scholarly journals Cervical cytology and associated factors among tribal women of Karnataka, India

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0248963
Author(s):  
Supriti Ghosh ◽  
Sanjay M. Pattanshetty ◽  
Sneha D. Mallya ◽  
Deeksha Pandey ◽  
Vasudeva Guddattu ◽  
...  
Keyword(s):  
Pap Smear ◽  
Sexual Debut ◽  
Early Stage ◽  
Initial Period ◽  
Well Being ◽  
Cervical Cytology ◽  
Tribal Women ◽  
Younger Age ◽  
Reactive Changes ◽  
Microbial Infections

Background Reproductive well-being is a crucial element of women’s health. Due to the asymptomatic nature of gynaecological morbidities, women rarely seek medical advice in the initial period leading to delayed diagnosis and poor prognosis of subsequent disease. The present study aimed to explore the cervical cytology and its associated risk factors among women from tribal communities of the southern part of coastal Karnataka, India. Methods Papanicolaou (Pap) smear test was performed among 1140 women from three tribal populations, to detect cervical lesions, infections and reactive changes. A semi-structured questionnaire was administered to collect data on socio-demographic and reproductive characteristics of the study population. Results The most predominant gynaecological complaint among the participants was severe lower back ache (77.6%), followed by white discharge per vagina (29.0%) and menstrual irregularities (25.9%). Of the 1140 women screened, 12.4% showed cervical microbial infections, 23.6% were reported to have reactive changes, and 0.2% had epithelial cell abnormalities in the cervix. Cervical microbial infections were found to be associated with younger age group, low socio-economic status and younger age at sexual debut. Conclusion Most of the symptoms suggestive of gynaecological morbidities reported in this study are preventable or treatable. Strengthening ongoing cervical cancer screening programme and implementation of health education programmes among tribal population would be the right policy approach to prevent, detect and treat these symptoms at an early stage and to achieve acceptable health outcomes among tribal women.

Breast carcinoma in young females below the age of 35 years - histopathological and prognostic significance

1970 ◽  
Vol 2 (3) ◽  
pp. 198-202
Author(s):  
D Ghartimagar ◽  
A Ghosh ◽  
OP Talwar ◽  
R Narasimhan
Keyword(s):  
Breast Carcinoma ◽  
Young Women ◽  
Early Stage ◽  
Prognostic Significance ◽  
Age Group ◽  
Breast Cancers ◽  
Young Females ◽  
Younger Age ◽  
Grade 3 ◽  
Group Grade

Background: Breast cancers rarely occur in young women but are known to have more aggressive behaviors and poorer outcome. We here compare the significance of breast carcinoma in female below the age of 35 to the age over 35 whose specimens were submitted to Manipal teaching hospital, Pokhara. Materials and Methods: All cases of mastectomy with carcinoma from January 2000 to September 2011 were included in the study. Clinical and histopathological datas of all cases were reviewed and collated. Results: A total of 148 mastectomy specimens were received, among which, 23 cases (16%) were below 35 years; whereas 125 cases (84%) were above 35 years of age. In both groups, Stage II was the commonest stage but stage III was much more common in older group (33% versus 9%) and stage I was more common in younger age group (39% versus 27%). Bloom Richardson grading showed that in the older age group, grade 1 is the commonest grade (50%) while in the younger group; grade 3 is the commonest (39%). Patients were followed for a varying period of 6 months to 5 years. Two cases (2% of followed up cases) in older group and 3 cases (15% of followed up cases) in the younger group showed recurrence. Conclusion: Breast carcinoma in the patients younger than 35 years though presented at an early stage has higher grade tumor and poorer outcome. DOI: http://dx.doi.org/10.3126/jpn.v2i3.6021 JPN 2012; 2(3): 198-202

scholarly journals A contour property based approach to segment nuclei in cervical cytology images

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Iram Tazim Hoque ◽  
Nabil Ibtehaz ◽  
Saumitra Chakravarty ◽  
M. Saifur Rahman ◽  
M. Sohel Rahman
Keyword(s):  
Pap Smear ◽  
State Of The Art ◽  
Cervical Cytology ◽  
Average Intensity ◽  
Nucleus Size ◽  
Real Dataset ◽  
Art Methods ◽  
Convolution Filter ◽  
Cervical Cells ◽  
Nucleus Segmentation

