scholarly journals Improved BioGents® Sentinel trap with heat (BGSH) for outdoor collections of Anopheline species in Burkina Faso and Mali, West Africa

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Amadou Guindo ◽  
Patric Stephane Epopa ◽  
Sidy Doumbia ◽  
Abdoul-Azize Millogo ◽  
Brehima Diallo ◽  
...  
Keyword(s):  
Heat Source ◽  
Burkina Faso ◽  
Disease Surveillance ◽  
Large Scale ◽  
Indoor Residual Spraying ◽  
Fold Increase ◽  
Host Seeking ◽  
Close Proximity ◽  
Control Programmes ◽  
Trap Colour

Abstract Background Since the late 1990s, malaria control programmes have relied extensively on mass bednet distribution and indoor residual spraying. Both interventions use pesticides and target mosquitoes coming indoors either to feed or to rest. Unfortunately, these intensified vector control campaigns have resulted in mosquito populations with high levels of resistance to most of the chemical compounds used against them and which are increasingly exophagic and exophillic, hence difficult to monitor indoors. Consequently, there is an urgent need for novel tools to sample outdoor anopheline populations for monitoring interventions and disease surveillance programmes. Methodologies In this study, we tested several modifications and configurations of the BioGents® Sentinel (BGS) trap, designed with the aim to increase its efficacy for sampling malaria vector species. Traps were used with chemical attractants and CO2, and the impacts of trap position, trap colour contrast combination and the addition of a heat source were tested in two studies conducted in the Sudano-Sahelian region of Burkina Faso and Mali. Results The results show that of all the configurations tested, the addition of a heat source to the BGS trap with the original colour combination and an upward positioning resulted in a 1.8- and 5.9-fold increase in host-seeking Anopheles gambiae (s.l.) females in the experiments performed in Burkina Faso and Mali, respectively. BGS with heat traps, referred to as BGSH traps, captured An. gambiae (s.l.), An. pharoensis, An. coustani, Culex and Mansonia spp. Importantly, the results suggest that their efficacy does not depend on the close proximity of nearby hosts in houses. Conclusions The results suggest that BGSH traps can be an effective scalable tool for sampling outdoor anopheline vector populations. Further developments enabling CO2 and heat generation for longer periods of time would further improve the trap’s versatility for large-scale surveillance programmes.

Interpreting Seventeenth-Century Probate Documents: John Carter, Master Carpenter in St Albans

2011 ◽  
pp. 66-83
Author(s):  
Jane Harris ◽  
Pat Howe
Keyword(s):  
Seventeenth Century ◽  
Large Scale ◽  
Local Context ◽  
Social Standing ◽  
Close Proximity ◽  
Market Town ◽  
Consumer Age

This is a study of a successful seventeenth-century carpenter in St Albans, John Carter, using probate and other documents, assisted by a large-scale computer database of St Albans residents of the period. Sections of the article cover his family, his work and his house and its contents, which have been reconstructed from his probate inventory and from knowledge of the structure of other local houses of the period. Carter's social standing is discussed, both in its local context and in relation to previous probate inventory analyses. This micro-study sheds unusual light upon aspects of the life of a 'middling sort' of person, living in a thriving market town in close proximity to London, at the beginning of the consumer age.

scholarly journals Insecticide resistance status of malaria vectors Anopheles gambiae (s.l.) of southwest Burkina Faso and residual efficacy of indoor residual spraying with microencapsulated pirimiphos-methyl insecticide

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Dieudonné Diloma Soma ◽  
Barnabas Zogo ◽  
Domonbabele François de Sales Hien ◽  
Aristide Sawdetuo Hien ◽  
Didier Alexandre Kaboré ◽  
...  
Keyword(s):  
Insecticide Resistance ◽  
Burkina Faso ◽  
Anopheles Gambiae ◽  
Local Population ◽  
Residual Activity ◽  
Indoor Residual Spraying ◽  
Susceptible Strain ◽  
Malaria Vectors ◽  
Pirimiphos Methyl ◽  
Residual Efficacy

