Physical exercise and goal attainment after shunt surgery in idiopathic normal pressure hydrocephalus: a randomised clinical trial

Abstract Background Rehabilitation in iNPH is suggested to be an important factor to improve patients’ functions but there are lack of clinical trials evaluating the effect of rehabilitation interventions after shunt surgery in iNPH. The objective of this study was to evaluate the effect of a physical exercise programme and goal attainment for patients with idiopathic normal pressure hydrocephalus (iNPH) after surgery compared to a control group. Methods This was a dual centre randomised controlled trial with assessor blinding, intention-to-treat (ITT) and per protocol (PP) analysis. Individuals diagnosed with iNPH scheduled to undergo shunt surgery at the Linköping University Hospital in Linköping and Sahlgrenska University Hospital in Gothenburg, Sweden were consecutively eligible for inclusion. Inclusion was conducted between January 2016 and June 2018. The patients were randomised 1:1 using sequentially numbered sealed envelopes to receive either written exercise information (control group) or written information and an additional supervised high-intensity, functional exercise programme (HIFE) executed twice weekly over 12 weeks (exercise group). Preoperatively, the patients set individual goals. The primary outcome was change from baseline in the total iNPH scale score at the post-intervention follow-up. Secondary outcomes were goal attainment, and change in the separate scores of gait, balance, neuropsychology and continence and in the total score after 6 months. Results In total, 127 participants were randomised to the exercise group (n = 62) and to the control group (n = 65). In the ITT population (exercise group, n = 50; control group, n = 59), there were no between-group differences in the primary outcome, but the attrition rate in the exercise group was high. The exercise group improved more than the control group in the balance domain scores after 6 months. Post-intervention, the PP exercise population achieved their set goals to a greater extent than the controls. Conclusions An additional effect of the 12-week HIFE-programme on the overall improvement according to the iNPH-scale after shunt surgery in iNPH was not shown. This could be due to high attrition rate. However, the long-term effect on balance and higher goal achievement indicate beneficial influences of supervised physical exercise. Trial registration clinicaltrials.gov, NCT02659111. Registered 20 January 2016, https://clinicaltrials.gov/ct2/show/NCT02659111

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Physical activity during pregnancy and its influence on delivery time: a randomized clinical trial

PeerJ ◽

10.7717/peerj.6370 ◽

2019 ◽

Vol 7 ◽

pp. e6370 ◽

Cited By ~ 1

Author(s):

Raquel Rodríguez-Blanque ◽

Juan Carlos Sánchez-García ◽

Antonio Manuel Sánchez-López ◽

María José Aguilar-Cordero

Keyword(s):

Physical Exercise ◽

Pregnant Women ◽

Intervention Program ◽

Total Duration ◽

Perinatal Outcomes ◽

Exercise Group ◽

University Hospital ◽

Control Group ◽

Beneficial Effects ◽

The Difference

Introduction During pregnancy, women often change their lifestyle for fear of harmful effects on the child or themselves. In this respect, many women reduce the amount of physical exercise they take, despite its beneficial effects. Objective To determine the duration of labor in pregnant women who completed a program of moderate physical exercise in water and subsequently presented eutocic birth. Methods A randomized trial was performed with 140 healthy pregnant women, divided into an exercise group (EG) (n = 70) and a control group (CG) (n = 70). The women who composed the study population were recruited at 12 weeks of gestation. The intervention program, termed SWEP (Study of Water Exercise during Pregnancy) began in week 20 of gestation and ended in week 37. Perinatal outcomes were determined by examining the corresponding partographs, recorded by the Maternity Service at the Granada University Hospital Complex. Results The intervention phase of the study took place from June through October 2016, with the 120 women finally included in EG and CG (60 in each group). At term, 63% of the women in EG and 56% of those in CG had a eutocic birth. The average total duration of labor was 389.33 ± 216.18 min for the women in EG and 561.30 ± 199.94 min for those in CG, a difference of approximately three hours (p < 0.001). Conclusions The women who exercised in water during their pregnancy presented a shorter duration of labor than those who did not. The difference was especially marked with respect to the duration of the first and second stages of labor.

