scholarly journals MORPHOLOGICAL STRUCTURE OF THE THYMUS IN NEWBORNS WITH CONGENITAL CYTOMEGALOVIRUS INFECTION

2018 ◽  
Vol 1 (69) ◽  
pp. 64-69
Author(s):  
Ирина Андриевская ◽  
Irina Andrievskaya ◽  
Игорь Гориков ◽  
Igor Gorikov ◽  
Лариса Сомова ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Blood Vessels ◽  
Cytomegalovirus Infection ◽  
Comparison Group ◽  
Morphological Structure ◽  
Main Group ◽  
The Body ◽  
Thymus Gland ◽  
Fibrous Connective Tissue ◽  
General Plan

The aim of the work was to study the morphological structure of the thymus gland in 36 full-term newborns who died at the 2-5 day of life. The main group included 16 newborns who were diagnosed with intrauterine cytomegalovirus infection by the serological method and polymerase chain reaction. Cerebral ischemia of moderate and severe degree, subarachnoid and periventricular hemorrhages, as well as markers of local and generalized forms of congenital infection were revealed in children of this group. The comparison group was represented by 20 newborns with antenatal ontogenesis, uncomplicated by acute respiratory and herpes-virus infections, moderate and severe somatic and obstetric pathology in their mothers during pregnancy. The cause of their death was birth trauma, intranatal and postnatal hypoxia. In the description of the neonatal thymus, attention was paid to the following features: the general plan of the structure; structural changes in the capsule of the gland; the structure of the cortical and brain matter; violation of loose fibrous connective tissue and blood vessels of the organ. It was found out that the structure of the thymus gland in the main group was different from that in the comparison group, especially a predominance of neonates with increase and decrease in the organ mass. With the growth of the mass of the thymus there was frequently revealed subcapsular hemorrhage; the sharpness of borders decreased or completely disappeared between cortical and medullary substance; the areas of crust delymphatisation, Hassall’s corpuscles filled with detritus were often identified. The edema of the interlobular loose fibrous connective tissue increased, the endothelial edema and its desquamation in the lumen of blood vessels were noted. Lymphocyte clusters in the interlobular connective tissue were clearly visualized. In the case of a decrease in the body mass, small lobules, excessive formation of collagen fibers in the interlobular connective tissue, the loss of lymphocytes in the cortical substance and small Hassal’s bodies were more often recorded. Stimulation of thymus growth may be associated with the direct cytodestructive effect of the virus and intrauterine stress, leading to a drop in cortisol content. In the inhibition of immunopoesis growth, prolonged antenatal antigenic stimulation, higher level of cortisol against progressing alterative processes in glandulocyte of the cortex of suprarenal glands of the fetus play an important role.

scholarly journals PATHOMORPHOLOGIC CHARACTERISTIC OF BRONCHOPULMONARY SYSTEM IN THE DIED NEWBORNS WITH THE INBORN CYTOMEGALOVIRUS INFECTION

2018 ◽  
Vol 1 (68) ◽  
pp. 63-67
Author(s):  
Игорь Гориков ◽  
Igor Gorikov ◽  
Лариса Сомова ◽  
Larisa Somova ◽  
Ирина Андриевская ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Cytomegalovirus Infection ◽  
Viral Infections ◽  
Comparison Group ◽  
Morphological Structure ◽  
Bronchial Epithelium ◽  
Bronchial Tree ◽  
Main Group ◽  
Vascular Congestion ◽  
Term Newborns

The aim of the research was to study a morphological structure of airway and respiratory parts of lungs in 36 full-term newborns who died at the 2-5th day of life. The main group included 16 died newborns with the inborn cytomegalovirus infection who were diagnosed with moderate to severe cerebral ischemia with hypertension-hydrocephalic syndrome, pseudocysts of the blood vessels plexus, subependymal and subarachnoid haemorrhages, monocytosis, vesiculitis, pneumonia, hepatitis and meningocephalitis against intrauterine hypoxia and chronic subcompensated placental insufficiency. The comparison group consisted of 20 newborns whose mothers during the gestation period did not have acute respiratory viral infections, moderate and severe somatic and obstetrical pathology. The cause of their death was a birth trauma, intranatal and postnatal hypoxia. Describing lungs the following morphologic features were emphasized: 1) the changes of the general composition of the organ; 2) the state of the lumen of the large, medial and small bronchi; 3) the reaction of the epithelial lining, conjunctive tissue and the blood channel of the bronchial tree and aero-hematic barrier. As a result of the studies it was found out that in the newborns of the main group in comparison with the children of the comparison group in the lumen of large bronchi there was a rare case of mucus, there were often found erythrocytes and desquamated epithelial cells. Only infected children were found to have leucocytes. More intensified were alterative processes in epithelial cells; there were often found cells of the bronchial epithelium without ciliary structures, desquamation of highly differential ciliary and goblet cells, cell elements with a small hyperchromic nucleus and light cytoplasm in the cambial layer, sharply expressed vascular congestion, proliferative changes in the bronchial epithelium as well as hydropic-hemorrhagic and aspiration syndromes. Pneumonia and signs of the virus metamorphosis were diagnosed only in the main group.

