scholarly journals Conservative treatment of Fibrous Dysplasia

2019 ◽  
Vol 35 (3) ◽  
Author(s):  
Besime Ahu Kaynak
Keyword(s):  
Conservative Treatment ◽  
Fibrous Dysplasia ◽  
Developmental Disorder ◽  
Unusual Case ◽  
Histopathological Examination ◽  
Facial Bones ◽  
Creative Commons ◽  
One Year ◽  
Bony Enlargement ◽  
Open Access Article

Fibrous Dysplasia (FD) is a developmental disorder of bone that can affect one bone (monostotic type) or multiple bones (polyostotic type). The disease can be associated with hyperpigmentation and endocrinological disorders. In general, FD is found in teenagers, in the second decade of life. It often involves the long bones, craniofacial bones, ribs and pelvis. Approximately 30% of monostotic FD (MFD) lesions are found in the cranial, rather facial bones. It frequently appears in the posterior region of the jaw bone and is usually unilateral. The etiology of FD is not clear but even so genetic predisposition is suspected. The diagnosis is based on radiological and histopathological examination. We present an unusual case of symptomatic FD. A 15-year-old female patient was admitted to the clinic, complaining gradually increased swelling on her left side of the mandible one year ego with severe and unusual pain at related region. The bony enlargement was extending from median mandible to the crestal marginal level. Surgical shaving and recountering of mandible through the delicate preservation of the mental nerve in the left side of mandible was carried out. The aim of this report is to present the conservative treatment as sufficient treatment modality for the treatment of FD during puberty. doi: https://doi.org/10.12669/pjms.35.3.14 How to cite this:Kaynak BA. Conservative treatment of Fibrous Dysplasia. Pak J Med Sci. 2019;35(3):---------. doi: https://doi.org/10.12669/pjms.35.3.14 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Emerging resistance of van genotype in enterococci: A potential menace for therapeutic failure

2019 ◽  
Vol 35 (6) ◽  
Author(s):  
Hasan Ejaz
Keyword(s):  
Culture Media ◽  
Therapeutic Option ◽  
Therapeutic Failure ◽  
Pcr Assay ◽  
Creative Commons ◽  
Multiplex Pcr Assay ◽  
Vancomycin Resistant ◽  
One Year ◽  
The One ◽  
Open Access Article

Objectives: Emerging cases of vancomycin-resistant enterococci (VRE) are detrimental for the patients. The current study aimed to ascertain the occurrence of VRE, their antibiogram and the van genotype responsible for vancomycin resistance. Methods: A total number of 2,958 clinical specimens were processed at Microbiology Department of the Alrazi Health Care, Lahore during the one year (2016-2017) using microbiological culture media, biochemical and serology. Antibiogram of enterococcal strains was performed using disc diffusion and E-test. ATCC Enterococcus faecalis 29212 was used as a quality control strain. The detection of van genotypes was accomplished by multiplex PCR assay. Results: Out of the 147 enterococci, 139 (94.6%) were E. faecalis, and 8 (5.4%) were E. faecium. Statistically significant associations of urine (p < 0.001), pus (p < 0.001) and wound swabs (p = 0.001) were observed with E. faecalis. A significant correlation of enterococcal infections (p = 0.05) was seen with female patients. Four (2.9%) strains of E. faecalis found to be VRE with vanB (75%) and vanA (25%) genotypes. Conclusion: The emerging strains of VRE (vanB and vanA genotype) in the current study are a potential menace for therapeutic failure, which left the physicians with only linezolid as a therapeutic option. doi: https://doi.org/10.12669/pjms.35.6.1145 How to cite this:Ejaz H. Emerging resistance of van genotype in enterococci: A potential menace for therapeutic failure. Pak J Med Sci. 2019;35(6):1659-1663. doi: https://doi.org/10.12669/pjms.35.6.1145 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Comparison of Caffeine versus Theophylline for apnea of prematurity

