Herpes zoster and HIV infection in Tanzania

2000 ◽  
Vol 11 (4) ◽  
pp. 254-256 ◽  
Author(s):  
A E Naburi ◽  
Barbara Leppard
Keyword(s):  
Herpes Zoster ◽  
Hiv Infection ◽  
Medical Centre ◽  
Hiv Positive ◽  
Age Group ◽  
Very Elderly ◽  
Kilimanjaro Christian Medical Centre ◽  
Disseminated Disease

Two hundred consecutive patients with herpes zoster attending the skin clinic at the Kilimanjaro Christian Medical Centre (KCMC) were examined and checked for HIV infection. They ranged in age from 10 months to 86 years with the majority in their 20s and 30s. The dermatomes involved were thoracic (97), trigeminal (50), cervical (37), lumbar (19) and sacral (3). Six (3%) had more than one dermatome involved and 2 (1%) had disseminated disease. Only 2 (1%) had severe ulceration of the skin and all healed in less than 4 weeks. In children under the age of 10 years and in adults between the ages of 20 and 49 years virtually 100% were HIV positive; even in the age group 50-59 more than three-quarters were HIV positive. We conclude that the presence of herpes zoster at any site is a good indication that the patient is HIV positive except in the teens and the very elderly.

scholarly journals Scenerio of HIV patients reported to University Kebangsaan Medical Centre during 2006-2009

1970 ◽  
Vol 10 (1) ◽  
pp. 21-28
Author(s):  
MM Rahman ◽  
WK Ken ◽  
MR Norzuriza ◽  
I Isahak ◽  
SS Azura ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Medical Science ◽  
Age Groups ◽  
Ethnic Origin ◽  
Vital Role ◽  
Agglutination Test ◽  
Medical Centre ◽  
Hiv Positive ◽  
Age Group ◽  
Keywords Hiv

Objective: A study was undertaken to identify the HIV-positive cases from suspected patients reported to University Kebangsaan Malaysia Medical Centre (UKMMC) from January, 2006 to December; 2009. Methods: Cases were identified and confirmed by three established sero-diagnostic tests: Micro particulate Enzyme Immunoassay, Passive Particle Agglutination Test and Line Immunoassay. Results: A total of 256 HIV positive patients were identified and highlighted about their age, sex, ethnic origin and year wise distribution of cases. Frequency distribution of HIV-positive cases among different age groups indicated that, 144 (%) were aged between 21 to 40 years, 81 (%) were aged 41 to 60, 19 (%) were aged above 60 and 12 (%) were in the age group of 0-20 years. It revealed that the highest number of HIV-positive patients was in the age group of 21-40 years. Among the 4 groups of people living in Malaysia, HIV infection was found more in Chinese community (101), followed by Malaya community (97), Other community (Sikhs, tribes, foreigners) living in Malaysia (30) and Indian community (28). A total of 179 male and 77 female were positive for HIV infection. Monthly records of case detection indicate more or less similar prevalence pattern throughout the study period. Conclusions: It reveals from the report that the Malysian patients are mostly infected at the adulthood unlike other countries where majority of infections occur in young age .A high percent of HIV infection in males in the country indicates that they might played a vital role in carrying and disseminating infectiions to their female parterners. Keywords: HIV/AIDS; Sero-diagnosis; Socio-demographic profile; Malaysia. DOI: 10.3329/bjms.v10i1.7315 Bangladesh Journal of Medical Science Vol.10 No.1 Jan 2010 pp.21-28  

scholarly journals The prevalence of hepatitis B virus among HIV-positive patients at Kilimanjaro Christian Medical Centre Referral Hospital, Northern Tanzania

2017 ◽  
Vol 28 ◽  
Author(s):  
Tasilo Kamenya ◽  
Damian Jeremia Dami ◽  
James Samwel Ngocho ◽  
Rune Nathanael Philemon ◽  
Michael Johnson Mahande ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Referral Hospital ◽  
Medical Centre ◽  
Hiv Positive ◽  
Northern Tanzania ◽  
B Virus ◽  
Kilimanjaro Christian Medical Centre

scholarly journals Change in profile of cutaneous manifestations of HIV after the advent of antiretroviral therapy: a retrospective analysis