scholarly journals MORPHOLOGICAL STRUCTURE OF ADRENAL CORTEX IN FULL-TERM NEWBORNS WITH CONGENITAL CYTOMEGALOVIRUS INFECTION

2018 ◽  
Vol 1 (69) ◽  
pp. 70-73
Author(s):  
Игорь Гориков ◽  
Igor Gorikov ◽  
Лариса Сомова ◽  
Larisa Somova ◽  
Ирина Андриевская ◽  
...  
Keyword(s):  
Adrenal Cortex ◽  
Cytomegalovirus Infection ◽  
Comparison Group ◽  
Main Group ◽  
Full Term ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
General Plan ◽  
Suprarenal Glands ◽  
Term Newborns

The aim was to study the structure of the adrenal cortex in 36 dead full-term newborns. The main group consisted of 16 newborns with congenital cytomegalovirus infection, clinically manifested by moderate and severe cerebral ischemia, predominance of hypertensive-hydrocephalic syndrome, pseudocysts of the vascular plexus, sub-perpendicular and subarachnoid hemorrhages, monocytosis, vesiculosis, pneumonia, hepatitis and meningoencephalitis. The comparison group consisted of 20 dead newborns from mothers who did not have infectious diseases during pregnancy, as well as moderate and severe somatic and obstetric pathology. Birth trauma, intranatal and postnatal hypoxia were the main cause of their death. The evaluation of the pathomorphological picture of the adrenal cortex included a description of the general plan of the structure, the severity of alterative changes in glandulocytes, the number of adenomatous-like structures and their morphological forms, the reaction of loose fibrous connective tissue. It was found out that in suprarenal glands in children of the main group unlike the comparison group there was often detected a breach of the strands of granulocytes, there were found pronounced alterative changes in the cells; there were revealed large adenomatous-like structures in the lumen of which eosinophilic mass was often found and there was observed strongly-pronounced plethora of vessels. Only in the main group there were determined areas of thinning of the cortical substance of the glands, several adenomatous-like formations and anatomical forms containing in their lumen red blood cells and erythroblasts, as well as large hemorrhages. These structural changes indicated inhibition of adrenal cortex formation and prolonged antenatal stimulation of steroidogenesis under the influence of congenital cytomegalovirus infection leading to a decrease in glucocorticoid function of the suprarenal glands in children after birth.

PECULIARITY OF ADAPTATION OF BABIES ARE BORN PREMATURELY FROM MOTHERS WITH UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA

2021 ◽  
Vol 74 (10) ◽  
pp. 2566-2568
Author(s):  
Tunzala V. Ibadova ◽  
Vitalii V. Maliar ◽  
Volodymyr V. Maliar ◽  
Vasyl V. Maliar
Keyword(s):  
Connective Tissue ◽  
Premature Infants ◽  
Distress Syndrome ◽  
Comparison Group ◽  
Clinical Manifestations ◽  
Main Group ◽  
Phenotypic Markers ◽  
Group I ◽  
Neonatal Respiratory Distress ◽  
Connective Tissue Dysplasia

