3D Printing in Healthcare

2020 ◽  
pp. 220-227
Author(s):  
Nilmini Wickramasinghe
Keyword(s):  
3D Printing ◽  
Personalized Medicine ◽  
Healthcare Delivery ◽  
Healthcare Sector ◽  
Disruptive Technology ◽  
3D Printed ◽  
Average User ◽  
The Way ◽  
Aerospace And Defense

3D printing has developed as a modification of an old injection printer. Today, it is rapidly expanding offering novel possibilities as well as new exciting applications for various sectors including healthcare, automotive, aerospace, and defense industries. This chapter presents key application areas within the healthcare sector. In medicine, 3D printing is revolutionizing the way operations are carried out, disrupting prosthesis and implant markets as well as dentistry. The relatively new field of bioprinting has come to be because of advances with this technology. As will be discussed, numerous applications of 3D printing in healthcare relate to personalized medicine. For instance, implants or prostheses are 3D printed for a specific user's body, optimizing the technology to work for an individual, not an average user as with most mass-produced products. In addition, 3D printing has applications on the nanoscale with printing of drugs and other smaller items. Hence, 3D printing represents a disruptive technology for healthcare delivery.

3D Printing in Healthcare

2021 ◽  
pp. 696-703
Author(s):  
Nilmini Wickramasinghe
Keyword(s):  
3D Printing ◽  
Personalized Medicine ◽  
Healthcare Delivery ◽  
Healthcare Sector ◽  
Disruptive Technology ◽  
3D Printed ◽  
Average User ◽  
The Way ◽  
Aerospace And Defense

3D printing has developed as a modification of an old injection printer. Today, it is rapidly expanding offering novel possibilities as well as new exciting applications for various sectors including healthcare, automotive, aerospace, and defense industries. This chapter presents key application areas within the healthcare sector. In medicine, 3D printing is revolutionizing the way operations are carried out, disrupting prosthesis and implant markets as well as dentistry. The relatively new field of bioprinting has come to be because of advances with this technology. As will be discussed, numerous applications of 3D printing in healthcare relate to personalized medicine. For instance, implants or prostheses are 3D printed for a specific user's body, optimizing the technology to work for an individual, not an average user as with most mass-produced products. In addition, 3D printing has applications on the nanoscale with printing of drugs and other smaller items. Hence, 3D printing represents a disruptive technology for healthcare delivery.

scholarly journals 4D Printing: The Dawn of “Smart” Drug Delivery Systems and Biomedical Applications

2021 ◽  
Vol 11 (5-S) ◽  
pp. 131-137
Author(s):  
Ahmar Khan ◽  
Mir Javid Iqbal ◽  
Saima Amin ◽  
Humaira Bilal ◽  
, Bilquees ◽  
...  
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Patient Compliance ◽  
Smart Materials ◽  
Healthcare Sector ◽  
Massachusetts Institute Of Technology ◽  
4D Printing ◽  
3D Printed ◽  
Smart Drug ◽  
Smart Drug Delivery

With the approval of first 3D printed drug “spritam” by USFDA, 3D printing is gaining acceptance in healthcare, engineering and other aspects of life. Taking 3D printing towards the next step gives birth to what is referred to as “4D printing”. The full credit behind the unveiling of 4D printing technology in front of the world goes to Massachusetts Institute of Technology (MIT), who revealed “time” in this technology as the fourth dimension.  4D printing is a renovation of 3D printing wherein special materials (referred to as smart materials) are incorporated which change their morphology post printing in response to a stimulus. Depending upon the applicability of this technology, there may be a variety of stimuli, most common among them being pH, water, heat, wind and other forms of energy.  The upper hand of 4D printing over 3D printing is that 3D printed structures are generally immobile, rigid and inanimate whereas 4D printed structures are flexible, mobile and able to interact with the surrounding environment based on the stimulus. This capability of 4D printing to transform 3D structures into smart structures in response to various stimuli promises a great potential for biomedical and bioengineering applications. The potential of 4D printing in developing pre-programmed biomaterials that can undergo transformations lays new foundations for enabling smart pharmacology, personalized medicine, and smart drug delivery, all of which can help in combating diseases in a smarter way. Hence, the theme of this paper is about the potential of 4D printing in creating smart drug delivery, smart pharmacology, targeted drug delivery and better patient compliance. The paper highlights the recent advancements of 4D printing in healthcare sector and ways by which 4D printing is doing wonders in creating smart drug delivery and tailored medicine. The major constraints in the approach have also been highlighted. Keywords: 4D printing, smart, drug delivery system, patient compliance, biomaterials, tailored medicine

scholarly journals 3D Printing as a Promising Tool in Personalized Medicine

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Vanessa Marcia Vaz ◽  
Lalit Kumar
Keyword(s):  
3D Printing ◽  
Personalized Medicine ◽  
Clinical Setting ◽  
Three Dimensional ◽  
Pharmaceutical Products ◽  
Healthcare Sector ◽  
Future Application ◽  
Genetic Profile ◽  
Pharmaceutical Dosage Forms ◽  
Multiple Drugs

