A randomized control study on the effects of prescriptive exercise on lean mass and fatigue in breast cancer patients undergoing treatment

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 19560-19560
Author(s):  
C. Battaglini ◽  
C. A. Dennehy
Keyword(s):  
Lean Mass ◽  
Repeated Measures ◽  
Mixed Model ◽  
Caloric Intake ◽  
Breast Cancer Patients ◽  
Significant Interaction Effect ◽  
Post Surgery ◽  
Significant Difference ◽  
Post Hoc ◽  
And Control

19560 Background: Loss of lean mass during cancer treatment has been correlated with increases in fatigue (F) levels. Exercise is related to decreases treatment related fatigue and has been shown to thwart muscle loss. Methods: Twenty female subjects, ages ranging from 35 to 70 years, were recruited for the 21 week study. A randomized two-group (exercise and control) design with multiple measurements [Pre-surgery (PS), Post-surgery (POS), 1st assessment during Chemotherapy (Chemo1), 2nd assessment (Chemo 2), 3rd assessment (Chemo 3), and at the end of the experiment (FA)] was used. Percent of lean body mass (%LBM) and F levels were measured as dependent variables. Also, creatine kinase (CK) and total caloric intake (TCI) were measured to explain changes in %LBM and F. Data were analyzed using a two-way mixed model ANOVA with repeated-measures. Results: No significant difference in %LBM from PS to FA (p = 0.82) was observed. However, a significant interaction effect between groups and %LBM from PS to FA was observed (p<0.000). Post hoc analyses revealed significant difference in %LBM between groups at the FA (p = 0.004). Significant differences in F scores were observed between PS and FA (p=0.008). Post hoc analyses revealed significant difference in F scores between groups at Chemo 1, (p=0.001), Chemo 2, (p=0.005), and FA (p=0.000). No differences in CK were noted, however significant differences were noted between groups at PS (p=0.000) and FA (p=0.000) for TCI. Conclusions: The results suggest that initiating a regular individualized prescriptive exercise immediately following surgical recovery and continuing through at least 12 weeks during chemotherapy treatment positively impacts %LBM and deceases F when compared to patients not involved in any exercise. No significant financial relationships to disclose.

Effect of communication skills based group counseling on mothers’ sex dialogue with their adolescent daughters

2018 ◽  
Vol 0 (0) ◽  
Author(s):  
Tayebe Ziaei ◽  
Maryam Ghanbari Gorji ◽  
Naser Behnampour ◽  
Masumeh Rezaei Aval
Keyword(s):  
Communication Skills ◽  
Group Counseling ◽  
Repeated Measures ◽  
Intervention Group ◽  
Health Centers ◽  
Chi Square ◽  
Significant Difference ◽  
Mother And Daughter ◽  
Post Hoc ◽  
And Control

AbstractBackgroundSex dialogue is one of the most critical and challenging topics between mothers and adolescents. The knowledge and skills of mothers in sex dialogue with their daughters are essential. The purpose of this study is to determine the effect of group counseling based on communication skills on mothers through their sex dialogue with their daughters.MethodsA randomized controlled field trial was conducted on 168 couples of mothers and their daughters selected by the stratified matching method and randomly divided into two control and intervention groups. The mothers in the intervention group participated in a communication-based consultation in groups consisting of 6–12 people for 6–7 weekly sessions, each one lasting 60 min. The data collection tool was a Persian-translated questionnaire by Jaccard for sex dialogue between mother and daughter. The data were analyzed using Chi-square (χ2), ANOVA with repeated measures and modified post hoc Bonferroni tests.ResultsThere was a significant difference in the mean score of mother-daughter sex dialogue 1 week after intervention between the intervention (34.48 ± 8.74) and control (40.44 ± 9.49) groups (p = 0.001) and 1 month after the intervention between the intervention (30.41 ± 10.07) and control (42.47 ± 9.62) groups (p < 0.001).ConclusionThrough applying communication skills, an increase in mother-daughter sex dialogue frequency was observed after group counseling. Therefore, it is suggested to promote mother-daughter communication skills by accessing the mothers via schools, health centers and with the aid of midwifery counselors, midwives and other trained caretakers.

