Body Weight Gain Blunts Brain Beneficial Effects Of Physical Training In Old Apoe-/- Mice

2015 ◽  
Vol 47 ◽  
pp. 672-673
Author(s):  
Vincent Pialoux ◽  
Di Cataldo Vanessa ◽  
Erica N. Chirico ◽  
Emmanuelle Canet-Soulas
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Physical Training ◽  
Body Weight Gain ◽  
Beneficial Effects

scholarly journals Eicosapentaenoic acid actions on adiposity and insulin resistance in control and high-fat-fed rats: role of apoptosis, adiponectin and tumour necrosis factor-α

2007 ◽  
Vol 97 (2) ◽  
pp. 389-398 ◽  
Author(s):  
Patricia Pérez-Matute ◽  
Nerea Pérez-Echarri ◽  
J. Alfredo Martínez ◽  
Amelia Marti ◽  
María J. Moreno-Aliaga
Keyword(s):  
Gene Expression ◽  
Insulin Resistance ◽  
Body Weight ◽  
Adipose Tissue ◽  
Weight Gain ◽  
Body Weight Gain ◽  
Control Diet ◽  
Cafeteria Diet ◽  
High Fat ◽  
Beneficial Effects

n-3 PUFA have shown potential anti-obesity and insulin-sensitising properties. However, the mechanisms involved are not clearly established. The aim of the present study was to assess the effects of EPA administration, one of the n-3 PUFA, on body-weight gain and adiposity in rats fed on a standard or a high-fat (cafeteria) diet. The actions on white adipose tissue lipolysis, apoptosis and on several genes related to obesity and insulin resistance were also studied. Control and cafeteria-induced overweight male Wistar rats were assigned into two subgroups, one of them daily received EPA ethyl ester (1 g/kg) for 5 weeks by oral administration. The high-fat diet induced a very significant increase in both body weight and fat mass. Rats fed with the cafeteria diet and orally treated with EPA showed a marginally lower body-weight gain (P = 0·09), a decrease in food intake (P < 0·01) and an increase in leptin production (P < 0·05). EPA administration reduced retroperitoneal adipose tissue weight (P < 0·05) which could be secondary to the inhibition of the adipogenic transcription factor PPARγ gene expression (P < 0·001), and also to the increase in apoptosis (P < 0·05) found in rats fed with a control diet. TNFα gene expression was significantly increased (P < 0·05) by the cafeteria diet, while EPA treatment was able to prevent (P < 0·01) the rise in this inflammatory cytokine. Adiposity-corrected adiponectin plasma levels were increased by EPA. These actions on both TNFα and adiponectin could explain the beneficial effects of EPA on insulin resistance induced by the cafeteria diet.

scholarly journals Effects of supplemental phytase on performance and tibia ash of broilers fed different cereals based diets

2011 ◽  
Vol 49 (No. 12) ◽  
pp. 542-548 ◽  
Author(s):  
J. Pintar ◽  
B. Homen ◽  
K. Gazić ◽  
D. Grbeša ◽  
M. Sikirić ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Body Weight Gain ◽  
Dietary Calcium ◽  
Feed Consumption ◽  
Feed Conversion ◽  
Control Groups ◽  
Broiler Performance ◽  
Beneficial Effects ◽  
Tibia Ash

A 21-day experiment with day-old broilers was conducted in order to assess the effect of phytase supplementation to different cereals-soybean meal based diets on broiler performance and tibia ash. Diets were formulated to contain 4 different cereals (maize, wheat, triticale and barley), 2 levels of dietary calcium (0.6 and 1.0%) and 3 levels of supplemental phytase (0, 500 and 1 000 PU/kg). Supplemented phytase had beneficial effects on broiler performance. It significantly increased body weight gain (P &lt; 0.0003) and feed consumption (P &lt; 0.0361) by 6 and 7% in comparison with the control groups, respectively. No influence on feed conversion ratio and tibia ash was detected. Both body weight gain and feed intake were also significantly influenced by different cereals (P &lt; 0.0001 and 0.0348, respectively). The increasing dietary calcium level resulted in a significant increase in body weight gain (P &lt; 0.0024) and tibia ash (P &lt; 0.0016). Effects of 500 and 1 000 PU/kg were not statistically different between themselves. &nbsp;

scholarly journals Dietary Cyanidin-3-Glucoside Attenuates High-Fat-Diet–Induced Body-Weight Gain and Impairment of Glucose Tolerance in Mice via Effects on the Hepatic Hormone FGF21

