scholarly journals Metabolic and oxidative status of West African dwarf does at different reproductive stages in southwest Nigeria

2019 ◽  
Vol 43 (1) ◽  
Author(s):  
Abubakar Olatunji Jimoh ◽  
Olayinka Abosede Ojo ◽  
Uchechi Daureen Gift Ihejirika
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Antioxidant Activity ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
First Trimester ◽  
West African ◽  
Late Gestation ◽  
West African Dwarf ◽  
Serum Biochemical

Abstract Background A study was conducted to investigate changes in oxidative stress indicators of West African dwarf (WAD) goats at different reproductive stages. There are a total of 35 dry does, 30 gravid does at first trimester (40–45 days post-mating), 33 gravid does at second trimester (85–90 days post-mating), 31 gravid does at third trimester (135–140 days post-mating), and 40 postpartum does (30–35 days postpartum). Fastened blood samples were collected from all tagged animals and serum obtained. Serum was assayed for lipid peroxidation, total antioxidant activity, glutathione peroxidase, catalase and superoxide dismutase, serum biochemical, glucose, total protein, albumin, cholesterol, triglyceride, high-density lipoprotein, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, urea, and creatinine using standard procedures. Results Result revealed that intense metabolic changes were associated with late prepartum and postpartum does as pronounced in oxidative and biochemical indicators of WAD does. Significant differences were found in serum biochemical indices across the different physiological stages of the doe except for triglyceride and low-density lipoprotein. Antioxidant defense is higher at early and mid-gestation and dry does, through low lipid peroxidation and high antioxidant activity as compared to late gestation and lactation does. Conclusion The observed result shows that the WAD does display oxidative stress during late gestation and lactation owing to intense metabolism. Antioxidant fortification should be employed especially during late gestation and lactation to counteract the oxidative stress in WAD goats.

scholarly journals Assessment of oxidative stress indicators of West African Dwarf sheep under semi intensive management system

2021 ◽  
Vol 43 (2) ◽  
pp. 78-83
Author(s):  
A. A Jack ◽  
O. A. Jimoh ◽  
U. G. Ihejirika ◽  
U. C. Uwaeziozi ◽  
O. O. Adenekan
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Antioxidant Activity ◽  
Superoxide Dismutase ◽  
Serum Biochemistry ◽  
West African ◽  
Total Antioxidant Activity ◽  
West African Dwarf ◽  
Total Antioxidant ◽  
Serum Biochemical

Oxidative stress results from increased production of free radicals and reactive oxygen species, and a decrease in antioxidant defense. This study was conducted to assess sexual dimorphism in serum biochemistry and oxidative status of West African dwarf lambs. Sixteen each of rams and ewes 8months old were randomly selected from a herd purchase from livestock market, Oyo. The average body weights of the lambs were 12.08±3.26 and 12.76kg ewes and rams, respectively. Fastened blood samples were collected from the sheep and assayed for serum biochemical, lipid peroxidation, total antioxidant activity, catalase and superoxide dismutase using standard procedures, data obtained were subjected to T-test. The result indicated that both sex had similar serum biochemical indices except total protein. Ewes had significantly higher serum protein than ram. Rams had apparently higher total antioxidant activity and significantly higher serum catalase activity than ewes, while serum lipid peroxidation and superoxide dismutase were statistically similar in both sexes. This indicates that rams have better antioxidant activity than ewes. During oxidative stress prone conditions and environment, measures to boost antioxidant activity of ewes should be emphasized.

Assessment of oxidative stress indicators of West African Dwarf sheep under semi intensive management system

2021 ◽  
Vol 43 (1) ◽  
pp. 78-83
Author(s):  
A. A. Jack ◽  
O. A. Jimoh ◽  
U. G. Ihejirika ◽  
U. C, Uwaeziozi ◽  
O. O. Adenekan
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Antioxidant Activity ◽  
Superoxide Dismutase ◽  
Serum Biochemistry ◽  
West African ◽  
Total Antioxidant Activity ◽  
West African Dwarf ◽  
Total Antioxidant ◽  
Serum Biochemical