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Physical exercise accelerates reentrainment of human sleep-wake cycle but not of plasma melatonin rhythm to 8-h phase-advanced sleep schedule

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.00345.2009 ◽

2010 ◽

Vol 298 (3) ◽

pp. R681-R691 ◽

Cited By ~ 48

Author(s):

Yujiro Yamanaka ◽

Satoko Hashimoto ◽

Yusuke Tanahashi ◽

Shin-ya Nishide ◽

Sato Honma ◽

...

Keyword(s):

Circadian Rhythms ◽

Physical Exercise ◽

Sleep Onset ◽

Exercise Group ◽

Control Group ◽

Temporal Isolation ◽

Melatonin Rhythm ◽

Plasma Melatonin ◽

Shift Schedule ◽

Sleep Schedule

Effects of timed physical exercise were examined on the reentrainment of sleep-wake cycle and circadian rhythms to an 8-h phase-advanced sleep schedule. Seventeen male adults spent 12 days in a temporal isolation facility with dim light conditions (<10 lux). The sleep schedule was phase-advanced by 8 h from their habitual sleep times for 4 days, which was followed by a free-run session for 6 days, during which the subjects were deprived of time cues. During the shift schedule, the exercise group ( n = 9) performed physical exercise with a bicycle ergometer in the early and middle waking period for 2 h each. The control group ( n = 8) sat on a chair at those times. Their sleep-wake cycles were monitored every day by polysomnography and/or weight sensor equipped with a bed. The circadian rhythm in plasma melatonin was measured on the baseline day before phase shift: on the 4th day of shift schedule and the 5th day of free-run. As a result, the sleep-onset on the first day of free-run in the exercise group was significantly phase-advanced from that in the control and from the baseline. On the other hand, the circadian melatonin rhythm was significantly phase-delayed in the both groups, showing internal desynchronization of the circadian rhythms. The sleep-wake cycle resynchronized to the melatonin rhythm by either phase-advance or phase-delay shifts in the free-run session. These findings indicate that the reentrainment of the sleep-wake cycle to a phase-advanced schedule occurs independent of the circadian pacemaker and is accelerated by timed physical exercise.

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PHYSICAL EXERCISE ON THE RECOVERY OF OBESITY MYOCARDIAL INFARCTION

Revista Brasileira de Medicina do Esporte ◽

10.1590/1517-8692202127082021_0368 ◽

2021 ◽

Vol 27 (8) ◽

pp. 783-785

Author(s):

Mian Wang ◽

Fan Wu

Keyword(s):

Quality Of Life ◽

Myocardial Infarction ◽

Physical Exercise ◽

Nursing Intervention ◽

Exercise Group ◽

Control Group ◽

Level Of Evidence ◽

Early Exercise ◽

Physical Functions

ABSTRACT Introduction: Myocardial infarction caused by human obesity can cause a decline in mobility and a decline in the quality of a healthy life. Sports training is beneficial to maintain early physical functions after myocardial infarction. Objective: This article deals with the effect of applying walking aerobic exercise in the rehabilitation treatment of patients with myocardial infarction. Methods: We enrolled 91 patients with myocardial infarction in the early exercise group and 90 patients in the control group. The control group received the routine nursing intervention, and the early exercise group received early physical exercise rehabilitation therapy. Results: The actual quality of life of the early exercise group was higher than that of the control group. The incidence of cardiovascular adverse events was lower than that of the control group. Conclusion: Physical exercise therapy used in acute myocardial infarction can reduce adverse cardiovascular events and improve the quality of life of patients. Level of evidence II; Therapeutic studies - investigation of treatment results.

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β-endorphin response to aerobic and anaerobic exercises in Wistar male rats

Medical Journal of Indonesia ◽

10.13181/mji.oa.203569 ◽

2020 ◽

Vol 29 (3) ◽

pp. 245-9

Author(s):

Rostika Flora ◽

Mohammad Zulkarnain ◽

Sukirno

Keyword(s):

