scholarly journals Anticancer activity of benzoxazole derivative (2015 onwards): a review

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Tanay Ghoshal ◽  
Tarun M. Patel
Keyword(s):  
Anticancer Activity ◽  
Heterocyclic Compounds ◽  
Drug Research ◽  
World Health ◽  
Therapeutic Area ◽  
Design And Synthesis ◽  
The World ◽  
Recent Developments ◽  
Health Organization ◽  
Made In

Abstract Background According to the report published recently by the World Health Organization, the number of cancer cases in the world will increase to 22 million by 2030. So the anticancer drug research and development is taking place in the direction where the new entities are developed which are low in toxicity and are with improved activity. Benzoxazole and its derivative represent a very important class of heterocyclic compounds, which have a diverse therapeutic area. Recently, many active compounds synthesized are very effective; natural products isolated with benzoxazole moiety have also shown to be potent towards cancer. Main text In the last few years, many research groups have designed and developed many novel compounds with benzoxazole as their backbone and checked their anticancer activity. In the review article, the recent developments (mostly after 2015) made in the direction of design and synthesis of new scaffolds with very potent anticancer activity are briefly described. The effect of various heterocycles attached to the benzoxazole and their effect on the anticancer activity are thoroughly studied and recorded in the review. Conclusion These compiled data in the article will surely update the scientific community with the recent development in this area and will provide direction for further research in this area.

Heterocycles in the Treatment of Neglected Tropical Diseases

2020 ◽  
Vol 27 ◽  
Author(s):  
Kush K. Maheshwari ◽  
Debasish Bandyopadhyay
Keyword(s):  
Developing Countries ◽  
Heterocyclic Compounds ◽  
Neglected Tropical Diseases ◽  
World Health ◽  
Current Status ◽  
Poor People ◽  
Tropical Diseases ◽  
Concise Review ◽  
The World ◽  
Health Organization

Background: Neglected tropical diseases (NTDs) affect a huge population of the world and majority of the victims belong to the poor community of the developing countries. Until now, the World Health Organization (WHO) has identified 20 tropical diseases as NTDs that must be addressed with high priority. However, many heterocyclic scaffolds have demonstrated potent therapeutic activity against several NTDs. Objective: There are three major objectives: (1) To discuss the causes, symptoms, and current status of all the 20 NTDs; (2) To explore the available heterocyclic drugs, and their mechanism of actions (if known) that are being used to treat NTDs; (3) To develop general awareness on NTDs among the medicinal/health research community and beyond. Methods: The 20 NTDs have been discussed according to their alphabetic orders along with the possible heterocyclic remedies. Current status of treatment with an emphasis on the heterocyclic drugs (commercially available and investigational) has been outlined. In addition, brief discussion of the impacts of NTDs on socio-economic condition is included. Results: NTDs are often difficult to diagnose and the problem is worsened by the unhealthy hygiene, improper awareness, and inadequate healthcare in the developing countries where these diseases primarily affect poor people. The statistics include duration of suffering, numbers affected, and access to healthcare and medication. The mechanism of actions of various heterocyclic drugs, if reported, have been briefly summarized. Conclusion: Scientists and pharmaceutical corporations should allocate more resources to reveal the in-depth mechanism of actions of many heterocyclic drugs that are currently being used for the treatment of NTDs. Analysis of current heterocyclic compounds and development of new medications can help in the fight to reduce/remove the devastating effects of NTDs. An opinion-based concise review has been presented. Based on available literature, this is the first effect to present all the 20 NTDs and related heterocyclic compounds under the same umbrella.

scholarly journals The effects of COVID-19 pandemic on the provision of urgent surgery: a perspective from the USA

2020 ◽  
Vol 2020 (4) ◽  
Author(s):  
Abhiman Cheeyandira
Keyword(s):  
Disease Control ◽  
Surgical Care ◽  
Lessons Learned ◽  
World Health ◽  
Urgent Surgery ◽  
The World ◽  
Control And Prevention ◽  
The Usa ◽  
Health Organization ◽  
Made In

Abstract Corona virus pandemic has affected all the 50 states in the USA. States such as NY, CA and WA being the most affected. According to the Centers for Disease Control and Prevention (CDC) website, as of 28 March 2020, the total number of cases in the USA is over 103 300 and number of deaths to 1668. In the coming weeks, COVID-19 rates are expected to begin skyrocketing and hit a peak in late April/May/June given lessons learned from China, Italy and others. COVID-19 has been declared a pandemic by the World Health Organization (WHO) as confirmed cases approach 575 444 patients with 26 654 deaths across over 160 countries, as of 28 March 2020. There is a lot of impact on management of the urgent and emergent cases. This article highlights the changes that are being made in delivering urgent and emergent surgical care during the pandemic.

