scholarly journals ELIXIR and Toxicology: a community in development

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 1129
Author(s):  
Marvin Martens ◽  
Rob Stierum ◽  
Emma L. Schymanski ◽  
Chris T. Evelo ◽  
Reza Aalizadeh ◽  
...  
Keyword(s):  
Life Science ◽  
High Gain ◽  
Research Field ◽  
Predictive Toxicology ◽  
Chemical Risk Assessment ◽  
The Past ◽  
Government Involvement ◽  
Active Research ◽  
New Community ◽  
The Eu

Toxicology has been an active research field for many decades, with academic, industrial and government involvement. Modern omics and computational approaches are changing the field, from merely disease-specific observational models into target-specific predictive models. Traditionally, toxicology has strong links with other fields such as biology, chemistry, pharmacology and medicine. With the rise of synthetic and new engineered materials, alongside ongoing prioritisation needs in chemical risk assessment for existing chemicals, early predictive evaluations are becoming of utmost importance to both scientific and regulatory purposes. ELIXIR is an intergovernmental organisation that brings together life science resources from across Europe. To coordinate the linkage of various life science efforts around modern predictive toxicology, the establishment of a new ELIXIR Community is seen as instrumental. In the past few years, joint efforts, building on incidental overlap, have been piloted in the context of ELIXIR. For example, the EU-ToxRisk, diXa, HeCaToS, transQST, and the nanotoxicology community have worked with the ELIXIR TeSS, Bioschemas, and Compute Platforms and activities. In 2018, a core group of interested parties wrote a proposal, outlining a sketch of what this new ELIXIR Toxicology Community would look like. A recent workshop (held September 30th to October 1st, 2020) extended this into an ELIXIR Toxicology roadmap and a shortlist of limited investment-high gain collaborations to give body to this new community. This Whitepaper outlines the results of these efforts and defines our vision of the ELIXIR Toxicology Community and how it complements other ELIXIR activities.

scholarly journals Recent Advances in bis-Chalcone-Based Photoinitiators of Polymerization: From Mechanistic Investigations to Applications

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3192
Author(s):  
Nicolas Giacoletto ◽  
Frédéric Dumur
Keyword(s):  
Free Radical ◽  
Radical Polymerization ◽  
Cationic Polymerization ◽  
Free Radical Polymerization ◽  
Research Field ◽  
4D Printing ◽  
Unique Structure ◽  
The Past ◽  
Mechanistic Investigations ◽  
Active Research

Over the past several decades, photopolymerization has become an active research field, and the ongoing efforts to develop new photoinitiating systems are supported by the different applications in which this polymerization technique is involved—including dentistry, 3D and 4D printing, adhesives, and laser writing. In the search for new structures, bis-chalcones that combine two chalcones’ moieties within a unique structure were determined as being promising photosensitizers to initiate both the free-radical polymerization of acrylates and the cationic polymerization of epoxides. In this review, an overview of the different bis-chalcones reported to date is provided. Parallel to the mechanistic investigations aiming at elucidating the polymerization mechanisms, bis-chalcones-based photoinitiating systems were used for different applications, which are detailed in this review.

scholarly journals A Bibliometric Review of the Keap1/Nrf2 Pathway and its Related Antioxidant Compounds

Antioxidants ◽  
2019 ◽  
Vol 8 (9) ◽  
pp. 353 ◽  
Author(s):  
Ana Paunkov ◽  
Dionysios V. Chartoumpekis ◽  
Panos G. Ziros ◽  
Gerasimos P. Sykiotis
Keyword(s):  
Web Of Science ◽  
Research Field ◽  
Antioxidant Compounds ◽  
Nrf2 Pathway ◽  
The Past ◽  
Reverse Pattern ◽  
The Usa ◽  
Bibliometric Review ◽  
The Subject ◽  
Active Research

Nrf2 is a master transcriptional regulator of antioxidant and cytoprotective pathways. Currently in its third decade, research on Nrf2 has expanded to encompass not only basic but also clinical studies. In the present bibliometric review, we employed the VOSviewer tool to describe the existing Nrf2 literature landscape. As of July 2019, 11,931 papers on Nrf2 were listed in the “Web of Science” database, with more than 1000 new papers published each year. As expected, terms related to oxidative stress and antioxidant molecules occur very often in the Nrf2 literature throughout the years. Interestingly, there is also a gradual increase in the occurrence of terms related to diseases or to natural compounds, the most prominent being sulforaphane, curcumin, and resveratrol that modulate the Nrf2 pathway. Going beyond molecular biology/biochemistry and related fields, Nrf2 research has begun to spread into more clinical areas like endocrinology/metabolism, cardiology, and nephrology, likely reflecting an increased interest in clinical applications of Nrf2 pathway activators. China has become the most prolific producer of Nrf2 papers the last five years followed by the USA and Japan, a reverse pattern compared to the past. In conclusion, Nrf2 is the subject of a globally active research field that keeps growing and extends from bench to bedside.

scholarly journals A Review of Active Hand Exoskeletons for Rehabilitation and Assistance