Abstract Background The rapid spread of insecticide resistance in malaria vectors and the rebound in malaria cases observed recently in some endemic areas underscore the urgent need to evaluate and deploy new effective control interventions. A randomized control trial (RCT) was conducted with the aim to investigate the benefit of deploying complementary strategies, including indoor residual spraying (IRS) with pirimiphos-methyl in addition to long-lasting insecticidal nets (LLINs) in Diébougou, southwest Burkina Faso. Methods We measured the susceptibility of the Anopheles gambiae (s.l.) population from Diébougou to conventional insecticides. We further monitored the efficacy and residual activity of pirimiphos-methyl on both cement and mud walls using a laboratory susceptible strain (Kisumu) and the local An. gambiae (s.l.) population. Results An. gambiae (s.l.) from Diébougou was resistant to DDT, pyrethroids (deltamethrin, permethrin and alphacypermethrin) and bendiocarb but showed susceptibility to organophosphates (pirimiphos-methyl and chlorpyrimiphos-methyl). A mixed-effect generalized linear model predicted that pirimiphos-methyl applied on cement or mud walls was effective for 210 days against the laboratory susceptible strain and 247 days against the local population. The residual efficacy of pirimiphos-methyl against the local population on walls made of mud was similar to that of cement (OR = 0.792, [0.55–1.12], Tukey’s test p-value = 0.19). Conclusions If data on malaria transmission and malaria cases (as measured trough the RCT) are consistent with data on residual activity of pirimiphos-methyl regardless of the type of wall, one round of IRS with pirimiphos-methyl would have the potential to control malaria in a context of multi-resistant An. gambiae (s.l.) for at least 7 months.

scholarly journals A therapeutic vascular conduit to support in vivo cell-secreted therapy

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Edward X. Han ◽  
Hong Qian ◽  
Bo Jiang ◽  
Maria Figetakis ◽  
Natalia Kosyakova ◽  
...  
Keyword(s):  
Vascular Graft ◽  
Large Scale ◽  
Biological Effects ◽  
Therapeutic Protein ◽  
Close Proximity ◽  
Delivery Platform ◽  
Stage Renal Disease ◽  
End Stage

AbstractA significant barrier to implementation of cell-based therapies is providing adequate vascularization to provide oxygen and nutrients. Here we describe an approach for cell transplantation termed the Therapeutic Vascular Conduit (TVC), which uses an acellular vessel as a scaffold for a hydrogel sheath containing cells designed to secrete a therapeutic protein. The TVC can be directly anastomosed as a vascular graft. Modeling supports the concept that the TVC allows oxygenated blood to flow in close proximity to the transplanted cells to prevent hypoxia. As a proof-of-principle study, we used erythropoietin (EPO) as a model therapeutic protein. If implanted as an arteriovenous vascular graft, such a construct could serve a dual role as an EPO delivery platform and hemodialysis access for patients with end-stage renal disease. When implanted into nude rats, TVCs containing EPO-secreting fibroblasts were able to increase serum EPO and hemoglobin levels for up to 4 weeks. However, constitutive EPO expression resulted in macrophage infiltration and luminal obstruction of the TVC, thus limiting longer-term efficacy. Follow-up in vitro studies support the hypothesis that EPO also functions to recruit macrophages. The TVC is a promising approach to cell-based therapeutic delivery that has the potential to overcome the oxygenation barrier to large-scale cellular implantation and could thus be used for a myriad of clinical disorders. However, a complete understanding of the biological effects of the selected therapeutic is absolutely essential.

scholarly journals Genotypic distribution of human oncogenic papillomaviruses in sexually active women in Burkina Faso: Central, Central-Eastern and Hauts-Bassins regions

2020 ◽  
Vol 11 (1) ◽  
pp. 125-136
Author(s):  
Rogomenoma Alice Ouedraogo ◽  
Théodora Mahoukèdè Zohoncon ◽  
Ina Marie Angèle Traore ◽  
Abdoul Karim Ouattara ◽  
Sindimalgdé Patricia Guigma ◽  
...  
Keyword(s):  
Burkina Faso ◽  
Large Scale ◽  
Hpv Infection ◽  
Cross Sectional Study ◽  
Sexually Active ◽  
Cervical Lesions ◽  
Cross Sectional ◽  
Genotypic Distribution ◽  
Hpv Genotypes ◽  
Central Eastern