Abstract Background Segmentation of nuclei in cervical cytology pap smear images is a crucial stage in automated cervical cancer screening. The task itself is challenging due to the presence of cervical cells with spurious edges, overlapping cells, neutrophils, and artifacts. Methods After the initial preprocessing steps of adaptive thresholding, in our approach, the image passes through a convolution filter to filter out some noise. Then, contours from the resultant image are filtered by their distinctive contour properties followed by a nucleus size recovery procedure based on contour average intensity value. Results We evaluate our method on a public (benchmark) dataset collected from ISBI and also a private real dataset. The results show that our algorithm outperforms other state-of-the-art methods in nucleus segmentation on the ISBI dataset with a precision of 0.978 and recall of 0.933. A promising precision of 0.770 and a formidable recall of 0.886 on the private real dataset indicate that our algorithm can effectively detect and segment nuclei on real cervical cytology images. Tuning various parameters, the precision could be increased to as high as 0.949 with an acceptable decrease of recall to 0.759. Our method also managed an Aggregated Jaccard Index of 0.681 outperforming other state-of-the-art methods on the real dataset. Conclusion We have proposed a contour property-based approach for segmentation of nuclei. Our algorithm has several tunable parameters and is flexible enough to adapt to real practical scenarios and requirements.

Current measures of distress may not account for what's most important in existential care interventions: Results of the outlook trial

2020 ◽  
Vol 18 (6) ◽  
pp. 648-657
Author(s):  
Karen E. Steinhauser ◽  
Karen M. Stechuchak ◽  
Katherine Ramos ◽  
Joseph Winger ◽  
James A. Tulsky ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Early Stage ◽  
Well Being ◽  
Primary Analysis ◽  
Significant Difference ◽  
Spiritual Well Being ◽  
Screening For Distress ◽  
Secondary Outcomes ◽  
Stage Renal Disease

AbstractObjectiveCompare the efficacy of two interventions addressing emotional and existential well-being in early life-limiting illness.MethodPrimary trial analysis (n = 135) included patients with advanced cancer, congestive heart failure, or end-stage renal disease; Arm 1 received the Outlook intervention, addressing issues of life completion and preparation, and Arm 2 received relaxation meditation (RM). Primary outcomes at five weeks (primary endpoint) and seven weeks (secondary): completion and preparation (QUAL-E); secondary outcomes: anxiety (POMS) quality of life (FACT-G) and spiritual well-being (FACIT-Sp) subscales of faith, meaning, and peace.ResultsAverage age was 62; 56% were post-high school-educated, 54% were married, 52% white, 44% female, and 70% had a cancer diagnosis. At baseline, participants demonstrated low levels of anxiety (<5 on POMS subscale) and depression (<10 on CESD) relative to population norms. Results of the primary analysis revealed no significant differences in mean Preparation by treatment arm at five weeks (14.4 Outlook vs. 14.8 RM; between-group difference −0.4 [95% CI, −1.6, 0.8], p = 0.49) or seven weeks (15.2 vs.15.4; between-group difference −0.2 [95% CI, −1.5, 1.0], p = 0.73). There were also no significant differences in mean Life Completion by treatment arm between five weeks (26.6 Outlook vs. 26.3 RM; between-group difference 0.2 [95% CI, −1.2, 1.7], p = 0.76) or seven weeks (26.5 vs. 27.5; between-group difference −1.0 [95% CI, −2.7, 0.7], p = 0.23). Compared to RM, Outlook participants did not have significant differences over time in the secondary outcomes of overall quality of life, anxiety, depression, FACT-G subscales, and FACIT-Sp subscales.DiscussionIn early-stage life-limiting illness, Outlook did not demonstrate a significant difference in primary or secondary outcomes relative to RM. Results underscore the importance of pre-screening for distress. Qualitatively, Outlook participants were able to express suppressed emotions, place illness context, reflect on adaptations, and strengthen identity. Screening for distress and identifying specified measures of distress, beyond anxiety and depression, is essential in our ability to adequately assess the multi-dimensional mechanisms that decrease existential suffering.