Robotics ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 40
Author(s):  
Tiaan du Plessis ◽  
Karim Djouani ◽  
Christiaan Oosthuizen
Keyword(s):  
Intelligent Systems ◽  
Life Quality ◽  
Research Field ◽  
Detection Techniques ◽  
The Past ◽  
Complex Anatomy ◽  
Global Issue ◽  
Hand Exoskeleton ◽  
Active Research ◽  
Developing Area

Disabilities are a global issue due to the decrease in life quality and mobility of patients, especially people suffering from hand disabilities. This paper presents a review of active hand exoskeleton technologies, over the past decade, for rehabilitation, assistance, augmentation, and haptic devices. Hand exoskeletons are still an active research field due to challenges that engineers face and are trying to solve. Each hand exoskeleton has certain requirements to fulfil to achieve their aims. These requirements have been extracted and categorized into two sections: general and specific, to give a common platform for developing future devices. Since this is still a developing area, the requirements are also shaped according to the advances in the field. Technical challenges, such as size requirements, weight, ergonomics, rehabilitation, actuators, and sensors are all due to the complex anatomy and biomechanics of the hand. The hand is one of the most complex structures in the human body; therefore, to understand certain design approaches, the anatomy and biomechanics of the hand are addressed in this paper. The control of these devices is also an arising challenge due to the implementation of intelligent systems and new rehabilitation techniques. This includes intention detection techniques (electroencephalography (EEG), electromyography (EMG), admittance) and estimating applied assistance. Therefore, this paper summarizes the technology in a systematic approach and reviews the state of the art of active hand exoskeletons with a focus on rehabilitation and assistive devices.

Iris Movement and Eye Gaze Tracking

2021 ◽  
Vol 12 (4) ◽  
pp. 1224-1233
Author(s):  
Villuri Gnaneswar
Keyword(s):  
Computer Vision ◽  
Human Computer Interaction ◽  
Eye Tracking ◽  
Eye Gaze ◽  
Industrial Area ◽  
Research Field ◽  
Efficient Technique ◽  
Gaze Tracking ◽  
The Past ◽  
Active Research

Iris Movement and gaze tracking has been an active research field in the past years as it adds convenience to a variety of applications. It is considered a significant untraditional method of human-computer interaction. The goal of this paper is to present a study on the existing literature on Iris Movement and Gaze Tracking and Develop an Efficient Technique that can revolutionize the field of Computer Vision. With the uptrend of systems based on eye Tracking in many different areas of life in recent years, this subject has gained much more attention by in the academic and industrial area.

The past, present and future of food consumption databases

2012 ◽  
Vol 153 (43) ◽  
pp. 1692-1700
Author(s):  
Viktória Szűcs ◽  
Erzsébet Szabó ◽  
Diána Bánáti
Keyword(s):  
Data Collection ◽  
Food Consumption ◽  
Age Groups ◽  
Collection Method ◽  
The Past ◽  
Consumption Data ◽  
Food Consumption Data ◽  
International Projects ◽  
Collection Methods ◽  
The Eu

Results of the food consumption surveys are utilized in many areas, such as for example risk assessment, cognition of consumer trends, health education and planning of prevention projects. Standardization of national consumption data for international comparison is an important task. The intention work began in the 1970s. Because of the widespread utilization of food consumption data, many international projects have been done with the aim of their harmonization. The present study shows data collection methods for groups of the food consumption data, their utilization, furthermore, the stations of the international harmonization works in details. The authors underline that for the application of the food consumption data on the international level, it is crucial to harmonize the surveys’ parameters (e.g. time of data collection, method, number of participants, number of the analysed days and the age groups). For this purpose the efforts of the EU menu project, started in 2012, are promising. Orv. Hetil., 2012, 153, 1692–1700.

Metal and Non-Metal Catalysts in the Synthesis of Five-Membered S-Heterocycles

2019 ◽  
Vol 16 (2) ◽  
pp. 258-275 ◽  
Author(s):  
Navjeet Kaur
Keyword(s):  
Organic Synthesis ◽  
Biological Activities ◽  
Reaction Times ◽  
Research Field ◽  
Environmentally Benign ◽  
Metal Catalyst ◽  
Efficient Synthesis ◽  
Heterocyclic Molecules ◽  
The Past ◽  
Harsh Conditions

Background:A wide variety of biological activities are exhibited by N, O and S containing heterocycles and recently, many reports appeared for the synthesis of these heterocycles. The synthesis of heterocycles with the help of metal and non-metal catalyst has become a highly rewarding and important method in organic synthesis. This review article concentrated on the synthesis of S-heterocylces in the presence of metal and non-metal catalyst. The synthesis of five-membered S-heterocycles is described here.Objective:There is a need for the development of rapid, efficient and versatile strategy for the synthesis of heterocyclic rings. Metal, non-metal and organocatalysis involving methods have gained prominence because traditional conditions have disadvantages such as long reaction times, harsh conditions and limited substrate scope.Conclusion:The metal-, non-metal-, and organocatalyst assisted organic synthesis is a highly dynamic research field. For ßthe chemoselective and efficient synthesis of heterocyclic molecules, this protocol has emerged as a powerful route. Various methodologies in the past few years have been pointed out to pursue more sustainable, efficient and environmentally benign procedures and products. Among these processes, the development of new protocols (catalysis), which avoided the use of toxic reagents, are the focus of intense research.

