HPV test self collection versus CO-testing (2015-2018): New experience in a screening program in a northern province of Argentina, Tucumán.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e13063-e13063
Author(s):  
Juan Jose Zarba ◽  
Silvia Victoria Holgado ◽  
Conrado Oscar Cinto ◽  
Veronica Ali ◽  
Maria Fernanda Arrieta ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
At Risk ◽  
Biological Material ◽  
Pap Smear ◽  
Screening Program ◽  
Pap Test ◽  
Uterine Cervical Cancer ◽  
Cervical Cancer Prevention ◽  
Population Screening ◽  
Hpv Test

e13063 Background: The benefits of population screening under the program in women at risk of uterine cervical cancer both methodsof detection, the search of lesions by gynecological cytology or the search for infection by oncogenic virus of the VPH family is widely demonstrated. Each of them has considerations to favor and others against. In Tucuman the two are applied since December 2014. Objective:to analyze partial results of the first stage of application of two methods under population screening program in women at risk of cervical cancer in Tucumán, Argentina. Methods: We analized the period December 2014 December 2018 of the files of the national register (SITAM: Sistema de Información de tamizaje- It is an on-line information system that allows the nominalized registration of women who access studies, diagnoses and treatments for the prevention of cervical cancer).49337samples from non-pregnant, aged 30 and older women without health insurance were included. 2 collection methods were applied: "Co-testing" (CT), cytological for PAP test and biological sampling for HPV Test ((T-HPV) and "Self-collected sampling" (SC) biological material for T-HPV. In cytology, Pap smear were stained with Papanicolaou and for the biological material, T-HPV Hybrid Capture was applied to detect 13 oncogenic HPV types. Bethesda System was used for cytological diagnosis. Results: until 2019 January, 49337 samples were processed, 7352 (14,8%) womenhave HPV oncogenic. Conclusions: the application of T-HPV to SC samples showed a interesting positivity,demonstrating once again T-HPV is an important strategy in the cervical cáncer prevention program.[Table: see text]

scholarly journals Breakthroughs and Issues in HPV Genital Infections in relation to Cervical Cancer

2012 ◽  
Vol 1 (2) ◽  
pp. 27-30
Author(s):  
Farhat Hussain ◽  
Khairun Nahar ◽  
Kaniz Fatema ◽  
Mahbuba Khan
Keyword(s):  
Cervical Cancer ◽  
Pap Smear ◽  
Pap Test ◽  
Cervical Cancer Prevention ◽  
Cervical Lesions ◽  
Related Condition ◽  
Papilloma Virus ◽  
Medical College ◽  
Hpv Test ◽  
Neoplastic Process

The field of cervical cancer prevention is rapidly evolving because of identification of the cause of disease. Human Papilloma Virus (HPV) has been recognized as a necessary cause of cervical cancer, and the association applies equally to both squamous cell and adenocarcinoma and is consistent worldwide. HPV 16 and 18 together attribute 70% of world's cervical cancer. HPV is highly prevalent among sexually active women and traceable in its natural history with technology that can detect HPV DMA at all stages of infection and neoplastic process. HPV DMA testing represents the scientifically obvious next step after Pap test for secondary prevention. A clinically validated and FDA approved HPV test has proven a substantial gain in sensitivity with a limited loss in speciality as compared to the standard Pap smear. We are now in the fortunate position of having two highly promising HPV vaccines in the pipeline. These vaccines today represent new hope for protection against cervical cancer, pre-cancerous cervical lesions and other HPV related condition for the current generation of adolescents, for the young and middle aged women as well as for the future generations. DOI: http://dx.doi.org/10.3329/jssmc.v1i2.12163 Journal of Shaheed Suhrawardy Medical College Vol.1, No.2, December 2009 p.27-30

scholarly journals A community based study to determine incidence of cervical cancer and willingness of women to participate in cervical cancer screening program in Navsari, Gujarat, India