Oxidative stress results from increased production of free radicals and reactive oxygen species, and a decrease in antioxidant defense. This study was conducted to assess sexual dimorphism in serum biochemistry and oxidative status of West African dwarf lambs. Sixteen each of rams and ewes 8months old were randomly selected from a herd purchase from livestock market, Oyo. The average body weights of the lambs were 12.08±3.26 and 12.76kg ewes and rams, respectively. Fastened blood samples were collected from the sheep and assayed for serum biochemical, lipid peroxidation, total antioxidant activity, catalase and superoxide dismutase using standard procedures, data obtained were subjected to T-test. The result indicated that both sex had similar serum biochemical indices except total protein. Ewes had significantly higher serum protein than ram. Rams had apparently higher total antioxidant activity and significantly higher serum catalase activity than ewes, while serum lipid peroxidation and superoxide dismutase were statistically similar in both sexes. This indicates that rams have better antioxidant activity than ewes. During oxidative stress prone conditions and environment, measures to boost antioxidant activity of ewes should be emphasized.

scholarly journals Evaluation of Oxidative Stress, Antioxidant and Thyroid Hormone Status in Patients with Diabetes Mellitus

1970 ◽  
Vol 10 (2) ◽  
pp. 60-66 ◽  
Author(s):  
P Pasupathi ◽  
V Chandrasekar ◽  
U Senthil Kumar
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Thyroid Hormones ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Diabetic Patients ◽  
Low Density Lipoprotein Cholesterol ◽  
Hormone Status ◽  
Patients With Diabetes

Oxidative stress is currently suggested as mechanism underlying diabetes and diabetic complications. The aim of the study was to evaluate the magnitude of oxidative stress in patients with diabetes by measuring the lipid peroxidation as well as the status of the antioxidant defense system, thyroid hormones status and other biochemical variables. The study population consisted of 100 subjects divided into two groups viz. diabetic (n=50) and healthy controls (n=50). Changes in the levels of lipid peroxidation and antioxidants and thyroid hormones status were determined in diabetic and non-diabetic subjects. The level of thiobarbituric acid reactive substances (TBARS) was found to be increased significantly in diabetic patients compared to healthy controls. On the other hand, the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST), reduced glutathione (GSH), vitamin A, vitamin E and vitamin C were found to be decreased significantly in diabetics when compared to control subjects. We also noticed a marked increase in serum total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), and decrease in highdensity lipoprotein cholesterol (HDL-C), total protein and albumin in diabetic patients. The level of TSH was significantly decreased whereas the levels of T4 and FT4 were significantly increased in diabetic patients than the control subjects. However, the T3 and FT3 levels did not differ significantly between groups. Our findings indicate that changes in oxidant and antioxidant equilibrium will have biological and possibly pathological role in the development of secondary complications. It also demonstrate that detection of thyroid hormone status in the early stage of the disease will help the patients to improve quality of life and reduce the morbidity rate. Key Words: Diabetes mellitus, Oxidative stress, Lipid peroxidation, Antioxidant status, Thyroid hormones.   doi: 10.3329/jom.v10i2.2816 J MEDICINE 2009; 10 : 60-66

scholarly journals Effect of Saudi and Egyptian Pomegranate Polyphenols in Regulating the Activity of Pon1, Pon2 and Lipid Profile for Preventing Coronary Heart Disease

2019 ◽  
Author(s):  
Wedad Saeed Alqahtani
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Heart Diseases ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Pomegranate Juice ◽  
Atherogenic Index ◽  
Paraoxonase 1 ◽  
Protective Effects ◽  
Serum Triglycerides

Saudi and Egyptian pomegranate juice (APJ and EPJ) contains potent polyphenols, antioxidants that were found to reduce serum and macrophage oxidative stress. The protective effects of APJ and EPJ against atherogenicity were evaluated by feeding mice a hypercholesterolemic diet that was supplemented with PJ.PJ consumption reduced mice serum triglycerides (TG), total cholesterol (TC) and (low density lipoprotein (LDL-c) and increased the high-density lipoprotein (HDL-c) when compared to mice with a control or atherogenic diet. The risk ratio and atherogenic index were significantly lower in both APJ or EPJ supplemented groups. Paraoxonase 1 (PON1), which remains associated with HDL, had a significant increase in activity in mice supplemented with PJ, compared to mice with aatherogenic diet (AD). PJ consumption significantly reduced lipid peroxidation and increased glutathione levels. The reduction in lipid peroxidation varied from 57 to 76%. PJ supplementation reduced peritoneal macrophage (MPM)-mediated oxidation of LDL by 68 to 82% and decreased mouse MPM Ox-LDL uptake by 31 to 48%. A significant up-regulation of macrophage PON2 activity was induced by PJ reducing the macrophage oxidative stress. In conclusion, PJ consumption resulted in anti-oxidative and anti-atherogenic effect on serum and macrophages, which could prevent atherosclerosis and coronary heart diseases.