scholarly journals Efficacy of galcanezumab in patients with migraine who did not benefit from commonly prescribed preventive treatments

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Dulanji K. Kuruppu ◽  
Joshua Tobin ◽  
Yan Dong ◽  
Sheena K. Aurora ◽  
Laura Yunes-Medina ◽  
...  
Keyword(s):  
Repeated Measures ◽  
Migraine Headache ◽  
Mixed Model ◽  
Preventive Treatment ◽  
Response Rates ◽  
Toxin A ◽  
Double Blind ◽  
Preventive Medication ◽  
Onabotulinum Toxin A ◽  
Post Hoc

Abstract Background Galcanezumab is a calcitonin gene-related peptide (CGRP) monoclonal antibody (mAb) indicated for the preventive treatment of migraine. While galcanezumab has demonstrated efficacy in patients who did not respond to prior preventive medications in general, its efficacy in patients who did not benefit from individual, commonly prescribed preventive treatments due to inadequate efficacy or safety/tolerability remains unknown. Methods CONQUER was a 3-month, randomized, double-blind, placebo-controlled, phase 3b study that enrolled patients with episodic or chronic migraine who had 2 to 4 migraine preventive medication category failures in the past 10 years. Patients were randomly assigned 1:1 to receive placebo (N = 230) or galcanezumab 120 mg/month (240 mg loading dose; N = 232). Post hoc analyses were conducted to determine the efficacy of galcanezumab in patients who had not benefited from six of the most commonly prescribed migraine preventive medications. The mean change from baseline in monthly migraine headache days and ≥ 50 % response rates were assessed over months 1–3. Improvement in Migraine-Specific Questionnaire Role Function-Restrictive (MSQ-RFR) scores were assessed at month 3. The endpoints were estimated via mixed model with repeated measures. Results The most common treatment failures due to inadequate efficacy or safety/tolerability, which at least 20 % of patients reported trying without benefit, included topiramate, amitriptyline, propranolol, valproate or divalproex, onabotulinum toxin A, and metoprolol. Patients who had not previously benefited from these treatments had a greater mean reduction in monthly migraine headache days across months 1–3 in the galcanezumab group compared to placebo (all p < 0.01). More patients treated with galcanezumab experienced a ≥ 50 % reduction from baseline in monthly migraine headache days across months 1–3 compared to placebo (all p < 0.05). Galcanezumab-treated patients had a greater improvement in mean MSQ-RFR scores at month 3 compared to placebo (all p < 0.01). Conclusions In this population, galcanezumab was effective in reducing monthly migraine headache days, improving response rates, and enhancing quality of life in patients who had not previously benefited from topiramate, amitriptyline, propranolol, valproate or divalproex, onabotulinum toxin A, and/or metoprolol due to inadequate efficacy or safety/tolerability. Trial registration ClinicalTrials.gov NCT03559257 (CONQUER).

scholarly journals Effect of Educational Workshops on Disaster Risk Perception in Nurses

2020 ◽  
pp. 270-278
Keyword(s):  
Risk Perception ◽  
Repeated Measures ◽  
Intervention Group ◽  
Round Table ◽  
Disaster Risk ◽  
National Standards ◽  
Control Group ◽  
Repeated Measures Analysis ◽  
Post Hoc ◽  
And Control

INTRODUCTION: The enhancement of nurses’ risk perception plays a significant role in their preparedness during disasters and emergencies. Therefore, this study aimed to investigate the effect of educational workshops on disaster risk perception in nurses METHODS: This randomized controlled field trial study included 62 nurses working at Razi Hospital, Birjand, Iran. The participants were divided into intervention and control groups. The intervention group was then requested to participate in a one-day intensive educational workshop based on the current national standards. The workshop content included a combination of lecturing methods, round-table exercises, and film display. The data were collected using the demographic characteristic form and researcher-made questionnaires measuring the nurses’ risk perception during disasters and emergencies. Subsequently, the data were analyzed using independent t-test, repeated measures analysis, and Bonferroni post hoc tests. FINDINGS: The mean total score of risk perception were significantly higher in the intervention group before, immediately, and two months after the workshop session, compared to those in the control group (P˂0.001). CONCLUSION: The implementation of nurses’ national preparation program during disasters and emergencies can result in an increase in the nurses’ risk perception during these events. Therefore, regarding the importance of nurses’ preparedness in confrontation with disasters and emergencies, it seems necessary to integrate the National Preparedness Program into the educational programs immediately after recruitment and in the form of in-service courses.

