scholarly journals Types and clinical outcomes of chemical ingestion in emergency departments in South Korea (2011-2016)

PLoS ONE ◽  
2020 ◽  
Vol 15 (3) ◽  
pp. e0229939
Author(s):  
Jae Hee Lee ◽  
Duk Hee Lee
Keyword(s):  
South Korea ◽  
Clinical Outcomes ◽  
Emergency Departments

Projecting the long-term benefits of single pill combination therapy for patients with hypertension in five countries

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
C Borghi ◽  
J.G Wang ◽  
A.V Rodionov ◽  
M Rosas ◽  
I.S Sohn ◽  
...  
Keyword(s):  
Combination Therapy ◽  
South Korea ◽  
Health Outcomes ◽  
Clinical Outcomes ◽  
Funding Source ◽  
Combination Therapies ◽  
Private Company ◽  
Treatment Pathways ◽  
Single Pill ◽  
The Impact

Abstract Background It is well established that single pill combination (SPC) therapies have the potential to improve patient adherence versus multi-pill regimens, thereby improving blood pressure control and clinical outcomes in populations with hypertension. Purpose To develop a microsimulation model, capturing different treatment pathways, to project the impact on clinical outcomes of using single pill combination therapies for the management of hypertension in five countries (Italy, Russia, China, South Korea and Mexico). Methods The model was designed to project health outcomes between 2020 and 2030 for populations with hypertension managed according to four different treatment pathways: current treatment practices [CTP], single drug with dosage titration first then sequential addition of other agents [start low and go slow, SLGS], free choice combination with multiple pills [FCC] and combination therapy in the form of a single pill [SPC]. Model inputs were derived from Global Burden of Disease 2017 dataset, including demographics, health status/risk factors, transition probabilities and treatment attributes/healthcare utilization, and the model incorporated real-world challenges to healthcare delivery such as access to care, SBP measurement error, adherence and therapeutic inertia. Simulated outcomes of mortality, incidence of chronic kidney disease (CKD), stroke and ischemic heart disease (IHD), and disability-adjusted life years (DALYs) due to these conditions were estimated for population of 1,000,000 simulated patients for each treatment pathway and country. Results SPC therapy was projected to improve health outcomes over SLGS, FCC and CTP over 10 years in all five countries. SPC was forecast to reduce mortality by 5.4% (Italy), 4.9% (Russia), 4.5% (China), 2.3% (South Korea) and 3.6% (Mexico) versus CTP and showed greater projected reductions in mortality than SLGS and FCC. DALYs were projected to be reduced with SPC therapy by between 5.7% (Italy) and 2.2% (South Korea) compared with CTP and reductions in the incidence of clinical events were also projected with SPC therapy, with decreases in the range of 11.5% (Italy) to 4.9% (South Korea) versus CTP. Conclusions Ten-year projections of clinical outcomes associated with different anti-hypertensive treatment pathways in five countries indicated that both combination therapies (FCC and SPC) are likely to reduce the disease burden of hypertension compared with conventional management approaches, with SPC showing the greatest overall benefits due to improved adherence. Funding Acknowledgement Type of funding source: Private company. Main funding source(s): Sanofi, Gentilly, France

scholarly journals Clinical outcomes and healthcare costs of inpatients with tetanus in Korea, 2011–2019

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sohyun Bae ◽  
Minsik Go ◽  
Yoonjung Kim ◽  
Soyoon Hwang ◽  
Shin-Woo Kim ◽  
...  
Keyword(s):  
South Korea ◽  
Clinical Outcomes ◽  
Medical Costs ◽  
Common Symptom ◽  
University Hospitals ◽  
South Korean ◽  
National University ◽  
Hospital Stays ◽  
Serious Disease ◽  
Vaccination Completion

Abstract Background Tetanus is a rare, vaccine-preventable but extremely serious disease. We investigated the recent trend of the clinical outcomes and medical costs for inpatients with tetanus in South Korea over 10 years. Methods We conducted a retrospective review to determine the clinical factors and medical costs associated with tetanus at two national university hospitals in South Korea between January 2011 and October 2019. Results Forty-nine patients were admitted for tetanus (mean age, 67.0 years [range, 53.0–80.0 years]; 32 women [57.1%]). All the patients had generalized tetanus, and 5 (10.2%) died during hospitalization. The median duration from symptom onset to hospital admission was 4 days. Trismus (85.7%) was the most common symptom, and the median hospital stay was 39 days. Thirty-two patients (65.3%) required mechanical ventilation, and 20 (40.8%) developed aspiration pneumonia. The median total healthcare cost per patient was US $18,011. After discharge, 35 patients (71.4%) recovered sufficiently to walk without disability. Conclusions Tetanus requires long hospital stays and high medical expenditures in South Korea; however, the vaccination completion rate is low. Medical staff should therefore promote medical advice and policies on the management of tetanus to the general South Korean population.

