African Flora as Potential Sources of Medicinal Plants : Towards the Chemotherapy of Major Parasitic and Other Infectious Diseases : A Review

2013 ◽  
Vol 6 (2) ◽  
pp. 77-84 ◽  
Author(s):  
Ameenah Gurib-Fakim ◽  
Mohamad F. Mahomoodally
Tuberculosis ◽  
2020 ◽  
Vol 124 ◽  
pp. 101987
Author(s):  
Naasson Tuyiringire ◽  
Serawit Deyno ◽  
Anke Weisheit ◽  
Casim Umba Tolo ◽  
Deusdedit Tusubira ◽  
...  

2009 ◽  
Vol 75 (19) ◽  
pp. 6176-6186 ◽  
Author(s):  
Sheng Qin ◽  
Jie Li ◽  
Hua-Hong Chen ◽  
Guo-Zhen Zhao ◽  
Wen-Yong Zhu ◽  
...  

ABSTRACT Endophytic actinobacteria are relatively unexplored as potential sources of novel species and novel natural products for medical and commercial exploitation. Xishuangbanna is recognized throughout the world for its diverse flora, especially the rain forest plants, many of which have indigenous pharmaceutical histories. However, little is known about the endophytic actinobacteria of this tropical area. In this work, we studied the diversity of actinobacteria isolated from medicinal plants collected from tropical rain forests in Xishuangbanna. By the use of different selective isolation media and methods, a total of 2,174 actinobacteria were isolated. Forty-six isolates were selected on the basis of their morphologies on different media and were further characterized by 16S rRNA gene sequencing. The results showed an unexpected level of diversity, with 32 different genera. To our knowledge, this is the first report describing the isolation of Saccharopolyspora, Dietzia, Blastococcus, Dactylosporangium, Promicromonospora, Oerskovia, Actinocorallia, and Jiangella species from endophytic environments. At least 19 isolates are considered novel taxa by our current research. In addition, all 46 isolates were tested for antimicrobial activity and were screened for the presence of genes encoding polyketide synthetases and nonribosomal peptide synthetases. The results confirm that the medicinal plants of Xishuangbanna represent an extremely rich reservoir for the isolation of a significant diversity of actinobacteria, including novel species, that are potential sources for the discovery of biologically active compounds.


2015 ◽  
Vol 5 (10) ◽  
pp. 858-864 ◽  
Author(s):  
Mahmoud Bahmani ◽  
Kourosh Saki ◽  
Somayeh Shahsavari ◽  
Mahmoud Rafieian-Kopaei ◽  
Reza Sepahvand ◽  
...  

Author(s):  
Ian Dianto ◽  
Syariful Anam ◽  
Akhmad Khumaidi

Ethnomedicinal study on LedoKaili tribe has been conducted from January to April 2015 in Sigi Regency, Central Sulawesi. This study aims to know and to inventory the various species of plants, their parts, and ways of utilization used to treat any types of disease and how the by the tribe. This research is descriptive using qualitative methods and snowball sampling technique through open-ended interviews to 10 informants by using questionnaire. Based on the study results, plants used as medicine were known as many as 86 species coming from  37 familia in which four species have notbeen identified yet. The most widely used plants are from familia Zingiberaceae (8 species). Plant parts used include leaf, stem, fruit, root, rhizome, tuber, herb, bark, sap, and flower. Leafisthe part of the plant used with the highest percentage (53%). Local people use medicinal plants for purposes of chronic, infectious, and non-infectious diseases. Besides being able to treat people's illnesses,the plants were also used for body health care as well as dietary supplements. Ways of processing medicinal plants is done by boiling, crushing, squeezing, shredding and soaking. The most widely is boiled with percentage of 60%. As for how to use medicinal plants, the people use them in ways of drinking, eating, rubbing, dropping, and tapping/attaching. Drinking is the most usual way to use them with a percentage of 74%


Antioxidants ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1362
Author(s):  
Halyna Hachkova ◽  
Mariia Nagalievska ◽  
Zoriana Soliljak ◽  
Olena Kanyuka ◽  
Alicja Zofia Kucharska ◽  
...  

Hypoglycemic and antioxidant properties of extracts of medicinal plants Galega officinalis L. (aboveground part) and yacon (Smallanthus sonchifolius Poepp. & Endl.) (leaves) as potential sources of biologically active substances with antidiabetic action have been studied. The pronounced hypoglycemic effect of Galega officinalis extract, devoid of alkaloids, at a dose of 600 mg/kg in experimental diabetes mellitus (DM) has been proven. The established effect is evidenced by a decrease in the concentration of glucose and glycosylated hemoglobin in the blood, increase glucose tolerance of cells, increase C-peptide and insulin content in the plasma of rats’ blood. The effective hypoglycemic effect of the extract in the studied pathology was confirmed by histological examination of the pancreas. The cytoprotective effect of the studied extract on pancreatic cells at a dose of 1200 mg/kg was experimentally confirmed. In the standard cut area, an increase was found in the number of Langerhans islets, their average area, diameter, volume, and a number of β-cells relative to these indicators in animals with diabetes. Comparative screening of the antioxidant properties of 30, 50, 70, and 96% water–ethanol extracts of yacon indicates the highest potential of 50% water-ethanol extract to block free radicals in in vitro model experiments. The non-alkaloid fraction of Galega officinalis extract showed moderate antioxidant activity and was inferior to yacon extract in its ability to neutralize reactive oxygen species (ROS) and bind metal ions of variable valence. The level of antioxidant potential of the studied extracts is due to differences in the quantitative content of compounds of phenolic nature in their compositions. The obtained data on the biological effects of Galega officinalis extract on the structural and functional state of β-cells of the pancreas and antioxidant properties of Galega officinalis and yacon extracts substantiate the prospects of using these plants to create antidiabetic medicines and functional foods based on them.


2015 ◽  
Vol 2015 ◽  
pp. 1-16 ◽  
Author(s):  
Patrick Valere Tsouh Fokou ◽  
Alexander Kwadwo Nyarko ◽  
Regina Appiah-Opong ◽  
Lauve Rachel Tchokouaha Yamthe ◽  
Mark Ofosuhene ◽  
...  

Mycobacterium ulceransdisease has been a serious threat for people living in rural remote areas. Due to poverty or availability of traditional medicine these populations rely on herbal remedies. Currently, data on the anti-Mycobacterium ulceransactivity of plants, so far considered community-based knowledge, have been scientifically confirmed, concomitantly with some medicinal plants used to treat infectious diseases in general. Products derived from plants usually responsible for the biological properties may potentially controlMycobacterium ulceransdisease; numerous studies have aimed to describe the chemical composition of these plant antimicrobials. Thus, the present work provides the first compilation of medicinal plants that demonstrated inhibitory potential onMycobacterium ulcerans. This work shows that the natural products represent potential alternatives to standard therapies for use as curative medicine forMycobacterium ulceransdisease.


2016 ◽  
Vol 5 (03) ◽  
pp. 4915
Author(s):  
Phani Kumari Uddandapu* ◽  
Venkateswar Rao, Y. ◽  
Chandrasekhara Naidu K.

The Plant kingdom is a storehouse of potential drugs. Plant derived medicines have made large contributions to human health and well-being. They play dual role in the development of new drugs. At first they act as a natural blueprint for the development of new drugs and secondly they can be used for the treatment of infectious diseases. Many evidences gathered from earlier studies which confirmed that the presence of variety of phytochemicals in plants contribute medicinal properties. In this present review, an attempt has been made to give an overview of few south Indian medicinal plants and their phytochemicals which are useful in the treatment of several infectious diseases.


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