2019 ◽  
Vol 8 (10) ◽  
pp. 3954
Author(s):  
Parth H. Vyas ◽  
Kanchan Dhadwe ◽  
Harsha A. Shah ◽  
Hiral M. Dave ◽  
Ashwin A. Shah
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Cervical Cancer Screening ◽  
Pap Smear ◽  
Screening Program ◽  
Pap Test ◽  
Health Seeking ◽  
Positive Health ◽  
Cytological Examination ◽  
Major Health Problem

Background: Carcinoma of the uterine cervix is a major health problem faced by the Indian women. Regular cervical cytological examination by all sexually active women can prevent the occurrence of carcinoma cervix. Early detection of cervical cancer is possible with Pap smear tests. Methods: Women above 25 years of age, living in study area and want to participate in study were included. Total 2352 women were enrolled in study. House to house visits were conducted in all the village area by using simple random sampling method. Information about cervical cancer was given. Pap test for cervical cancer screening was carried out by gynaecologist. Cytological examination and confirmation was done by pathologists.Results: A total of 3001 women had attended village level IEC session and out that, 2352 (78.4%) women took part in the screening program. Out of these 2352 women, 2007 women (85.3% compliance) had given consent for physical cervical examination and Pap smear. The incidence of cervical cancer was 0.2% on the basis of clinical examination and biopsy.Conclusions: Higher compliance for undergoing vaginal examination and Pap test shows the positive health seeking behaviour of the women but for that, strong IEC and sensitization about the disease must be done to improve the participation. Sensitivity of Pap test was poor and couldn’t find true positive cases.

PP62 Cost-Effectiveness Of Cervical Cancer Screening In Estonia

2019 ◽  
Vol 35 (S1) ◽  
pp. 49-49
Author(s):  
Triin Võrno ◽  
Kaja-Triin Laisaar ◽  
Terje Raud ◽  
Kai Jõers ◽  
Doris Meigas-Tohver ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cost Effectiveness ◽  
Cancer Screening ◽  
Cervical Cancer Screening ◽  
Screening Program ◽  
Pap Test ◽  
Cancer Screening Program ◽  
Hpv Test ◽  
Cervical Cancer Screening Program ◽  
The Cost

IntroductionIn Estonia, organized cervical cancer screening program is targeted at women aged 30–55(59) years and Pap-tests are taken every five years. Since cervical cancer is associated with human papillomavirus (HPV), a number of countries have introduced the HPV-test as the primary method of screening. The objective of this study was to evaluate the cost-effectiveness of organized cervical cancer screening program in Estonia by comparing HPV- and Pap-test based strategies.MethodsFor the cost-effectiveness analysis, a Markov cohort model was developed. The model was used to estimate costs and quality-adjusted life-years (QALYs) of eight screening strategies, varying the primary screening test and triage scenarios, upper age limit of screening, and testing interval. Incremental cost-effectiveness ratios (ICERs) were calculated in comparison to current screening practice as well as to the next best option. Sensitivity analysis was performed by varying one or more similar parameter(s) at a time, while holding others at their base case value. The analysis was performed from the healthcare payer perspective adopting a five percent annual discount rate for both costs and utilities.ResultsIn the base-case scenario, ICER for HPV-test based strategies in comparison to the current screening practice was estimated at EUR 8,596–9,786 per QALY. For alternative Pap-test based strategies ICER was estimated at EUR 2,332–2,425 per QALY. In comparison to the next best option, HPV-test based strategies were dominated by Pap-test based strategies. At the cost-effectiveness threshold of EUR 10,000 per QALY Pap-testing every three years would be the cost-effective strategy for women participating in the screening program from age 30 to 63 (ICER being EUR 3,112 per QALY).ConclusionsDecreasing Pap-test based screening interval or changing to HPV-test based screening can both improve the effectiveness of cervical cancer screening program in Estonia, but based on the current cost-effectiveness study Pap-test based screening every three years should be preferred.

scholarly journals Socio-demographic and Clinical Characteristic of Women Availing Pap Smear Services in Samtse District, Bhutan