2019 ◽  
Vol 35 (1) ◽  
Author(s):  
Arif Zulqarnain ◽  
Muddasser Hussain ◽  
Khalid Munir Suleri ◽  
Zafar Ali Ch.
Keyword(s):  
Numerical Data ◽  
Study Data ◽  
T Test ◽  
P Value ◽  
Medical College ◽  
Creative Commons ◽  
Hospital Ethics ◽  
One Year ◽  
Apnea Of Prematurity ◽  
Open Access Article

Objective: To make a comparison between standard doses of theophylline and caffeine for the treatment of apnea of prematurity. Methods: A randomised control trail was conducted in Department of Pediatrics Medicine Govt. Khawaja Muhammad Safdar Medical College and Govt. Allama Iqbal Memorial Teaching Hospital, Sialkot over duration of one year from August 2017 to August 2018 after approval from the hospital ethics committee. An informed consent in the form of written document was also taken from the parents of each infant participating in the study. Data was analyzed by using SPSS version 24. Mean and SD was calculated for numerical data like gestational age and mean concentration of caffeine and theophylline. Frequency and percentages were calculated for categorical data like nasal continuous positive airway pressure (CPAP), supplemental oxyen and intrventricular hemorrhage (IVH) grade I. Student t-test was applied in order to determine the significance of results. P value ≤ 0.05 was considered significant. Results: A total of 100 infants were enrolled in this study. This study was further divided into two equal groups by lottery method i.e. 50% in each, treated with Theophylline and Caffeine respectively. Mean apnea events/day in neonates administrated by theophylline was 1±0.1, 2±0.12, 2±1.1, 1±0.10 and 2±o.12 for 0, 1-3, 4-7, 8-14 and 15-21 days respectively. While, the mean apnea events/day in neonates administrated by Caffeine was 2±0.3, 1±0.22, 2±1.5, 1±0.13 and 2±0.14 for 0, 1-3, 4-7, 8-14 and 15-21 days respectively. The differences were statistically significant for 1-3 days and 4-7 days p<0.05 according to student t test. Conclusion: Results of our study revealed that caffeine being more effective than Theophylline for treating apnea of prematurity. How to cite this:Zulqarnain A, Hussain M, Suleri KM, Ali Ch. Z. Comparison of Caffeine versus Theophylline for apnea of prematurity. Pak J Med Sci. 2019;35(1):---------. doi: https://doi.org/10.12669/pjms.35.1.94 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Outcome of modified interlaminar decompression: A conservative decompressive surgery for lumbar spine stenosis

2020 ◽  
Vol 36 (4) ◽  
Author(s):  
Farooq Azam ◽  
Seema Sharafat ◽  
Zahid Khan ◽  
Mumtaz Ali
Keyword(s):  
Lumbar Spine ◽  
Decompressive Surgery ◽  
Degenerative Lumbar Spinal Stenosis ◽  
Creative Commons ◽  
One Year ◽  
Complication Of Surgery ◽  
Lumbar Spinal ◽  
Open Access Article ◽  
Structured Questionnaire

Objective: To evaluate the outcomes of modified interlaminar decompression in patients with degenerative lumbar spinal stenosis (LSS). Methods: This descriptive observational study was conducted at the Department of Neurosurgery, Lady Reading Hospital Peshawar from July 2014 to June 2018. All patients with degenerative LSS who underwent modified interlaminar decompression during the study period were included in the study. The patients were followed up to one year after surgery. The data was entered into a structured questionnaire designed according to the study which was then analyzed using SPSS version 21. Results: A total of 182 LSS cases were included in the study and 236 levels were operated during the study period. According to the records increased prevalence of LSS was found among males i.e. 58.8%. The common level with degenerative stenosis involved was L4-5. Good to excellent outcomes were observed in 93.9% patients in the 1st follow-up visit. The most common complication of surgery was dural tear followed by wound infection. Conclusion: Modified interlaminar decompression is a conservative surgical technique, proved to be a potential approach with acceptable complications, satisfactory outcomes and it is easy to learn. doi: https://doi.org/10.12669/pjms.36.4.1170 How to cite this:Azam F, Sharafat S, Khan Z, Ali M. Outcome of modified interlaminar decompression: A conservative decompressive surgery for lumbar spine stenosis. Pak J Med Sci. 2020;36(4):---------. doi: https://doi.org/10.12669/pjms.36.4.1170 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Analysis of Eradication, Recurrence and Levels of 25-hydroxyvitamin D3 and Interleukin-1β in paediatric patients with Helicobacter Pylori Infection-related Gastritis