Insulin safety: what is all the fuss about?

2020 ◽  
Vol 31 (11) ◽  
pp. 467-471
Author(s):  
Anne Cartwright
Keyword(s):  
Insulin Therapy ◽  
World Health ◽  
Potential Harm ◽  
The World ◽  
National Patient ◽  
The Common ◽  
Medication Incidents ◽  
Global Initiative ◽  
Health Organization ◽  
Made In

Errors in the prescribing, dispensing and administration of insulin can cause serious harm. Anne Cartwright raises awareness of the risks In 2010 National Patient Safety Alerts produced a rapid response report ‘Safer Use of Insulin’ in response to an increasing number of medication incidents leading to severe harm or death as a result of errors with insulin therapy. In 2017 the World Health Organization launched a global initiative to reduce avoidable medication error by 50% over 5 years. This article aims to raise awareness of the risks of insulin therapy, the common mistakes that can be made in the prescribing, dispensing and administration of insulin, and to inform health professionals who are involved in caring for people on insulin therapy how to reduce the risk of potential harm.

The Origins of a Global Standard for Food Quality and Safety: Codex Alimentarius Austriacus and FAO/WHO Codex Alimentarius

2012 ◽  
Vol 82 (3) ◽  
pp. 223-227 ◽  
Author(s):  
Franz Vojir ◽  
Erwin Schübl ◽  
Ibrahim Elmadfa
Keyword(s):  
Food Samples ◽  
European Countries ◽  
World Health ◽  
Trade Barriers ◽  
Codex Alimentarius ◽  
Codex Alimentarius Commission ◽  
Food And Agriculture ◽  
The World ◽  
Health Organization ◽  
Made In

In the second half of the 19th century the incidence of food adulterations increased very rapidly, prompting many European countries to put into force food laws to fight these practices. A number of parallel attempts were undertaken to establish a collection of instructions for the assessment of food samples to warrant the comparability of results obtained and interpreted by different experts. The first official steps towards such a standardization was made in 1891 at an international meeting of food chemists and microscopic scientists in Vienna. As a consequence, Austria installed a “Scientific Commission” in 1891, which drafted chapters for a future Codex Alimentarius Austriacus. In 1907, a Codex Commission was installed by the Ministry of Interior, but it took about four years, from 1907 to 1911, before the first edition of this compendium was published. So far, four editions have followed. The Codex Alimentarius Austriacus is a set of standards and guidelines for stakeholders, authorities, and law courts as a base for their activities. It has evolved over the past 100 years to become a flexible instrument, which has become indispensable for Austria. After 1945, attempts were made in different parts of the world to develop standardized rules for the testing of food samples to prevent trade barriers within the respective region. In Europe for instance, the development of a Codex Alimentarius Europaeus initiated by the Austrian Hans Frenzel, and based upon the model of the Codex Alimentarius Austriacus, made good progress. A number of other European countries were involved in this project. However, the Food and Agriculture Organization (FAO) and the World Health Organization (WHO) of the United Nations were intent on impeding such regional activities to prevent trade barriers at a global level. Between 1960 and 1963, steps were taken to install a FAO/WHO Codex partly in close cooperation with the Codex Alimentarius Europaeus. Since 1963, the FAO/WHO Codex Commission has issued the FAO/WHO Codex Alimentarius, which took its name and some organizational aspects from Codex Alimentarius Europaeus, that was itself modeled after the Codex Alimentarius Austriacus. The Codex Alimentarius Europaeus was incorporated into the Codex Alimentarius Commission as the regional coordinating committee for Europe, thus providing a model for the six regional coordination committees of the Codex Alimentarius Commission existing today.

