scholarly journals A study of the aphrodisiac properties of Cordyceps militaris in streptozotocin-induced diabetic male rats

2021 ◽  
Vol 14 (2) ◽  
pp. 537-544
Author(s):  
Toan Van Nguyen ◽  
Pramote Chumnanpuen ◽  
Kongphop Parunyakul ◽  
Krittika Srisuksai ◽  
Wirasak Fungfuang
Keyword(s):  
Testosterone Level ◽  
Serum Testosterone ◽  
Diabetic Rats ◽  
Cordyceps Militaris ◽  
The Body ◽  
Male Rats ◽  
Serum Testosterone Level ◽  
Control Group ◽  
Epididymal Sperm ◽  
Sperm Parameter

Background and Aim: Cordyceps militaris (CM) is a fungus that has been used to enhance aphrodisiac activity in men, but to date, no studies have focused on its antidiabetic properties. This study aimed to investigate the effects of CM on reproductive performance of streptozotocin (STZ)-induced diabetic male rats. Materials and Methods: Six-week-old Wistar rats were randomly divided into four groups: control Group 1 consisting of healthy rats; Group 2, healthy rats treated with CM (100 mg/kg); Group 3, diabetic untreated rats; and Group 4, diabetic rats treated with CM (100 mg/kg). Rats were orally administered with vehicle or CM for 21 days. The body weight, blood glucose level, food intake, epididymal sperm parameter, sexual behavior, serum testosterone level, and antioxidant parameters were determined. Results: The results indicated that CM treatment in STZ-induced diabetic rats significantly improved the epididymal sperm parameter and serum testosterone level and, in turn, their copulatory behavior. CM treatment in diabetic rats significantly ameliorated malondialdehyde level and significantly improved the glutathione and catalase levels. Conclusion: These results provide new information on the pharmacological properties of CM in ameliorating testicular damage due to oxidative stress and improving sexual performance in diabetic male rats.

scholarly journals Effects of curcumin on sperm parameters abnormalities induced by morphine in rat

2017 ◽  
Vol 6 (2) ◽  
pp. 1-10
Author(s):  
S.H. Roshankhah ◽  
M.R. Salahshoor ◽  
S. Aryanfar ◽  
F. Jalili ◽  
M. Sohrabil ◽  
...  
Keyword(s):  
Sperm Motility ◽  
Testosterone Level ◽  
Sperm Count ◽  
Serum Testosterone ◽  
Treated Group ◽  
Sperm Parameters ◽  
Male Rats ◽  
Serum Testosterone Level ◽  
Seminiferous Tubules ◽  
Control Group

Opioids are the most potent and effective analgesics available and have become accepted as appropriate treatment for acute, cancer and non-cancer. Morphine, which is commonly used for the treatment of severe pain, gastrointestinal tract and kidneys. Curcumin petals consist of, glycosides, flavonoids, and anthocyanin. The study aims at evaluating curcumin effect and morphine on sperm parameters, testis tissue and serum testosterone level in rat. In this experimental study, 48 male rats with 28 weeks of age and limited weight of 270 to 300g were selected. They were divided into eight groups of 6, untreated control group; morphine – treated group (20 mg/kg/day); curcumin -treated groups (10, 30, 60 mg/kg/day); and morphine and curcumin treated group intraperitoneal administration for successive 28 days. After 24hours animals were killed. Sperm motility was measured using WHO protocols. The sperm parameter such as motility, sperm count, morphology, seminiferous tubules diameter, weight testis, and serum testosterone level were analyzed (oneway ANOVA). Curcumin (10, 30 and 60 mg/kg) significantly increased mean percentage of sperm motility, count, testis weight, and serum testosterone level compared to control group (p<0.05). Testosterone level decreased significantly in rats treated with morphine. Co-administration of curcumin to morphine-treated rats improved the histopathological alterations induced by morphine in testis and increased the sperm count. Curcumin has a very strong antioxidant effects at applied doses and it can probably be used as an antioxidant and food supplement in reproductive disorders.Journal of Medical and Biomedical Sciences (2017) 6(2), 1-10

Toxicological evaluation of hydroethanol leaf extract of Pupalia lappacea (Linn.) Juss. (Amaranthaceae) in rodents

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Murtala Akanji Abdullahi ◽  
Elijah Oladapo Oyinloye ◽  
Akinyinka Alabi ◽  
Aderonke Adeyinka Aderinola ◽  
Luqman Opeyemi Ogunjimi ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Density Lipoprotein ◽  
Serum Testosterone ◽  
Female Rats ◽  
Male Rats ◽  
Laboratory Animals ◽  
Serum Testosterone Level ◽  
Control Group ◽  
Toxicological Evaluation ◽  
Liver And Kidney