Physical Exercise ◽

Aerobic Exercise ◽

Brain Tissue ◽

Exercise Group ◽

Anaerobic Exercise ◽

Treadmill Running ◽

Male Rats ◽

Enzyme Linked Immunosorbent Assay ◽

Control Group ◽

Aerobic And Anaerobic

BACKGROUND Physical exercise is strongly associated with the release of β-endorphin. It is assumed that the type and intensity of physical exercise contributes to the release of β-endorphin. This study aimed to compare levels of β-endorphin in brain tissue in response to aerobic and anaerobic physical exercise. METHODS This study was an experimental laboratory study using 35 male Wistar rats divided into one control group and two physical exercise treatment groups: aerobic and anaerobic. Physical exercise was conducted on an animal treadmill running at aspeed of 20 m/min for 30 min of aerobic exercise and 35 m/min with 1-min intervals every 5 min for 20 min for anaerobic exercises. Each aerobic and anaerobic exercise group was furtherly classified into three subgroups (1×/week, 3×/week, and 7×/week). β-endorphin levels were determined using enzyme-linked immunosorbent assay. The data were analyzed using independent t-test and one-way analysis of variance. RESULTS The highest mean of β-endorphin level was found in the weekly exercise (54.45 [1.41] pg/ml) of aerobic exercise group and daily exercise (70.50 [11.67] pg/ml) of anaerobic exercise group. Mean of β-endorphin level in control group was 33.34 (3.54) pg/ml. A significant increased of β-endorphin mean level (p<0.001) was found in all aerobic and anaerobic exercise groups except the aerobic exercise 7×/week group(37.37 [6.30] pg/ml) compared to control. CONCLUSIONS Both aerobic and anaerobic physical exercise conducted for 6 weeks could increase the level of β-endorphin in brain tissue.

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Grape juice and aerobic exercise on blood pressure

Nutrition & Food Science ◽

10.1108/nfs-08-2019-0256 ◽

2019 ◽

Vol 50 (5) ◽

pp. 987-998 ◽

Cited By ~ 1

Author(s):

Juliane Barroso Leal ◽

Juçara Barroso Leal ◽

Joaline Barroso Portela Leal ◽

Yan de Lima Borges ◽

Maria Ivone Leal de Moura ◽

...

Keyword(s):

Blood Pressure ◽

Physical Exercise ◽

Aerobic Exercise ◽

Diastolic Pressure ◽

Systolic Pressure ◽

Grape Juice ◽

Exercise Group ◽

Control Group ◽

Content Type ◽

Before And After

Purpose This paper aims to verify the effect of 12 weeks of grape juice (GJ) consumption associated with aerobic exercise on the variation of the hypertensive elderly pressure. Design/methodology/approach A total of 45 hypertensive elderly of both sexes were distributed into: control group (CG, n = 10), exercise group (EG, n = 10), juice group (JG, n = 12) and juice and exercise group (JEG, n = 13). Blood pressure and heart rate were checked weekly before exercise in JG and JEG, and before and after intervention in all groups, with JG and JEG supplemented with 200 mL of GJ. Three weekly sessions of moderate walking were applied. Findings There was a reduction in EG, JG and JEG for systolic pressure and diastolic only for JG and JEG. The GJ consumption to the practice of aerobic exercise provided reductions in the arterial pressure of hypertensive, in addition to stabilization of the diastolic pressure. Research limitations/implications Although the objective of the study was to compare the effect and value of intervention with controls, the study had no intervention in food consumption, which could have led to more significant results. There was a limitation in the control drink, leading the study not to be blind, which may have impaired the results. However, it is probably not a bias, as the groups were divided by residence area, and therefore, had no direct contact with the other groups. Another limitation was that the sample size was still small, which would lead to more reliable results. Finally, although the existing limitations cannot be disregarded, the results of this research are very promising, especially when the objective is the effect of GJ and aerobic exercise on blood pressure, with the possibility of implementing supplemental GJ and the inclusion or not of exercise to the hypertensive elderly. Originality/value The paper deals with the benefits of GJ consumption associated with aerobic physical exercise on the blood pressure of elderly hypertensive patients. Considering that GJ along with physical exercise was enough to reduce the blood pressure of hypertensive elderly, this may be a new model to be used to reduce and/or control blood pressure, and GJ and the exercise to be part of the daily life of the population.

