scholarly journals Changes in circulating kisspeptin levels during each trimester in women with antenatal complications

2021 ◽  
Author(s):  
Ali Abbara ◽  
Maya Al-Memar ◽  
Maria Phylactou ◽  
Elisabeth Daniels ◽  
Bijal Patel ◽  
...  
Keyword(s):  
Maternal Age ◽  
Multivariable Analysis ◽  
Hypertensive Disorders Of Pregnancy ◽  
Limited Data ◽  
Third Trimester ◽  
Placental Function ◽  
Placental Dysfunction ◽  
Assessment Unit ◽  
Hammersmith Hospital ◽  
Putative Marker

Abstract Context Antenatal complications such as hypertensive disorders of pregnancy (HDP), fetal growth restriction (FGR), gestational diabetes (GDM), and preterm birth (PTB) are associated with placental dysfunction. Kisspeptin has emerged as a putative marker of placental function, but limited data exist describing circulating kisspeptin levels across all three trimesters in women with antenatal complications. Objective To assess whether kisspeptin levels are altered in women with antenatal complications. Design Women with antenatal complications (n=105) and those with uncomplicated pregnancies (n=265) underwent serial ultrasound scans and blood-sampling at least once during each trimester (March 2014 to March 2017). Setting Early Pregnancy Assessment Unit at Hammersmith Hospital, UK. Participants Women with antenatal complications: HDP (n=32), FGR (n=17), GDM (n=35) and PTB (n=11), and 10 women with multiple complications, provided 373 blood samples, and a further 265 controls provided 930 samples. Main outcome Differences in circulating kisspeptin levels. Results Third trimester kisspeptin levels were higher than controls in HDP but lower in FGR. The odds of HDP adjusted for gestational age, maternal age, ethnicity, BMI, smoking and parity were increased by 30% (95%CI 16-47%; p<0.0001), and of FGR were reduced by 28% (95%CI 4-46%; p=0.025), for every 1 nmol/L increase in plasma kisspeptin. Multiple of gestation-specific median values of kisspeptin were higher in pregnancies affected by PTB (p=0.014), and lower in those affected by GDM (p=0.020), but not significantly on multivariable analysis. Conclusion We delineate changes in circulating kisspeptin levels at different trimesters and evaluate the potential of kisspeptin as a biomarker for antenatal complications.

Pengaruh Umur Ibu Hamil Dan Dukungan Keluarga Terhadap Kepatuhan Mengkonsumsi Tablet Besi (Fe) Dan Anemia Pada Ibu Hamil Di Puskesmas Kota Wilayah Selatan Kota Kediri

2017 ◽  
Vol 4 (1) ◽  
Author(s):  
Dina Dewi Anggraini
Keyword(s):  
Pregnant Women ◽  
Health Center ◽  
Family Support ◽  
Random Sampling ◽  
Maternal Age ◽  
Sampling Technique ◽  
Deficiency Anemia ◽  
Third Trimester ◽  
Regional Health ◽  
Cross Sectional

