Green to Gone? Regional Institutional Logics and Firm Survival in Moral Markets

A growing body of scholarship studies the emergence of moral markets—sectors offering market-based solutions to social and environmental issues. To date, researchers have largely focused on the drivers of firm entry into these values-laden sectors. However, we know comparatively little about postentry dynamics or the determinants of firm survival in moral markets. This study examines how regional institutional logics—spatially bound, socially constructed meaning systems that legitimize specific practices and goals within a community—shape firm survival in emerging moral markets. Using a unique panel of firms entering the first eight years of the U.S. green building supply industry, we find that (1) a regional market logic amplifies the impacts of market forces by increasing the positive impact of market adoption and the negative impact of localized competition on firm survival, (2) a regional proenvironmental logic dampens the impacts of adoption and competition on firm survival, and (3) institutional complexity—the co-occurrence of both market and proenvironmental logics in a region—negates the traditional advantages of de alio (diversifying incumbent) firms, creating an opportunity for de novo (entrepreneurial entrant) firms to compete more effectively. Our study integrates research on industry emergence, institutional logics, and firm survival to address important gaps in our knowledge regarding the evolution and growth of environmental entrepreneurship in moral markets.

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The Aberrations of Cytogenetics and Molecular Genetics in Core Binding Factor Acute Myeloid Leukemia

Blood ◽

10.1182/blood.v126.23.4802.4802 ◽

2015 ◽

Vol 126 (23) ◽

pp. 4802-4802

Author(s):

Aining Sun ◽

Ding Chao ◽

Suning Chen ◽

Haiping Dai ◽

Wu Depei

Keyword(s):

Cell Lines ◽

Mirna Expression ◽

Expression Profiling ◽

De Novo ◽

Negative Impact ◽

Positive Impact ◽

Molecular Genetic ◽

Expression Level ◽

Genetic Characteristics ◽

Mirna Expression Profiling

Abstract Objective: 1. To investgate the clinical, cytogenetic, and molecular genetic characteristics of 873 patients with de novo core binding factor acute myeloid leukemia (CBF-AML). 2. To evaluate the prognostic value of additional chromosome abnormalities, mutations, and the transcriptional levels of RUNX1-RUNX1T1, CBFβ-MYH11 in patients with CBF-AML. 3. To identify up-regulated or down-regulated microRNAs in CBF-AML by the Bead-based miRNA expression profiling and Q-PCR and analyze their biological effects. Methods 1. All the samples were studied by R-band karyotypic analysis after using direct method and/or short-term culture for chromosome preparation. The clinical, laboratory, cytogenetic and molecular genetic characteristics of CBF-AML were evaluated. A variety of CBF-AML related mutations were evaluated by PCR amplification and direct DNA sequencing, namely: KIT, FLT3-TKD, FLT3-ITD, N-RAS, K-RAS, CBL, JAK2, CEBPA, NPM, ASXL1, IDH1, IDH2, WT1, EZH2, TET2 and DNMT3A. 2. We identified a cluster of up-regulated or down-regulated microRNAs in CBF-AML by the Bead-based miRNA expression profiling and Q-PCR. The pathologic role of these miRs in primary cells and leukemia cell lines of CBF-AML was studied by multiple in vitro medthods. Results: 1. After reviewing the cytogenetic and molecular analysis database, 873 cases admitted to the Jingsu Institute of Hematology between June 1985 and January 2013 fulfilled WHO-2008 criteria for CBF-AML, including 767 patients with t(8;21) /RUNX1-RUNX1T1 and 106 with inv(16)/t(16;16)/CBFβ-MYH11. This cohort comprises 497 males and 57 females. The median age was 31 years. The patients with inv(16)/t(16;16)/CBFβ-MYH11 had a significantly higher median WBC, Hb, and Blast than those with t(8;21)/RUNX1-RUNX1T1 (P<0.05). About 71.6% of patients with t(8;21) were classified as M2 according to the FAB creteria, while 45.3% of patients with inv(16)/t(16; 16) were classified as M4Eo. There were 452 (52.1%) CBF-AML patients had at least one additional chromosomal abnormality (ACA) besides t(8;21) or inv(16)/t(16; 16), 72 (8.3%) patients had two or more ACAs. The frequency of t(8;21) patients with ACA was higher than patients with inv(16). The most common ACA in t(8;21)-AML was loss of sex chromosomes (either X or Y) and del(9q), while the most common ACA in inv(16)-AML was +22. There were 63 cases presented with normal karotype and positive fusion transcripts showed by Q-PCR or/and FISH. Mutation analysis was perfomed in 258 CBF-AML patients for whom genomic DNA and RNA were available. Overall, 138 patients (53.5%) were found to have at least one mutation, classified with: KIT (34.1%), FLT3 (12.5%), TET2 (11.7%), RAS (9.7%), WT1(6.7%), NPM1(3.3%), CBL (3.2%), CEBPA (2.3%), EZH2(1.7%)、ASXL1 (1.7%)、IDH2(1.7%)、DNMT3A (1.7%) and JAK2V617F (1.0%). 2. The mutations in exon 17 of the KIT and FLT3 genes had negative impact on overall survival (OS) and event-free survival (EFS) in CBF-AML patients. However, RAS mutations and ACAs had no impact on the outcome of CBF-AML patients. A higher than 3-log MRD reduction after first consolidation had positive impact on OS, but not on EFS. 3. The bead-based miRNA expression profiling was performed in 157 de novo AML samples. We identified a cohort of up-regulated or down-regulated microRNAs in CBF-AML. The expression level of miR-99a/100 was downregulated in the primary leukemia cells from CBF-AML patients and several CBF-AML cell lines (Skno-1, Kasumi-1, and ME-1) and associated with better outcome. The expression level of miR-130a is upregulated in the primary leukemia cells from CBF-AML patients and CBF-AML cell lines (Skno-1, Kasumi-1, and ME-1). Conclusion 1. The most common ACAs in t(8;21)-AML was loss of sex chromosomes, while the most common ACA in inv(16)-AML was +22. The most common mutation in t(8;21)-AML patients was KIT mutation (especially exon17),but in inv(16)-AML was exon8. 2. The mutations in exon 17 of the KIT and FLT3 genes had negative impact on the outcome of CBF-AML patients. A higher than 3-log MRD reduction after first consolidation had positive impact on OS of CBF-AML patients.Sex should be considered too. 3. The expression level of miR-99a/100 was downregulated in CBF-AML and associated with better outcome. The expression level of miR-130a is upregulated in CBF-AML and may plays important role in the leukmogenesis of RUNX1-RUNX1T1 by downregulating HOXA10 and PTEN. Disclosures No relevant conflicts of interest to declare.

