scholarly journals 3D Printing as a Promising Tool in Personalized Medicine

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Vanessa Marcia Vaz ◽  
Lalit Kumar
Keyword(s):  
3D Printing ◽  
Personalized Medicine ◽  
Clinical Setting ◽  
Three Dimensional ◽  
Pharmaceutical Products ◽  
Healthcare Sector ◽  
Future Application ◽  
Genetic Profile ◽  
Pharmaceutical Dosage Forms ◽  
Multiple Drugs

AbstractPersonalized medicine has the potential to revolutionize the healthcare sector, its goal being to tailor medication to a particular individual by taking into consideration the physiology, drug response, and genetic profile of that individual. There are many technologies emerging to cause this paradigm shift from the conventional “one size fits all” to personalized medicine, the major one being three-dimensional (3D) printing. 3D printing involves the establishment of a three-dimensional object, in a layer upon layer manner using various computer software. 3D printing can be used to construct a wide variety of pharmaceutical dosage forms varying in shape, release profile, and drug combination. The major technological platforms of 3D printing researched on in the pharmaceutical sector include inkjet printing, binder jetting, fused filament fabrication, selective laser sintering, stereolithography, and pressure-assisted microsyringe. A possible future application of this technology could be in a clinical setting, where prescriptions could be dispensed based on individual needs. This manuscript points out the various 3D printing technologies and their applications in research for fabricating pharmaceutical products, along with their pros and cons. It also presents its potential in personalized medicine by individualizing the dose, release profiles, and incorporating multiple drugs in a polypill. An insight on how it tends to various populations is also provided. An approach of how it can be used in a clinical setting is also highlighted. Also, various challenges faced are pointed out, which must be overcome for the success of this technology in personalized medicine.

3D Printing in Healthcare

2021 ◽  
pp. 696-703
Author(s):  
Nilmini Wickramasinghe
Keyword(s):  
3D Printing ◽  
Personalized Medicine ◽  
Healthcare Delivery ◽  
Healthcare Sector ◽  
Disruptive Technology ◽  
3D Printed ◽  
Average User ◽  
The Way ◽  
Aerospace And Defense

3D printing has developed as a modification of an old injection printer. Today, it is rapidly expanding offering novel possibilities as well as new exciting applications for various sectors including healthcare, automotive, aerospace, and defense industries. This chapter presents key application areas within the healthcare sector. In medicine, 3D printing is revolutionizing the way operations are carried out, disrupting prosthesis and implant markets as well as dentistry. The relatively new field of bioprinting has come to be because of advances with this technology. As will be discussed, numerous applications of 3D printing in healthcare relate to personalized medicine. For instance, implants or prostheses are 3D printed for a specific user's body, optimizing the technology to work for an individual, not an average user as with most mass-produced products. In addition, 3D printing has applications on the nanoscale with printing of drugs and other smaller items. Hence, 3D printing represents a disruptive technology for healthcare delivery.

scholarly journals Assessment of Pharmacist’s Knowledge and Perception toward 3D Printing Technology as a Dispensing Method for Personalized Medicine and the Readiness for Implementation

Pharmacy ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 68
Author(s):  
Mohammed S. Algahtani
Keyword(s):  
3D Printing ◽  
Personalized Medicine ◽  
New Technology ◽  
Hospital Pharmacist ◽  
Three Dimensional ◽  
Pharmacy Practice ◽  
Printing Technology ◽  
Drug Dispensing ◽  
3D Printing Technology ◽  
Knowledge And Attitude

The main user of three dimensional (3D) printing for drug dispensing will be the hospital pharmacist. Yet despite the tremendous amount of research and industrial initiatives, there is no evaluation of the pharmacist’s knowledge and opinion of this technology. The present study aimed to assess knowledge and attitude among pharmacists about 3D printing technology as an innovative dispensing method for personalized medicine and the barriers to implementation in Saudi Arabia. We found that 53% of participants were aware of 3D printing technology in general, but only 14–16% of pharmacists were aware of the specific application of 3D printing in drug dispensing. Participants showed a positive perception regarding the concept of personalized medicine and that 3D printing could provide a promising solution to formulate and dispense personalized medicine in the pharmacy. It was also found that 67% of pharmacists were encouraged to adopt this new technology for drug dispensing, reflecting their willingness to learn new innovations. However, the technology cost, regulation, and the shortage of practicing pharmacists were also reported as the top barriers for implementation. Facilitating the implementation of this technology in the pharmacy practice will require a strategic plan in which pharmacists collaborate with regulatory bodies and 3D printing engineers to overcome challenges and barriers to implement such promising technology.

