Characteristics and clinical outcomes of patients hospitalized with laboratory-confirmed COVID-19—Puerto Rico, March–August 2020

Hispanics are the majority ethnic population in Puerto Rico where we reviewed charts of 109 hospitalized COVID-19 patients to better understand demographic and clinical characteristics of COVID-19 and determine risk factors for poor outcomes. Eligible medical records of hospitalized patients with confirmed COVID-19 illnesses were reviewed at four participating hospitals in population centers across Puerto Rico and data were abstracted that described the clinical course, interventions, and outcomes. We found hospitalized patients had a median of 3 underlying conditions with obesity and diabetes as the most frequently reported conditions. Intensive care unit (ICU) admission occurred among 28% of patients and 18% of patients died during the hospitalization. Patients 65 or older or with immune deficiencies had a higher risk for death. Common symptoms included cough, dyspnea, and fatigue; less than half of patients in the study reported fever which was less frequent than reported elsewhere in the literature. It is important for interventions within Hispanic communities to protect high-risk groups.

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Frequency and clinical characteristics of adverse transfusion reactions in hospitalized patients: A retrospective review of electronic medical records

Allergy Asthma & Respiratory Disease ◽

10.4168/aard.2021.9.4.225 ◽

2021 ◽

Vol 9 (4) ◽

pp. 225

Author(s):

Yong-Hyun Kim ◽

Jang-Ho Seo ◽

Kyung-Min Ahn ◽

Min-Suk Yang ◽

Sae-Hoon Kim ◽

...

Keyword(s):

Electronic Medical Records ◽

Retrospective Review ◽

Medical Records ◽

Clinical Characteristics ◽

Hospitalized Patients ◽

Transfusion Reactions

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DEVELOPMENT OF ALGORITHMS TO PREDICT PAIN IN HOSPITALIZED PATIENTS WITH SICKLE CELL DISEASE USING OBJECTIVE DATA FROM MEDICAL RECORDS

10.26226/morressier.5ab3c880a874c60026558cf2 ◽

2018 ◽

Author(s):

Nirmish Shah

Keyword(s):

Sickle Cell Disease ◽

Sickle Cell ◽

Medical Records ◽

Hospitalized Patients ◽

Objective Data ◽

Cell Disease

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Anemia predicts poor outcomes of COVID-19 in hospitalized patients: a prospective study in Iran

BMC Infectious Diseases ◽

10.1186/s12879-021-05868-4 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Masood Faghih Dinevari ◽

Mohammad Hossein Somi ◽

Elham Sadeghi Majd ◽

Mahdieh Abbasalizad Farhangi ◽

Zeinab Nikniaz

Keyword(s):

Prospective Study ◽

High Sensitivity ◽

Hospitalized Patients ◽

Icu Admission ◽

Reactive Protein ◽

Hs Crp ◽

Prospective Association ◽

Poor Outcomes ◽

A Prospective Study ◽

Ventilator Requirement

Abstract Background There are limited number of studies with controversial findings regarding the association between anemia at admission and coronavirus disease 2019 (COVID-19) outcomes. Therefore, in this research, we aimed to investigate the prospective association between anemia and COVID-19 outcomes in hospitalized patients in Iran. Methods In this prospective study, the data of 1274 consecutive patients hospitalized due to COVID-19 were statistically analyzed. All biomarkers, including hemoglobin and high-sensitivity C-reactive protein (hs-CRP) levels were measured using standard methods. Anemia was defined as a hemoglobin (Hb) concentration of less than 13 g/dL and 12 g/dL in males and females, respectively. Assessing the association between anemia and COVID-19 survival in hospitalized patients was our primary endpoint. Results The mean age of the participants was 64.43 ± 17.16 years, out of whom 615 (48.27%) were anemic subjects. Patients with anemia were significantly older (P = 0.02) and had a higher frequency of cardiovascular diseases, hypertension, kidney disease, diabetes, and cancer (P < 0.05). The frequency of death (anemic: 23.9% vs. nonanemic: 13.8%), ICU admission (anemic: 27.8% vs. nonanemic:14.71%), and ventilator requirement (anemic: 35.93% vs. nonanemic: 20.63%) were significantly higher in anemic patients than in nonanemic patients (P < 0.001). According to the results of regression analysis, after adjusting for significant covariate in the univariable model, anemia was independently associated with mortality (OR: 1.68, 95% CI: 1.10, 2.57, P = 0.01), ventilator requirement (OR: 1.74, 95% CI: 1.19, 2.54, P = 0.004), and the risk of ICU admission (OR: 2.06, 95% CI: 1.46, 2.90, P < 0.001). Conclusion The prevalence of anemia in hospitalized patients with COVID-19 was high and was associated with poor outcomes of COVID-19.