Clinical outcomes for chest pain patients discharged home from emergency departments using high-sensitivity versus conventional cardiac troponin assays

2020 ◽  
Vol 221 ◽  
pp. 84-94 ◽  
Author(s):  
Geoffrey Lau ◽  
Maria Koh ◽  
Peter A. Kavsak ◽  
Michael J. Schull ◽  
David W.J. Armstrong ◽  
...  
Keyword(s):  
Chest Pain ◽  
Clinical Outcomes ◽  
Emergency Departments ◽  
Cardiac Troponin ◽  
High Sensitivity ◽  
Pain Patients

A Systematic Review and Meta-Analysis of Personality Disorder Prevalence and Patient Outcomes in Emergency Departments

2020 ◽  
Vol 34 (3) ◽  
pp. 324-347
Author(s):  
Alexander Collins ◽  
Kirsten Barnicot ◽  
Piyal Sen
Keyword(s):  
Systematic Review ◽  
Clinical Outcomes ◽  
Emergency Departments ◽  
Meta Analysis ◽  
Assessment Method ◽  
Screening Tools ◽  
Future Research ◽  
Prevalence Rates ◽  
Self Harm ◽  
Improve Patient Management

The objectives of this study were to perform a systematic review and meta-analysis of studies reporting prevalence of personality disorders (PDs) in emergency departments (EDs) and evaluate the effect of comorbid PDs on clinical outcomes. A systematic search of five databases along with manual searching and expert consultation was performed. A quality appraisal was conducted. A total of 29 articles were included. Prevalence of PDs in ED attendees varied depending on presenting complaint, Q(4) = 577.5, p < .01, with meta-analytic prevalence rates of suicide and self-harm at 35% and 22%, respectively. The assessment method had a significant effect on prevalence rates, Q(3) = 17.36, p < .01. Comorbid PD was a risk factor for repeating presenting complaint, subsequent ED return, and hospitalization. Better identification of PDs using screening tools in EDs could improve patient management and clinical outcomes. Future research should focus on PD prevalence in unselected ED populations using validated diagnostic interviews.

scholarly journals Comparative Risk of Incidence and Clinical Outcomes of COVID-19 among Proton Pump Inhibitor and Histamine-2 Receptor Antagonist Users: A Nationwide Retrospective Cohort Study

2021 ◽  
Author(s):  
Jimyung Park ◽  
Seng Chan You ◽  
Jaehyeong Cho ◽  
Chan Hyuk Park ◽  
Woon Shin ◽  
...  
Keyword(s):  
Cohort Study ◽  
South Korea ◽  
Receptor Antagonist ◽  
Clinical Outcomes ◽  
Respiratory Disease ◽  
Proton Pump ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Large Scale ◽  
All Cause Mortality

Abstract Background: This study aimed to evaluate incidence risk and severe clinical outcomes in COVID-19 disease among short-term users of acid-suppressants in South Korea.Methods: This retrospective cohort study, conducted using a nationwide claims database for South Korea, used data from patients with COVID-19 tested between January 1 and May 15, 2020. Patients aged over 18 years and prescribed proton pump inhibitors (PPI) or histamine-2 receptor antagonist (H2RA) for more than 7 days were identified. Primary outcome was COVID-19 while secondary outcomes were all-cause mortality, hospitalization with respiratory disease, or intensive respiratory intervention. Large-scale propensity scores were used to match patients, while the Cox proportional hazard model was utilized to evaluate any association between exposure and outcome(s). The risk estimates were calibrated by using 123 falsification endpoints.Results: We identified 26,166 PPI users and 62,117 H2RA users. After propensity score matching, compared to H2RA use, PPI use was not significantly associated with lower risk of COVID-19 (calibrated hazard ratio [HR], 0.81 [95% confidence interval (CI), 0.30–2.19]); moreover, PPI use was not associated with adverse clinical outcomes in COVID-19, namely, hospitalization with respiratory disease (calibrated HR, 0.88 [95% CI, 0.72–1.08]), intensive respiratory interventions (calibrated HR, 0.92 [95% CI, 0.46–1.82]), except for all-cause mortality (calibrated HR, 0.54 [95% CI, 0.31–0.95]).Conclusions: In this study, we found that the PPI user was not associated with risk of COVID-19 compared to H2RA users. There was no significant relationship between severe clinical outcomes of COVID-19 and exposure to PPI compared with H2RA, except for all-cause mortality.