2020 ◽  
Vol 5 (2) ◽  
pp. 63-70
Author(s):  
Thinley Dorji ◽  
Hari Prasad Pokhrel ◽  
Tshokey Tshokey
Keyword(s):  
Cervical Cancer ◽  
Pap Smear ◽  
Screening Program ◽  
Age Groups ◽  
Malignant Lesion ◽  
Pap Test ◽  
Reproductive Age ◽  
Test Results ◽  
Malignant Lesions ◽  
Reproductive Age Group

Background: The case burden of cervical cancer has been increasing globally especially in developing countries without proper health system. Cervical cancer can be eliminated with timely vaccination and screening program as it usually takes years for pre-malignant lesions to develop into malignant lesion. Bhutan has committed to eliminate cervical cancer. Thus, it is important to understand the factors associated with abnormal Pap test findings. Methodology: A retrospective study was conducted using the Pap smear data for the year 2018. It was extracted from the records maintained in the cytology unit of Samtse General Hospital. Result: The abnormal slide rate in this study was 2.5%. The majority of women seeking Pap smear services were women in reproductive age group and housewife by occupation. There were significant differences between age groups and marital status among normal in the Pap test results. Conclusion: The slide abnormality of Pap smear in Samtse District is low. The abnormality is more common among married and older women. Therefore, additional screening efforts needs to be put into this group to detect pre-malignant lesions.

scholarly journals Immunological study of cervical biopsy specimen for human papiloma virus

2014 ◽  
Vol 2 (3) ◽  
pp. 145-148
Author(s):  
Surya Prabha V ◽  
Kanaka Bushanam GVVS ◽  
Sakuntaladevi G ◽  
Dharani Priya B
Keyword(s):  
Cervical Cancer ◽  
General Hospital ◽  
Pap Smear ◽  
Squamous Metaplasia ◽  
Pap Test ◽  
Cervical Cancer Prevention ◽  
Severe Dysplasia ◽  
Immunological Study ◽  
Cervical Biopsy ◽  
Visakhapatnam District

Background: Cervical cancer is one of the most common cancers among women worldwide and its rates are higher in low and middle income countries. India is one not exemplified from the developing countries. Aims: The main aim of the present work is a preliminary prospective screening study to observe the incidence of human papilloma virus (HPV) virus in the specimens of cervical biopsy taken from the patients of gynecology department of Visakha Steel General Hospital, RINL, Visakhapatnam district. Screening procedures like Pap smear, Colposcopy Immunohistochemistry (IHC) were done to identify the prevalence of HPV. It is an effort to assess and also improving the quality of cervical cancer prevention and treatment services in Visakhapatnam district of North coastal Andhra Pradesh. Settings and design: This prospective study was conducted at the department of obstetrics and gynaecology, Visakha Steel General Hospital, RINL, Visakhapatnam district from January 2010 to December 2010. Materials and methods: The Pap test and colposcopic examination were conducted on 161 patients and IHC was done on 24 cervical biopsy patients. Results: The 87.58% of women was observed with abnormal Pap smear among that the severe dysplasia is around 10%. The abnormal cervix was seen by colposcopy is 89.44%. The 24 squamous metaplasia cases were subjected to IHC and 8 cases were found to be positive. Conclusion: Pap smear, colposcopy along with cervical biopsy for HPV can provide enough information for an accurate diagnosis of cervical cancer and also from the future course of action for the treatment of the patients.

scholarly journals Genetic Screening of Cervical Cancer

OBM Genetics ◽  
2021 ◽  
Vol 05 (03) ◽  
pp. 1-1
Author(s):  
Ciro Comparetto ◽  
◽  
Franco Borruto ◽  
Keyword(s):  
Cervical Cancer ◽  
Molecular Biology ◽  
Pap Smear ◽  
Pap Test ◽  
Prevention Programs ◽  
Small Sample ◽  
Screening Programs ◽  
Pap Smear Screening ◽  
Hpv Test ◽  
Screening And Prevention

