The Relationship Between Adiposity and Risk factors for Cadiovascular Disease at Normal Body Weight Male

2003 ◽  
Vol 20 (1) ◽  
pp. 62
Author(s):  
Woo Sung Kwon ◽  
Jun Su Kim ◽  
Jin Wook Chae ◽  
Keun Mi Lee ◽  
Seung Pil Jung ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Weight ◽  
Normal Body ◽  
Normal Body Weight ◽  
The Relationship

scholarly journals Metabolic Obesity in People with Normal Body Weight (MONW)—Review of Diagnostic Criteria

2022 ◽  
Vol 19 (2) ◽  
pp. 624
Author(s):  
Waldemar Pluta ◽  
Wioleta Dudzińska ◽  
Anna Lubkowska
Keyword(s):  
Body Weight ◽  
Diagnostic Criteria ◽  
Normal Body ◽  
Risk Of Mortality ◽  
Diagnostic Models ◽  
Normal Body Weight ◽  
Definition Of ◽  
The Relationship ◽  
Apparently Healthy

Disorders of metabolic obesity with normal body weight (MONW) are widely recognized risk factors for the development of cardiovascular diseases and type 2 diabetes. Despite this, MONW is not diagnosed in clinical practice. There is no consensus on the definition of MONW, and measuring the degree of insulin resistance or obesity among apparently healthy, non-obese patients is not widely applicable. The awareness of the relationship between metabolic disorders such as MONW and a higher risk of mortality from cardiovascular causes and other related diseases prompts the need for action to be taken aimed at creating appropriate diagnostic models that will allow for the effective detection of those with metabolic abnormalities among people with normal body weight. Such actions are decisive in the prevention and treatment of diseases. Therefore, the purpose of this article is to review the MONW diagnostic criteria used over the years.

Neuropeptide Y as a potential biomarker in patients with asthma and obesity

2021 ◽  
Vol 31 (6) ◽  
pp. 759-767
Author(s):  
Yanina S. Shkatova ◽  
Sergey N. Avdeev ◽  
Andrey V. Budnevsky ◽  
Ludmila V. Tribuntceva
Keyword(s):  
Body Weight ◽  
Oxidative Damage ◽  
Neuropeptide Y ◽  
Asthma Control ◽  
Clinical Course ◽  
Inverse Correlation ◽  
Positive Correlation ◽  
Normal Body ◽  
Normal Body Weight ◽  
The Relationship

The phenotype of asthma with obesity is particularly difficult to treat, while its prevalence is increasing. In recent years, special attention has been paid to neuropeptide Y (NPY) due to its possible effect on the severity of the clinical course of asthma.Aim. To identify the relationship between the level of NPY and the clinical course of asthma in patients with obesity and overweight.Methods. The study included 113 patients (27, or 23.89% of men and 86, or 76.11% of women) diagnosed with asthma of moderate severity, whose average age was 57.81 ± 13.05 years. Patients were divided into three groups — with normal body weight, overweight, and obesity. The examination included spirometry, body mass index (BMI), and a questionnaire. Also, Asthma Control Test (ACT) was used. The levels of leptin, adiponectin, NPY, and general oxidative damage were measured in all patients.Results. Asthma control was significantly lower in the group of patients with asthma and obesity compared with the normal body weight and overweight patients. Leptin level was significantly higher in the group of patients with asthma and obesity compared with the normal body weight and overweight patients. The level of NPY was significantly higher in the group of patients with obesity than in the patients with normal body weight and overweight. No significant differences in the level of adiponectin were found between the groups. The NPY level had a high inverse correlation with VLC index, a moderate/medium inverse correlation with forced expiratory volume in 1 sec, forced expiratory flow (FEF) at 25%; forced vital capacity, Tiffno index, FEF 50%, peak expiratory flow, ACT score, and a moderate positive correlation with the level of total oxidative damage.Conclusion. A higher level of NPY is observed in patients with asthma and obesity. This level has an inverse correlation with spirometric parameters, asthma control (evaluated via ACT) and a positive correlation with the level of general oxidative damage, which indicates a possible proinflammatory effect of NPY that contributes to an unfavorable course of asthma. Thus, further studies are required to establish the nature of the relationship between NPY and asthma exacerbations, as well as the mechanism of NPY influence on asthma pathogenesis.