scholarly journals Acridine-Based Antimalarials—From the Very First Synthetic Antimalarial to Recent Developments

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 600
Author(s):  
Mélanie Fonte ◽  
Natália Tassi ◽  
Paula Gomes ◽  
Cátia Teixeira
Keyword(s):  
Low Cost ◽  
Antimalarial Drugs ◽  
World Health ◽  
Cost Strategy ◽  
The World ◽  
Recent Developments ◽  
Low Cost Strategy ◽  
Health Organization ◽  
Emergence Of Resistance ◽  
Artemisinin Combination Therapies

Malaria is among the deadliest infectious diseases in the world caused by Plasmodium parasites. Due to the high complexity of the parasite’s life cycle, we partly depend on antimalarial drugs to fight this disease. However, the emergence of resistance, mainly by Plasmodium falciparum, has dethroned most of the antimalarials developed to date. Given recent reports of resistance to artemisinin combination therapies, first-line treatment currently recommended by the World Health Organization, in Western Cambodia and across the Greater Mekong sub-region, it seems very likely that artemisinin and its derivatives will follow the same path of other antimalarial drugs. Consequently, novel, safe and efficient antimalarial drugs are urgently needed. One fast and low-cost strategy to accelerate antimalarial development is by recycling classical pharmacophores. Quinacrine, an acridine-based compound and the first clinically tested synthetic antimalarial drug with potent blood schizonticide but serious side effects, has attracted attention due to its broad spectrum of biological activity. In this sense, the present review will focus on efforts made in the last 20 years for the development of more efficient, safer and affordable antimalarial compounds, through recycling the classical quinacrine drug.

World Health Organization

1959 ◽  
Vol 13 (1) ◽  
pp. 159-161 ◽  
Keyword(s):  
World Health Organization ◽  
World Health ◽  
Director General ◽  
Health Work ◽  
Inaugural Address ◽  
The World ◽  
Training Activities ◽  
Health Organization ◽  
Regular Session ◽  
Made In

To mark the celebration of the tenth anniversary of the World Health Organization (WHO), the eleventh regular session of the Assembly was preceded by a special two-day tenth anniversary commemorative session. The eleventh session was held in Minneapolis, Minnesota, from May 28 to June 13, 1958. The President of the Assembly (Dr. Leroy E. Burney) stated in his inaugural address that WHO's efforts during its first ten years had been concentrated largely on the fight against the major communicable diseases. He emphasized the necessity for more research, the importance of intensifying training activities, and the need for wider public participation in health work. The Director-General, introducing his report on the work of WHO during 1957, stated that one indication of the direction in which WHO's work was likely to develop in the future was to be found in the repeated references made in the report to the coordination of research. He stated that one of the most pressing immediate needs continued to be the strengthening of national health services. He proposed an effective working budget for 1959 of $14,287,600, which represented an increase of 5.3 percent over the effective working budget for 1958. The Assembly approved the proposed budget.

World Health Organization

1960 ◽  
Vol 14 (3) ◽  
pp. 473-475 ◽  
Keyword(s):  
Medical Research ◽  
World Health Organization ◽  
Research Program ◽  
World Health ◽  
Executive Board ◽  
The World ◽  
Percent Increase ◽  
Health Organization ◽  
Outstanding Work ◽  
Made In

The Executive Board of the World Health Organization (WHO) held its 25th session in Geneva, January 19—February 1, 1960, under the chairmanship of Professor E. Aujaleu. At the onset, the Board unanimously recommended that the World Health Assembly adopt a working budget of $18,569,620 for 1961, representing a 10 percent increase over the preceding year, due to the growth of the Organization's activities. The Board also considered a report, based on the recommendations of its Advisory Committee on Medical Research, on the general development of the medical research program; it dealt with such subjects as malaria, tuberculosis, leprosy, and insecticide resistance, among others. It recommended that priority be given to the following: 1) services to research, such as the standardization of nomenclature and techniques and equipment to ensure comparable results in different parts of the world; 2) setting up reference centers; and 3) improving the training of research workers and communications among them. Noting these priorities, the Board expressed its satisfaction with the proposed research program for 1960–1961. The Board also considered a UN resolution on the encouragement of international cancer research through awarding prizes for outstanding work in this field; however, on the basis of a study made in connection with the intensification of its medical research program, the Board expressed doubt whether awarding prizes was the most suitable means of encouraging research.