AbstractPersonalized medicine has the potential to revolutionize the healthcare sector, its goal being to tailor medication to a particular individual by taking into consideration the physiology, drug response, and genetic profile of that individual. There are many technologies emerging to cause this paradigm shift from the conventional “one size fits all” to personalized medicine, the major one being three-dimensional (3D) printing. 3D printing involves the establishment of a three-dimensional object, in a layer upon layer manner using various computer software. 3D printing can be used to construct a wide variety of pharmaceutical dosage forms varying in shape, release profile, and drug combination. The major technological platforms of 3D printing researched on in the pharmaceutical sector include inkjet printing, binder jetting, fused filament fabrication, selective laser sintering, stereolithography, and pressure-assisted microsyringe. A possible future application of this technology could be in a clinical setting, where prescriptions could be dispensed based on individual needs. This manuscript points out the various 3D printing technologies and their applications in research for fabricating pharmaceutical products, along with their pros and cons. It also presents its potential in personalized medicine by individualizing the dose, release profiles, and incorporating multiple drugs in a polypill. An insight on how it tends to various populations is also provided. An approach of how it can be used in a clinical setting is also highlighted. Also, various challenges faced are pointed out, which must be overcome for the success of this technology in personalized medicine.

Pharmaceutical Product Development Exploiting 3D Printing Technology: Conventional to Novel Drug Delivery System

2019 ◽  
Vol 24 (42) ◽  
pp. 5029-5038 ◽  
Author(s):  
Md. Shoaib Alam ◽  
Ayesha Akhtar ◽  
Iftikhar Ahsan ◽  
Sheikh Shafiq-un-Nabi
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Personalized Medicine ◽  
Drug Delivery System ◽  
Delivery System ◽  
Printing Technology ◽  
3D Printing Technology ◽  
3D Printed ◽  
Novel Drug Delivery System ◽  
Novel Drug

Background: 3D printed pharmaceutical products are revolutionizing the pharmaceutical industry as a prospective mean to achieve a personalized method of treatments acquired to the specially designed need of each patient. It will depend upon age, weight, concomitants, pharmacogenetics and pharmacokinetic profile of the patient and thus transforming the current pharmaceutical market as a potential alternative to conventional medicine. 3D printing technology is getting more consideration in new medicine formulation development as a modern and better alternative to control many challenges associated with conventional medicinal products. There are many advantages of 3D printed medicines which create tremendous opportunities for improving the acceptance, accuracy and effectiveness of these medicines. In 2015, United State Food and Drug Administration has approved the first 3D printed tablet (Spritam®) and had shown the emerging importance of this technology. Methods: This review article summarizes as how in-depth knowledge of drugs and their manufacturing processes can assist to manage different strategies for various 3D printing methods. The principal goal of this review is to provide a brief introduction about the present techniques employed in tech -medicine evolution from conventional to a novel drug delivery system. Results: It is evidenced that through its unparalleled advantages of high-throughput, versatility, automation, precise spatial control and fabrication of hierarchical structures, the implementation of 3D printing for the expansion and delivery of controlled drugs acts as a pivotal role. Conclusion: 3D printing technology has an extraordinary ability to provide elasticity in the manufacturing and designing of composite products that can be utilized in programmable and personalized medicine. Personalized medicine helps in improving drug safety and minimizes side effects such as toxicity to individual human being which is associated with unsuitable drug dose.

scholarly journals Effect of Printing Parameters of 3D Printed PLA Parts on Mechanical Properties

2021 ◽  
Author(s):  
Jayakumar N ◽  
◽  
Senthilkumar G ◽  
Pradeep A D ◽  
◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Process Parameters ◽  
Design Method ◽  
Consumer Electronics ◽  
Disruptive Technology ◽  
Mean Values ◽  
Good Surface ◽  
3D Printed ◽  
Nozzle Temperature ◽  
The Way