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Clinical characteristics of inpatients with coronavirus disease 2019 (COVID-19) in Sichuan province

BMC Infectious Diseases ◽

10.1186/s12879-021-05825-1 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Wen Wang ◽

Lei Chen ◽

Qiao He ◽

Mingqi Wang ◽

Mei Liu ◽

...

Keyword(s):

Mechanical Ventilation ◽

Clinical Features ◽

Medical Records ◽

Clinical Characteristics ◽

Sichuan Province ◽

Chest Ct ◽

Shortness Of Breath ◽

Course Of Disease ◽

West China ◽

Radiologic Abnormality

Abstract Background The outbreak of COVID-19 has resulted in serious concerns in China and abroad. To investigate clinical features of confirmed and suspected patients with COVID-19 in west China, and to examine differences between severe versus non-severe patients. Methods Patients admitted for COVID-19 between January 21 and February 11 from fifteen hospitals in Sichuan Province, China were included. Experienced clinicians trained with methods abstracted data from medical records using pre-defined, pilot-tested forms. Clinical characteristics between severe and non-severe patients were compared. Results Of the 169 patients included, 147 were laboratory-confirmed, 22 were suspected. For confirmed cases, the most common symptoms from onset to admission were cough (70·7%), fever (70·5%) and sputum (33·3%), and the most common chest CT patterns were patchy or stripes shadowing (78·0%); throughout the course of disease, 19·0% had no fever, and 12·4% had no radiologic abnormality; twelve (8·2%) received mechanical ventilation, four (2·7%) were transferred to ICU, and no death occurred. Compared to non-severe cases, severe ones were more likely to have underlying comorbidities (62·5% vs 26·2%, P = 0·001), to present with cough (92·0% vs 66·4%, P = 0·02), sputum (60·0% vs 27·9%, P = 0·004) and shortness of breath (40·0% vs 8·2%, P < 0·0001), and to have more frequent lymphopenia (79·2% vs 43·7%, P = 0·003) and eosinopenia (84·2% vs 57·0%, P = 0·046). Conclusions The symptoms of patients in west China were relatively mild, and an appreciable proportion of infected cases had no fever, warranting special attention.

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A triple combination of treatments on moderate COVID-19

Open Medicine ◽

10.1515/med-2021-0279 ◽

2021 ◽

Vol 16 (1) ◽

pp. 769-772

Author(s):

ChunMiao Bao ◽

BinBin Li ◽

YuFeng Zhou

Keyword(s):

Medical Records ◽

Clinical Characteristics ◽

Smoking Status ◽

Length Of Hospital Stay ◽

Convincing Evidence ◽

Triple Combination ◽

Viral Shedding ◽

Null Effect ◽

Treatment Start

Abstract Objective A triple combination of interferon (IFN) α-2b, lopinavir tablets, and umifenovir was used to treat COVID-19 patients. It is important to explore whether the benefit of this therapy is time dependent. Methods A cohort of moderate COVID-19 patients (n = 54) was admitted for hospitalization. The demographic (age, gender, and smoking status) and clinical characteristics (epidemiological trace and comorbidity) were collected from the digital medical records. The length of hospital stay (LOS) and the viral shedding time (VST) were set as the outcomes for COVID-19 cases. Results After control for age, sex, epidemiological trace, smoking, and comorbidity, the time of treatment start had null effect on VST (IRR = 1.09; 95% CI = 0.91–1.30; p = 0.33) or LOS (IRR = 1.10; 95% CI = 0.94–1.28; p = 0.23). Conclusion There is no convincing evidence to support a pivotal role of the timing of the therapy in the prognosis of moderate COVID-19 cases.

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Machine learning based on clinical characteristics and chest CT quantitative measurements for prediction of adverse clinical outcomes in hospitalized patients with COVID-19

European Radiology ◽

10.1007/s00330-021-07957-z ◽

2021 ◽

Author(s):

Zhichao Feng ◽

Hui Shen ◽

Kai Gao ◽

Jianpo Su ◽

Shanhu Yao ◽

...

Keyword(s):

Machine Learning ◽

Clinical Outcomes ◽

Clinical Characteristics ◽

Chest Ct ◽

Hospitalized Patients ◽

Quantitative Measurements

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Hydroxychloroquine and Azithromycin Treatment of Hospitalized Patients Infected with SARS-CoV-2 in Senegal from March to October 2020

Journal of Clinical Medicine ◽

10.3390/jcm10132954 ◽

2021 ◽

Vol 10 (13) ◽

pp. 2954

Author(s):

Fabien Taieb ◽

Khardiata Diallo Mbaye ◽

Billo Tall ◽

Ndèye Aïssatou Lakhe ◽

Cheikh Talla ◽

...