2020 ◽  
Vol 36 (6) ◽  
Author(s):  
Yuanda Zhang ◽  
Binbin Bi ◽  
Xu Guo ◽  
Shaohui Zhang
Keyword(s):  
Helicobacter Pylori ◽  
Helicobacter Pylori Infection ◽  
Interleukin 1Β ◽  
Control Group ◽  
Creative Commons ◽  
Paediatric Patients ◽  
One Year ◽  
Recurrence Group ◽  
Open Access Article

Objective: To study whether the levels of 25-hydroxyvitamin D3 (25-(OH)D3) and Interleukin-1β (IL-1β) are correlated to the eradication and recurrence of helicobacter pylori (Hp) in paediatric patients with Hp infection-related gastritis. Methods: A total of 142 paediatric patients with Hp infection-related gastritis from November 2017 to March 2018 in Baoding Children’s Hospital were selected as study subjectswere selected as study subjects and were followed up for one year. Paediatric patients were grouped and analyzed according to the effect of follow-up treatment and recurrence. Results: The levels of 25-(OH) D3 in the non-eradication group were lower than those in the eradication group and the control group (F=27.087, P<0.05); the levels of IL-1β were higher than those in the eradication group and the control group (F=16.610, P<0.05). Recurrence during follow-up visits: The levels of 25-(OH) D3 in the recurrence group were lower than those in the non-recurrence group and the control group (F=33.837, P<0.05); the levels of IL-1β in the recurrence group were higher than those in the non-recurrence group and the control group (F=7.896, P<0.05). Correlation analysis showed the levels of 25-(OH) D3 and IL-1β in the eradication group and the non-eradication group were negatively correlated (r=-0.232, P<0.05); the levels of 25-(OH) D3 and IL-1β in the recurrence group and the non-recurrence group were negatively correlated (r=-0.225, P<0.05). Conclusion: Relatively high levels of IL-1β may be correlated to the difficulty in eradicating the Hp infection in paediatric patients. Relatively low levels of 25-(OH) D3 may be correlated to the difficulty in eradicating the Hp infection and recurrence in paediatric patients. doi: https://doi.org/10.12669/pjms.36.6.2292 How to cite this:Zhang Y, Bi B, Guo X, Zhang S. Analysis of Eradication, Recurrence and Levels of 25-hydroxyvitamin D3 and Interleukin-1β in paediatric patients with Helicobacter Pylori Infection-related Gastritis. Pak J Med Sci. 2020;36(6):---------.   doi: https://doi.org/10.12669/pjms.36.6.2292 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals CT Imaging of Craniofacial Fibrous Dysplasia

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Zerrin Unal Erzurumlu ◽  
Peruze Celenk ◽  
Emel Bulut ◽  
Yakup Sancar Barıs
Keyword(s):  
Skull Base ◽  
Fibrous Dysplasia ◽  
Panoramic Radiography ◽  
Imaging Technique ◽  
Histopathological Examination ◽  
Bone Dysplasia ◽  
Facial Bones ◽  
Axial Ct ◽  
Maxilla And Mandible ◽  
The Right

Fibrous dysplasia is a benign fibroosseous bone dysplasia that can involve single (monostotic) or multiple (polyostotic) bones. Monostotic form is more frequent in the jaws. It is termed as craniofacial fibrous dysplasia, when it involves, though rarely, adjacent craniofacial bones. A 16-year-old girl consulted for a painless swelling in the right posterior mandible for two years. Panoramic radiography revealed ground-glass ill-defined lesions in the three different regions of the maxilla and mandible. Axial CT scan (bone window) showed multiple lesions involving skull base and facial bones. Despite lesions in the skull base, the patient had no abnormal neurological findings. The lesion was diagnosed as fibrous dysplasia based on radiological and histopathological examination. In this paper, CT findings and differential diagnosis of CFD are discussed. CT is a useful imaging technique for CFD cases.