3D Printing in Healthcare

2020 ◽  
pp. 220-227
Author(s):  
Nilmini Wickramasinghe
Keyword(s):  
3D Printing ◽  
Personalized Medicine ◽  
Healthcare Delivery ◽  
Healthcare Sector ◽  
Disruptive Technology ◽  
3D Printed ◽  
Average User ◽  
The Way ◽  
Aerospace And Defense

3D printing has developed as a modification of an old injection printer. Today, it is rapidly expanding offering novel possibilities as well as new exciting applications for various sectors including healthcare, automotive, aerospace, and defense industries. This chapter presents key application areas within the healthcare sector. In medicine, 3D printing is revolutionizing the way operations are carried out, disrupting prosthesis and implant markets as well as dentistry. The relatively new field of bioprinting has come to be because of advances with this technology. As will be discussed, numerous applications of 3D printing in healthcare relate to personalized medicine. For instance, implants or prostheses are 3D printed for a specific user's body, optimizing the technology to work for an individual, not an average user as with most mass-produced products. In addition, 3D printing has applications on the nanoscale with printing of drugs and other smaller items. Hence, 3D printing represents a disruptive technology for healthcare delivery.

scholarly journals The Effect of Chemical Cleaning on Mechanical Properties of Three-Dimensional Printed Polylactic Acid

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Julie C. Fleischer ◽  
Jan C. Diehl ◽  
Linda S. G. L. Wauben ◽  
Jenny Dankelman
Keyword(s):  
Mechanical Properties ◽  
3D Printing ◽  
Polylactic Acid ◽  
Three Dimensional ◽  
Spare Parts ◽  
Healthcare Sector ◽  
Strength Increase ◽  
Chemical Cleaning ◽  
Middle Income ◽  
3D Printed

Abstract Three-dimensional (3D) printing may be a solution to shortages of equipment and spare parts in the healthcare sector of low- and middle-income countries (LMICs). Polylactic acid (PLA) for 3D printing is widely available and biocompatible, but there is a gap in knowledge concerning its compatibility with chemical disinfectants. In this study, 3D-printed PLA tensile samples were created with six different printer settings. Each of these six batches consisted of five sets with five or six samples. The first set remained untreated, the others were soaked in Cidex OPA or in a chlorine solution. These were applied for seven consecutive days or in 25 short cycles. All samples were weighed before and after treatment and subjected to a tensile test. Results showed that a third of the treatments led to an increase of the median weight with a maximum of 8.3%, however, the samples with the best surface quality did not change. The median strength increase was 12.5% and the largest decrease was 8.8%. The median stiffness decreased 3.6% in one set and increased in three others up to 13.6%. When 3D printing PLA medical tools, surface porosity must be minimized to prevent transfer of disinfectants to people. The wide variability of mechanical properties due to 3D printing itself and as a consequence of disinfection must be considered when designing medical tools by selecting appropriate printer settings. If these conditions are met, reusing 3D-printed PLA medical tools seems safe from a mechanical point of view.

Big Data, 3D Printing Technology, and Industry of the Future

2017 ◽  
Vol 2 (2) ◽  
pp. 1-20
Author(s):  
Micheal Omotayo Alabi
Keyword(s):  
Big Data ◽  
3D Printing ◽  
Industry 4.0 ◽  
High Speed ◽  
Healthcare Sector ◽  
Future Application ◽  
Future Research ◽  
Printing Technology ◽  
3D Printing Technology ◽  
3D Printed

This article describes how 3D printing technology, also referred to as additive manufacturing (AM), is a process of creating a physical object from 3-dimensional digital model layers upon layers. 3D printing technologies have been identified as an emerging technology of the 21st century and are becoming popular around the world with a wide variety of potential application areas such as healthcare, automotive, aerospace, manufacturing, etc. Big Data is a large amount of imprecise data in a variety of formats which is generated from different sources with high-speed. Recently, Big Data and 3D printing technologies is a new research area and have been identified as types of technologies that will launch the fourth industrial revolution (Industry 4.0). As Big Data and 3D printing technology is wide spreading across different sectors in the era of industry 4.0, the healthcare sector is not left out of the vast development in this field; for instance, the Big Data and 3D printing technologies providing needed tools to support healthcare systems to accumulate, manage, analyse large volume of data, early disease detection, 3D printed medical implant, 3D printed customized titanium prosthetic, etc. Therefore, this article presents the recent trends in 3D printing technologies, Big Data and Industry 4.0; including the benefits and the application areas of these technologies. Emerging and near future application areas of 3D printing, and possible future research areas in 3D printing and Big Data technologies as relating to industry 4.0.