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TURN-OVER GURU PADA MADRASAH ALIYAH NAHDLATUL ULAMA

JURNAL PENELITIAN ◽

10.28918/jupe.v13i1.704 ◽

1970 ◽

Vol 13 (1) ◽

Author(s):

Mochamad Iskarim

Keyword(s):

Data Collection ◽

Negative Impact ◽

Positive Impact ◽

New Teacher ◽

Qualitative Approach ◽

Depth Interview ◽

Nahdlatul Ulama ◽

Turn Over ◽

Interview Questionnaire ◽

Collection Methods

Penelitian ini dimaksudkan untuk mengetahui dampak positif dan negatif dari adanya pergantian (turn-over) guru di Madrasah Aliyah Nahdlatul Ulama Banyuputih kabupaten Batang. Penelitian inimenggunakan pendekatan kualitatif deskriptif analitis dengan metode pengumpulan data berupa wawancara mendalam, angket, dan dokumentasi. Hasil penelitian menunjukkan adanya turn-over yang tinggi pada guru atau pendidik di madrasah tersebut; keuntungan yang bersifat positif justru didapatkan ketika adanya turn-over guru dibandingkan dampak negatifnya; dan kehadiran guru baru menjadi hal yang sangat disukai oleh siswa dalam hal kreativitas, inovasi pembelajaran, motivasi, dan lain sebagainya.The aims of this research were to know the positive and negative impact of teacher turn over at Madrasah Aliyah Nahdlatul Ulama Banyuputih Kabupaten Batang. This research was use analytical descriptive qualitative approach with depth interview, questionnaire and documentation as data collection methods. The results of this research shows that the positive impact occur more than the negative impact when there was teacher turn over; and the presence of a new teacher become student’s favourite on creativity, learning innovation, and motivation aspects.