scholarly journals Evidence-Based Design in Architectural Education: Designing the First Maggie’s Centre in Israel

2021 ◽  
pp. 193758672110079
Author(s):  
Nirit Putievsky Pilosof ◽  
Yasha Jacob Grobman
Keyword(s):  
Literature Review ◽  
Architectural Design ◽  
Early Stage ◽  
Scientific Research ◽  
Well Being ◽  
Architectural Education ◽  
Local Context ◽  
Evidence Based ◽  
Architecture Education ◽  
The Impact

Objective The study examines the integration of the Evidence-based Design (EBD) approach in healthcare architecture education in the context of an academic design studio. Background Previous research addressed the gap between scientific research and architectural practice and the lack of research on the use of the EBD approach in architectural education. Methods The research examines an undergraduate architectural studio to design a Maggie’s Centre for cancer care in Israel and evaluates the impact of the EBD approach on the design process and design outcomes. The research investigates the impact of the integration of three predesign tasks: (1) literature review of healing architecture research, (2) analysis and comparison of existing Maggie’s Centres, and (3) analysis of the context of the design project. Results The literature review of scientific research supported the conceptual design and development of the projects. The analysis of existing Maggie’s centers, which demonstrated the interpretation of the evidence by different architects, developed the students’ ability to evaluate EBD in practice critically, and the study of the projects’ local context led the students to define the relevance of the evidence to support their vision for the project. Conclusions The research demonstrates the advantages of practicing EBD at an early stage in healthcare architectural education to enhance awareness of the impact of architectural design on the users’ health and well-being and the potential to support creativity and innovative design. More studies in design studios are needed to assess the full impact of integrating EBD in architectural education.

Gastric-type adenocarcinoma of the cervix in patients with Peutz-Jeghers syndrome: a systematic review of the literature with proposed screening guidelines

2021 ◽  
pp. ijgc-2021-002997
Author(s):  
Sushmita B Gordhandas ◽  
Ryan Kahn ◽  
Dib Sassine ◽  
Emeline M Aviki ◽  
Becky Baltich Nelson ◽  
...  
Keyword(s):  
Systematic Review ◽  
Overall Survival ◽  
Pap Smear ◽  
Early Stage ◽  
Case Reports ◽  
High Risk Population ◽  
Normal Cytology ◽  
Presenting Symptoms ◽  
Gastric Type ◽  
Peutz Jeghers Syndrome

ObjectivesTo perform a systematic review of gastric-type adenocarcinoma of the cervix and lobular endocervical glandular hyperplasia (a possible precursor lesion) in Peutz-Jeghers syndrome, and to analyze data from the literature, along with our institutional experience, to determine recommendations for screening and detection.MethodsA comprehensive literature searc and retrospective search of pathology records at our institutio were conducted. Articles were screened by two independent reviewers. Case reports/series on lobular endocervical glandular hyperplasia/gastric-type adenocarcinoma of the cervix in Peutz-Jeghers syndrome were included. Demographic, clinical, and radiologic information was collected.ResultsA total of 1564 publications were reviewed; 38 met the inclusion criteria. Forty-nine were included in the analysis (43 from the literature, 6 from our institution). Forty-three reported on gastric-type adenocarcinoma alone, 4 on lobular endocervical glandular hyperplasia alone, and 2 on concurrent lobular endocervical glandular hyperplasia/gastric-type adenocarcinoma. Median age at diagnosis was 17 (range, 4–52) for patients with lobular endocervical glandular hyperplasia alone and 35 (range, 15–72) for those with gastric-type adenocarcinoma. The most common presenting symptoms were abdominal/pelvic pain and vaginal bleeding/discharge. Imaging was reported for 27 patients; 24 (89%) had abnormal cervical features. Papanicolaou (Pap) smear prior to diagnosis was reported for 12 patients; 6 (50%) had normal cytology, 4 (33%) atypical glandular cells, and 2 (17%) atypical cells not otherwise specified. Patients with gastric-type adenocarcinoma (n=45) were treated with surgery alone (n=16), surgery/chemotherapy/radiation (n=11), surgery/chemotherapy (n=9), surgery/radiation (n=5), or radiation/chemotherapy (n=4). Twelve (27%) of 45 patients recurred; median progression-free survival was 10 months (range, 1–148). Twenty patients (44%) died; median overall survival was 26 months (range, 2–156). Thirteen patients (27%) were alive with no evidence of disease.ConclusionsGastric-type adenocarcinoma in Peutz-Jeghers syndrome is associated with poor outcomes and short progression-free and overall survival. Screening recommendations, including pathognomonic symptom review and physical examination, with a low threshold for imaging and biopsy, may detect precursor lesions and early-stage gastric-type adenocarcinoma, leading to better outcomes in this high-risk population.PROSPERO registration numberCRD42019118151