Additive manufacturing significantly reduces the lead time of the product development cycle in the way of design trials and thus reduces delivery time to the market. The essence has been understood by many sectors including, education, manufacturing industries, automotive, medical, aerospace, consumer electronics, bio-medical and even fashion enthusiasts. It is used to prepare this PLA for the used plastics and landfills. By this way, it can reduce the plastics waste from the earth. Compare with ABS plastics, PLA plastics are cheaper. This disruptive technology going to the change the way of manufacturing goods and sets a new narrow path to the future industries. During usage of filament material, it’s got failure due to not enough quality printing because of not proper process parameters. Also, the printed part does not have good surface quality. So, the PLA material requires improved mechanical properties. The objective of this study is to create 3D printed parts with good quality with the optimized process parameters.The selected process parameters are infill density (%), Nozzle temperature (º) and print orientation. Taguchi orthogonal array (L9) design method has been chosen for generating design of experiments. The samples are produced according to its ASTM standards. The specimens were tested for identifying the mechanical properties like tensile strength, compression strength and impact strength. From the results obtained from the tests, taking the mean values and conclude the better infill density, orientation and the nozzle temperature the PLA.

scholarly journals The Effect of Chemical Cleaning on Mechanical Properties of Three-Dimensional Printed Polylactic Acid

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Julie C. Fleischer ◽  
Jan C. Diehl ◽  
Linda S. G. L. Wauben ◽  
Jenny Dankelman
Keyword(s):  
Mechanical Properties ◽  
3D Printing ◽  
Polylactic Acid ◽  
Three Dimensional ◽  
Spare Parts ◽  
Healthcare Sector ◽  
Strength Increase ◽  
Chemical Cleaning ◽  
Middle Income ◽  
3D Printed

Abstract Three-dimensional (3D) printing may be a solution to shortages of equipment and spare parts in the healthcare sector of low- and middle-income countries (LMICs). Polylactic acid (PLA) for 3D printing is widely available and biocompatible, but there is a gap in knowledge concerning its compatibility with chemical disinfectants. In this study, 3D-printed PLA tensile samples were created with six different printer settings. Each of these six batches consisted of five sets with five or six samples. The first set remained untreated, the others were soaked in Cidex OPA or in a chlorine solution. These were applied for seven consecutive days or in 25 short cycles. All samples were weighed before and after treatment and subjected to a tensile test. Results showed that a third of the treatments led to an increase of the median weight with a maximum of 8.3%, however, the samples with the best surface quality did not change. The median strength increase was 12.5% and the largest decrease was 8.8%. The median stiffness decreased 3.6% in one set and increased in three others up to 13.6%. When 3D printing PLA medical tools, surface porosity must be minimized to prevent transfer of disinfectants to people. The wide variability of mechanical properties due to 3D printing itself and as a consequence of disinfection must be considered when designing medical tools by selecting appropriate printer settings. If these conditions are met, reusing 3D-printed PLA medical tools seems safe from a mechanical point of view.

Big Data, 3D Printing Technology, and Industry of the Future

2017 ◽  
Vol 2 (2) ◽  
pp. 1-20
Author(s):  
Micheal Omotayo Alabi
Keyword(s):  
Big Data ◽  
3D Printing ◽  
Industry 4.0 ◽  
High Speed ◽  
Healthcare Sector ◽  
Future Application ◽  
Future Research ◽  
Printing Technology ◽  
3D Printing Technology ◽  
3D Printed

This article describes how 3D printing technology, also referred to as additive manufacturing (AM), is a process of creating a physical object from 3-dimensional digital model layers upon layers. 3D printing technologies have been identified as an emerging technology of the 21st century and are becoming popular around the world with a wide variety of potential application areas such as healthcare, automotive, aerospace, manufacturing, etc. Big Data is a large amount of imprecise data in a variety of formats which is generated from different sources with high-speed. Recently, Big Data and 3D printing technologies is a new research area and have been identified as types of technologies that will launch the fourth industrial revolution (Industry 4.0). As Big Data and 3D printing technology is wide spreading across different sectors in the era of industry 4.0, the healthcare sector is not left out of the vast development in this field; for instance, the Big Data and 3D printing technologies providing needed tools to support healthcare systems to accumulate, manage, analyse large volume of data, early disease detection, 3D printed medical implant, 3D printed customized titanium prosthetic, etc. Therefore, this article presents the recent trends in 3D printing technologies, Big Data and Industry 4.0; including the benefits and the application areas of these technologies. Emerging and near future application areas of 3D printing, and possible future research areas in 3D printing and Big Data technologies as relating to industry 4.0.