scholarly journals Lipid status and oxidative stress in menopausal women with obstructive apnea syndrome

2019 ◽  
Vol 91 (10) ◽  
pp. 48-53
Author(s):  
L I Kolesnikova ◽  
N V Semenova ◽  
E V Osipova ◽  
I M Madaeva
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Postmenopausal Women ◽  
Antioxidant System ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Menopausal Women ◽  
Perimenopausal Women ◽  
Total Antioxidant

Aim: to assess lipid profile, lipid peroxidation and antioxidant system parameters in peri - and postmenopausal women with obstructive sleep apnea syndrome (OSAS). Materials and methods. 37 perimenopausal women and 43 postmenopausal ones were examined. OSAS diagnosis was made on the basis of the clinical picture and the polysomnography results. In perimenopause, the main group consisted of 18 women, in postmenopausal women - 17. All comparison groups are comparable by age and body mass index. Lipid profile, lipid peroxidation and antioxidant system parameters by spectrophotometric methods were determined. Non - parametric criteria were used to analyze the group differences for the independent samples. Results and discussion. The increase of total cholesterol (TC) and low - density lipoprotein cholesterol (LDL-C) levels were observed in perimenopausal women with OSAS as compared to control. The increase of TC, triacylglycerol (TG), LDL-C, very - low - density lipoprotein cholesterol (VLDL-C) levels and decrease of high - density lipoprotein cholesterol (HDL-D) level were found in postmenopausal women with OSAS as compared to control. Accumulation of ketodienes and conjugated trienes in perimenopausal women with OSAS and thiobarbituric acid reactants with a decrease of total antioxidant activity of blood serum in postmenopausal women with OSAS as compared to control was observed. Moreover, postmenopausal women with OSAS have a higher lipid peroxidation substrates and diene conjugates levels with a lower α-tocopherol level and total antioxidant activity compared with perimenopausal patients.The integral indicator of oxidative stress assessment indicates an imbalance in the lipid peroxidation and antioxidant system in menopausal women with OSAS. Conclusion. The results obtained indicate a violation of lipid metabolism and the development of oxidative stress in patients with OSAS. This is most pronounced in the postmenopause due to the aggravation of the pathological condition.

scholarly journals Oxidative Stress and Inflammation in Sows with Excess Backfat: Up-Regulated Cytokine Expression and Elevated Oxidative Stress Biomarkers in Placenta

Animals ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 796
Author(s):  
Yuanfei Zhou ◽  
Tao Xu ◽  
Yinghui Wu ◽  
Hongkui Wei ◽  
Jian Peng
Keyword(s):  
Oxidative Stress ◽  
Mrna Expression ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Late Gestation ◽  
Backfat Thickness ◽  
Mrna Levels ◽  
Oxidative Stress Biomarkers ◽  
Total Antioxidant ◽  
The Impact

In sows, excess backfat during late gestation is associated with increased farrowing difficulties and influences the fetus, but the impact of backfat thickness on placental inflammation, oxidative stress, and vascular development has not been defined. In this study, 120 sows were divided into six groups based on backfat thickness (≤16, 17–18, 19–20, 21–22, 23–24, and ≥25 mm) in late gestation. The placental lipids, reactive oxygen species (ROS), malondialdehyde (MDA), and total antioxidant capacity (TAC) levels, inflammatory-related cytokine and angiogenesis were determined. The concentrations of triglycerides, total cholesterol, low density lipoprotein cholesterol (LDL–C), and free fatty acid (FFA) linearly increased (p < 0.05) associated with increased late gestation backfat. ROS and MDA increased and TAC decreased (p < 0.05) as the backfat thickness increased. The mRNA expression of toll-like receptors (TLR) 2, TLR4, tumor necrosis factor (TNF) α, interleukin (IL)–1β, IL–6, and monocyte chemoattractant protein (MCP)–1 increased with increased backfat in late gestation. There were no differences in IL–8 and IL–10 mRNA expression among sows with different backfat thickness. Placental vessel density initially increased and then decreased with increasing backfat thickness of sows. Similarly, the mRNA levels of vascular endothelial growth factor (VEGF) were also increased and then decreased. Excessive backfat in late gestation was associated with greater oxidative stress, greater expression of proinflammatory cytokines, and decreased expression of placental angiogenic regulators.

Melatonin Improves Lipid Profile and Ameliorates Lipid Peroxidation in Patients with Chronic Kidney Disease.