The aim: To evaluate the peculiarity of clinical manifestations of neonatal respiratory distress syndrome (NRDS) in deeply premature infants from mothers with phenotypic markers of undifferentiated connective tissue dysplasia (UCTD). Materials and methods: The study represent the results of a retrospective clinical and statistical analysis of 268 premature birth report card and newborn report sheet. .The main (1 group) included 50 pregnants with obvious phenotypic markers of UCTD, the comparison group (group 2) consisted of 50 pregnant women without phenotypic markers of UDCTD. Results: According to the study, in 12 (24%) pregnant women of the main group at the time of admission to the clinic had contractions,which required specific therapy. Cervical cerclage was performed in 38 (76%) patients of the main group due to the presence of cervical insufficiency (CI). In these cases, the severity of the CI on the Steinber scale was 7.2 ± 0.4 points in the main group against 4.4 ± 0.2 points in the comparison group (p <0.05). Group I patients were more likely to have complications of labor such as:premature rupture of membranes, uterine contraction abnormalities and fetal distress, which required in most cases cesarean delivery (7% and 2%), respectively (p <0.05). The incidence of neonatal complications requiring respiratory support was 67% in group I and 48% in group II. According to our observations, the clinical manifestations of bronchopulmonary dysplasia were twice as high in infants of the main group (66%) against (44%) of the comparison group (p <0.05). Conclusions:1.Neonatal respiratory distress syndrome in premature infants is more often associated from mothers with UDCTD. 2. The high importance of steroid prophylaxis of NRDS and antioxidant therapy in reducing the frequency of mechanical ventilation and the development of bronchopulmonary pathology, especially in infants from mothers with UDCTD syndrome, has been proven. 3. The possibility of diagnosing disorders of functional maturation of the lungs in the fetal period using a non-invasive method of ultrasonography has been confirmed.

scholarly journals Enamel Matrix Derivative in Diffusion Chamber Implanted Subcutaneously in Rat Induces Formation of Fibrous Connective Tissue Containing Abundant Blood Vessels

In Vivo ◽  
2021 ◽  
Vol 35 (1) ◽  
pp. 313-317
Author(s):  
SATOSHI YOKOSE ◽  
YUKA KATO ◽  
KATSUTOSHI MATSUMOTO ◽  
PERRY R. KLOKKEVOLD ◽  
HENRY H. TAKEI ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Blood Vessels ◽  
Diffusion Chamber ◽  
Enamel Matrix Derivative ◽  
Fibrous Connective Tissue ◽  
Enamel Matrix ◽  
Matrix Derivative

scholarly journals Morphofunctional and immunohistochemical characteristics of the large omentum in ovarian cancer

2020 ◽  
Vol 9 (3) ◽  
pp. 64-71
Author(s):  
N. N. Shevlyuk ◽  
L. V. Khalikova ◽  
A. A. Khalikov
Keyword(s):  
Ovarian Cancer ◽  
Connective Tissue ◽  
Protein Expression ◽  
Blood Vessels ◽  
Lymphoid Tissue ◽  
P53 Protein ◽  
Individual Variability ◽  
The Body ◽  
Great Omentum ◽  
Low Grade

The aim of the study was to establish morphofunctional and immunohistochemical characteristics of large omentum in women with ovarian cancer.Material and methods. The large omenta of 48 women with ovarian cancer (low-grade differentiated seropapillary adenocarcinoma of high-grade malignancy) of II stage (n=20) and III stage (n=28) were studied. Histological sections were stained with overview histological and immunohistochemical methods (to reveal ki67, P53, CD34, CD7, CD4, CD8, CD61 proteins expression). Results. In patients, the size of the large omentum was characterized by high individual variability; in the presence of metastasis, the size of the omentum was reduced. Intensive development of blood vessels in the organ was noted, but in the presence of metastases stasis of blood corpuscles, leucocytic infiltration, and moderate edema of connective tissue were observed in the organ’s vessels. Areas of lymphoid tissue, both small lymphatic follicles and diffusely located lymphoid tissue, were revealed in the omentum. In most follicles, reactive centers were not marked, and the number of follicles was reduced in the presence of metastases in the omentum. The analysis of CD34+ cells distribution showed that they were identified both in the tumor and in the areas of the omentum adjacent to the tumor, which indicates a pronounced angiogenesis. An irregular distribution of CD7+ and CD8+ and CD4+ cells was revealed in the tumor tissues, as well as in the surroundings. Simultaneously with the expression of P53 protein, ki67 protein expression is revealed in the significant number of tumor cells (including endothelial cells of tumor blood vessels). The proportion of ki67+ cells in the tumor cell population was 60.1±3.3%. The presence of a large number of ki67+cells in the presence of P53 protein expression in them indicates the aggressiveness of the tumor, as well as a disturbance of apoptosis regulatory mechanisms in the cells. Ki67 expression was low in the omentum areas unaffected by metastases, and it was revealed in the certain areas of connective tissue in fibroblastic programmed differentiation cells. Conclusion. The results obtained indicate significant plasticity and reactivity of great omentum in the presence of tumor process in the body and confirm the important role of great omentum in protective reactions.