2020 ◽  
Vol 150 (8) ◽  
pp. 2101-2111 ◽  
Author(s):  
Lili Tian ◽  
Hongmei Ning ◽  
Weijuan Shao ◽  
Zhuolun Song ◽  
Yasaman Badakhshi ◽  
...  
Keyword(s):  
Drinking Water ◽  
Body Weight ◽  
Weight Gain ◽  
Glucose Tolerance ◽  
High Fat Diet ◽  
Body Weight Gain ◽  
Fibroblast Growth Factor 21 ◽  
High Fat ◽  
Beneficial Effects ◽  
Fgf21 Expression

ABSTRACT Background Dietary polyphenols including anthocyanins target multiple organs. Objective We aimed to assess the involvement of glucagon-like peptide 1 (GLP-1), leptin, insulin and fibroblast growth factor 21 (FGF21) in mediating metabolic beneficial effects of purified anthocyanin cyanidin-3-glucoside (Cy3G). Methods Intestinal proglucagon gene (Gcg; encoding GLP-1) and liver Fgf21 expression were assessed in 6-wk-old male C57BL-6J mice fed a low-fat-diet (LFD; 10% of energy from fat), alone or with 1.6 mg Cy3G/L in drinking water for 3 wk [experiment (Exp.) 1; n = 5/group]. Similar mice were fed the LFD or a high-fat diet (HFD; 60% energy from fat) with or without Cy3G for 20 wk. Half of the mice administered Cy3G also received 4 broad-spectrum antibiotics (ABs) in drinking water between weeks 11 and 14, for a total of 6 groups (n = 8/group). Metabolic tolerance tests were conducted between weeks 2 and 16. Relevant hormone gene expression and plasma hormone concentrations were assessed mainly at the end of 20 wk (Exp. 2). Results In Exp. 1, Cy3G administration increased ileal but not colonic Gcg level by 2-fold (P &lt; 0.05). In Exp. 2, Cy3G attenuated HFD-induced body-weight gain (20.3% at week 16), and improved glucose tolerance (26.5% at week 15) but not insulin tolerance. Although Cy3G had no effect on glucose tolerance in LFD mice, LFD/Cy3G/AB mice showed better glucose tolerance than LFD/Cy3G mice (23%). In contrast, HFD/Cy3G/AB mice showed worse glucose tolerance compared with HFD/Cy3G mice (15%). Beneficial effects of Cy3G in HFD mice were not associated with changes in plasma leptin, insulin or GLP-1 concentrations. However, Cy3G increased hepatic Fgf21 expression in mice in Exp. 1 by 4-fold and attenuated Fgf21 overexpression in HFD mice (Exp. 2, 22%), associated with increased expression of genes that encode FGFR1 and β-klotho (&gt;3-fold, P &lt; 0.05). Conclusions Dietary Cy3G may reduce body weight and exert metabolic homeostatic effects in mice via changes in hepatic FGF21.

scholarly journals Beneficial Effects of a Low-dose of Conjugated Linoleic Acid on Body Weight Gain and other Cardiometabolic Risk Factors in Cafeteria Diet-fed Rats

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 408 ◽  
Author(s):  
Miguel Z Martín-González ◽  
Héctor Palacios ◽  
Miguel A Rodríguez ◽  
Lluís Arola ◽  
Gerard Aragonès ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Low Dose ◽  
Body Weight Gain ◽  
Total Phospholipid ◽  
Low Doses ◽  
Metabolic Disturbances ◽  
Beneficial Effects

Conjugated linoleic acid (CLA) is a dietary supplement that has been shown to improve obesity. However, some authors have associated high doses of CLA supplementation with liver impairment and insulin resistance. The aim of this study was to assess whether the consumption of low doses of CLA maintained the beneficial effects on the main metabolic disturbances associated with metabolic syndrome (MetS) but prevented the occurrence of non-desirable outcomes associated with its consumption. Male Wistar rats, fed standard or cafeteria (CAF) diet for 12 weeks, were supplemented with three different low doses of CLA in the last three weeks. Both biochemical and H1 NMR-based metabolomics profiles were analysed in serum and liver. The consumption of 100 mg/kg CLA, but not doses of 200 and 300 mg/kg, ameliorated the increase in body weight gain as well as the serum concentrations of glucose, insulin, cholesterol, triglyceride, diglyceride, and total phospholipid induced by a CAF diet. In turn, CLA reverted the increase in lactate, alanine, and glucose concentrations in the liver of these animals, but enhanced hepatic cholesterol accumulation without any detrimental effect on liver function. In conclusion, a low dose of CLA corrected the adverse effects associated with MetS without compromising other metabolic parameters.