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Physical Exercise as Prophylaxis against Involutional Vertebral Bone Loss: A Controlled Trial

Clinical Science ◽

10.1042/cs0640541 ◽

1983 ◽

Vol 64 (5) ◽

pp. 541-546 ◽

Cited By ~ 292

Author(s):

Bjørn Krølner ◽

Birte Toft ◽

Stig Pors Nielsen ◽

Erik Tøndevold

Keyword(s):

Lumbar Spine ◽

Bone Loss ◽

Physical Exercise ◽

Bone Mineral Content ◽

Bone Mineral ◽

Mineral Content ◽

Controlled Trial ◽

Exercise Group ◽

Control Group ◽

Normal Women

1. The skeletal effects of physical training were studied in a controlled trial involving 31 healthy women (aged 50–73 years) with previous Colles' fracture of the forearm. The bone mineral content of the lumbar spine and both distal forearms was measured by dual-photon (153Gd) absorptiometry. 2. The participants were allocated to either a physical exercise group or a control group. The former group followed a standardized exercise programme, exercising for 1 h twice weekly during 8 months. 3. Twenty-seven women completed the study. Lumbar spine bone mineral content of the exercise group increased by 3.5%, whereas that of the control group decreased by 2.7%. The rate of bone loss in the control group equalled that of age-matched normal women. 4. The changes in forearm bone mineral content appeared to be independent of the exercise. The bone mineral content of the previously fractured forearm remained nearly unchanged. The bone mineral content of the uninjured forearm decreased on average by 3.5%. 5. The data suggest that physical exercise can inhibit or reverse the involutional bone loss from the lumbar vertebrae in normal women. Physical exercise may prevent spinal osteoporosis.

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Upper limb isometric exercise protocolled programme and arteriovenous fistula maturation process

Clinical Kidney Journal ◽

10.1093/ckj/sfz194 ◽

2020 ◽

Cited By ~ 2

Author(s):

Irati Tapia González ◽

Vicent Esteve Simó ◽

Sara Ibañez Pallares ◽

Fátima Moreno Guzman ◽

Miquel Fulquet Nicolás ◽

...

Keyword(s):

Arteriovenous Fistula ◽

Upper Limb ◽

Scientific Evidence ◽

Demographic Data ◽

Isometric Exercise ◽

Exercise Programme ◽

Exercise Group ◽

Control Group ◽

Hand Grip ◽

End Stage

Abstract Introduction Arteriovenous fistula (AVF) is the gold standard for vascular access (VA) for end-stage chronic kidney disease (CKD) patients. Post-operative exercises may help to improve maturation. Nevertheless, scarce scientific evidence has been reported about their utility to date. Our objective was to assess the effect of a post-operative isometric exercise programme on native VA maturation in patients with stage 5–5D CKD. Methods We performed a 24-month prospective study. After surgery, patients were randomized to the isometric exercise group (EG) or control group (CG). An isometric exercise protocolled programme was performed in the EG. The CG received usual care. Demographic data, muscle strength using a hand-grip (HG) dynamometer, main Doppler ultrasound (DUS) measurements, clinical and DUS maturation and VA complications were assessed at 4 and 8 weeks post-operatively. Results For 60 sixty patients (30 in the EG), demographic data and HG and DUS measurements at baseline were similar. A significant increase in HG was observed only in the EG at the end of the study (20.7 ± 8.1 versus 25.1 ± 10.3 kg, P = 0.001). The EG obtained the highest clinical maturation at 4 (CG 33.3% versus EG 70%, P = 0.009) and 8 weeks (CG 33.3% versus EG 76.7%, P = 0.002). Similarly, DUS maturation was better in the EG at 4 (CG 40% versus EG 80%, P = 0.003) and 8 weeks (CG 43.3% versus EG 83.3%, P = 0.003) and remained so in the EG for both distal and proximal VA territories for all these periods. Conclusions The upper limb isometric exercise protocolled programme improved clinical and DUS maturation in our patients in both the distal and proximal VA territories. Further studies are required to support these results.