2018 ◽  
pp. 38-45
Keyword(s):  
Lipid Peroxidation ◽  
Placebo Group ◽  
Lipid Profile ◽  
Kidney Diseases ◽  
Oxidized Ldl ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Before And After ◽  
Inhibit Lipid Peroxidation ◽  
Controlled Clinical Study

Dyslipidemia and oxidative modifications of lipid are frequently associated in patients with chronic kidney diseases (CKD) and considered the most important risk factors for cardiovascular events. Melatonin is a well-known potent antioxidant and has beneficial effect on lipid metabolism. the study was designed to evaluate if Melatonin could improve lipid profile and ameliorates lipid peroxidation. This single blind placebo controlled clinical study carried out on 41 patients with CKD who were randomized into two groups, control groups (n=20) those who received placebo cap and melatonin group those who received 5mg melatonin (n=21). Lipid profile [total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C)] and parameters of lipid peroxidation [oxidized LDL (oxLDL) and malondialdehyde (MDA) were measured before and after 12 weeks of the treatment. After 12 weeks of treatment, melatonin significantly increased HDL-C and decreased LDL-C compared to the initial value. The elevation in HDL-C and reduction in LDL-C were significantly different from that in placebo group. Also, both oxLDL and MDA levels significantly lowered by melatonin compared to the baseline and to the placebo group. Collectively, the results of our study showed that melatonin has advantageous effect on lipid profile and inhibit lipid peroxidation in patients with CKD.

Effect of Turmeric and Ginger on Lipid Profile in Male Rats Exposed to Oxidative Stress

2019 ◽  
Vol 10 (01) ◽  
Author(s):  
Eman A. Al-Rekabi ◽  
Dheyaa K. Alomer ◽  
Rana Talib Al-Muswie ◽  
Khalid G. Al-Fartosi
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Drinking Water ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Male Rats ◽  
Control Group ◽  
Very Low Density Lipoprotein ◽  
Low Density

The present study aimed to investigate the effect of turmeric and ginger on lipid profile of male rats exposed to oxidative stress induced by hydrogen peroxide H2O2 at a concentration of 1% given with consumed drinking water to male rats. Methods: 200 mg/kg from turmeric and ginger were used, and the animals were treatment for 30 days. Results: the results showed a significant increase in cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipoprotein (VLDL), whereas it explained a significant decrease in high density lipoprotein (HDL) of male rats exposed to oxidative stress when compared with control group. the results showed a significant decrease in cholesterol, triglycerides, (LDL), (VLDL), whereas it explained a significant increase in (HDL) of rats treated with turmeric and ginger at dose 200 mg/kg when compared with male rats exposed to oxidative stress.

Antidyslipidemic and Antioxidant Activities of Matricaria pubescens (Desf.) Shultz.in Streptozotocin-Induced Diabetic Rats

2020 ◽  
Vol 18 ◽  
Author(s):  
Ayoub Amssayef ◽  
Bouchra Azzaou ◽  
Mohammed Ajebli ◽  
Mohamed Eddouks
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Activities ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Diabetic Rats ◽  
Favorable Effect ◽  
Lipoprotein Profile ◽  
Phytochemical Compounds ◽  
Asteraceae Family

Aims: The study aimed to evaluate the antihyperlipidemic and antioxidant activities of Matricaria pubescens. Background: Matricaria pubescens (Desf.) Shultz belongs to Asteraceae family and it is commonly used traditionally for handling diabetes mellitus. Objective: The objective of this study was to assess the antioxidant activity of Matricaria pubescens (Desf.) Shultz and its effect on lipid and lipoprotein profile in normal and streptozotocin-induced diabetic rats. Methods: The effect of repeated (7 days of treatment) oral administration of the aqueous extract of aerial part of Matricaria pubescens (MPAE) at a dose of 40 mg/kg on lipid and lipoprotein profile was examined in normal and streptozotocin-induced diabetic rats. Furthermore, a preliminary phytochemical screening and the quantification of phenolic, flavonoid and tannin contents as well as the antioxidant activity using two methods (FRAP and ABTS) were carried out. Results: MPAE demonstrated a potent antidyslipidemic effect in diabetic rats by reducing serum levels of triglycerides, total cholesterol and low-density lipoprotein (LDL). In addition, the results showed that the extract is rich in several phytochemical compounds and revealed an important antioxidant activity. Conclusion: In summary, this study proved that Matricaria pubescens (Desf.) Shultz. has a favorable effect on diabetic dyslipidemia.

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