ABSTRAKPerdarahan merupakan prosentase tertinggi penyebab terjadinya kematian ibu. Dan anemia zat besi merupakan penyebab utama terjadinya perdarahan. Pencegahan anemia gizi besi dilakukan melalui pemberian tablet besi dengan dosis pemberian sebanyak 1 tablet berturut-turut minimal selama 90 hari selama kehamilan. Pada kecamatan dan Puskesmas Kota Kediri 2014, cakupan Fe1 dan Fe3 yang terendah adalah pada Kecamatan Kota, yaitu Puskesmas Kota Wilayah Selatan, dengan Fe1 sebesar 69,81% dan Fe3 sebesar 66,29%. Penelitian dilakukan untuk menganalisis pengaruh umur ibu hamil dan dukungan keluarga terhadap kepatuhan mengkonsumsi tablet besi dan anemia pada ibu hamil di Puskesmas Kota Wilayah Selatan Kota Kediri 2016. Metode pada penelitian ini dengan observasi analitik dan rancang bangun cross sectional. Populasi pada penelitian ini 63 orang ibu hamil trimester III dan sampelnya 34 orang ibu hamil trimester III yang telah mendapatkan 90 tablet besi (Fe), dengan teknik simpel random sampling. Data diperoleh dari kuesioner, buku Kesehatan Ibu dan Anak, dan wawancara yang mendalam. Analisis data yang dilakukan dengan menggunakan regresi ordinal dan regresi logistik. Hasil uji didapatkan nilai p = 0,000 0,05 untuk variabel umur ibu hamil 20 tahun terhadap kepatuhan mengkonsumsi tablet besi (Fe), nilai p = 0,238 0,05 untuk variabel dukungan keluarga terhadap kepatuhan mengkonsumsi tablet besi (Fe), dan nilai p = 0,012 0,05 untuk variabel kepatuhan yang cukup dalam mengkonsumsi tablet besi (Fe) terhadap anemia pada ibu hamil. Semakin tinggi faktor risiko umur pada ibu hamil, maka semakin cenderung ibu hamil untuk patuh mengkonsumsi tablet besi (Fe) pada masa kehamilan. Semakin tinggi tingkat kepatuhan ibu hamil dalam mengkonsumsi tablet besi (Fe), maka semakin tinggi pula kecenderungan ibu hamil untuk tidak terkena anemia pada masa kehamilan. Kata kunci: Umur, Dukungan Keluarga, Kepatuhan, Anemia.   ABSTRACTBleeding is the highest percentage of the causes of maternal mortality. And iron anemia is a major cause of bleeding. Prevention of iron deficiency anemia is done through the provision of iron tablets with doses as much as 1 tablet in a row for a minimum of 90 days during pregnancy. In the town of Kediri district and health center in 2014, Fe1 and Fe3 coverage is lowest in the City District, the Southern Regional Health Center, with Fe1 amounted to 69,81% and amounted to 66,29% Fe3. The study was conducted to analyze the effect of maternal age and family support for adherence to consume iron tablets and anemia in pregnant women in the South Regional Health Center of Kediri, 2016. The method in this study with analytic observation and cross sectional design. The population in this study 63 third trimester pregnant women and the sample 34 third trimester pregnant women who have received 90 tablets of iron (Fe), with a simple random sampling technique. Data obtained from questionnaires, books Maternal and Child Health, and in-depth interviews. Data analysis was performed using ordinal regression and logistic regression. The test results obtained value of p = 0,000 0,05 for the variable maternal age 20 years of adherence to consume tablets of iron (Fe), p = 0,238 0,05 for the variable of family support for adherence to consume tablets of iron (Fe), and p = 0,012 0,05 for the variable adherence sufficient to consume iron tablet (Fe) against anemia in pregnant women. The higher the risk factors of age in pregnant women, pregnant women, the more it tends to stick to consume tablets of iron (Fe) during pregnancy. The higher the level of adherence of pregnant women consume iron tablet (Fe), the higher the tendency of pregnant women not exposed to anemia during pregnancy. Keywords: Age, Family Support, Adherence, Anemia.

scholarly journals Paternal and maternal age at pregnancy and autism spectrum disorders in offspring

2016 ◽  
Vol 55 (6) ◽  
pp. 345 ◽  
Author(s):  
Luh Putu Rihayani Budi ◽  
Mei Neni Sitaresmi ◽  
I Gusti Ayu Trisna Windiani
Keyword(s):  
Autism Spectrum Disorders ◽  
Maternal Age ◽  
Multivariable Analysis ◽  
Autism Spectrum ◽  
Paternal Age ◽  
Control Group ◽  
Smoking During Pregnancy ◽  
Past Half Century ◽  
Spectrum Disorders ◽  
Paternal Smoking