Microbial ecology of untreated and copper–chrome–arsenic treated stakes exposed in a tropical soil. 1. The initial invaders

1972 ◽  
Vol 18 (12) ◽  
pp. 1923-1931 ◽  
Author(s):  
H. Greaves
Keyword(s):  
Microbial Ecology ◽  
Early Stage ◽  
Initial Period ◽  
Trichoderma Viride ◽  
Untreated Wood ◽  
Soft Rot ◽  
Eucalyptus Regnans ◽  
Ground Treatment ◽  
Colonization Period ◽  
Copper Chrome Arsenic

A study of the microbial ecology of copper–chrome–arsenic treated and untreated Pinus radiata and Eucalyptus regnans sapwood ground stakes exposed for a total of [Formula: see text] years is currently being made. The results presented in this report cover the initial colonization period during the first 7 months of exposure. Soft rot in the outer layers of both species of untreated wood occurs after only 1 month in the ground. Treatment with CCA prevents the early attack of pine but is not as effective in the eucalypt, nor does it appear to have a significant effect upon the diversity of microorganisms which colonize the two woods. For the first 2 months Penicillia are the predominating members of the population. Trichoderma viride, Paecilomyces fumo-roseus, and Cladosporium spp. are also frequently isolated. At 4 months more active soft-rotting fungi can be isolated, e.g. Chaetomium globosum and Humicola grisea, together with Fusaria and Phycomycetes. Bacteria colonize the stakes at a very early stage, the population changing little over this initial period of the study. Actinomycetes were not isolated until the wood had been in the ground for a month or more after which their importance in the population has steadily increased. Basidiomycetes were microscopically observed in sections of the stakes but have not been isolated to date.

scholarly journals Acting Instead of Reacting—Ensuring Employee Retention during Successful Introduction of i4.0

2021 ◽  
Vol 4 (4) ◽  
pp. 97
Author(s):  
Steffen C. Eickemeyer ◽  
Jan Busch ◽  
Chia-Te Liu ◽  
Sonia Lippke
Keyword(s):  
Online Survey ◽  
Early Stage ◽  
Health Indicators ◽  
Software Tool ◽  
Well Being ◽  
Successful Implementation ◽  
German Population ◽  
Older Individuals ◽  
Home Office ◽  
Negative Attitudes

The increasing implementation of digital technologies has various positive impacts on companies. However, many companies often rush into such an implementation of technological trends without sufficient preparation and pay insufficient attention to the human factors involved in digitization. This phenomenon can be exacerbated when these technologies become highly dependent, as during the COVID-19 pandemic. This study aims to better understand challenges and to propose solutions for a successful implementation of digitized technology. A literature review is combined with survey results and specific consulting strategies. Data from the first wave of the COVID-19 pandemic in Germany were collected by means of an online survey, with a representative sample of the German population. However, we did not reveal any correlation between home office and suffering, mental health, and physical health (indicators of digitization usage to cope with COVID-19 pandemic), but rather that younger workers are more prone to using digitized technology. Based on previous findings that older individuals tend to have negative attitudes toward digital transformation, appropriate countermeasures are needed to help them become more tech-savvy. Accordingly, a software tool is proposed. The tool can help the management team to manage digitization efficiently. Employee well-being can be increased as companies are made aware of necessary measures such as training for individuals and groups at an early stage.