Abstract Objectives Several studies have established the ethnobotanical benefits of Pupalia lappacea (PL) in laboratory animals without extensive toxicological evaluation of its safety profiles. Thus, an extensive toxicological investigation of sub-chronic oral administration of the hydroethanol leaf extract of P. lappacea in rodents was carried out in this study. Methods Different groups of rats were treated orally with the extract (10, 50 and 250 mg/kg) daily for 90 consecutive days. The control group received distilled water (10 mL/kg). After 90 days, some rats were left for additional 30 days without treatment for reversibility study. Blood and organs samples were collected for different evaluations at the end of study periods. Results The extract decreased the bodyweights, feeding and water intakes in female rats. PL increased the weights of the liver and kidney in male rats. PL increased the red blood cell (RBC), packed cell volume (PCV), hemoglobin (Hb), triglycerides (TRIG), cholesterol and high density lipoprotein (HDL) contents in rats. PL (250 mg/kg) significantly reduced the sperm motility and serum testosterone level. Cyto-architectural distortions of the testes, liver and spleen were visible. Conclusions The findings showed that P. lappacea is relatively safe at lower doses but cautions should be taken at higher dose.

Vitamin C ameliorates the adverse effects of dexamethasone on sperm motility, testosterone level, and spermatogenesis indexes in mice

2018 ◽  
Vol 38 (4) ◽  
pp. 409-418 ◽  
Author(s):  
F Sadeghzadeh ◽  
MS Mehranjani ◽  
M Mahmoodi
Keyword(s):  
Adverse Effects ◽  
Vitamin C ◽  
Sperm Motility ◽  
Testosterone Level ◽  
Leydig Cells ◽  
Serum Testosterone ◽  
Serum Testosterone Level ◽  
Control Group ◽  
The Mean ◽  
Vit C

Background: Dexamethasone (DEX) is a common medicine that is capable of causing malformation in the male reproductive system. The aim of this study was to investigate the effect of vitamin C (Vit-C) on spermatogenesis indexes and daily sperm production (DSP) in adult mice treated with DEX. Methods: Male Naval Medical Research Institute (NMRI) mice were divided into four groups: Control, DEX (7 mg/kg/day), Vit-C (100 mg/kg/day), and DEX +Vit-C and treated for 7 days with intraperitoneal injection. Results: A significant increase in the mean levels of serum and tissue malondialdehyde (MDA) and apoptosis of Leydig cells was found in the DEX group compared to the control group. Sperm motility, DSP, tubular differentiation index, meiotic index, spermatogenesis index, the mean number of spermatocytes, round and long spermatids, and Leydig cells, and also serum testosterone level decreased in the DEX group compared to the control group. The results of this study indicate that Vit-C can significantly prevent the adverse effects of DEX on the mean number of spermatocyte, spermatid, and Leydig cells, tubular differentiation, meiotic and spermatogenesis index, DSP, sperm motility, and the mean levels of serum MDA. Conclusion: In conclusion, our results showed that coadministration of Vit-C and DEX prevents the adverse effects of DEX on the spermatogenesis indexes and DSP.

scholarly journals Effect of age and season on the Epididymal Sperm and testosterone level in camel (camelus dromedarius)

2014 ◽  
Vol 38 (1) ◽  
pp. 24-29
Author(s):  
Ali A. Abd
Keyword(s):  
Testosterone Level ◽  
Sperm Concentration ◽  
Serum Testosterone ◽  
Cold Season ◽  
Serum Testosterone Level ◽  
Epididymal Sperm ◽  
Hot Season ◽  
Live Sperm ◽  
Effect Of Age