Background The prevalence of autism spectrum disorders(ASDs) has increased 10 times over the past half century,while paternal and maternal age at pregnancy has alsoincreased. Studies looking for an association between paternalor maternal age at pregnancy and ASDs in offspring have notbeen conclusive.Objective To assess for possible associations between paternaland maternal age at pregnancy and ASDs in offspring.Methods This case-control study had 50 case and 100control subjects, each case was matched for age and genderto two controls. Case subjects were obtained by consecutivesampling of patients aged 18 months to 7 years who visited theDevelopmental Behavioral & Community Pediatrics OutpatientClinic and private growth and development centers from Januaryto April 2013, while control group were children of the sameage range and same gender who visited pediatric outpatientclinic at Sanglah Hospital mostly due to acute respiratory tractinfection, without ASDs as assessed by the DSM-IV-TR criteria.We interviewed parents to collect the following data: maternaland paternal age at pregnancy, child’s birth weight, historyof asphyxia, hospital admission during the neonatal period,pathological labor, maternal smoking during pregnancy, paternalsmoking, and gestational age. Data analysis was performed withChi-square and Fisher’s exact tests.Results Multivariable analysis showed that higher paternal ageat pregnancy was associated with ASDs in offspring (OR 6.3;95%CI 2.0 to 19.3; P 0.001). However, there was no significantassociation between maternal age during pregnancy and theincidence of ASDs. Asphyxia and paternal smoking were alsoassociated with higher incidence of ASDs in the offspring (OR10.3; 95%CI 1.9 to 56.5; P 0.007 and OR 3.2; 95%CI 1.5 to 6.9;P 0.003, respectively).Conclusion􀀃􀀳􀁄􀁗􀁈􀁕􀁑􀁄􀁏􀀃􀁄􀁊􀁈􀀃􀂕􀀗􀀓􀀃􀁜􀁈􀁄􀁕􀁖􀀃􀁌􀁑􀁆􀁕􀁈􀁄􀁖􀁈􀁇􀀃􀁗􀁋􀁈􀀃􀁕􀁌􀁖􀁎􀀃􀁒􀁉􀀃􀀤􀀶'􀁖􀀃in offspring by 6.3 times. In addition, paternal smoking increased the risk of ASDs in offspring by 3.2 times and asphyxia increasedthe risk of ASDs in offspring by 10.3 times.

scholarly journals Placental Dysfunction Underlies Increased Risk of Fetal Growth Restriction and Stillbirth in Advanced Maternal Age Women

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Samantha C. Lean ◽  
Alexander E. P. Heazell ◽  
Mark R. Dilworth ◽  
Tracey A. Mills ◽  
Rebecca L. Jones
Keyword(s):  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Maternal Age ◽  
Advanced Maternal Age ◽  
Growth Restriction ◽  
Placental Dysfunction ◽  
Increased Risk

scholarly journals Feeding Practice during Diarrheal Episode among Children Aged between 6 to 23 Months in Mirab Abaya District, Gamo Gofa Zone, Southern Ethiopia

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Teshale Fikadu ◽  
Shimels Girma
Keyword(s):  
Maternal Age ◽  
Diarrheal Disease ◽  
Multivariable Analysis ◽  
Feeding Practices ◽  
Fluid Replacement ◽  
Southern Ethiopia ◽  
Feeding Practice ◽  
Under Five ◽  
Diarrheal Episode ◽  
Gamo Gofa

Background. Diarrheal disease is one of the main causes of childhood malnutrition. In developing countries 30% of pediatric beds are occupied with children having diarrheal disease. Fluid replacement, continued feeding, and increasing appropriate fluid at home during the diarrhea episodes are the cornerstone of treatment package. The purpose of this study was to assess feeding practice during diarrheal episodes among children aged 6 to 23 months in Mirab Abaya district, Gamo Gofa Zone, South Ethiopia. Methods. Community-based cross-sectional study design was conducted from February to March 2016 among children aged 6 to 23 months. A multistage sampling technique was used to select the study participants. A total of 661 participants were included in our study. Data were entered into Epi data version 3.1 and exported to SPSS 20.0 statistical software for analysis. Bivariate and multivariable analysis were done to assess factors associated with feeding practices during a diarrheal episode. Odds ratio with 95% CI was used to identify a statistically significant association between independent variables and feeding practice during diarrheal episode. Result. The proportion of proper feeding practice during diarrheal episode was 467 (70.7%). Boy children were about 1.6 times [AOR; 1.62 (95%CI=1.04, 2.50)] more likely to receive increased food and fluid than girl children. Mothers who have one under-five child were 2 times [AOR 2.11 (95% CI =1. 38, 3.23)] more likely to have proper feeding practice during diarrheal episode as compared to those have two and more under-five children. The likelihood of increasing food and fluid during diarrheal episodes was 2 times [AOR 2.46 (95% CI=1. 55, 3.88)] higher among children from maternal age of 30-39 years than those from 20-29 years. Mothers who get information about feeding practices during diarrheal episodes were 2 times [AOR 2.19 (95% CI=1. 43, 3.36)] more likely to increase food and fluid to their child compared to their counterparts. Conclusion. In this study educational status, number of antenatal care visits, sex, number of under-5 children, maternal age, and mothers information about feeding practice were independently associated with feeding practices during a diarrheal episode. Therefore, intensive intervention programme should focus on these determinants to reduce child mortality and morbidity and realize sustainable development goals.