scholarly journals A HISTOLOGICAL STUDY OF THE SKIN LESIONS OF PELLAGRA

1911 ◽  
Vol 13 (1) ◽  
pp. 98-114
Author(s):  
Fraser B. Gurd
Keyword(s):  
Epithelial Cells ◽  
Connective Tissue ◽  
Blood Vessels ◽  
Pathological Condition ◽  
Histological Study ◽  
The Body ◽  
Lymphoid Cells ◽  
Cutaneous Lesions ◽  
Predisposing Factor ◽  
Pigment Formation

The cutaneous lesions in pellagra consist of an early erythema, or, in occasional cases, of vesicles or bullous formations which are followed by hyperkeratosis and pigmentation, resulting in a dry, dark brown scaliness. These various lesions are similar to those normally produced by the action of sunlight, but are much more marked. The histological phenomena of the erythematous and bullous stage are those of a mild acute inflammatory reaction, together with a degeneration in the superficial layers of the corium. Following this degeneration, which involves not only the general connective tissue but the connective tissue of the blood vessels, there is a reparative change evidenced histologically by an increased cellularity of the corium and the presence of fibroblasts. The capillaries also are increased in number and much dilated. Apparently as a result of this increased vascularity of the corium, there is an increased proliferation of the epithelium resulting in a thickening of the epidermis. This increase in thickness of the epithelial layer is especially marked in the prickle cells and the stratum granulosum. In the later stages, in an effort to secure a firm basement membrane, the epithelium is seen to dip down deeply into the rarefied connective tissue. About the blood vessels during the reactionary process are found collections of lymphoid cells, a few plasma cells, but no mast cells or eosinophiles. That the irritant producing the degeneration in the corium is sunlight in the presence of some predisposing factor, is suggested by the enormous increase in pigment formation in the epithelial cells and by the large number of chromatophores in the superficial layers of the corium. This pigmentation is autochthonous in both types of cell. There is no reason for believing that the pigment is formed in the cells of the corium and thence discharged into the epithelium, or that the reverse process takes place. The predisposing factor inducing the changes in the corium is, apparently, a lessened resistance of the epithelium to the violet and ultra-violet rays, due to some metabolic insufficiency on the part of the epithelial cells. Further observation may justify the conclusion that throughout the body, pellagra is a disease essentially of the epithelium, including the nervous system, this pathological condition manifesting itself by an insufficient or altered function.

scholarly journals The role of a balanced diet in the metabolism of nutrients

2021 ◽  
Vol 100 (4) ◽  
pp. 333-338
Author(s):  
Zoya I. Zholdakova ◽  
Rofail S. Rakhmanov ◽  
Elena S. Bogomolova ◽  
Rashid Sh. Khayrov ◽  
Ekaterina A. Olyushina
Keyword(s):  
Uric Acid ◽  
Total Cholesterol ◽  
Comparison Group ◽  
Density Lipoprotein ◽  
Food Products ◽  
Main Group ◽  
The Body ◽  
Metabolic Status ◽  
Low Density ◽  
Blood Indices

The purpose of the study was to assess the metabolic status of the body when correcting the diet with a concentrated natural product. Materials and methods. The diet of athletes was analyzed. The leading group (n = 15) received concentrated food products (CNP) for 20 days: No. 1 - 30.0 g and No. 2 - 20 g each. Blood indices including (total protein, uric acid, urea, creatinine, total cholesterol, high and low-density lipoprotein cholesterol, triglycerides, glucose, amylase) were assessed metabolic status: taken before, after, and in one month of taking CNP Results. The diet’s calorie content was 5953.2-6494.4 kcal/day in the main and the comparison group corresponding to this cohort’s physiological need. The proportions of protein and fat exceeded the recommended ones; deficiency of carbohydrates accounted for 8.7%. The inclusion of CNP increased the ratio of slow carbohydrates, vitamins, minerals, and minor food components. In the leading group, the increase in urea and uric acid was less significant in terms of average indices, and the proportion of such people increased. Creatinine was significantly higher than baseline within one month after CNP administration. The increase in the proportion of people with increased total cholesterol is 2.9 times less; the share with a borderline high level decreased by 15.5%, in the comparison group, it increased by 5.6%. The proportion with low-density lipoproteins exceeding the reference value decreased from 61.5% to 30.0% in the comparison group - without dynamics (55.6%) and signs of dyslipidemia increased. In the main group, within the normal range, 76.9% of individuals had an increase in glucose, amylase by 5.7% (p = 0.049). Conclusion. The diet is not macronutrient balanced. The use of CNP affected the metabolism of proteins, fats, and carbohydrates. It proved a more adequate energy supply for the activities of the persons of the main group. There has been shown the possibility of correcting the body’s metabolic processes with food products that reduces the risk of developing prenosological conditions during physical exertion, particularly fatigue and cardiovascular pathology.