scholarly journals Frequency of autoimmune thyroiditis in children with Celiac disease and effect of gluten free diet

2020 ◽  
Vol 36 (6) ◽  
Author(s):  
Javaria Rasheed ◽  
Rushan Hassan ◽  
Muhammad Khalid ◽  
Fauzia Zafar
Keyword(s):  
Celiac Disease ◽  
Autoimmune Thyroiditis ◽  
Prospective Observational Study ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Creative Commons ◽  
Euthyroid Status ◽  
One Year ◽  
Open Access Article

Objective: To determine the frequency of autoimmune thyroiditis in children with Celiac disease and the effect of gluten free diet on autoimmune thyroiditis. Methods: We enrolled 100 patients, age 1-12 years of either gender diagnosed as Celiac disease (CD) in this prospective observational study in the Department of Pediatric Medicine, from 1st January 2018 to 30th June 2019. Diagnosis of autoimmune thyroiditis was made if anti–thyroperoxidase >35 iu/ml or anti–thyroglobulin >20 iu/ml at diagnosis of CD and then at one year on gluten free diet (GFD) in all cases. Children with repeat anti-tTG levels > 10 times upper limit normal at 6-months after enrollment were labelled as non-compliant to GFD. Descriptive statistics were used to analyze the data. Results: Mean age of the participants was 5.94±3.16 years and 53% were females. Fourteen cases of autoimmune thyroiditis were detected at enrollment and six (7%, n/N = 6/86) were later diagnosed on follow-up who were initially negative. Seven hypothyroid cases among the autoimmune thyroiditis were treated with thyroxine and became euthyroid on follow-up testing. Compliance to GFD was 52%. Autoimmune thyroiditis improved on gluten free diet in four cases (28.6%). Of the six euthyroid cases at diagnosis three cases became hypothyroid and all were non-compliant. Conclusion: Frequency of autoimmune thyroiditis was 20% over a follow-up period of one year. Good compliance with the GFD has some effect on improving autoimmune thyroiditis and maintaining euthyroid status of CD patients. doi: https://doi.org/10.12669/pjms.36.6.2226 How to cite this:Rasheed J, Hassan R, Khalid M, Zafar F. Frequency of autoimmune thyroiditis in children with Celiac disease and effect of gluten free diet . Pak J Med Sci. 2020;36(6):---------. doi: https://doi.org/10.12669/pjms.36.6.2226 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Frequency of success and complications of primary endoscopic third ventriculostomy in infants with obstructive hydrocephalous

2021 ◽  
Vol 38 (1) ◽  
Author(s):  
Seema Sharafat ◽  
Zahid Khan ◽  
Farooq Azam ◽  
Mumtaz Ali
Keyword(s):  
Success Rate ◽  
Endoscopic Third Ventriculostomy ◽  
Case Series ◽  
Csf Leak ◽  
Third Ventriculostomy ◽  
Creative Commons ◽  
Male Patients ◽  
One Year ◽  
Open Access Article