Medical genetics plays an important role in the screening and prevention of numerous diseases. Thus, it is important to develop effective screening and prevention programs and improve the assessment of the susceptibility of diseases. The development of screening and prevention programs depends on the identification of early biomarkers (including functional and behavioral) for the risk and onset of the disease, and such programs need to be designed according to internationally accepted criteria. Cervical cancer represents a very relevant disease from the health and social perspective; around 528,000 new cases are diagnosed every year globally, of which, 85% are from developing countries, representing almost 12% of all cancers in females. Substantial reductions in the incidence of and mortality from cervical cancer have been observed after the introduction of prevention campaigns with the implementation of cervical screening programs through Papanicolaou (Pap) tests and, in particular, following the introduction of organized programs which guarantee a high level of screening coverage, as well as, the quality and continuity of diagnostic-therapeutic procedures. It is estimated that Pap smear screening every 3-5 years provides 80% protection against the onset of cancer. Advances in diagnostic techniques, particularly the development of easy-to-use molecular genetic tests, are replacing the use of the established Pap smear as a screening tool. This is possible owing to the discovery in 1975 that some cellular morphological changes (koilocytosis) were related to the presence of a Human Papillomavirus (HPV) infection. The HPV test is performed on a small sample of cells taken from the cervix, similar to the Pap test; however, it is not a morphological exam but a molecular biology exam that detects the presence of HPV by identifying its deoxyribonucleic acid (DNA) or messenger ribonucleic acid (mRNA). The results of numerous experimental studies have demonstrated a greater sensitivity of this test compared to the sensitivity of the traditional Pap test. However, the HPV test has a lower specificity due to two main factors: 1) The HPV test is based on the search for the types of viruses that have a greater oncogenic potential, and 2) It does not discriminate between transient infections and persistent and productive infections. The most widely used molecular tests are based on the search for HPV sequences and genotyping using molecular biology techniques, such as direct hybridization, qualitative polymerase chain reaction (PCR), and viral nucleotide sequencing.

scholarly journals Attitudes Towards Cervical Cancer Screening

2006 ◽  
Vol 4 (2) ◽  
pp. 13-24 ◽  
Author(s):  
Myriam Leyva ◽  
Theresa Byrd ◽  
Patrick Tarwater
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Cervical Cancer Screening ◽  
Pap Smear ◽  
Screening Program ◽  
Pap Test ◽  
Mexican Women ◽  
Cancer Screening Program ◽  
Cervical Cancer Screening Program ◽  
Smear Testing

Pap smear testing continues to be the single most effective tool in reducing deaths due to cervical cancer (Watkins, Gabali, Winkleby, Gaona & Lebaron, 2002). Despite the creation of a national cervical cancer screening program, more than 4,000 women die every year in Mexico from this disease. This study explored the knowledge, attitudes, and behaviors of Mexican women regarding cervical cancer screening, and identified beliefs and barriers that may influence cervical health. All analyses compared women who had ever had a Pap test in their lives (“ever”) with women who had never had a Pap test (“never”). In bivariate analyses, the following variables were significantly associated (p

scholarly journals Potentialities in integral care: uterine cervical cancer prevention according to the users of the family health strategy

2007 ◽  
Vol 15 (3) ◽  
pp. 426-430 ◽  
Author(s):  
Michele Mandagará de Oliveira ◽  
Ione Carvalho Pinto ◽  
Valéria Cristina Christello Coimbra
Keyword(s):  
Cervical Cancer ◽  
Cancer Prevention ◽  
Pap Smear ◽  
Family Health ◽  
Uterine Cervical Cancer ◽  
Cervical Cancer Prevention ◽  
Study Data ◽  
Health Strategy ◽  
The Family ◽  
Family Health Strategy

This study aimed to analyze the integral care in the uterine cervical cancer prevention practices in the conception of users of the Family Health Strategy through an exploratory and descriptive research with a qualitative approach. A total of 14 users who performed the Pap smear in December 2002 in four Family Health Units affiliated to Higher Education institutions were selected for the study. Data were collected between April and June 2003. We found that the users analyze and assess the praxis by issuing a value judgment about the care they receive, mainly in terms of light (relational) technologies. Concluding, humanized practices provided by professional/team favor integral care, strengthening the bond between users and health services, as well as health promotion.