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Accidental Sustainability

10.1093/oso/9780198706977.003.0005 ◽

2017 ◽

Author(s):

Geoffrey Jones

Keyword(s):

Large Scale ◽

Negative Impact ◽

Positive Impact ◽

Organic Food ◽

The United States ◽

Air Travel ◽

Business Leaders ◽

Natural Beauty ◽

And Diffusion ◽

Whole Foods

This chapter examines the scaling and diffusion of green entrepreneurship between 1980 and the present. It explores how entrepreneurs and business leaders promoted the idea that business and sustainability were compatible. It then examines the rapid growth of organic foods, natural beauty, ecological architecture, and eco-tourism. Green firms sometimes grew to a large scale, such as the retailer Whole Foods Market in the United States. The chapter explores how greater mainstreaming of these businesses resulted in a new set of challenges arising from scaling. Organic food was now transported across large distances causing a negative impact on carbon emissions. More eco-tourism resulted in more air travel and bigger airports. In other industries scaling had a more positive impact. Towns were major polluters, so more ecological buildings had a positive impact.

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Socioeconomic Conditions and Landowners’ Perception Affect the Intention to Restore Polylepis Forests in the Central Andes of Peru

Forests ◽

10.3390/f12020118 ◽

2021 ◽

Vol 12 (2) ◽

pp. 118

Author(s):

Lunel Joseph ◽

Raúl Marino Yaranga Cano ◽

Marco Arizapana-Almonacid ◽

Marcela Venelli Pyles ◽

Flávia Freire de Siqueira ◽

...

Keyword(s):

Rural Communities ◽

Mixed Model ◽

Linear Mixed Model ◽

Negative Impact ◽

Positive Impact ◽

Central Andes ◽

Socioeconomic Conditions ◽

Native Flora ◽

The Family ◽

Andes Region

Research Highlights: Families more dependent on crops as the main source of income of properties have a greater intention of restoring Polylepis forest areas. However, this intention reduces with the increase of family dependence on subsistence products supplied by Polylepis forests. Properties where the chances of restoration of Polylepis forests are greater are those where the educational and technical level is better. Objectives: We aimed to comprehend which socioeconomic factors of rural properties and families’ perception were determinant for the intention to restore Polylepis forests in the Central Andes region of Peru. Material and Methods: We collected data through visits and the application of questionnaires. We selected 13 rural communities in the Tulumayo River Basin. We randomly sampled 10 to 20 families in each community, depending on its size, totaling 200 families. We used generalized linear mixed model (GLMM) to test which variables affect the intention to restore the forest. Results: When crops are the main source of income in the property, the families have more intention to restore Polylepis areas, on the other hand, when Polylepis forests are an important source of products for the family subsistence, the intention to restore forests reduces, indicating that higher technological status has a positive impact on restoration. The perception that Polylepis forests are important for the existence of water sources had a positive impact on the families’ intention to restore the areas. However, the perception that Polylepis forests are important for native flora persistence had a negative impact on the intention to restore their areas. Conclusions: Our results showed that investment in improving the productivity of the properties and in the education of their landowners should increase the success of eventual programs for restoration of Polylepis forests.

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043 Sleep Restriction Affects Memory in Healthy Adults: Preliminary Findings

SLEEP ◽

10.1093/sleep/zsab072.042 ◽

2021 ◽

Vol 44 (Supplement_2) ◽

pp. A18-A19

Author(s):

Molly Zimmerman ◽

Christiane Hale ◽

Adam Brickman ◽

Lok-Kin Yeung ◽

Justin Cochran ◽

...

Keyword(s):