AbstractObjectivethis study was conducted to determine the distribution of high-risk human papillomavirus (HR-HPV) genotypes in women in the general population of three regions of Burkina Faso.MethodThis multicenter, descriptive cross-sectional study involved 1321 sexually active women in five cities in three regions of Burkina Faso: Central, Central-Eastern and Hauts-Bassins regions. After collection of endocervical specimens, pre-cervical lesions were screened by visual inspection with acetic acid and lugol (VIA / VILI). HR-HPV genotypes were characterized by multiplex real-time PCR after extraction of viral DNA.ResultsThe mean age of women was 31.98 ± 10.09 years. The HR-HPV infection in the three regions ranged from 26.16% to 43.26% with 35.42% as overall prevalence in women. The most common HR-HPV genotypes in descending order were: HPV 56, 52, 66, 59, 39, 51, 18, 35. The prevalence of bivalent vaccine genotypes (HPV16 / 18) was 7.83% against 63.78% of genotypes not covered by HPV vaccine; 36.32% (170/468) of women had multiple concomitant HR-HPV infections.Conclusionthis study showed significant regional variation and high prevalence of HR-HPV infection in women. The predominant genotypes differ from those covered by available vaccines in Burkina Faso. These results will help guide our health policies towards better prevention of cervical cancer. The diversity of oncogenic genotypes is sparking a large-scale study in the West African sub-region, particularly in cases of cancer and the introduction of the nonavalent vaccine which includes HPV 52 found among the predominant genotypes in this study.

Aquaculture in North America: An Assessment of Future Prospects

1982 ◽  
Vol 39 (1) ◽  
pp. 151-154 ◽  
Author(s):  
P. A. Larkin
Keyword(s):  
North America ◽  
Large Scale ◽  
Geographical Location ◽  
Aquatic Environments ◽  
Future Prospects ◽  
Growing Period ◽  
Close Proximity ◽  
Cheap Alternative ◽  
Alternative Sources ◽  
Simple Technology

The farming of aquatic environments is already a large-scale world enterprise involving relatively simple technology, but aquacultural production in North America is only a small part of the world total. Aquaculture is only economically rewarding where high rates of production over a long growing period can be coupled with close proximity to large markets in which there are few cheap alternative sources of protein. Much of North American aquaculture is aimed at meeting demands of recreational fishermen rather than as a way of producing food. There are many opportunities for development of aquaculture in North America and it seems reasonable to project substantial increases in production in the next two decades.Key words: aquaculture, geographical location, North America, future prospects, economics

scholarly journals Information Communication Technologies (ICTs), Crisis Communication Principles and the COVID-19 Response in South Korea

2021 ◽  
pp. 097325862098117
Author(s):  
Hye-Jin Paek ◽  
Thomas Hove
Keyword(s):  
Crisis Communication ◽  
Large Scale ◽  
Communication Strategies ◽  
Disease Outbreaks ◽  
Information Communication ◽  
Information And Communications Technologies ◽  
The South ◽  
South Korean ◽  
Infectious Disease Outbreaks ◽  
Control Programmes

This case study highlights several communication insights that have emerged from the South Korean national response to COVID-19. In particular, it focuses on how innovative disease control programmes and information and communications technologies (ICT) have been used in conjunction with appropriate message strategies. The South Korean government used ICTs in a variety of ways to enhance crisis communication, coordinate large-scale public health efforts and supply chains, and facilitate widespread adoption of preventive measures such as social distancing and mask wearing. The response and communication strategies were based on principles established by research in social sciences and recommended for pandemic response, including social marketing, crisis communication, and normative influence. South Korea’s COVID-19 response and communication strategies can provide useful insights for national efforts to manage COVID-19 and other possible future infectious disease outbreaks.