scholarly journals Women’s knowledge, awareness and prevention of cervical cancer and infection from HPV in Greece

2021 ◽  
Vol 31 (Supplement_3) ◽  
Author(s):  
B Giota ◽  
KS Kitsou ◽  
M Bakola ◽  
P Kallianezos ◽  
G Charalambous ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Educational Level ◽  
Pap Smear ◽  
Cervical Cancer Prevention ◽  
University Education ◽  
Papanicolaou Test ◽  
Cross Sectional ◽  
Screening Programs ◽  
Hpv Test ◽  
And Behaviors

Abstract Background Cervical cancer prevention can be obtained by regular screening with Papanicolaou test. However, in recent years HPV DNA test and mRNA HPV test are available for the screening for cervical cancer. The HPV vaccine helps protect against HPV- related cancers. Our aim was to investigate the beliefs and knowledge of women living in a city in northwestern Thessaly, Greece, regarding the prevention of cervical cancer. Methods A cross sectional study was conducted among 119 women, 18-65 years old and living in Trikala, Greece. They completed a 45-item self-administered questionnaire, investigating their knowledge, perceptions, and behaviors regarding the prevention of cervical cancer, the infection with HPV, the Papanicolaou test and vaccination. Furthermore, associations between knowledge and behaviors as well as with various demographic factors were explored. Results Most of the women had at least university education (77%). More than 90% declared to visit an obstetrician-gynecologist at least once a year and 68.4% regularly have a Pap smear once a year. 95.8% were aware of the importance of a Pap smear and 82% declared a positive attitude regarding HPV vaccination. Higher knowledge regarding examination and vaccination, was associated with marital status (married) (p = 0.002) and educational level (higher educational level) (p = 0.001). Conclusions The majority of women in our sample know why they should do the Pap test; however, they need to be further informed with additional details about the diagnostic test. Although most of the women were aware about the importance of testing, one third of them were not regularly tested for cervical cancer detection or had lacked knowledge about vaccination. Key messages A high percentage of women is aware about the benefits of cervical cancer screening. However, information campaigns and establishment of national screening programs are required to facilitate the access to such programs for all women.

scholarly journals A Deep Learning Ensemble Method to Assist Cytopathologists in Pap Test Image Classification

2021 ◽  
Vol 7 (7) ◽  
pp. 111
Author(s):  
Débora N. Diniz ◽  
Mariana T. Rezende ◽  
Andrea G. C. Bianchi ◽  
Claudia M. Carneiro ◽  
Eduardo J. S. Luz ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Deep Learning ◽  
Image Classification ◽  
Pap Smear ◽  
Pap Test ◽  
Cervical Cancer Prevention ◽  
Machine Learning Techniques ◽  
Pap Smears ◽  
Cell Nuclei ◽  
Deep Convolutional Neural Networks

In recent years, deep learning methods have outperformed previous state-of-the-art machine learning techniques for several problems, including image classification. Classifying cells in Pap smear images is very challenging, and it is still of paramount importance for cytopathologists. The Pap test is a cervical cancer prevention test that tracks preneoplastic changes in cervical epithelial cells. Carrying out this exam is important in that early detection. It is directly related to a greater chance of curing or reducing the number of deaths caused by the disease. The analysis of Pap smears is exhaustive and repetitive, as it is performed manually by cytopathologists. Therefore, a tool that assists cytopathologists is needed. This work considers 10 deep convolutional neural networks and proposes an ensemble of the three best architectures to classify cervical cancer upon cell nuclei and reduce the professionals’ workload. The dataset used in the experiments is available in the Center for Recognition and Inspection of Cells (CRIC) Searchable Image Database. Considering the metrics of precision, recall, F1-score, accuracy, and sensitivity, the proposed ensemble improves previous methods shown in the literature for two- and three-class classification. We also introduce the six-class classification outcome.

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