Analysis of Correlation Between Contrast and Component of Polylatic Acid Composite for Fused Deposition Modeling 3D Printing

2020 ◽  
Vol 20 (8) ◽  
pp. 5107-5111
Author(s):  
Kyu-Hyon Son ◽  
Jung-Hun Kim ◽  
Dong-Eun Kim ◽  
Min-Sik Kang ◽  
Joo-Heon Song ◽  
...  
Keyword(s):  
3D Printing ◽  
Fused Deposition Modeling ◽  
Three Dimensional ◽  
Disruptive Technology ◽  
X Ray ◽  
Fused Deposition ◽  
Potential Applicability ◽  
Deposition Modeling ◽  
3D Printed ◽  
Cie Lab

Additive manufacturing or three-dimensional (3D) printing is considered a disruptive technology for producing components with topologically optimized complex geometries as well as functionalities that are not achievable by traditional methods. 3D printing is expected to revolutionize the manufacturing of components. While several 3D printing systems are available, printing based on fused-deposition modeling (FDM) using thermoplastics is particularly widespread because of the simplicity and potential applicability of the method. In this study, we report the analysis of correlation between contrast and component of polylactic acid (PLA) based composite for FDM 3D printing. The pre-fabricated white composite and black composite were mixed in the fraction of 100:0, 90:10, 75:25, 50:50, 25:75, and 0:100% (v/v) and the obtained mixture was extruded using HX-35 3D filament extrusion line. The samples in different contrast were printed in disk like shape, and the gray scale filaments and 3D printed samples were measured the morphology and components using a field emission scanning electron microscope and energy dispersive X-ray spectroscopy. The CIE-lab values of the samples were measured using a colorimeter and the correlation between CIE-lab values and the components were analyzed. Although the component of Ti was linearly increased, the CIE-lab values show a clear exponential increase by increasing the white composite.

scholarly journals Chemical analysis using 3D printed glass microfluidics

2019 ◽  
Vol 11 (13) ◽  
pp. 1802-1810 ◽  
Author(s):  
Eran Gal-Or ◽  
Yaniv Gershoni ◽  
Gianmario Scotti ◽  
Sofia M. E. Nilsson ◽  
Jukka Saarinen ◽  
...  
Keyword(s):  
Additive Manufacturing ◽  
3D Printing ◽  
Chemical Analysis ◽  
Production Systems ◽  
Disruptive Technology ◽  
3D Printed ◽  
Glass Microfluidics

Additive manufacturing (3D printing) is a disruptive technology that is changing production systems globally.

Biodegradable 3D Printed Polymer Microneedles for Transdermal Drug Delivery

2018 ◽  
Author(s):  
Michael A. Luzuriaga ◽  
Danielle R. Berry ◽  
John C. Reagan ◽  
Ronald A. Smaldone ◽  
Jeremiah J. Gassensmith
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Transdermal Drug Delivery ◽  
Fused Deposition Modeling ◽  
Fused Deposition ◽  
Modeling Software ◽  
Deposition Modeling ◽  
3D Printed ◽  
Microfabrication Technique ◽  
Mechanical Strengths

Biodegradable polymer microneedle (MN) arrays are an emerging class of transdermal drug delivery devices that promise a painless and sanitary alternative to syringes; however, prototyping bespoke needle architectures is expensive and requires production of new master templates. Here, we present a new microfabrication technique for MNs using fused deposition modeling (FDM) 3D printing using polylactic acid, an FDA approved, renewable, biodegradable, thermoplastic material. We show how this natural degradability can be exploited to overcome a key challenge of FDM 3D printing, in particular the low resolution of these printers. We improved the feature size of the printed parts significantly by developing a post fabrication chemical etching protocol, which allowed us to access tip sizes as small as 1 μm. With 3D modeling software, various MN shapes were designed and printed rapidly with custom needle density, length, and shape. Scanning electron microscopy confirmed that our method resulted in needle tip sizes in the range of 1 – 55 µm, which could successfully penetrate and break off into porcine skin. We have also shown that these MNs have comparable mechanical strengths to currently fabricated MNs and we further demonstrated how the swellability of PLA can be exploited to load small molecule drugs and how its degradability in skin can release those small molecules over time.

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