scholarly journals Incidence and Predictors of Flares in the Postpartum Year Among Women With Inflammatory Bowel Disease

2020 ◽  
Vol 26 (12) ◽  
pp. 1926-1932 ◽  
Author(s):  
Amy Yu ◽  
Sonia Friedman ◽  
Ashwin N Ananthakrishnan
Keyword(s):  
Inflammatory Bowel Disease ◽  
Disease Activity ◽  
Bowel Disease ◽  
Multivariable Analysis ◽  
Third Trimester ◽  
Disease Flare ◽  
Entire Cohort ◽  
Duration Of Disease ◽  
Inflammatory Bowel ◽  
Relevant Covariates

Abstract Background The postpartum period is marked by physiological and psychological stresses that may impact activity in inflammatory bowel disease. The predictors and outcomes of disease activity during this period have not been well characterized. Methods We performed a retrospective review of inflammatory bowel disease patients who underwent successful pregnancy and live birth at 2 referral institutions. Data on patient and disease factors including disease activity before and during pregnancy were abstracted from the medical records. We noted whether therapy was dose-reduced or stopped during pregnancy at each trimester and after delivery. Multivariable logistic regression of independent predictors of postpartum flare was performed, adjusting for relevant covariates. Results We identified a total of 206 eligible women (mean age, 33.2 years). Of these, 97 (47%) had a diagnosis of Crohn’s disease, whereas the remainder had ulcerative colitis. Nearly half the women delivered vaginally (53%), and the rest delivered by Caesarean section (47%). In the entire cohort, 65 (31.6%) experienced a postpartum flare within the year after delivery. In multivariable analysis, development of a postpartum flare was predicted by disease activity during the third trimester (odds ratio [OR], 6.27; 95% confidence interval [CI], 2.81–17.27), therapy de-escalation during pregnancy (OR, 3.00; 95% CI, 1.03–8.68), and therapy de-escalation after pregnancy (OR, 4.43; 95% CI, 1.55–12.65). Postpartum disease flare was not related to disease type, duration of disease, or mode of childbirth. Conclusions One-third of women with inflammatory bowel disease may experience disease flare during the postpartum year. Continued optimization of therapy before, during, and after pregnancy is essential to prevent this morbidity.

The Impact of a Colorectal Care Bundle for Surgical Site Infections at an Academic Disproportionate Share Hospital With a Level I Trauma Center

2020 ◽  
Vol 86 (7) ◽  
pp. 848-855
Author(s):  
Luv N. Hajirawala ◽  
Timothy B. Legare ◽  
Simon Peter T. Tiu ◽  
Amy M. DeKerlegand ◽  
Jeffrey S. Barton ◽  
...  
Keyword(s):  
Multivariable Analysis ◽  
Surgical Site Infections ◽  
Care Bundle ◽  
Limited Data ◽  
Elective Colorectal Surgery ◽  
Care Bundles ◽  
Risk Patients ◽  
Multivariable Analyses ◽  
Level I ◽  
The Impact