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PO-285 A review of effects of exercise on the quality of life in breast cancer survivors

Exercise Biochemistry Review ◽

10.14428/ebr.v1i5.13103 ◽

2018 ◽

Vol 1 (5) ◽

Author(s):

Feng Hong

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Physical Exercise ◽

Cancer Survivors ◽

Aerobic Exercise ◽

Breast Cancer Survivors ◽

Exercise Group ◽

Control Group ◽

Supervised Exercise

Objective Breast cancer is one of the most common malignant tumors in women.The number of women diagnosed with breast cancer each year is also increasing.It is also the leading cause of cancer deaths in women, accounting for 14-23% of cancer deaths.However, with the development of medical technology, the survival rate of breast cancer patients is improving.In general, the treatment of breast cancer mainly includes surgical treatment, adjuvant chemotherapy and radiotherapy，But these treatments can do a lot of damage to breast cancer patients.These injuries can limit some of the physical activity of breast cancer patients, and can be accompanied by significant psychological damage，Therefore, the quality of life of breast survivors is largely destroyed.Physical exercise is one of the important ways to improve the overall health of the human body.It also plays an important role in increasing people's mood and quality of life.So whether physical exercise has a positive impact on improving the quality of life of breast cancer survivors or there is some doubt.Therefore, the main purpose of this study is to explore the impact of physical exercise on the quality of life of breast cancer survivors, and then to prove the impact of supervised exercise and individual exercise on the quality of life of breast cancer survivors. Methods Data bases searched were MEDLINE, EMBASE, CINAHL, PubMed.Keywords were“breast cancer and quality of life” in combination with “exercise”or “physical activity”.At the same time, the references of the included articles were reviewed to obtain more relevant studies.In terms of the criteria for inclusion and exclusion of literature, the paper was initially screened to determine whether the title and abstract of the paper were consistent with the research topic.The criteria for inclusion are ①the subjects were breast cancer survivors,②the type of intervention was physical exercise,③the measured result is quality of life,④the type of experiment is randomized controlled trial.The exclusion criteria of the article are ①the subject's occupation was athlete，②quality of life is not measured on a formal scale，③article type is review or abstract. Results A total of 14 articles are included in our review.Quality of life was measured using scale tools in all included studies, of which two scales were used in all included articles.The two scales used can reflect the real life quality of the subjects, of which FACT-G is a mass life quality scale and FACT-B is a life quality scale designed specifically for breast cancer patients. Both scales are globally recognized by the public.In our review, we found that exercise significantly improved the quality of life of breast cancer survivors, particularly aerobic exercise.In the studies included in our study, except Nanette et al. used aerobic exercise combined with resistance strength training as the intervention method in their study, all the other studies used aerobic exercise as the intervention method for the subjects.Among the 14 included studies, 10 indicated that physical exercise significantly increased the quality of life of breast cancer survivors, and 4 found that compared with the control group, the quality of life of breast cancer survivors did not have significant changes, but there was a trend of improving the quality of life.At the same time, our review found that monitoring breast cancer survivors improved quality of life.In two of the studies we included, subjects were divided into individual exercise groups and supervised exercise groups.In their study, Anne et al. divided the recruited research samples into the supervision intervention group and the routine control group. Among them, the supervision intervention group received physical exercise 5 times a week for 12 weeks, and the quality of life of breast cancer survivors was significantly improved.In the study of Cadmus et al., the subjects recruited were divided into individual exercise group, supervised exercise group and routine control group, and the exercise group performed physical exercise with the same load and frequency. The result was that there was no physical activity in the home individual exercise group or the routine control group that improved the quality of life for breast cancer survivors.However, in the supervised exercise group, breast cancer survivors' scores for FACT-B and SF-36 (a measure reflecting quality of life) were significantly improved. Conclusions Exercise can improve the quality of life for breast cancer survivors, especially aerobic exercise. Supervised exercise intervention for breast cancer survivors can better improve their quality of life and alleviate social and psychological problems than individual exercise.The supervised aerobic exercise can be integrated into the life of breast cancer survivors so as to better promote the recovery of breast cancer survivors.

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Correlation Between Insulin Levels and Thyroid Hormones in Diabetic Animals After Caffeine Consumption Associated with Exercise

Current Nutrition & Food Science ◽

10.2174/1573401315666181211144036 ◽

2020 ◽

Vol 16 (3) ◽

pp. 364-367

Author(s):

Luiz Augusto da Silva ◽

Jéssica Wouk ◽

Vinícius Müller Reis Weber ◽

Pablo de Almeida ◽

Julio C.L. Martins ◽

...

