stability by protecting them from harsh conditions such as light, oxygen, temperature, pH, enzymes, and others. Consequently, the API’s dissolution rate and bioavailability are tremendously improved. Conventional techniques used in the production of these drug carrier formulations have several drawbacks, including thermal and chemical stability of the APIs, excessive use of organic solvents, high residual solvent levels, difficult particle size control and distributions, drug loading-related challenges, and time and energy consumption. This review illustrates how supercritical fluid (SCF) technologies can be superior in controlling the morphology of API particles and in the production of drug carriers due to SCF’s non-toxic, inert, economical, and environmentally friendly properties. The SCF’s advantages, benefits, and various preparation methods are discussed. Drug carrier formulations discussed in this review include microparticles, nanoparticles, polymeric membranes, aerogels, microporous foams, solid lipid nanoparticles, and liposomes.

An Overview of Second Generation Nanoparticles− Nanostructure Lipid Carrier Drug Delivery System

2020 ◽  
Vol 13 (6) ◽  
pp. 5181-5189
Author(s):  
Prabhat Kumar Sahoo ◽  
Neha S.L ◽  
Arzoo Pannu
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Second Generation ◽  
Drug Loading ◽  
Scale Up ◽  
Delivery Systems ◽  
Route Of Administration ◽  
Random Structure ◽  
Stability Parameters

Lipids are used as vehicles for the preparation of various formulations prescribed for administrations, including emulsions, ointments, suspension, tablets, and suppositories. The first parental nano-emulsion was discovered from the 1950s when it was added to the intravenous administration of lipid and lipid-soluble substances. Lipid-based drug delivery systems are important nowadays. Solid nanoparticles (SLN) and Nanostructured lipid carriers (NLC) are very proficient due to the ease of production process, scale-up capability, bio-compatibility, the biodegradability of formulation components and other specific features of the proposed route. The administration or nature of the materials must be loaded into these delivery systems. The main objectives of this review are to discuss an overview of second-generation nanoparticles, their limitations, structures, and route of administration, with emphasis on the effectiveness of such formulations. NLC is the second generation of lipid nanoparticles having a structure like nanoemulsion. The first generation of nanoparticles was SLN. The difference between both of them is at its core. Both of them are a colloidal carrier in submicron size in the range of 40-1000 nm. NLC is the most promising novel drug delivery system over the SLN due to solving the problem of drug loading and drug crystallinity. Solid and liquid lipids combination in NLC formation, improve its quality as compare to SLN. NLC has three types of structures: random, amorphous, and multiple. The random structure containing solid-liquid lipids and consisting crystal and the liquid lipid irregular in shape; thereby enhance the ability of the lipid layer to pass through the membrane. The second is the amorphous structure. It is less crystalline in nature and can prevent the leakage of the loaded drug. The third type is multiple structures, which have higher liquid lipid concentrations than other types. The excipients used to form the NLC are bio-compatible, biodegradable and non-irritating, most of which can be detected using GRAS. NLC is a promising delivery system to deliver the drug through pulmonary, ocular, CNS, and oral route of administration. Various methods of preparation and composition of NLC influence its stability Parameters. In recent years at the educational level, the potential of NLC as a delivery mechanism targeting various organs has been investigated in detail.

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