scholarly journals Supplementation with Lactiplantibacillus Plantarum IMC 510 Modifies Microbiota Composition and Prevents Body Weight Gain Induced by Cafeteria Diet in Rats

2021 ◽  
Vol 22 (20) ◽  
pp. 11171
Author(s):  
Maria Vittoria Micioni Di Bonaventura ◽  
Maria Magdalena Coman ◽  
Daniele Tomassoni ◽  
Emanuela Micioni Di Bonaventura ◽  
Luca Botticelli ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Body Weight Gain ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Probiotic Strain ◽  
Hepatic Lipid Accumulation ◽  
Beneficial Effects ◽  
Diet Induced Obesity ◽  
The Impact

Changes in functionality and composition of gut microbiota (GM) have been associated and may contribute to the development and maintenance of obesity and related diseases. The aim of our study was to investigate for the first time the impact of Lactiplantibacillus (L.) plantarum IMC 510 in a rat model of diet-induced obesity, specifically in the cafeteria (CAF) diet. This diet provides a strong motivation to voluntary overeat, due to the palatability and variety of selected energy-dense foods. The oral administration for 84 days of this probiotic strain, added to the CAF diet, decreased food intake and body weight gain. Accordingly, it ameliorated body mass index, liver and white adipose tissue weight, hepatic lipid accumulation, adipocyte size, serum parameters, including glycemia and low-density lipoprotein levels, in CAF fed rats, potentially through leptin control. In this scenario, L. plantarum IMC 510 showed also beneficial effects on GM, limiting the microbial imbalance established by long exposure to CAF diet and preserving the proportion of different bacterial taxa. Further research is necessary to better elucidate the relationship between GM and overweight and then the mechanism of action by which L. plantarum IMC 510 modifies weight. However, these promising results prompt a clear advantage of probiotic supplementation and identify a new potential probiotic as a novel and safe therapeutic approach in obesity prevention and management.

Body weight gain impairs physical training benefits in old apoE -/- mice

2014 ◽  
Vol 235 (2) ◽  
pp. e73
Author(s):  
V. Di Cataldo ◽  
E.N. Chirico ◽  
A. Geloen ◽  
J.B. Langlois ◽  
H. Vidal ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Physical Training ◽  
Body Weight Gain

PENGEMBANGAN TANAMAN RAMI (Boehmeria nivea L. Gaud) DAN PEMANFAATAN LIMBAH DAUN RAMI UNTUK PENGGEMUKKAN DOMBA WONOSOBO

2018 ◽  
Vol 16 (2) ◽  
pp. 201-210
Author(s):  
Muryanto Muryanto ◽  
Pita Sudrajad ◽  
Amrih Prasetyo
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Plant Development ◽  
Body Weight Gain ◽  
Survey Methods ◽  
The Body ◽  
Boehmeria Nivea ◽  
Central Java ◽  
Potential Capacity ◽  
The Given

The aim of the study was to determine the development of ramie plants (Boehmeria nivea L. Gaud) and the effect of using ramie leaves on feed on the body weight gain of Wonosobo Sheep (Dombos). Research on the development of ramie plants using survey methods in the area of ramie plant development in Wonosobo Regency. While the research on the use of ramie leaves for fattening was carried out in Butuh Village, Kalikajar District, Wonosobo Regency in 2018. 21 male Dombos were divided into 3 feed treatments with forage proportions of 70%, 50% and 30 ramie leaves respectively. %. The results showed that currently ramie plants were being developed in Wonosobo Regency by CV. Ramindo Berkah Persada Sejahtera in Gandok Village, Kalikajar District, Wonosobo Regency, Central Java. Until now the area of the crop has reached 13 ha. Of this area will produce ramie leaves 195,000 kg / year. If one sheep needs 4 kg of ramie / tail / day leaves, then the potential capacity of sheep is 135 heads / year, if the given one is 50% then the Jurnal Litbang Provinsi Jawa Tengah, Volume 16 202 Nomor 2 – Desember 2018potential capacity is 270 heads / year and if it is reduced again to 25% of ramie leaves then the potential capacity 440 heads / year. The use of ramie leaves as a feed for Wonosobo Sheep fattening can be given as much as 30% in fresh form.

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