Objectives Colorectal care bundles for surgical site infections (CRCB-SSIs) have been shown to reduce SSIs following elective colorectal surgery (CRS). There are limited data evaluating the effect of CRCB-SSI at Academic Disproportionate Share Hospitals (ADSH) with significant rates of urgent and emergent cases. Methods A CRCB-SSI was implemented in April 2016. We reviewed medical records of all patients undergoing colon resections between August 2015 and December 2017. Patients were divided into preimplementation and postimplementation groups. The primary endpoint was the SSI rate, and the secondary endpoint included types of SSI (superficial, deep, organ space). Univariable and multivariable analyses were performed. A subset analysis was performed in elective cases. Results We analyzed a total of 417 patients. Of these, 116 (28%) and 301 (72%) patients were in the preimplementation and postimplementation groups, respectively. The rate of SSI decreased from 30.1% to 15.9% in the postimplementation group ( P = .0012); however, it was not statistically significant after adjusting for baseline differences (relative risk [RR] 0.65; 95% CI 0.41-1.02). The elective subset included 219 patients. The rate of SSI in this cohort decreased from 25% to 10.5% in the postimplementation group ( P = .0012) and remained significant following multivariable analysis (RR 0.41, 95% CI 0.19- 0.88). There were no differences in the subtypes of SSI. Discussion While the CRCB-SSI was effective in decreasing the postoperative SSI rate for elective cases, its effect on the overall patient population was limited. CRCB-SSIs are not enough to bring SSI rates to accepted rates in high-risk patients such as those seen at ADSH.

scholarly journals Maternal Age During Pregnancy Is Associated With Third Trimester Blood Pressure Level: The Generation R Study

2011 ◽  
Vol 24 (9) ◽  
pp. 1046-1053 ◽  
Author(s):  
Romy Gaillard ◽  
Rachel Bakker ◽  
Eric A.P. Steegers ◽  
Albert Hofman ◽  
Vincent W.V. Jaddoe
Keyword(s):  
Blood Pressure ◽  
Maternal Age ◽  
Blood Pressure Level ◽  
Pressure Level ◽  
Third Trimester

THE RELATIONSHIPS BETWEEN MOTHER AGES, AGE OF PREGNANCY AND GRAVIDA THROUGH THE INCIDENT OF PREEKLAMPSIA IN RSUD HOSPITAL

2018 ◽  
Vol 10 (2) ◽  
pp. 32-43
Author(s):  
Desi Desi Nurseha Meirita
Keyword(s):  
Multivariate Analysis ◽  
Mortality Rate ◽  
Maternal Mortality ◽  
Gestational Age ◽  
Medical Records ◽  
Maternal Age ◽  
P Value ◽  
Third Trimester ◽  
Maternal Mortality Rate ◽  
Secondary Methods

Based on the 2016 National Health Indicator Survey the maternal mortality rate in Indonesia is still high at 305 dead mothers per 100,000 people. The high maternal mortality rate was influenced by 28.8% due to preeclampsia. With the SDGs planned, 13 targets in point number three, one of which mentions by 2030, reduce maternal mortality to below 70 per 100,000 live births. Find out the correlation of maternal age, gestational age and gravides with the incidence of preeclampsia in RSUD Hospital Bogor in 2018. This type of research is analytical with retrospective research design. The researcher use 89 respondents to conudct this research. The Date collection is obtained by secondary methods, namely data taken from medical records. The analysis used is univariate, bivariate and multivariate analysis. Based on the results of the study found maternal age as many as 56 (62.9%) respondents, gestational age in the third trimester 70 (78.7%) respondents, multigravida as many as 59 (66.3%). Bivariate variables were found to correlate maternal age with the incidence of preeclampsia with p value of 0,004, The correlation of gestational age and the incidence of preeclampsia with p value of 0,069, The correlation of gravida with the incidence of preeclampsia with p value of 0,013. The results of multivariate analysis showed that the maternal age gravida variable had an opportunity of 0,013times greater than the gravida who experienced the incidence of preeclampsia. Maternal age variables have a greater chance of 3,006 times compared to the gravidaand gestational age that experienced the incidence of preeclampsia.

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