2021 ◽  
Vol 7 (6) ◽  
pp. 755
Author(s):  
Ireen C. Bwalya ◽  
Som Lakhani ◽  
Christian Aldridge
Keyword(s):  
Herpes Zoster ◽  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
Kaposi's Sarcoma ◽  
Oral Candidiasis ◽  
Kaposi’S Sarcoma ◽  
Hiv Positive ◽  
Herpes Labialis ◽  
Inclusion Criteria ◽  
Cutaneous Manifestations

<p><strong>Background: </strong>To date, there has been no study conducted in Zambia to determine the prevalence of mucocutaneous conditions among HIV positive patients on antiretroviral therapy.<strong></strong></p><p><strong>Methods: </strong>The aim of the study was to determine the differences in cutaneous manifestations of HIV between HIV positive adult patients on antiretroviral therapy and antiretroviral naïve patients.</p><p><strong>Results: </strong>A total of 143 adult HIV/AIDS patients with dermatological manifestations, and fulfilling inclusion criteria, were included. Among the 58 patients on antiretroviral therapy, the most common dermatoses were hyper-pigmentation (18.97%), fungal dermatitis (17.24%) genital herpes (8.62%), papular pruritic eruption (8.62%), oral candidiasis (8.62%) and Kaposi’s sarcoma (6.9%). The most common dermatoses among the 85 antiretroviral naive patients were oral candidiasis (34.12%), herpes Zoster (17.65%), hyper pigmentation (8.24%), eosinophillic folliculitis (7.06%), abscesses (5.88%), herpes labialis (4.71%) and Kaposi's sarcoma (4.71%). Among patients in Stage III of HIV infection, the proportion of patients with infectious dermatoses was significantly greater than the proportion of patients with non-infectious dermatoses (47.5% versus 28.6%; p=0.036).The odds of having an infectious dermatosis were 28% lower for patients on antiretroviral therapy as compared to antiretroviral naive patients (p=0.001).<strong></strong></p><p><strong>Conclusions: </strong>There is a changing profile of muco-cutaneous conditions in HIV infected patients. Infectious dermatoses such as oral candidiasis and Herpes Zoster infections occur more frequently in antiretroviral naïve patients, as compared to patients on ART. Prevention of infectious dermatological conditions occurs with the use of ART.<strong></strong></p>

scholarly journals Clinical profile of HIV positive patients attending ART centre of a tertiary care hospital

2018 ◽  
Vol 7 (8) ◽  
pp. 1542
Author(s):  
Tejas M. Doshi ◽  
Rusva A. Mistry ◽  
Manish N. Mehta
Keyword(s):  
Hiv Infection ◽  
Tertiary Care ◽  
Clinical Profile ◽  
Reproductive Age ◽  
Hiv Positive ◽  
Common Symptom ◽  
Care Hospital ◽  
Age Group ◽  
Route Of Transmission ◽  
Common Opportunistic Infection

Background: HIV infection/AIDS is a global pandemic greatly exceeds earlier prediction. With widespread availability and uses of Anti Retroviral Therapy (ART), HIV becomes a chronic manageable illness but immediate and long term side effects become a major problem. The objective of the study was to study clinical profile of HIV positive patients attending A.R.T. centre of a tertiary care hospital.Methods: Observational and prospective study was carried out over 100 HIV positive Patients attending ART centre of G.G.G Hospital, Jamnagar, Saurastra, Gujarat over a period of 12 months.Results: Out of 100 HIV positive studied patients, maximum cases (95%) were in the age group of 15-49 years, 75% were males. (58%) cases were from rural area and (56%) were illiterate. Maximum cases were having sexual (79%) route of transmission. Most common symptom among HIV positive patients was weight loss (62%) followed by fever (58%). Mycobacterium tuberculosis (65%) was the most common opportunistic infection. (84%) patients had CD4 count between 50-200/cub.mm, (66%) were in stage III. ART was well tolerated, ADRs were found in 43% of patients.Conclusions: HIV is more common in reproductive age group with males being more affected and major route of transmission of HIV infection remains heterosexual mode.