scholarly journals Effect of Carnatic Music Listening Training on Speech in Noise Performance in Adults

2021 ◽  
Vol 25 (1) ◽  
pp. 22-26
Author(s):  
Raksha Amemane ◽  
Archana Gundmi ◽  
Kishan Madikeri Mohan
Keyword(s):  
Repeated Measures ◽  
Functional Organization ◽  
Control Group ◽  
Music Listening ◽  
Noise Performance ◽  
Short Term ◽  
Speech In Noise ◽  
Carnatic Music ◽  
Significant Difference ◽  
And Control

Background and Objectives: Music listening has a concomitant effect on structural and functional organization of the brain. It helps in relaxation, mind training and neural strengthening. In relation to it, the present study was aimed to find the effect of Carnatic music listening training (MLT) on speech in noise performance in adults.Subjects and Methods: A total of 28 participants (40-70 years) were recruited in the study. Based on randomized control trial, they were divided into intervention and control group. Intervention group underwent a short-term MLT. Quick Speech-in-Noise in Kannada was used as an outcome measure.Results: Results were analysed using mixed method analysis of variance (ANOVA) and repeated measures ANOVA. There was a significant difference between intervention and control group post MLT. The results of the second continuum revealed no statistically significant difference between post training and follow-up scores in both the groups.Conclusions: In conclusion short-term MLT resulted in betterment of speech in noise performance. MLT can be hence used as a viable tool in formal auditory training for better prognosis.

Appetite-stimulating effect of gabapentin vs mirtazapine in healthy cats post-ovariectomy

2020 ◽  
Vol 22 (12) ◽  
pp. 1176-1183
Author(s):  
Marco Fantinati ◽  
Julien Trnka ◽  
Amélia Signor ◽  
Séverine Dumond ◽  
Géraldine Jourdan ◽  
...  
Keyword(s):  
Placebo Group ◽  
Food Intake ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Repeated Measure ◽  
Mixed Model Analysis ◽  
Treatment Groups ◽  
Significant Difference ◽  
Post Hoc ◽  
Difference Test

Objectives The aim of the study was to evaluate the appetite-stimulating effect of gabapentin by comparing it with mirtazapine in healthy cats in the first 8 h after ovariectomy surgery. Methods This double-masked, placebo-controlled, prospective clinical trial included 60 healthy cats presented to the hospital for ovariectomy: 20 received gabapentin, 21 received mirtazapine and 19 received a placebo immediately before and 6 h after surgery. Food was offered at 2, 4, 6 and 8 h post-ovariectomy. After each meal, food intake was measured. Data were analysed using repeated-measure ANOVA and a linear mixed-model analysis. Post-hoc Tukey’s honest significant difference test was performed for multiple comparisons. Results Food intake increased in both treatment groups vs placebo. No statistically significant difference was found between cats treated with gabapentin or mirtazapine. Conclusions and relevance Cats receiving gabapentin ate more than cats in the placebo group. Thirty percent of cats in the gabapentin group covered their resting energy requirements, while none of the cats in the placebo group did. Gabapentin and mirtazapine produced similar effects on food intake.

Post hoc analysis of a randomised, placebo-controlled, active-reference 6-week study of brexpiprazole in acute schizophrenia

2020 ◽  
Vol 32 (3) ◽  
pp. 153-158 ◽  
Author(s):  
Stephen R. Marder ◽  
Hans Eriksson ◽  
Yudong Zhao ◽  
Mary Hobart
Keyword(s):  
Adverse Events ◽  
Repeated Measures ◽  
Mixed Model ◽  
Least Square ◽  
Analysis Of Covariance ◽  
Sensitivity Analyses ◽  
Symptom Improvement ◽  
Syndrome Scale ◽  
Quetiapine Xr ◽  
Post Hoc