Differences in Variability, Interactivity and Skills in Social Play of Young Chimpanzees Living in Peer Groups and in a Large Family Zoo Group

Behaviour ◽  
1996 ◽  
Vol 133 (9-10) ◽  
pp. 717-739 ◽  
Author(s):  
Jan A.R.A.M. van HOOFF ◽  
Herman Dienske ◽  
Warner Jens ◽  
René P. Spijkerman
Keyword(s):  
Early Stage ◽  
Sex Role ◽  
Peer Group ◽  
Peer Groups ◽  
Large Family ◽  
Social Play ◽  
Well Being ◽  
Detailed Comparison ◽  
Partner Choice ◽  
The Social

AbstractThis paper provides a detailed comparison of play characteristics of chimpanzees raised in peer-only groups and in a socially complex semi-natural zoo situation. We expected play in peer groups to be of a lesser quality, that is less variable, interactive and skillful. To test this we quantified details such as the diversity of social play types, the bout length, the way social play is started, maintained and stopped and the use of play signals. The differences in play-type frequencies between the groups are most likely caused by differences in housing conditions and demographics; the smaller sex difference in peer group adolescents is most likely due to a limited partner choice. We found no indication that chimpanzees raised in peer groups played less diversely than those in the zoo. The social play characteristics of peer group and zoo chimpanzees are similar, except for the frequency of gnaws before wrestle and the frequency of play-faces within wrestle. Overall, there are no results from which we can conclude directly that chimpanzees isolated from their mother at an early stage and placed in a peer group are less capable in social play, although possibly it is more clear to the zoo individuals that a next interaction will be 'play'; zoo individuals may need less regular removal of ambiguity about the intention of the behaviour. The few differences between peer group and zoo in their social play characteristics that can be related to peer group rearing conditions indicate that the social development in those chimpanzees raised in peer groups is similar to that of chimpanzees in the semi-natural zoo. This is not to say that providing more natural conditions than is usually done in laboratories is unnecessary. These may still add considerably to the animals' well-being and in terms of animal welfare, it can be concluded that a variety of partners in the housing condition is beneficial to speed of sex-role development in young chimpanzees.

scholarly journals Household Diversity and the Impacts of COVID-19 on Families in Portugal

2021 ◽  
Vol 6 ◽  
Author(s):  
Rita Gouveia ◽  
Vasco Ramos ◽  
Karin Wall
Keyword(s):  
Online Survey ◽  
Early Stage ◽  
Well Being ◽  
Social Needs ◽  
Family Routines ◽  
Public Authorities ◽  
The Social ◽  
Household Diversity ◽  
Probabilistic Sample ◽  
The Impact

Throughout the world, the COVID-19 pandemic disrupted family routines, relationships, projects and sociability, threatening the health, income, social cohesion, and well-being of individuals and their families. Lockdown restrictions imposed during the first wave of the pandemic challenged the theories, concepts, and methods used by family sociologists and the intersecting fields of gender and social inequality. By restricting physical interactions to co-resident family members, the household regained a privileged role as a crucial social laboratory for studying the impact of COVID-19 on family life. The difficulties encountered by individuals in maintaining and dealing with close relationships across households and geographical borders, in a context in which relational proximity was discouraged by the public authorities, exposed the linked nature of family and personal relationships beyond the limits of co-residence. The main aim of this article is to investigate the social impacts of the pandemic on different types of households during the first lockdown at an early stage of the pandemic in Portugal. Drawing on an online survey applied to a non-probabilistic sample of 11,508 households between 25 and 29 March 2020, the authors combined quantitative and qualitative methods, including bi-variate inferential statistics, cluster analysis and in-depth case studies. The article distinguishes between different household types: solo, couple with and without children, extended, friendship, lone-parent families, and intermittent arrangements, such as shared custody. A cross-tabulation of the quantitative data with open-ended responses was carried out to provide a refined analysis of the household reconfigurations brought about during lockdown. The analysis showed how pre-existing unequal structural living conditions shaped the pathways leading to household reconfiguration as families sought to cope with restrictions on mobility, social distancing norms, and other lockdown measures. The findings stress that, in dealing with a crisis, multilevel welfare interventions need to be considered if governments are to cater to the differentiated social needs and vulnerabilities faced by individuals and families.

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