Working Memory ◽

Negative Impact ◽

Positive Impact ◽

Healthy Adults ◽

Task Demands ◽

Sleep Restriction ◽

Neuropsychological Function ◽

Wake Time ◽

Sleep Condition ◽

The Impact

Abstract Introduction Sleep loss has a range of detrimental effects on cognitive ability. However, few studies have examined the impact of sleep restriction on neuropsychological function using an experimental design. The goal of this study was to examine the extent to which maintained insufficient sleep affects cognition in healthy adults compared to habitual adequate sleep. Methods This study used a randomized, crossover, outpatient sleep restriction design. Adults who regularly slept at least 7 h/night, verified by 2 weeks of screening with actigraphy, completed 2 phases of 6 weeks each: habitual sleep (>7 h of sleep/night) or sleep restriction (habitual sleep minus 1.5 h) separated by a 6-week washout period. During the sleep restriction phase, participants were asked to delay their bedtime by 1.5 hours/night while maintaining their habitual wake time. Neuropsychological function was evaluated with the NIH Toolbox Cognition Battery at baseline (week 0) and endpoint (week 6) of each intervention phase. The NIH Toolbox evaluates a range of cognitive abilities, including attention, executive functioning, and working memory. General linear models with post hoc paired t-tests were used to assess demographically-adjusted test scores prior to and following each sleep condition. Results At the time of analyses, 16 participants were enrolled (age 34.5□14.5 years, 9 women), 10 of whom had completed study procedures. An interaction between sleep condition and testing session revealed that individuals performed worse on List Sorting, a working memory test, after sleep restriction but improved slightly after habitual sleep (p<0.001). While not statistically reliable, the pattern of test results was similar on the other tests of processing speed, executive function, and attention. Conclusion In these preliminary results from this randomized experimental study, we demonstrated that sleep restriction has a negative impact while stable habitual adequate sleep has a positive impact on working memory, or the ability to temporarily hold information in mind while executing task demands. This finding contributes to our understanding of the complex interplay between different aspects of sleep quality (i.e., both sleep restriction as well as the maintenance of stable sleep patterns) on cognition and underscores the importance of routine sleep screening as part of medical evaluations. Support (if any):

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Exploring the Relationship between Communication and Success of Construction Projects: The Mediating Role of Conflict

Sustainability ◽

10.3390/su13084513 ◽

2021 ◽

Vol 13 (8) ◽

pp. 4513

Author(s):

Summaira Malik ◽

Muhammad Taqi ◽

José Moleiro Martins ◽

Mário Nuno Mata ◽

João Manuel Pereira ◽

...

Keyword(s):

Project Success ◽

Negative Impact ◽

Positive Impact ◽

Construction Project ◽

Project Team ◽

Relationship Conflict ◽

Team Members ◽

Mediating Role ◽

The Impact

The success of a construction project is a widely discussed topic, even today, and there exists a difference of opinion. The impact of communication and conflict on project success is an important, but least addressed, issue in literature, especially in the case of underdeveloped countries. Miscommunication and conflict not only hinder the success of a project but also may lead to conflicts. The focus of this paper was to examine the impact of communication on project success with the mediating role of conflict. By using SPSS, demographics, descriptive statistics and correlation were determined. Smart PLS version 3.0 was used for confirmatory factor analysis (CFA), internal accuracy and validity estimates, hypothesis checking and mediation testing. The results showed that formal communication has a negative impact on the success of a construction project, resulting in conflicts among project team members, whereas informal communication and communication willingness have a positive impact on project success because people tend to know each other, and trust is developed. Task, process and relationship conflicts were used as mediating variables. It was found that task conflict effects the relations positively because project team members suggest different ways to do a certain task, and, hence, project success is achieved. On the contrary, process conflict and relationship conflict have a negative impact on communication and project success. Both of these conflicts lead to miscommunication, and project success is compromised. Hence, it is the responsibility of the project manager to enhance communication among project team members and to reduce the detrimental effects of process and relationship conflict on project success.

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The Urbanisation Impacts on the Policy Effects of the Carbon Tax in China

Sustainability ◽

10.3390/su13126749 ◽

2021 ◽

Vol 13 (12) ◽

pp. 6749

Author(s):

Shuyang Chen

Keyword(s):

Energy Consumption ◽

Carbon Emissions ◽

Computable General Equilibrium ◽

Carbon Tax ◽

Negative Impact ◽

Positive Impact ◽

Evaluation Framework ◽

Socioeconomic Impacts ◽

Policy Effects ◽

Distributed Lag

In the literature, very few studies have focused on how urbanisation will influence the policy effects of a climate policy even though urbanisation does have profound socioeconomic impacts. This paper has explored the interrelations among the urbanisation, carbon emissions, GDP, and energy consumption in China using the autoregressive distributed lag (ARDL) model. Then, the unit urbanisation impacts are inputted into the policy evaluation framework of the Computable General Equilibrium (CGE) model in 2015–2030. The results show that the urbanisation had a positive impact on the GDP but a negative impact on the carbon emissions in 1980–2014. These impacts were statistically significant, but its impact on the energy consumption was not statistically significant. In 2015–2030, the urbanisation will have negative impacts on the carbon emissions and intensity. It will decrease the GDP and the household welfare under the carbon tax. The urbanisation will increase the average social cost of carbon (ASCC). Hence, the urbanisation will reinforce the policy effects of the carbon tax on the emissions and welfare.