scholarly journals Analysis of Characteristics, Methods of Suicide, and Clinical Outcomes in Elderly Suicide Attempters in South Korea by Age Subgroup

2020 ◽  
Keyword(s):  
Risk Factors ◽  
South Korea ◽  
Clinical Outcomes ◽  
Age Groups ◽  
The Elderly ◽  
Substance Exposure ◽  
South Korean ◽  
The Third ◽  
Elderly Suicide ◽  
Methods Of Suicide

Introduction: As the elderly comprise 14.3% of the South Korean population, suicide among the elderly has become a significant public concern. Methods: This study retrospectively analyzed data from the Emergency Department-Based Injury In-depth Surveillance nationwide of South Korea. Patients aged ≥ 65years old who intentionally caused self-injury were included. These elderly patients were subdivided into age groups, and their associated characteristics and correlation between suicide attempt methods and the clinical outcomes were analyzed. Results: A total of 5,333 cases were analyzed. The mean age of the subjects was 75.1 years old, comprising 3,039 males (57.0%) and 2,294 females (43.0%). Substance exposure was the most frequent method across all age groups. In terms of risk factors of admission, drowning, hanging, and asphyxia showed the following results: OR 2.372 for the first group; OR 2.224 for the second group; and OR 5.606 for the third group. Fall/slip was identified as a risk factor of admission in the first and second groups (OR 5.016 for the first group; OR 5.101 for the second group). In terms of risk factors of mortality, drowning, hanging, and asphyxia showed the following results: OR 9.066 for the first group; OR 7.320 for the second group; and OR 7.135 for the third group. With regard to fall/slip, the results were OR 14.596 for the first group; OR 10.096 for the second group; and OR 24.167 for the third group. Conclusions: This study showed that clinical outcomes were different according to the suicide-related characteristics and chosen suicide method. Based on these results, it is necessary to prepare measures to prevent suicide of the elderly in the future.

scholarly journals The effect of sex hormone on COVID-19: analysis of laboratory-confirmed 5061 patients in South Korea

2020 ◽  
Author(s):  
Jae Hoon Lee ◽  
Yong Chan Kim ◽  
Si Hyun Cho ◽  
Jinae Lee ◽  
Seng Chan You ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
South Korea ◽  
Clinical Outcomes ◽  
Sex Hormone ◽  
Significant Difference ◽  
Matched Case ◽  
Independent Risk Factors ◽  
Cox Analysis ◽  
To Receive

Abstract Limited data describing the effect of sex hormone on coronavirus disease (COVID-19) is available. We evaluated the effect of sex hormone on prevalence and clinical outcomes of COVID-19. Retrospective cohort study was performed using the nationwide claims data of 5061 adult patients with laboratory-confirmed COVID-19 in South Korea, from January 20 to April 8, 2020. COVID-19 was most prevalent in women of the 20-39 age group (1250 [44.14%]). Men were more likely to receive oxygen therapy (144 [6.46%] vs 131 [4.63%], P=0.004), be admitted to the intensive care unit (60 [2.69%] vs 53 [1.87%], P=0.049), and stay longer after admission to the intensive care unit (19.70±11.80 vs 14.75±9.23, P=0.016). However, there was no significant difference in mortality rates between men and women. In multivariable Cox analysis, independent risk factors for mortality were older age and underlying co-morbidities, rather than sex. To evaluate the effect of HRT among women, subgroup analysis was implemented using age-matched case-control data with a 1:3 ratio of females receiving HRT to those who did not. HRT did not have statistically significant association with clinical outcomes. This study suggests that sex hormone may not affect prevalence and clinical outcome of COVID-19 in South Korea.

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