Keyword(s):

Side Effects ◽

Clinical Characteristics ◽

Clinical Status ◽

Group Versus ◽

Patient Discharge ◽

Lower Proportion ◽

Hospitalized Patients ◽

African Countries ◽

Factors Associated ◽

High Clinical Risk

As of today, little data is available on COVID-19 in African countries, where the case management relied mainly on a treatment by association between hydroxychloroquine (HCQ) and azithromycin (AZM). This study aimed to understand the main clinical outcomes of COVID-19 hospitalized patients in Senegal from March to October 20202. We described the clinical characteristics of patients and analysed clinical status (alive and discharged versus hospitalized or died) at 15 days after Isolation and Treatment Centres (ITC) admission among adult patients who received HCQ plus AZM and those who did not receive this combination. A total of 926 patients were included in this analysis. Six hundred seventy-four (674) (72.8%) patients received a combination of HCQ and AZM. Results showed that the proportion of patient discharge at D15 was significantly higher for patients receiving HCQ plus AZM (OR: 1.63, IC 95% (1.09–2.43)). Factors associated with a lower proportion of patients discharged alive were: age ≥ 60 years (OR: 0.55, IC 95% (0.36–0.83)), having of at least one pre-existing disorder (OR: 0.61, IC 95% (0.42–0.90)), and a high clinical risk at admission following NEWS score (OR: 0.49, IC 95% (0.28–0.83)). Few side effects were reported including 2 cases of cardiac rhythmic disorders in the HCQ and AZM group versus 13 in without HCQ + AZM. An improvement of clinical status at 15 days was found for patients exposed to HCQ plus AZM combination.

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Poor Outcomes in Hospitalized Patients With Gastrointestinal Bleeding: Impact of Baseline Risk, Bleeding Severity, and Process of Care

The American Journal of Gastroenterology ◽

10.1038/ajg.2014.263 ◽

2014 ◽

Vol 109 (10) ◽

pp. 1603-1612 ◽

Cited By ~ 12

Author(s):

Vipul Jairath ◽

J Thompson ◽

B C Kahan ◽

R Daniel ◽

S A Hearnshaw ◽

...

Keyword(s):

Gastrointestinal Bleeding ◽

Hospitalized Patients ◽

Baseline Risk ◽

Process Of Care ◽

Poor Outcomes ◽

Bleeding Severity

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Resilience of Communities in Puerto Rico Following Hurricane Maria: Community-Based Preparedness and Communication Strategies

Disaster Medicine and Public Health Preparedness ◽

10.1017/dmp.2021.306 ◽

2021 ◽

pp. 1-6

Author(s):

Elizabeth L. Andrade ◽

Nicole D. Barrett ◽

Mark C. Edberg ◽

Matthew W. Seeger ◽

Carlos Santos-Burgoa

Keyword(s):

Puerto Rico ◽

Puerto Rican ◽

Interpersonal Communication ◽

Qualitative Interviews ◽

First Responders ◽

Risk Groups ◽

Community Leader ◽

Disaster Resilience ◽

Community Based ◽

Community Assets

Abstract Objective: This study aimed to examine factors that may have contributed to community disaster resilience following Hurricane Maria in Puerto Rico. Methods: In April 2018, qualitative interviews (n = 22) were conducted with stakeholders in 7 Puerto Rican municipalities (9% of total). Transcripts were deductively and inductively coded and analyzed to identify salient topics and themes, then examined according to strategic themes from the Federal Emergency Management Association’s (FEMA) Whole Community Approach. Results: Municipal preparedness efforts were coordinated, community-based, leveraged community assets, and prioritized vulnerable populations. Strategies included (1) multi-sectoral coordination and strategic personnel allocation; (2) neighborhood leader designation as support contacts; (3) leveraging of community leader expertise and social networks to protect vulnerable residents; (4) Censuses of at-risk groups, health professionals, and first responders; and (5) outreach for risk communication and locally tailored protective measures. In the context of collapsed telecommunications, communities implemented post-disaster strategies to facilitate communication with the Puerto Rican Government, between local first responders, and to keep residents informed, including the use of: (1) police radios; (2) vehicles with loudspeakers; (3) direct interpersonal communication; and (4) solar-powered Internet radio stations. Conclusions: Adaptive capacities and actions of Puerto Rican communities exemplify the importance of local solutions in disasters. Expanded research is recommended to better understand contributors to disaster resilience.

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