scholarly journals Substandard and Falsified Medicines in Myanmar

Pharmacy ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. 45
Author(s):  
Mirai Sakuda ◽  
Naoko Yoshida ◽  
Takashi Takaoka ◽  
Tomoko Sanada ◽  
Mohammad Sofiqur Rahman ◽  
...  
Keyword(s):  
World Health ◽  
Dissolution Test ◽  
Regulatory Guidance ◽  
Substandard Medicines ◽  
The World ◽  
Quality Testing ◽  
Falsified Medicines ◽  
Health Organization ◽  
The Relationship ◽  
Made In

Background: substandard and falsified medicines (SFMs) are a threat to public health. The availability of SFMs in Myanmar was reported by the World Health Organization (WHO) in 1999, but there have been few systematic surveys on falsified medicines in Myanmar since then. The aim of this study is to examine the extent of SFMs for sale in Myanmar. Methods: target medicines were tablets of candesartan, metformin, and pioglitazone, and infusions of ciprofloxacin and levofloxacin. Samples were collected from hospitals, pharmacies, and wholesalers located in the Mandalay region in 2015. We carried out observation testing, authenticity investigation, and quality testing to search for SFMs, and analyzed the relationship between SFMs and the price and store type. Results: There were no falsified medicines found in the authenticity check, though there remained a problem due to low response rates from manufacturers and regulatory authorities. In the quality test, some tablets of metformin and pioglitazone made in India failed the dissolution test. Conclusions: although no serious problems were found, some substandard medicines were detected. Regular surveys to monitor SFMs are therefore recommended, together with further regulatory guidance to improve conditions in all medicine manufacturers, distributors, and pharmacies.

Token Economies and Other Token Programmes in the United States

1978 ◽  
Vol 6 (3) ◽  
pp. 56-69
Author(s):  
J. Fernandez
Keyword(s):  
United States ◽  
The United States ◽  
Token Economy ◽  
World Health ◽  
Funding Agency ◽  
Final Report ◽  
Token Economies ◽  
The World ◽  
Health Organization ◽  
Made In

Following the setting-up of the token economy programme (T.E.P.) in St. Brendan's Hospital, Dublin in 1968 (Fingleton and Mccutchan, 1969) and completion of the first series of studies (Fernandez, 1972, a) this author was awarded a Travelling Fellowship by the World Health Organization, Geneva; which enabled him to visit a number of T.E. Programmes in the United States. Following the above visit, a Final Report was submitted to the funding agency (Fernandez, 1972, c). This paper will concern itself with a summary of all observations made in the above Report, and where relevant, these observations have been up-dated in the light of recent research developments and with other informal observations not mentioned in the Final Report.

scholarly journals Thoracic Surgery during Covid-19 Pandemic; Single Center Experience

Acta Medica ◽  
2020 ◽  
Vol 51 (3) ◽  
pp. 32-37
Author(s):  
İlknur Aytekin Çelik ◽  
Eray Cınar ◽  
Nurettin Karaoğlanoğlu
Keyword(s):  
Thoracic Surgery ◽  
Social Life ◽  
World Health ◽  
Clinical Procedures ◽  
Single Center Experience ◽  
The World ◽  
Health Institutions ◽  
Health Organization ◽  
Positive Results ◽  
Made In

  OBJECTIVE After the world health organization declared the Covid-19 epidemic as a pandemic, serious changes were made in the functioning of health institutions along with restrictions in social life. The aim of this study is investigating the operations and clinical procedures performed in a thoracic surgery clinic during covid pandemic. MATERIAL AND METHOD In this study, the surgical procedures performed in the thoracic surgery clinic between March 2020 and June 2020 which is accepted as the first wave dates for Covid-19 in our country are presented. RESULTS Totally, nineteen patients are operated during this period. Average age was 44 (12-68) years old. Forty-three covid PCR tests were performed for a total of 19 patients. Three of them were positive results for Covid-19. After operations one patient died due to septic shock during postoperative period. CONCLUSION Malignancy and emergency surgeries can be performed by following precautions in the outbreak of Covid-19.

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