Monocyte-associated chemokine expression in cells from subcutaneous adipose tissue isolated from operation material in patients during abdominoplasty

2017 ◽  
pp. 70-78
Author(s):  
А.Е. Копасов ◽  
С.Н. Блохин ◽  
С.Г. Морозов
Keyword(s):  
Body Weight ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Aesthetic Surgery ◽  
Normal Body ◽  
Chemokine Expression ◽  
Normal Body Weight ◽  
Functional Features ◽  
Subcutaneous Adipose ◽  
The Relationship

Цель работы - изучение взаимосвязи между уровнем хемокинов и интенсивностью воспалительного процесса в подкожно-жировой ткани (ПЖТ) у лиц с ожирением и нормальной массой тела. Задача работы - определение уровня экспрессии хемокинов, сопряженных с моноцитами/макрофагами, и их рецепторов в клетках ПЖТ, выделенных при проведении абдоминопластики. Пациенты. В период с 2013 по 2017 гг. в Клинике пластической и эстетической хирургии проведены операции абдоминопластики у 262 женщин, биологический материал которых использован в работе. Методы. Состав тела и процент жировой массы определяли методом биоимпедансного анализа. Из образцов ПЖТ из операционного материала выделяли клетки, окрашивали их меченными флуоресцеинами антителами к хемокинам и анализировали на проточном цитометре FACSCalibur по программе SimulSet. Статистический анализ проводили по программе ANOVA. Результаты. Показано, что наличие ожирения оказывает влияние на клеточный состав ПЖТ. Экспрессия хемокинов семейства CC, а также рецепторов хемокинов CCR1, CCR2 и CCR5 в ПЖТ у пациентов с ожирением достоверно выше, чем у пациентов с нормальной массой тела. Заключение. Различия в экспрессии хемокинов на клетках ПЖТ у пациентов с ожирением или с нормальной массой тела отражают функциональные особенности ПЖТ и могут оказывать влияние на развитие осложнений после проведения операции абдоминопластики. AIM: we study the relationship between chemokines and intensity of the inflammatory process in the subcutaneous adipose tissue (SAT) in individuals with obesity and normal body weight. Objective: we determined the expression levels of chemokines associated with monocyte/macrophages, as well as their receptors on the cells of SAT, that were obtained during abdominoplasty. Patients. In this work we have used the biological material of 262 women to whom has been performed an abdominoplasty in the Clinic of plastic and aesthetic surgery from 2013 to 2017 years. Methods. Body composition and the weight of body fat were determined by bioimpedance analysis. SATs have been obtained during abdominoplasty surgery. SAT cells were isolated followed by the staining with fluoresceine labeled antibodies which fluorescence was analyzed using a flow cytometer FACSCalibur according to the program SimulSet. Statistical analysis was carried out using ANOVA. Results. It has been shown that the progressing obesity may affect the SAT cellular composition. The expression of chemokines from CC family and its receptors (CCR1, CCR2 and CCR5) on cells from SAT were significantly higher in patients with obesity compared to the normal body weight patients. Conclusions. Differences in the chemokine expression on SAT cells between patients with obesity and with normal body weight may reflect the functional features of SAT itself and can modify the complication developments after abdominoplasty.

scholarly journals Age and sex differences in sleep disorders as risk factors and markers of hypertension in young people with normal body weight

2021 ◽  
Vol 27 (5) ◽  
pp. 553-561
Author(s):  
A. L. Kalinkin ◽  
A. S. Sorokin
Keyword(s):  
Risk Factors ◽  
Body Weight ◽  
Sex Differences ◽  
Sleep Apnea ◽  
Young People ◽  
Sleep Disorders ◽  
Old People ◽  
Normal Body ◽  
Normal Body Weight ◽  
Age And Sex