A Qualitative Study Exploring Harmful Cultural Practices and HIV Stigma in North Central Nigeria

2020 ◽  
Vol 6 (1) ◽  
pp. 5-11
Author(s):  
Bala Augustine Nalah ◽  
Azlinda Azman ◽  
Paramjit Singh Jamir Singh
Keyword(s):  
Hiv Infection ◽  
Hiv Transmission ◽  
Cultural Practices ◽  
Qualitative Interviews ◽  
Well Being ◽  
Cultural Practice ◽  
Hiv Stigma ◽  
Hiv Positive ◽  
North Central ◽  
Harmful Cultural Practices

Harmful cultural practices have psychosocial implications on stigmatization and vulnerability to HIV infection among HIV positive living in North Central Nigeria. To understand this, we conducted qualitative interviews with purposively selected 20 diagnosed HIV positive to explore how culture influences stigmatization and HIV transmission. Data was collected using audio-recorder, transcribed, and analyzed through thematic analysis using ATLAS.ti8 software to code and analyze interview transcripts. The coded data were presented using thematic network analysis to visualize the theme, sub-themes, and quotations in a model. The findings reveal that lack of education was a significant determinant for the continual practice of harmful cultural rites, thereby increasing the risk of HIV infection and stigmatization. Hence, six cultural facilitators have been identified to include female genital mutilation, lack of education, tribal marks and scarification, postpartum sexual abstinence during breastfeeding, sexual intercourse during menstruation, and gender inequality, polygamy, and inheritance law. We conclude that educational teachings and advocacy campaigns be organized in rural schools and public places on the implications of harmful cultural practice to health and psychological well-being. We recommend that the social workers and behavioral scientists should collaborate with other agencies to employ a behavioral-based intervention in eliminating cultural practices and HIV stigma.

scholarly journals 996. The Potential for Reducing Opioid and Analgesic Prescriptions Via Herpes Zoster Vaccination

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S527-S527
Author(s):  
Jean-Etienne Poirrier ◽  
Justin Carrico ◽  
Jessica K DeMartino ◽  
Katherine A Hicks ◽  
Jeffrey J Stoddard ◽  
...  
Keyword(s):  
Herpes Zoster ◽  
Age Group ◽  
Opioid Prescription ◽  
Varicella Zoster ◽  
Effectiveness Model ◽  
Prescription Rates ◽  
Medication Exposure ◽  
The Mean ◽  
The Impact ◽  
Analgesic Use