“The Past, Present, and Future of Accounting History”: A Comment on the State of Accounting History

2020 ◽  
Vol 47 (1) ◽  
pp. 89-95 ◽  
Author(s):  
Garry D. Carnegie
Keyword(s):  
English Language ◽  
Research Field ◽  
The State ◽  
International Accounting ◽  
Scholarly Research ◽  
Recent Contribution ◽  
Global Society ◽  
Accounting History ◽  
The Past

ABSTRACT This response to the recent contribution by Matthews (2019) entitled “The Past, Present, and Future of Accounting History” specifically deals with the issues associated with concentrating on counting publication numbers in examining the state of a scholarly research field at the start of the 2020s. It outlines several pitfalls with the narrowly focused publications count analysis, in selected English language journals only, as provided by Matthews. The commentary is based on three key arguments: (1) accounting history research and publication is far more than a “numbers game”; (2) trends in the quality of the research undertaken and published are paramount; and (3) international publication and accumulated knowledge in accounting history are indeed more than a collection of English language publications. The author seeks to contribute to discussion and debate between accounting historians and other researchers for the benefit and development of the international accounting history community and global society.

Epilogue

2017 ◽  
Author(s):  
Robert Schütze
Keyword(s):  
Internal Market ◽  
Positive Answer ◽  
The Past ◽  
Output Legitimacy ◽  
The Eu

Can the judicial creation of the EU internal market be justified? A famous—positive—answer has, in the past, been suggested by Miguel Maduro’s We the Court; and the first section explores the credentials of his ‘majoritarian activism’ thesis. The second section surveys alternative forms of legitimacy, such as ‘output legitimacy’ and ‘messianic legitimacy’, but it also offers a new Kantian approach to the legitimacy question.

scholarly journals A Bibliometric Analysis of Human-Machine Interaction Methodology for Electric-Powered Wheelchairs Driving from 1998 to 2020

2021 ◽  
Vol 18 (14) ◽  
pp. 7567
Author(s):  
Xiaochen Zhang ◽  
Lanxin Hui ◽  
Linchao Wei ◽  
Fuchuan Song ◽  
Fei Hu
Keyword(s):  
The Elderly ◽  
Research Field ◽  
Future Research ◽  
Human Machine Interaction ◽  
Research Directions ◽  
The Past ◽  
Power Wheelchairs ◽  
The Disabled ◽  
Future Research Directions ◽  
Machine Interaction

Electric power wheelchairs (EPWs) enhance the mobility capability of the elderly and the disabled, while the human-machine interaction (HMI) determines how well the human intention will be precisely delivered and how human-machine system cooperation will be efficiently conducted. A bibliometric quantitative analysis of 1154 publications related to this research field, published between 1998 and 2020, was conducted. We identified the development status, contributors, hot topics, and potential future research directions of this field. We believe that the combination of intelligence and humanization of an EPW HMI system based on human-machine collaboration is an emerging trend in EPW HMI methodology research. Particular attention should be paid to evaluating the applicability and benefits of the EPW HMI methodology for the users, as well as how much it contributes to society. This study offers researchers a comprehensive understanding of EPW HMI studies in the past 22 years and latest trends from the evolutionary footprints and forward-thinking insights regarding future research.

scholarly journals The Biosimilar Landscape: An Overview of Regulatory Approvals by the EMA and FDA

Pharmaceutics ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 48
Author(s):  
Ioana Gherghescu ◽  
M. Begoña Delgado-Charro
Keyword(s):  
Drug Administration ◽  
Action Plan ◽  
European Medicines Agency ◽  
Patient Access ◽  
Clinical Evaluations ◽  
The Past ◽  
The Us ◽  
Improve Patient ◽  
The Eu

Biosimilar medicines expand the biotherapeutic market and improve patient access. This work looked into the landscape of the European and US biosimilar products, their regulatory authorization, market availability, and clinical evaluation undergone prior to the regulatory approval. European Medicines Agency (EMEA, currently EMA) and Food and Drug Administration (FDA) repositories were searched to identify all biosimilar medicines approved before December 2019. Adalimumab biosimilars, and particularly their clinical evaluations, were used as a case study. In the past 13 years, the EMA has received 65 marketing authorization applications for biosimilar medicines with 55 approved biosimilars available in the EU market. Since the first biosimilar approval in 2015, the FDA has granted 26 approvals for biosimilars with only 11 being currently on the US market. Five adalimumab biosimilars have been approved in the EU and commercialized as eight different medicines through duplicate marketing authorizations. Whilst three of these are FDA-approved, the first adalimumab biosimilar will not be marketed in the US until 2023 due to Humira’s exclusivity period. The EU biosimilar market has developed faster than its US counterpart, as the latter is probably challenged by a series of patents and exclusivity periods protecting the bio-originator medicines, an issue addressed by the US’s latest ‘Biosimilar Action Plan’.

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