scholarly journals Biochemical indices of urine in children with allergic diseases of airways

2020 ◽  
Vol 23 (4) ◽  
pp. 223-228
Author(s):  
Elena V. Tush ◽  
Anna N. Obuhova ◽  
Ivan I. Balabolkin ◽  
Olga V. Haletskaya ◽  
Andrey B. Stroganov ◽  
...  
Keyword(s):  
Comparison Group ◽  
Biochemical Study ◽  
Allergic Diseases ◽  
Main Group ◽  
The Body ◽  
Daily Urine ◽  
Daily Excretion ◽  
Biochemical Indices ◽  
Excretion Of Urates ◽  
Oxalate Metabolism

Currently, unsatisfactory control of the course of allergic diseases of airways (ADA) remains. There is data on the potential involvement of urate and oxalate metabolism in the pathogenesis of ADA, which determines the need to study the corresponding biomarkers. Aim of the work - to evaluate the daily urinary excretion of urates and oxalates in ADA children. Materials and methods. We examined 100 children aged 2 to 9 years, boys - 22, girls - 78, with symptoms of crystalluria. The children were divided into the main group (42 children) and the comparison group (58 people). The main group included patients with established diagnoses of ADA, and the comparison group included patients without ADA. A biochemical study of daily urine was performed in all cases. Results. It was found that the daily excretion of oxalates in ADA patients was significantly increased compared to the control, 26.5 [22.1; 32.6] mg/day and 23.3 [20.1; 27.6] mg/day, respectively. Daily urate excretion in patients of the main group was also significantly increased compared to the control, both in absolute numbers - 1.45 [1.13; 2.13] mmol/day and 1.17 [0.89; 1.5] mmol/day, respectively (p = 0.005), and in normalized to the body surface area units. Conclusion. A statistically significant increase in daily urate excretion was found in ADA children. The clinical and pathogenetic significance of this phenomenon in children with ADA requires further study.

scholarly journals Modern approaches to treatment of superficial dermal burns

2020 ◽  
pp. 40-41
Author(s):  
O.M. Kovalenko ◽  
A.O. Kovalenko ◽  
O.I. Оsadcha ◽  
O.M. Lynnyk
Keyword(s):  
Comparison Group ◽  
Main Group ◽  
The Body ◽  
Water Soluble ◽  
Wound Dressings ◽  
Wound Management ◽  
Quantitative Composition ◽  
Closed Chamber ◽  
Microbial Association ◽  
Healing Wound

Objective. The aim of the study is improving the treatment’s effectiveness in patients with superficial dermal burns due to the usage of modern wound dressings. Materials and methods. Under observation were 150 patients with superficial dermal thermal lesions with an area of 5-30 % of the body surface aged 10-64 years, who were treated at the Kyiv City Clinical Hospital № 2 during 2016-2019. The main group consisted of 120 patients, whose burn’s treatment provided under wound dressings in a humid environment (hydrogel, spongy polyurethane foam, film coatings). Comparison group – 30 patients whose wounds were treated by applying wet-drying bandages or bandages with water-soluble antibacterial ointments. Results and discussion. At the beginning of the treatment, the pH of the wound content of dermal burns was 7.9-8.1. On the 3rd day of treatment in patients of the main group, the pH of wounds under wound dressings was defined as acidic (5.7). In patients of the comparison group on the 3rd and 4th day the pH of the wounds was determined as alkaline, and only on the 6th day it became slightly acidic. As the pH of the wounds increased, the rate of healing decreased. In the phase of acute inflammation and exudation, the pH of superficial dermal burns was alkaline 7.8-8.2, in the proliferation phase, under the wound coverings – acidic (5.5-4.1). The use of wound dressings led to a decrease in the number of microbial association in patients to 1.1±0.4 on 9-11th days after injury, the colonization of wound surfaces changed slightly to 3×102 per 1 g. In contrast, in patients of the comparison group in the sequestration period of superficial necrotic scab increased the number of microbial associates to 2.8±0.7, wound colonization increased to 105 per 1 g of tissue. The time of epithelialization with the use of wound dressings was 13.8±1.7 days, in patients of another group – 19.4±2.5 days. Conclusions. Wound dressings that keep the wound moist are an effective way to influence the wound process, which can be regulated. In the treatment of superficial dermal burns under wound dressings there is a change of the alkaline reaction to acidy, which stimulates wound healing. Wound management in a wet closed chamber changes the qualitative and quantitative composition of the wound microflora, reduces the microbial contamination of burn wounds by two orders of magnitude. Superficial dermal burns heal under wound dressings for 13.8 days against 19.4 in traditional treatment.