Abstract Background Herpes zoster (HZ), or shingles, is a common neurocutaneous disease caused by the reactivation of latent varicella zoster virus that often includes rash and neuropathic pain that may last for months. Opioids and other analgesics may be prescribed. Recombinant zoster vaccine (RZV) is preferentially recommended for the prevention of HZ in adults aged 50 years and older. This study aimed to assess the impact of RZV vaccination on opioid and other analgesic prescription-related outcomes. Methods Estimates of analgesic prescription rates (opioids, benzodiazepines, and other analgesics) among HZ cases were established using Truven claims data from 2012-2018 for adults aged 50 years and older. HZ case avoidance with RZV vaccination was calculated using a previously published cost-effectiveness model. This data was included in a calculator assessing the impact of RZV vaccination on analgesic prescription-related outcomes (compared to no vaccination). Results Between 24.4% and 28.0% of HZ cases in the observed claims had at least one opioid prescription, dependent on age group (4.5%-6.5% and 8.6%-19.6% for benzodiazepines and other analgesics, respectively). The mean number of opioid prescriptions per person in each age group with at least one opioid prescription was between 1.7 and 1.9 (1.7-2.3 and 1.7-2.0 prescriptions for benzodiazepines and other analgesics, respectively). Assuming a 1-million-person population and 65% RZV coverage, the calculator predicts RZV vaccination will prevent 75,002 cases of HZ and will prevent 19,311 people from being prescribed at least 1 HZ-related opioid, 4,502 people from being prescribed benzodiazepines, and 12,201 people from being prescribed other analgesics. Additionally, 34,520 HZ-related opioid prescriptions will be avoided (9,413 benzodiazepine prescriptions; 22,406 other analgesic prescriptions). Conclusion HZ is associated with high levels of opioid, benzodiazepine, and other analgesic use. Primary prevention of HZ by vaccination could potentially reduce opioid and other medication exposure. Disclosures Jean-Etienne Poirrier, PhD, MBA, The GSK group of companies (Employee, Shareholder) Justin Carrico, BS, GlaxoSmithKline (Consultant) Jessica K. DeMartino, PhD, The GlaxoSmithKline group of companies (Employee, Shareholder) Katherine A. Hicks, MS, BSPH, GlaxoSmithKline (Scientific Research Study Investigator, GSK pays my company for my contractual services.) Saurabh P. Nagar, MS, RTI Health Solutions (Employee) Juliana Meyers, MA, GlaxoSmithKline (Other Financial or Material Support, This study was funded by GlaxoSmithKline.)

scholarly journals Cryptococcal infection of the colon in a patient without concurrent human immunodeficiency infection: a case report and literature review

2021 ◽  
Author(s):  
Alvaro Quincho-Lopez ◽  
Noah Kojima ◽  
John M. Nesemann ◽  
Rogger Verona-Rubio ◽  
Dina Carayhua-Perez
Keyword(s):  
Human Immunodeficiency Virus ◽  
Literature Review ◽  
Hiv Infection ◽  
Chronic Diarrhea ◽  
Cryptococcal Infection ◽  
Pulmonary System ◽  
Immunodeficiency Virus ◽  
The Central Nervous System ◽  
Disseminated Disease ◽  
Histopathology Examination

AbstractCryptococcosis is a fungal infection that is rarely reported in patients without human immunodeficiency virus (HIV) infection, especially when the central nervous system (CNS) or pulmonary system is not involved. We report a case of isolated colonic cryptococcosis without disseminated disease in a 64-year-old immunocompetent woman without HIV infection who presented with chronic diarrhea and no episodes of fever or weight loss. The diagnosis was based on histopathology examination. Furthermore, we performed a literature review showing that few reports have been published so far and in the case of colonic cryptococcal infection, the prognosis is favorable among HIV-uninfected patients.

Clinical outcomes of syphilis in HIV-negative and HIV-positive MSM: occurrence of repeat syphilis episodes and non-treponemal serology responses

2021 ◽  
pp. sextrans-2020-054887
Author(s):  
Silvia Achia Nieuwenburg ◽  
Ricardo Jamie Sprenger ◽  
Maarten Franciscus Schim van der Loeff ◽  
Henry John Christiaan de Vries
Keyword(s):  
Hiv Infection ◽  
Controlled Trial ◽  
Clinical Manifestations ◽  
Response To Treatment ◽  
Disease Stage ◽  
Hiv Positive ◽  
Sexual Risk Behaviour ◽  
Serological Response ◽  
History Of ◽  
Hiv Negative