Six-fold increase in historical Northern Hemisphere concurrent large heatwaves driven by warming and changing atmospheric circulations

2021 ◽  
pp. 1-39
Author(s):  
Cassandra D.W. Rogers ◽  
Kai Kornhuber ◽  
Sarah E. Perkins-Kirkpatrick ◽  
Paul C. Loikith ◽  
Deepti Singh
Keyword(s):  
Northern Hemisphere ◽  
Large Scale ◽  
Warm Season ◽  
Fold Increase ◽  
Circulation Pattern ◽  
Positive Influence ◽  
Climate Risks ◽  
Circulation Patterns ◽  
Multiple Regions ◽  
Barents And Kara Seas

AbstractSimultaneous heatwaves affecting multiple regions (referred to as concurrent heatwaves), pose compounding threats to various natural and societal systems, including global food chains, emergency response systems, and reinsurance industries. While anthropogenic climate change is increasing heatwave risks across most regions, the interactions between warming and circulation changes that yield concurrent heatwaves remain understudied. Here, we quantify historical (1979-2019) trends in concurrent heatwaves during the warm-season (May-September, MJJAS) across the Northern Hemisphere mid- to high-latitudes. We find a significant increase of ~46% in the mean spatial extent of concurrent heatwaves, ~17% increase in their maximum intensity, and ~6-fold increase in their frequency. Using Self-Organising Maps, we identify large-scale circulation patterns (300 hPa) associated with specific concurrent heatwave configurations across Northern Hemisphere regions. We show that observed changes in the frequency of specific circulation patterns preferentially increase the risk of concurrent heatwaves across particular regions. Patterns linking concurrent heatwaves across eastern North America, eastern and northern Europe, parts of Asia, and the Barents and Kara Seas, show the largest increases in frequency (~5.9 additional days per decade). We also quantify the relative contributions of circulation pattern changes and warming to overall observed concurrent heatwave day frequency trends. While warming has a predominant and positive influence on increasing concurrent heatwaves, circulation pattern changes have a varying influence and account for up to 0.8 additional concurrent heatwave days per decade. Identifying regions with an elevated risk of concurrent heatwaves and understanding their drivers is indispensable for evaluating projected climate risks on interconnected societal systems and fostering regional preparedness in a changing climate.

scholarly journals Biotic stress accelerates formation of climate-relevant aerosols in boreal forests

2015 ◽  
Vol 15 (21) ◽  
pp. 12139-12157 ◽  
Author(s):  
J. Joutsensaari ◽  
P. Yli-Pirilä ◽  
H. Korhonen ◽  
A. Arola ◽  
J. D. Blande ◽  
...  
Keyword(s):  
Boreal Forests ◽  
Large Scale ◽  
Transport Model ◽  
Cloud Condensation Nuclei ◽  
Fold Increase ◽  
Global Scale ◽  
Satellite Observations ◽  
Insect Outbreaks ◽  
Voc Emissions ◽  
Scale Modelling

Abstract. Boreal forests are a major source of climate-relevant biogenic secondary organic aerosols (SOAs) and will be greatly influenced by increasing temperature. Global warming is predicted to not only increase emissions of reactive biogenic volatile organic compounds (BVOCs) from vegetation directly but also induce large-scale insect outbreaks, which significantly increase emissions of reactive BVOCs. Thus, climate change factors could substantially accelerate the formation of biogenic SOAs in the troposphere. In this study, we have combined results from field and laboratory experiments, satellite observations and global-scale modelling in order to evaluate the effects of insect herbivory and large-scale outbreaks on SOA formation and the Earth's climate. Field measurements demonstrated 11-fold and 20-fold increases in monoterpene and sesquiterpene emissions respectively from damaged trees during a pine sawfly (Neodiprion sertifer) outbreak in eastern Finland. Laboratory chamber experiments showed that feeding by pine weevils (Hylobius abietis) increased VOC emissions from Scots pine and Norway spruce seedlings by 10–50 fold, resulting in 200–1000-fold increases in SOA masses formed via ozonolysis. The influence of insect damage on aerosol concentrations in boreal forests was studied with a global chemical transport model GLOMAP and MODIS satellite observations. Global-scale modelling was performed using a 10-fold increase in monoterpene emission rates and assuming 10 % of the boreal forest area was experiencing outbreak. Results showed a clear increase in total particulate mass (local max. 480 %) and cloud condensation nuclei concentrations (45 %). Satellite observations indicated a 2-fold increase in aerosol optical depth over western Canada's pine forests in August during a bark beetle outbreak. These results suggest that more frequent insect outbreaks in a warming climate could result in substantial increase in biogenic SOA formation in the boreal zone and, thus, affect both aerosol direct and indirect forcing of climate at regional scales. The effect of insect outbreaks on VOC emissions and SOA formation should be considered in future climate predictions.

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