Keyword(s):

Physical Exercise ◽

Thyroid Hormones ◽

Intraperitoneal Administration ◽

Exercise Group ◽

Control Group ◽

Hormonal Changes ◽

Caffeine Consumption ◽

Insulin Levels ◽

Diabetes Model ◽

And Training

Introduction: Thyroid hormones (TH) are important determinants of glucose homeostasis, and in contrast, insulin is the first hormone responsible for glycemic control. Objective: The objective of the present study was to correlate the levels of insulin and thyroid hormones in diabetic animals after caffeine consumption associated with physical exercise. Methods: A total of 48 animals, 60 days old were allocated in eight experimental groups: Control, Diabetic, Exercise, Diabetes + exercise, Caffeine, Diabetes + Caffeine, Caffeine + Exercise, and Diabetes + Exercise + Caffeine. Diabetes model was induced by intraperitoneal administration of 120 mg/kg of alloxan. On the test day, 6 mg/kg of caffeine was administrated 30 minutes before physical exercise. After, animals performed a 60 minutes’ session of predominantly aerobic exercise, using an overload of 6% of their body’s weight. Blood has been collected by a caudal puncture to future insulin, TSH, T3, and T4 analyses. Results: After caffeine treatment and training, insulin values were higher for the control groups (231%) when compared to the diabetic groups. A significant increase in plasmatic insulin concentration was found in caffeine group (95%) and Exercise+Caffeine group (56%) when compared to Control and Exercise groups. TSH values were increased for Diabetes, Diabetes+Caffeine and Diabetes+ Exercise+Caffeine groups (30%) compared to the other groups. A reduction in T4 values occurred in the animals of groups Diabetes+Exercise and Diabetes +Caffeine (66%) compared to the Control group. T3 values were significantly increased for the Diabetes+Exercise group (70%) when compared to the Diabetes+Exercise+Caffeine group. Conclusion: Physical exercise and caffeine consumption were able to promote hormonal changes in diabetic animals after 30 days of training. The study showed a reduction in the serum concentration of thyroid hormones, but insulin levels were higher.

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Multicomponent exercise program in older adults with lung cancer during adjuvant/palliative treatment: A secondary analysis of an intervention study

The Journal of Frailty & Aging ◽

10.14283/jfa.2021.2 ◽

2021 ◽

pp. 1-7

Author(s):

N. Martínez-Velilla ◽

M.L. Saez de Asteasu ◽

R. Ramírez-Vélez ◽

I.D. Rosero ◽

A. Cedeño-Veloz ◽

...

Keyword(s):

Lung Cancer ◽

Older Adults ◽

Emergency Department ◽

Palliative Treatment ◽

Secondary Analysis ◽

Exercise Programme ◽

Control Group ◽

Post Intervention ◽

Frailty Status ◽

The Impact

Background: Lung cancer is the second most prevalent common cancer in the world and predominantly affects older adults. This study aimed to examine the impact of an exercise programme in the use of health resources in older adults and to assess their changes in frailty status. Design: This is a secondary analysis of a quasi-experimental study with a non-randomized control group. Setting: Oncogeriatrics Unit of the Complejo Hospitalario de Navarra, Spain. Participants: Newly diagnosed patients with NSCLC stage I–IV. Intervention: Multicomponent exercise programme that combined resistance, endurance, balance and flexibility exercises. Each session lasted 45–50 minutes, and the exercise protocol was performed twice a week over 10 weeks. Measurements: Mortality, readmissions and Visits to the Emergency Department. Change in frailty status according to Fried, VES-13 and G-8 scales. Results: 26 patients completed the 10-weeks intervention (IG). Mean age in the control group (CG) was 74.5 (3.6 SD) vs 79 (3 SD) in the IG, and 78,9% were male in the IG vs 71,4% in the CG. No major adverse events or health-related issues attributable to the testing or training sessions were noted. Significant between-group differences were obtained on visits to the emergency department during the year post-intervention (4 vs 1; p:0.034). No differences were found in mortality rate and readmissions, where an increasing trend was observed in the CG compared with the IG in the latter (2 vs 0; p 0.092). Fried scale was the unique indicator that seemed to be able to detect changes in frailty status after the intervention. Conclusions: A multicomponent exercise training programme seems to reduce the number of visits to the emergency department at one-year post-intervention in older adults with NSCLC during adjuvant therapy or palliative treatment, and is able to modify the frailty status when measured with the Fried scale.

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