ObjectivesHIV-positive men who have sex with men (MSM) may be at a higher risk of repeat syphilis, have different clinical manifestations and have a different serological response to treatment compared with HIV-negative MSM. The objective of this study was to assess whether HIV-negative and HIV-positive MSM with infectious syphilis (primary, secondary or early latent) differed in history of previous syphilis episodes, disease stage and non-treponemal titre of initial and repeat episodes, and the titre response 6 and 12 months after treatment. Furthermore, determinants associated with an inadequate titre response after treatment were explored.MethodsThis retrospective analysis used data of five longitudinal studies (four cohorts; one randomised controlled trial) conducted at the STI clinic in Amsterdam, the Netherlands. Participants were tested for syphilis and completed questionnaires on sexual risk behaviour every 3–6 months. We included data of participants with ≥1 syphilis diagnosis in 2014–2019. Pearson’s χ² test was used to compare HIV-negative and HIV-positive MSM in occurrence of previous syphilis episodes, disease stage of initial and repeat syphilis episode and non-treponemal titre treatment responses.ResultsWe included 355 participants with total 459 syphilis episodes. HIV-positive MSM were more likely to have a history of previous syphilis episodes compared with HIV-negative MSM (68/90 (75.6%) vs 96/265 (36.2%); p<0.001). Moreover, HIV-positive MSM with repeat syphilis were less often diagnosed with primary syphilis (7/73 (9.6%) vs 36/126 (28.6%)) and more often diagnosed with secondary syphilis (16/73 (21.9%) vs 17/126 (13.5%)) and early latent syphilis (50/73 (68.5%) vs 73/126 (57.9%)) (p=0.005). While not significantly different at 12 months, HIV-negative MSM were more likely to have an adequate titre response after 6 months compared with HIV-positive MSM (138/143 (96.5%) vs 66/74 (89.2%); p=0.032).ConclusionsIn repeat syphilis, HIV infection is associated with advanced syphilis stages and with higher non-treponemal titres. HIV infection affects the serological outcome after treatment, as an adequate titre response was observed earlier in HIV-negative MSM.

scholarly journals Correction to: Day case laparoscopic cholecystectomy at Kilimanjaro Christian Medical Centre, Tanzania

2021 ◽  
Author(s):  
Imogen Cullen ◽  
Fadlo Shaban ◽  
Oroog Ali ◽  
Matthew Breckons ◽  
Kondo Chilonga ◽  
...  
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Medical Centre ◽  
Day Case ◽  
Kilimanjaro Christian Medical Centre

scholarly journals Prescription Pattern of Primary Osteoarthritis in Tertiary Medical Centre

2017 ◽  
Vol 07 (04) ◽  
pp. 037-042
Author(s):  
Sowmya Sham Kanneppady ◽  
Sham Kishor Kanneppady ◽  
Vijaya Raghavan ◽  
Aung Myo Oo ◽  
Ohn Mar Lwin
Keyword(s):  
Vitamin D ◽  
Chondroitin Sulfate ◽  
Musculoskeletal Disorders ◽  
Therapeutic Agents ◽  
Medical Centre ◽  
Fixed Dose ◽  
Age Group ◽  
Prescription Pattern ◽  
Treatment Regimens ◽  
Dose Combination

Abstract Objectives: Osteoarthritis (OA) is one of the commonest joint/musculoskeletal disorders, affecting the middle aged and elderly, although younger people may be affected as a result of injury or overuse. The study aimed to analyze the data, evaluate the prescription pattern and rationality of the use of drugs in the treatment of primary OA with due emphasis on the available treatment regimens. Materials and methods: Medical case records of patients suffering from primary OA attending the department of Orthopedics of a tertiary medical centre were the source of data. The study was carried out prospectively for a period of 20 months (from December 2012 to July 2014). Results: 296 case records were collected in which the total number of drugs prescribed were 550. OA was more common in females (51.7%) and was more prevalent in the age group of 30–40 years (39%). Out of 550 drugs prescribed, Aceclofenac was the most frequently prescribed NSAID (29%) followed by Diclofenac (23%). Nimesulide and Paracetamol was the most commonly prescribed fixed dose combination (53). Among gastroprotectives, Ranitidine figured in 66 prescriptions. Glucocorticoids were prescribed orally and intraarticularly in 17 and 14 cases respectively. Dietary supplements like Calcium+Vitamin D (42) and Glucosamine Sulfate + Chondroitin Sulfate complex (19) were also prescribed. Conclusion: The above study highlights the rational use of therapeutic agents for primary OA.

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