scholarly journals CLINICAL ASSESSMENT OF THE EFFECTIVENESS APPLICATION "BIOCERULIN" IN THE COMPLEX TREATMENT OF THE PATIENTS WITH ONTOGENIC FLAGMONS OF THE MAXILLOFACIAL AREA

2019 ◽  
pp. 29-32
Author(s):  
D.V. Steblovskyi ◽  
V.V. Bondarenko ◽  
O.S. Ivanytska ◽  
V.M. Skrypnyk ◽  
I.O. Ivanytskyi
Keyword(s):  
General Condition ◽  
Inflammatory Process ◽  
New Technologies ◽  
Comparison Group ◽  
Main Group ◽  
The Body ◽  
Steady Increase ◽  
Complex Treatment ◽  
Maxillofacial Region ◽  
Traditional Therapy

Treatment of odontogenic phlegmon of the maxillofacial region remains an urgent problem of surgical dentistry due to the steady increase in their frequency, tendency to generalize the process and adverse effects. In this regard, there is a constant search for ways to improve the effectiveness of treatment of patients with odontogenic phlegmons of maxillofacial region. New technologies of drug treatment of this pathology are developed and put into practice. In recent years the attention of researchers in various conditions accompanied by the development of oxidative stress began to attract drugs that have antioxidant action, as it became known that the excess of reactive oxygen species in the regenerating wounds in the hearth of purulent inflammation affects the course of the course, wound healing. Interest in the treatment of various pathological conditions of the body is caused by the domestic antioxidant multifunctional enzyme "Bioceruline" which is composed of copper. In this regard, the purpose of our study was to evaluate the effectiveness of the use of "Biocerulin" in the complex treatment of patients with odontogenic phlegmon of maxillofacial region. The object of the clinical study was 45 patients with odontogenic phlegmons of the maxillofacial region from 18 to 55 years old, who were treated in the maxillofacial department of PU "Poltava M.V. Sklifosovskyi regional clinical hospital PRC». All patients were without somatic pathology in compensated clinical condition. Immediately after hospitalization, patients underwent an emergency opening of purulent lesion, revision and adequate drainage of the affected cellular spaces, removal of the "causal" tooth. The extent of surgery and the choice of optimal access depended on the location and prevalence of phlegmon. Depending on the treatment, patients were divided into comparison groups (22 patients) and the main group (23 patients). The traditional therapy was used in the comparison group. "Biocerulin"was prescribed for the patients of the main group in addition to the traditional therapy. Analysis of obtained data in the treatment of patients with phlegmon revealed that both groups of patients had clear differences in the clinical course of purulent-inflammatory process. On the 2nd day after the opening of the phlegmon theweakness, headache, and sleep disorders were noted in the most of the patients of the comparison group who received traditional therapy. Pain with varying degrees of intensity was present in all patients. Improvement of the general condition of patients of this group was noted not earlier than 3-5 days after surgery. The improvement of the general condition and reduction of pain, normalization or decrease in body temperature, the beginning of restoration of function of the jaw apparatuswere notedin patients of the main group on the background of the introduction of "Bioceruline" already on the 2-3rd day after surgery. Thus, on the basis of the conducted researches it is possible to conclude that the basic (traditional) conservative therapeutic measures used for patients of the comparison group are not effective enough for the relief of the local and general inflammatory process, which caused the prolonged nature of organ-specific and functional rehabilitation of patients as a whole. The use of "Bioceruline" in complex therapy of patients with odontogenicphlegmons of the maxillofacial regionprovides rapid and intensive recovery of the general condition of patients and accelerates reparative processes in the wound and shortens the treatment time via 1.4 bed-days.

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