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Environmental Regulation, Environmental Awareness and Environmental Governance Satisfaction

Sustainability ◽

10.3390/su13073960 ◽

2021 ◽

Vol 13 (7) ◽

pp. 3960

Author(s):

Meng-Meng Geng ◽

Ling-Yun He

Keyword(s):

Environmental Regulation ◽

Environmental Governance ◽

Negative Impact ◽

Positive Impact ◽

Subjective Evaluation ◽

Environmental Awareness ◽

General Social Survey ◽

Probit Model ◽

The People ◽

The Impact

It is a problem worth thinking about whether the government’s environmental regulation policies can meet the residents’ requirements for environmental quality, and benefit the people. The study of the public’s subjective evaluation can more intuitively judge whether the government’s environmental regulation has realized “ecological benefits for the people”. Based on the data of the Chinese General Social Survey (CGSS) in 2013, this paper studied the impact of environmental regulation and environmental awareness on environmental governance satisfaction by an ordered probit model. The study found that environmental regulation has a significant positive impact on environmental governance satisfaction, while environmental awareness has a significant negative impact on environmental governance satisfaction. We also found that when public environmental awareness is taken into account, the positive relationship between environmental regulation and environmental governance satisfaction is affected. The robustness test proved this conclusion.

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A performance model for mobile robot-based part feeding systems to supermarkets

Flexible Services and Manufacturing Journal ◽

10.1007/s10696-021-09427-6 ◽

2021 ◽

Author(s):

Emilio Moretti ◽

Elena Tappia ◽

Martina Mauri ◽

Marco Melacini

Keyword(s):

Negative Impact ◽

Positive Impact ◽

Waiting Times ◽

Performance Model ◽

Innovative Technology ◽

Shop Floor ◽

Storage And Retrieval ◽

Trade Offs ◽

Part Feeding ◽

Feeding Systems

AbstractIn a context where companies are striving to produce highly customised goods in small batches and within short lead times, increasing attention is being put on the design and management of part feeding systems. This research is the first to model automated part feeding to supermarkets in a factory environment, considering an innovative technology called vertical robotic storage and retrieval systems. This technology allows automating the storage, picking, and internal transportation activities in an integrated process, thanks to rack-climbing robots roaming in both the shop floor and the storage racks. We develop an analytical model based on the queuing network approach to analyse the system performance, and we use it to perform numerical experiments and to evaluate the design trade-offs with reference to a real case in the automotive industry. Results show that an increase in the number of robots leads to better performance since the positive impact on the response time is stronger than the negative impact on the waiting times of robots at the supermarkets due to congestion. Furthermore, a configuration with multiple small supermarkets improves the efficiency of the replenishment process, compared to a setting with few big supermarkets.

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The Impact of the Business Environment on the Formalization of Informal Firms. The Case of Kosovo

Südosteuropa ◽

10.1515/soeu-2020-0035 ◽

2020 ◽

Vol 68 (4) ◽

pp. 505-529

Author(s):

Kujtim Zylfijaj ◽

Dimitar Nikoloski ◽

Nadine Tournois

Keyword(s):

Negative Impact ◽

Positive Impact ◽

Business Environment ◽

Positive Influence ◽

Policy Implications ◽

Tax Reforms ◽

Firm Level ◽

Characteristics Analysis ◽

Significant Negative Impact ◽

The Impact

AbstractThe research presented here investigates the impact of the business environment on the formalization of informal firms, using firm-level data for 243 informal firms in Kosovo. The findings indicate that business-environment variables such as limited access to financing, the cost of financing, the unavailability of subsidies, tax rates, and corruption have a significant negative impact on the formalization of informal firms. In addition, firm-level characteristics analysis suggests that the age of the firm also exercises a significant negative impact, whereas sales volume exerts a significant positive impact on the formalization of informal firms. These findings have important policy implications and suggest that the abolition of barriers preventing access to financing, as well as tax reforms and a consistent struggle against corruption may have a positive influence on the formalization of informal firms. On the other hand, firm owners should consider formalization to be a means to help them have greater opportunities for survival and growth.

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