AbstractObjective:We provide a closer look at the result of a randomised, placebo-controlled, active-reference (quetiapine XR), flexible-dose, 6-week study of brexpiprazole in schizophrenia, which did not meet its primary endpoint – change from baseline in Positive and Negative Syndrome Scale (PANSS) total score. We also investigate potential expectancy bias from the well-known side-effect profile of the active reference that could have affected the study outcome.Methods:Pre-specified sensitivity analyses of the primary end point were performed using analysis of covariance (ANCOVA) last observation carried forward (LOCF) and observed cases (OC). Post hoc analyses of change from baseline in PANSS total score were performed using the mixed model for repeated measures approach with treatment groups split by having typical adverse events with potential for functional unblinding, for example, somnolence, increase in weight, dizziness, dry mouth and sedation.Results:Pre-specified sensitivity analyses showed separation from placebo for brexpiprazole at week 6: LOCF, ANCOVA: −4.3 [95% CI (−8.0, −0.5), p = 0.0254]. OC, ANCOVA: −3.9 [95% CI (−7.3, −0.5), p = 0.0260]. Patients treated with brexpiprazole experiencing typical adverse events with potential for functional unblinding before or at Week 2 had a least square (LS) mean PANSS change of −29.5 (improvement), with a difference in change from baseline to Week 6 in PANSS total score between brexpiprazole and placebo of −13.5 [95% CI (−23.1, −4.0), p = 0.0057], and those who did not had an LS mean change of −18.9 and a difference between brexpiprazole and placebo of −2.9 [95% CI (−7.2, 1.4), p = 0.1809].Conclusion:Pre-specified sensitivity analyses showed separation from placebo for brexpiprazole at Week 6. A post hoc analysis suggested a potential confounding of efficacy rating towards symptom improvement in patients who experience known side effects of quetiapine XR.

Music and mindfulness meditation: Comparing four music stimuli composed under similar principles

2020 ◽  
pp. 030573562096979
Author(s):  
Eugenia Hernandez-Ruiz ◽  
Abbey L Dvorak
Keyword(s):  
Repeated Measures ◽  
Mixed Model ◽  
Mindfulness Meditation ◽  
New Music ◽  
Original Music ◽  
Evidence Based ◽  
Supporting Evidence ◽  
Significant Preference ◽  
Repeated Measures Analysis ◽  
Significant Difference

Mindfulness meditation has frequently used sound and music as an important component. However, research on effective music stimuli is scarce. After a series of studies evaluating the most effective, useful, and preferred auditory stimuli, we were interested in exploring whether these effective musical features were transferred to new music. In this study, we evaluate our original music stimuli with three new stimuli composed under similar principles. Non-musician and musician participants ( N = 114) in a multisite study evaluated their mindfulness state after listening to four music stimuli, and rated their usefulness and preference. Results from a repeated-measures analysis of variance (ANOVA) at each site indicated no significant difference in mindfulness effectiveness. Friedman’s ANOVAs for the usefulness of the music stimuli showed similar non-significant results in both sites. A mixed model among sites did not show significant differences among groups. Preference rankings were not significantly different for non-musicians, but musicians did show a statistically significant preference of the Original stimuli over Stimulus 2, probably due to sound quality. These results indicate the feasibility of transferring previously researched and effective musical features to new stimuli. Identifying the effective “active ingredients” of music interventions may be one way of supporting evidence-based practice in music therapy.

Static and Dynamic Acute Stretching Effect on Gymnasts’ Speed in Vaulting

2003 ◽  
Vol 15 (4) ◽  
pp. 383-391 ◽  
Author(s):  
Theophanis Siatras ◽  
Georgios Papadopoulos ◽  
Dimitra Mameletzi ◽  
Vasilios Gerodimos ◽  
Spiros Kellis
Keyword(s):  
Repeated Measures ◽  
Acute Effect ◽  
Static Stretching ◽  
Warm Up ◽  
Dynamic Stretching ◽  
Significant Difference ◽  
Post Hoc ◽  
Stretching Effect ◽  
Stretching Exercises