scholarly journals Patient-Specific Surgical Implants Made of 3D Printed PEEK: Material, Technology, and Scope of Surgical Application

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Philipp Honigmann ◽  
Neha Sharma ◽  
Brando Okolo ◽  
Uwe Popp ◽  
Bilal Msallem ◽  
...  
Keyword(s):  
3D Printing ◽  
Three Dimensional ◽  
Healthcare Sector ◽  
Patient Specific ◽  
Fused Filament Fabrication ◽  
Material Technology ◽  
Patient Specific Implants ◽  
Alloplastic Materials ◽  
Surgical Implants ◽  
Surgical Application

Additive manufacturing (AM) is rapidly gaining acceptance in the healthcare sector. Three-dimensional (3D) virtual surgical planning, fabrication of anatomical models, and patient-specific implants (PSI) are well-established processes in the surgical fields. Polyetheretherketone (PEEK) has been used, mainly in the reconstructive surgeries as a reliable alternative to other alloplastic materials for the fabrication of PSI. Recently, it has become possible to fabricate PEEK PSI with Fused Filament Fabrication (FFF) technology. 3D printing of PEEK using FFF allows construction of almost any complex design geometry, which cannot be manufactured using other technologies. In this study, we fabricated various PEEK PSI by FFF 3D printer in an effort to check the feasibility of manufacturing PEEK with 3D printing. Based on these preliminary results, PEEK can be successfully used as an appropriate biomaterial to reconstruct the surgical defects in a “biomimetic” design.

3D Printing Technology in Pharmaceutical Dosage forms: Advantages and Challenges

2021 ◽  
Vol 22 ◽  
Author(s):  
Prasanna Kumar Desu ◽  
Balaji Maddiboyina ◽  
Vanitha K. ◽  
GSN Koteswara Rao ◽  
Anusha R. ◽  
...  
Keyword(s):  
3D Printing ◽  
Low Cost ◽  
Three Dimensional ◽  
Dosage Forms ◽  
Solid Dosage Forms ◽  
Printing Technology ◽  
Pharmaceutical Dosage Forms ◽  
3D Printing Technology ◽  
Solid Dosage ◽  
Personalized Medicines

Three Dimensional (3D) Printing is a promising method for quick prototyping and manufacturing of any material. It is similar to photocopy or printing, where the new materials are formed on layers (3D) like its mother component. Following its growth and advancement in the 1980s, its application in pharmaceuticals is still limited. It has become one of the most innovative and influential tools serving as a technology of precise manufacturing of developed dosage forms from the last decade. The potential of 3D printing to produce drugs for precise measurement customized to specific patients' needs has shown the possibility of developing personalized medicines to novel dosage forms. The breakthrough allows the clear perception of the dosage structures on different shapes, sizes, and surfaces challenging to deliver using Designed conditions. There are different difficulties related to the correct utilization of 3D imprinting in the pharmaceutical Part, which ought to be defeated to abuse the extent of this technology. Recent advancements in the field of 3D printing technology used in the pharmaceutical industry mainly focused on different techniques for the fabrication of different dosage forms. The Food and Drug Administration's (FDA) recent approval of the first 3D prescription highlights possibilities for 3D printing innovation in the pharmaceutical drug supply field. This analysis assesses 3D printing advancement possibilities, particularly in the area of custom prescriptions. This technology can be regarded as the future of demand-produced, low-cost solid dosage forms, and helps minimize side effects due to overdose.

scholarly journals Characterization of Hydrophilic Polymers as a Syringe Extrusion 3D Printing Material for Orodispersible Film

Polymers ◽  
2021 ◽  
Vol 13 (20) ◽  
pp. 3454
Author(s):  
Pattaraporn Panraksa ◽  
Sheng Qi ◽  
Suruk Udomsom ◽  
Pratchaya Tipduangta ◽  
Pornchai Rachtanapun ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
3D Printing ◽  
Hydroxypropyl Methylcellulose ◽  
Three Dimensional ◽  
Pharmaceutical Products ◽  
Hydrophilic Polymers ◽  
Sodium Carboxymethylcellulose ◽  
Disintegration Time ◽  
Orodispersible Films ◽  
3D Printed