Objective. To assess age and sex differences in sleep disorders as risk factors and markers of hypertension (HTN) in 18–39-year old people with normal body weight. Design and methods. We performed a cross-sectional study based on the internet survey of 18–39-year-old people with body mass index of 18–25 kg/m2  (n = 2094). The unvalidated questionnaire included 42 questions about various types of sleep disorders and sleep-associated symptoms (0 — never, 1 — rarely, 2 — from time to time, 3 — quite often, 4 — almost all the time). Results. The probability of detecting HTN in young men with normal body weight is higher than in women with similar characteristics (p < 0,001). In women, the probability of detecting HTN decreases, starting with the youngest category (18–24 years old), reaching a minimum in the age group 30–34 years old and then starts to increase. By the age of 40, the indicators for men and women become similar. Based on a multivariate analysis, the risk of HTN in young people with normal body weight is associated with both gender and age (p = 0,022). The contribution of gender to age-related changes in sleep complaints was found for snoring (p < 0,001), sleep apnea (p < 0,001), early awakenings (p = 0,002). The contribution of gender was also noted for various symptoms — daytime sleepiness, some symptoms of restless legs syndrome (RLS), anxiety, depression, leg cramps (p < 0,001) and nocturnal heartburn (p < 0,001). The contribution of age was noted for snoring (p < 0,001), sleep apnea (p < 0,001), early awakenings (p < 0,001) and for a variety of symptoms — daytime sleepiness, some symptoms of RLS, anxiety, nocturnal cough, and nocturnal choking. Conclusions. Our data can be considered when developing measures for HTN prevention, can be recommended for clinical use, as well as in subsequent clinical studies using validated questionnaires.

scholarly journals PREVALENCE AND RISK FACTORS FOR VITAMIN D DEFICIENCY IN OVERWEIGHT AND OBESE ADOLESCENTS IN UKRAINE

2019 ◽  
Vol 4 (2) ◽  
pp. 24-30
Author(s):  
A-M. A. Shulhai ◽  
H. A. Pavlyshyn
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Body Weight ◽  
Vitamin D Deficiency ◽  
Overweight And Obesity ◽  
Vitamin D Status ◽  
Obese Children ◽  
Obese Adolescents ◽  
Normal Body ◽  
Normal Body Weight

Background. Vitamin D affects the function of many organs and systems. Lipid metabolism disorder is established to be one of the risk factors for vitamin D deficiency, and the amount of adipose tissue is crucial. Objective. The aim of the study was to determine the prevalence and risk factors for vitamin D deficiency in overweight and obese adolescents. Methods. 146 children with excessive weight and obesity as well as 63 healthy children with normal body weight were examined. In the study groups, there were no children taking vitamin D. Vitamin D status was evaluated by the level of 25(OH)D in blood serum. Vitamin D deficiency was diagnosed at the level of 25(OH)D between 20 and 29 ng/ml, and significant deficiency – below 20 ng/ml, normal calcidiol content was 30-100 ng/ml. Results. The average level of 25(OH)D in the adolescents with normal body weight was 19.76±4.28 ng/ml, in the adolescents with excessive body weight – 15.24±3.47 ng/ml, and in the obese children – 13.87±2.71 ng/ml. The prevalence of vitamin D deficiency in the overweight adolescents was 70.62%, and in the adolescents with obesity – 77.19%. Conclusions. Vitamin D deficiency is prevalent in the adolescents with overweight and obesity. To prevent the development of hypovitaminosis and vitamin D deficiency, it is necessary to carry out educational activities with adolescents for promotion of healthy lifestyle and healthy food, as well as to develop an optimal program for improving vitamin D status in the obese children.

scholarly journals Heart rate features among men of working age with obesity and hypertension

2015 ◽  
Vol 13 (1) ◽  
pp. 30-35
Author(s):  
Nataliya S. Tsyplenkova ◽  
Elena I. Panova
Keyword(s):  
Risk Factors ◽  
Heart Rate ◽  
Body Weight ◽  
Arterial Hypertension ◽  
Left Atrium ◽  
Left Ventricular ◽  
Normal Body ◽  
Increased Risk ◽  
Excessive Body Weight ◽  
Normal Body Weight

Aim. To study features of heart rate of men with arterial hypertension and obesity, to identify factors associated with arrhythmia evolution.Materials and methods. The study included 3 groups of men (with obesity – 98 men, with excessive body weight – 46 men, with normal body weight – 40 men). The comparative analysis of heart rhythm was performed with Resting ECG and Holter ECG monitoring, blood pressure from daily monitoring, echocardiography, blood lipid spectrum, glycaemia. The adiponectin level was analyzed only for group with obesity.Results. Obesity in men with arterial hypertension increases the frequency of arrhythmias of atrial fibrillation (AF) type (15.3% vs. 0% in group with normal body weight, p=0.004) and increases the frequency of ventricular premature beats (VPB) (26.5% in group with obesity vs. 10% in group with normal body weight). We were also able to show the relation between arrhythmia and the severity of obesity. Obesity with arterial hypertension significantly increases the risk of various arrhythmias (more than 6 times for AF risk – p=0.004 and more than 5.31 times for frequent VPB – p=0.026. Risk factors for AF are statistically significant with the presence of obesity: left ventricular (LV) and left atrium (LA) dilation, II–III stage of hypertension and low level of high-density lipoprotein (p0.05). AF risk factors are significant without relation to obesity: left ventricular hypertrophy, dilatation LA, IHD (p0.05). But there is no relation between ischemic heart disease (IHD) and an increased risk of AF evolution. Also no relation was found between sleep apnea syndrome and arrhythmias.Conclusion. Men with excessive body weight or obesity in contrast to men with normal body weight have an increased risk of AF and VPB. Factors directly associated with arrhythmias: heart remodeling (hypertrophy and dilatation of the left ventricular, dilatation of the left atrium), advanced stages of arterial hypertension, dyslipidemia; IHD with obesity associated with risk of VPB and doesn’t affect the AF frequency. 