Although warm-up and stretching exercises are routinely performed by gymnasts, it is suggested that stretching immediately prior to an activity might affect negatively the athletic performance. The focus of this investigation was on the acute effect of a protocol, including warm-up and static and dynamic stretching exercises, on speed during vaulting in gymnastics. Eleven boys were asked to perform three different protocols consisting of warm-up, warm-up and static stretching and warm-up and dynamic stretching, on three nonconsecutive days. Each protocol was followed by a “handspring” vault. One-way analysis of variance for repeated-measures showed a significant difference in gymnasts’ speed, following the different protocols. Tukey’s post hoc analysis revealed that gymnasts mean speed during the run of vault was significantly decreased after the application of the static stretching protocol. The findings of the present study indicate the inhibitory role of an acute static stretching in running speed in young gymnasts.

Pairwise Multiple Comparisons in Repeated Measures Designs

1980 ◽  
Vol 5 (3) ◽  
pp. 269-287 ◽  
Author(s):  
Scott E. Maxwell
Keyword(s):  
Repeated Measures ◽  
Mixed Model ◽  
Multiple Comparisons ◽  
Error Rates ◽  
Type I ◽  
Omnibus Test ◽  
Mixed Model Approach ◽  
Significant Difference ◽  
Repeated Measures Designs ◽  
Necessary And Sufficient

Five methods of performing pairwise multiple comparisons in repeated measures designs were investigated. Tukey's Wholly Significant Difference (WSD) test, recommended by most experimental design texts, requires that all differences between pairs of means have a common variance. However, this assumption is equivalent to the sphericity condition that is necessary and sufficient for the validity of the mixed-model approach to the omnibus test. Monte Carlo methods revealed that Tukey's WSD leads to an inflated alpha level when the sphericity assumption is not met. Consideration of both Type I and Type II error rates found in the simulated conditions for the five procedures suggests that a Bonferroni method utilizing a separate error term for each comparison should be employed.

scholarly journals Comparison of the Effectiveness of Cognitive Behavioral Therapy and Neurofeedback: Reducing Insomnia Symptoms

2017 ◽  
Vol 9 (7) ◽  
pp. 35 ◽  
Author(s):  
Nooshin Basiri ◽  
Zahra Khayyer ◽  
Habib Hadianfard ◽  
Amirhossein Ghaderi
Keyword(s):  
Cognitive Behavioral Therapy ◽  
Behavioral Therapy ◽  
Cognitive Behavioral ◽  
Independent Effect ◽  
Control Group ◽  
Significant Difference ◽  
Post Hoc ◽  
And Control ◽  
Insomnia Symptoms ◽  
Selection Of

INTRODUCTION: The term sleep disorder refers to difficulty in initiating sleep, maintaining it or a relaxing sleep despite having enough time to sleep. Cognitive behavioral therapy is a non-drug multi-dimensional treatment that targets behavioral and cognitive factors of this disorder. Some pieces of research have shown that psychiatric and neurological disorders can be distinguished from distinct EEG patterns and neuro-feedback can be used to make a change in these patterns. This study aimed to compare the cognitive behavioral therapy and neuro-feedback in the treatment of insomnia.METHODS: The sample included people, who had already been diagnosed insomnia by a psychiatrist in Isfahan, Iran. Random sampling was employed to choose the participants. Pittsburg sleep quality index (PSQI) was used for the selection of the participants, too. The sample included 40 patients who were randomly selected and interviewed and then diagnostic tests performed on the PSQI, and then they were divided into 3 groups. Data were analyzed using ANOVA. Following the implementation of the independent effect of the treatment was significant and one-way ANOVA with post hoc test L.S.D were carried out on CBT and controls (p = 0.001), CBT, neuro-feedback therapy (p = 0.003), neuro-feedback treatment and control (p = 0.001).RESULTS: It was shown that there was a significant difference between the groups. Based on the descriptive statistics of the 2 abovementioned treatments, neuro-feedback therapy in first position and cognitive-behavioral therapy were most effective in the second position, and the control group showed the lowest efficiency.CONCLUSIONS: Both treatments were significantly effective, and so we can use both neuro-feedback and CBT for the treatment of insomnia.

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