Objectives: To determine the success rate and complications of primary endoscopic third ventri-culostomy (ETV) in infants with obstructive hydrocephalous. Methods: This case series was conducted at the Department of Neurosurgery, Medical and Teaching Institute, Lady Reading Hospital Peshawar from July 2016 to June 2018. All consecutive patients with age less than one year who underwent ETV for primary obstructive hydrocephalous, of both gender, were included in the study. The patients were followed up to six months after surgery. The data was entered in a specially designed Performa. Patients’ data was analyzed using SPSS version 21.0. Results: We had total 21 patients with age less than one year during the study period. Male patients were 11 (52.4%). Success rate of ETV at six months of follow up was 12 (57.1%). Post-op complications observed were in 9.52% (2/21) cases. One patient had cerebrospinal fluid CSF) leak and the other had significant bleed. Conclusion: ETV is successful in 57.1% of infants with obstructive type of hydrocephalous. The post op complications in case of ETV are lower than Ventriculo-peritoneal shunts. Therefore, ETV can be offered to infants having obstructive hydrocephalous. doi: https://doi.org/10.12669/pjms.38.1.4097 How to cite this:Sharafat S, Khan Z, Azam F, Ali M. Frequency of success and complications of primary endoscopic third ventriculostomy in infants with obstructive hydrocephalous. Pak J Med Sci. 2022;38(1):---------. doi: https://doi.org/10.12669/pjms.38.1.4097 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Evaluation of Breast Lumps by Ultrasound and Correlation with Histological Findings

2020 ◽  
Vol 23 (1) ◽  
pp. 10-12
Author(s):  
Nelema Jahan ◽  
Md. Mamunur Rahman ◽  
Mohammad Shahidul Alam ◽  
Md Saiful Islam
Keyword(s):  
Histopathological Examination ◽  
Breast Diseases ◽  
Histopathological Study ◽  
Common Symptom ◽  
Breast Lump ◽  
Histopathological Findings ◽  
Malignant Breast ◽  
Breast Lumps ◽  
One Year ◽  
A Prospective Study

Background: A breast lump is the most common symptom associated with both benign and malignant breast diseases. Therefore, a distinction of benign from malignant lump is of importance for proper management. Though a definitive diagnosis is possible with imaging for all the lesions, histopathological study is proven essential for confirming the diagnosis. Objective: The objective of this study was to evaluate the role of USG and histopathological findings of different breast lump in diagnosis and their comparison. Methods: A prospective study was conducted over a period of one year from January 2017 to December 2017. A total of 116 patients were included in this study. All breast lumps underwent surgery and the ultrasound findings of these lumps were compared with the histopathological findings. Data were collected from these patients by a preformed questionnaire and finally the data were analyzed. Results: Out of 116 patients only 21 cases were reported as malignant in ultrasound report but histopathology revealed 31 malignant patients. On histopathological examination 10 benign cases turned out to be malignant. Conclusion: The present study was undertaken to evaluate in diagnosing breast mass lesions individually by ultrasound and compared with histopathology for definitive management of a patient. Journal of Surgical Sciences (2019) Vol. 23 (1) : 10-12

Fibrous dysplasia of maxilla: An unusual case report

2016 ◽  
Vol 3 (1) ◽  
pp. 1-4
Author(s):  
Leena James ◽  
Tejavathi Nagaraj ◽  
Haritma Nigam ◽  
Yogesh
Keyword(s):  
Case Report ◽  
Fibrous Dysplasia ◽  
Unusual Case ◽  
Unusual Case Report

scholarly journals Cherubism: Report of a Case

2020 ◽  
Author(s):  
Sachin G. Ram ◽  
Vidya Ajila ◽  
Subhas G. Babu ◽  
Pushparaja Shetty ◽  
Shruthi Hegde ◽  
...  
Keyword(s):  
Fibrous Dysplasia ◽  
Developmental Disorder ◽  
Present Report ◽  
Maximum Growth ◽  
Posterior Region ◽  
Therapeutic Management ◽  
Age Group ◽  
Cystic Disease ◽  
Radiographic Features

AbstractCherubism, also known as familial fibrous dysplasia of the jaws or familial multilocular cystic disease is a rare hereditary, developmental disorder. This condition affects the posterior region of the jaws bilaterally in children belonging to the age group of 2 to 5 years. Maximum growth is recorded till puberty after which the lesion regresses over a period of time. Cherubism classically manifests radiographically as bilateral, multilocular radiolucencies affecting the posterior mandible and maxilla. Therapeutic management varies from patient to patient and is directed mainly by esthetic and functional concerns. The present report highlights the clinical and radiographic features of nonfamilial cherubism in a 6-year-old girl.

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