scholarly journals POS0358 EVALUATION OF THE EFFECT OF mTOR EXPRESSION ON THE CLINICAL MANIFESTATIONS OF KNEE OSTEOARTHRITIS IN OBESE AND NORMAL WEIGHT PATIENTS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 409.2-409
Author(s):  
E. Strebkova ◽  
E. Tchetina ◽  
L. Alekseeva
Keyword(s):  
Body Weight ◽  
Knee Pain ◽  
Mammalian Target Of Rapamycin ◽  
Clinical Manifestations ◽  
Normal Weight ◽  
Womac Pain ◽  
Obese Patients ◽  
Normal Body ◽  
Knee Oa ◽  
Normal Body Weight

Background:Currently, a large number of molecular biological and genetic markers are known to be involved in the development of osteoarthritis (OA). The mammalian target of rapamycin (mTOR) signaling pathway is responsible for chondrocyte proliferation, cartilage matrix production, and cell growth. OA is characterized by increased mTOR synthesis, which is accompanied by an increase in proliferative activity and destruction of chondrocytes. Obesity is an important factor in the progression of knee OA. The study of mTOR expression in patients with OA and obesity is an urgent task in the development of personalized OA therapy.Objectives:To determine the expression of mTOR in patients with knee OA in combination with obesity and normal body weight. To evaluate the effect of mTOR on the clinical manifestations of OA in patients with different body mass index (BMI).Methods:The study included 73 female patients aged 45-65 y.o. with Kellgren-Lawrence stage II-III knee OA. The patients were divided into 2 groups: group 1 (n=50) with obesity (BMI > 30 kg / cm2) and group 2 (n=23) with normal or increased body weight (BMI < 30 kg/cm2). The average age of patients with obesity is 56.5 ± 5.87 years, without obesity - 58.7 ± 5.43 years. Clinical manifestations were evaluated by a WOMAС. RNA was isolated from the patients ‘ blood samples, which was used to determine the expression of mTOR.Results:Patients with knee OA with and without obesity did not differ in age. OA develops at an earlier age in obese patients, than in non-obese patients (p < 0.001). Patients from 1 group had a high BMI > 30 kg/m2 at the onset of OA. Obese patients had more severe knee OA is significantly more often detected: Kellgren-Lawrence stage III was determined in 10% of obese patients and in 4.35% - without obesity (p < 0.001). Significantly higher values of the WOMAC index pain, stiffness, joint functional failure, and total WOMAC were observed in obese patients (p = 0.006, p = 0.039, p = 0.037, and p = 0.014, respectively). Obese patients had higher VAS pain scores (p < 0.05) compared to patients with a lower BMI. Obese patients had a higher mTOR expression (p < 0.05) of 8.02±8.62, compared to non-obese patients. High mTOR expression was associated with VAS knee pain (r=0.78; p < 0.05) and WOMAC pain (r=0.89; p<0.05) in obese patients (Table 1).Table 1.Correlation of m-TORParametersmTOR (1 group, n=50)mTOR (2 group, n=23)Body weightр > 0,05р > 0,05Pain (VAS)r=0,78; р<0,05p = 0,07; r = 0,45Pain (WOMAC)r=0,89; р<0,05р > 0,05Total WOMACр > 0,05р > 0,05Conclusion:Our study showed that patients with obesity and knee OA have higher rates of mTOR expression, compared to patients with normal body weight. High mTOR expression correlates with the severity of knee pain in obese patients. Thus, the evaluation of mTOR expression in obese patients and knee OA plays an important role in predicting the severity of clinical manifestations of OA, and may influence the choice of personalized therapy tactics for such patients.Disclosure of Interests:None declared

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