The application of hydrophilic polymers in designing and three-dimensional (3D) printing of pharmaceutical products in various dosage forms has recently been paid much attention. Use of hydrophilic polymers and syringe extrusion 3D printing technology in the fabrication of orodispersible films (ODFs) might hold great potential in rapid drug delivery, personalized medicine, and manufacturing time savings. In this study, the feasibility of 3D-printed ODFs fabrication through a syringe extrusion 3D printing technique and using five different hydrophilic polymers (e.g., hydroxypropyl methylcellulose E15, hydroxypropyl methylcellulose E50, high methoxyl pectin, sodium carboxymethylcellulose, and hydroxyethylcellulose) as film-forming polymers and printing materials has been investigated. Rheology properties and printability of printing gels and physicochemical and mechanical properties of 3D-printed ODFs were evaluated. Amongst the investigated hydrophilic polymers, sodium carboxymethylcellulose at a concentration of 5% w/v (SCMC-5) showed promising results with a good printing resolution and accurate dimensions of the 3D-printed ODFs. In addition, SCMC-5 3D-printed ODFs exhibited the fastest disintegration time within 3 s due to high wettability, roughness and porosity on the surface. However, the results of the mechanical properties study showed that SCMC-5 3D printed ODFs were rigid and brittle, thus requiring special packaging to prevent them from any damage before practical use.

Pharmaceutical Polymers - A Review

2019 ◽  
Vol 9 (01) ◽  
pp. 27-33
Author(s):  
Naveen Kumar ◽  
Sonia Pahuja ◽  
Ranjit Sharma
Keyword(s):  
Drug Release ◽  
Industrial Revolution ◽  
Pharmaceutical Formulations ◽  
Pharmaceutical Products ◽  
Water Soluble ◽  
Taste Masking ◽  
Natural Polymers ◽  
Pharmaceutical Dosage Forms ◽  
Pharmaceutical Applications ◽  
Pharmaceutical Industries

Humans have taken advantage of the adaptability of polymers for centuries in the form of resins, gums tars, and oils. However, it was not until the industrial revolution that the modern polymer industry began to develop. Polymers represent an important constituent of pharmaceutical dosage forms. Polymers have played vital roles in the formulation of pharmaceutical products. Polymers have been used as a major tool to manage the drug release rate from the formulations. Synthetic and natural-based polymers have found their way into the biomedical and pharmaceutical industries. Synthetic and Natural polymers can be produced with a broad range of strength, heat resistance, density, stiffness and even price. By constant research into the science and applications of polymers, they are playing an ever-increasing role in society. Diverse applications of polymers in the present pharmaceutical field are for controlled drug release. Based on solubility pharmaceutical polymers can be classified as water-soluble and water-insoluble. In general, the desirable polymer properties in pharmaceutical applications are film forming, adhesion, gelling, thickening, pH-dependent solubility and taste masking. General pharmaceutical applications of polymers in various pharmaceutical formulations are also discussed

scholarly journals Efficacy evaluation of three-dimensional printing assisted osteotomy guide plate in accurate osteotomy of adolescent cubitus varus deformity

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Yuan-Wei Zhang ◽  
Xin Xiao ◽  
Wen-Cheng Gao ◽  
Yan Xiao ◽  
Su-Li Zhang ◽  
...  
Keyword(s):  
3D Printing ◽  
Blood Loss ◽  
Three Dimensional ◽  
Operation Time ◽  
Varus Deformity ◽  
Conventional Group ◽  
Intraoperative Blood Loss ◽  
Cubitus Varus ◽  
Guide Plate ◽  
Significant Difference

Abstract Background This present study is aimed to retrospectively assess the efficacy of three-dimensional (3D) printing assisted osteotomy guide plate in accurate osteotomy of adolescent cubitus varus deformity. Material and methods Twenty-five patients (15 males and 10 females) with the cubitus varus deformity from June 2014 to December 2017 were included in this study and were enrolled into the conventional group (n = 11) and 3D printing group (n = 14) according to the different surgical approaches. The operation time, intraoperative blood loss, osteotomy degrees, osteotomy end union time, and postoperative complications between the two groups were observed and recorded. Results Compared with the conventional group, the 3D printing group has the advantages of shorter operation time, less intraoperative blood loss, higher rate of excellent correction, and higher rate of the parents’ excellent satisfaction with appearance after deformity correction (P < 0.001, P < 0.001, P = 0.019, P = 0.023). Nevertheless, no significant difference was presented in postoperative carrying angle of the deformed side and total complication rate between the two groups (P = 0.626, P = 0.371). Conclusions The operation assisted by 3D printing osteotomy guide plate to correct the adolescent cubitus varus deformity is feasible and effective, which might be an optional approach to promote the accurate osteotomy and optimize the efficacy.

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