The aim of this study was to evaluate the effect of age and season on the epididymal sperm and level of testosterone in camel. A total 103 camel testes samples were collected from Al-Najaf slaughter house during a cold season (December 2012, January and February 2013) and moderatehot season (March, April and May, 2013). Testes were divided into 3 Gs according to camel age, G1 included the testes of 2-3years, G 2 (3 – 4years) and over 4 years (G 3). Blood samples were collected for determination of serum testosterone level. The sperms were obtained from the tail of epididymis from all animals groups and the results of the sperms individual motility percentage was increased at the level of (P< 0.05) significantly with age progress in both seasons. Also, sperm motility of G3 recorded a significantly higher than those of G1 and G2 in cold and moderate-hot seasons .The live percentage of G 3 animals was 90.01% in cold season with a significantly higher than those of other Gs and in both seasons. However, the live sperm percentage of G 3 during moderate-hot season was 87.82% and G 2 during moderate-hot and cold seasons were 88.58 and 88.72% respectively, showed significantly higher than those of G1 during cold and moderate-hot seasons .The concentration of sperm obtained from epididymis tail of bulls camel significantly increase with age progress in both seasons. However, the mean of the sperm concentration in cold season showed significance higher than those in moderate-hot season in animals of G 1 and 3, respectively. The abnormal morphologically sperm percentage of animals G 1 in both cold and moderate-hot seasons were significantly higher than those of G3.The testosterone levels of the young animals (under 4 years) increased gradually and reached its peak in February 2.28 ng/ml and March 2.27ng/ml. In the same trend older animal (more than 4 years) was showed 8.14 and 7.35 ng/ml, respectively. The older animals showed a significantly monthly, higher values than those of the younger animals in their testosterone level started from January up to May. In conclusions during cold months the camel over 4 years shows higher percentage of epididymal sperms parameters (live and individual motility) and sperms concentration as well as serum testosterone level.

scholarly journals Free serum testosterone level in male rats treated with tribulus alatus extracts

2007 ◽  
Vol 33 (4) ◽  
pp. 554-559 ◽  
Author(s):  
Walid H. El-Tantawy ◽  
Abeer Temraz ◽  
Omayma D. El-Gindi
Keyword(s):  
Testosterone Level ◽  
Serum Testosterone ◽  
Male Rats ◽  
Serum Testosterone Level ◽  
Free Serum

scholarly journals The immune system cell populations were increased in salt-induced hypertensive rats without an increase in the serum testosterone level (Short communication)

2018 ◽  
Vol 105 (2) ◽  
pp. 110-115
Author(s):  
FO Awobajo ◽  
AE Okafor ◽  
HO Adebayo
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Testosterone Level ◽  
Serum Testosterone ◽  
Male Rats ◽  
Feed Consumption ◽  
Serum Testosterone Level ◽  
Dietary Salt ◽  
Blood Samples ◽  
Cell Counts

The consumption of dietary salt has significantly increased globally, especially in the developed countries. High dietary salt intake has been linked to onset and complications in hypertension with a dimorphism tendency. There is scanty information about the influence of high salt diet on the immune cell population and androgen level in circulation. Male Sprague–Dawley rats of 8 weeks old were used for this study. They were divided into control (fed 0.1% salted feed) and salt-loaded groups (fed 8% salted feed) for 8 weeks. All experimental rats were allowed access to clean drinking water; daily feed consumption was measured in addition to weekly weight. On confirmation of hypertension using PowerLab® data acquisitions system, the rats were sacrificed and blood samples were collected into EDTA and sterile sample bottles. EDTA-blood samples were used for white blood cell and CD4 counts while the serum was used for hormonal assays. All salt-loaded rats became hypertensive, with a significant increase in total white blood cell, lymphocyte, neutrophil, monocyte, and CD4 cell counts. However, the eosinophil count was significantly decreased in salt-loaded rats. This study showed no change in the serum testosterone in salt-loaded male rats compared with control. In summary, dietary salt loading while precipitating hypertension also activated increased production of white blood cells and CD4 cells without any change in the serum testosterone level.

Transient Rise of Serum Testosterone Level after Single Sildenafil Treatment of Adult Male Rats

2012 ◽  
Vol 9 (10) ◽  
pp. 2534-2543 ◽  
Author(s):  
Marija M. Janjic ◽  
Natasa J. Stojkov ◽  
Maja M. Bjelic ◽  
Aleksandar I. Mihajlovic ◽  
Silvana A. Andric ◽  
...  
Keyword(s):  
Adult Male ◽  
Testosterone Level ◽  
Serum Testosterone ◽  
Male Rats ◽  
Serum Testosterone Level ◽  
Transient Rise

Evaluate the Effect of Amlodipine Besylate on Testosterone and Fertility of Male albino Rats

2020 ◽  
Author(s):  
Shahid Ali
Keyword(s):  
Testosterone Level ◽  
Channel Blocker ◽  
Serum Testosterone ◽  
Serum Testosterone Level ◽  
Control Group ◽  
Albino Rats ◽  
Distilled Water ◽  
Ca Channel ◽  
Amlodipine Besylate ◽  
Group B

Background: Amlodipine is a Ca++ channel blocker, routinely used for treatment of hypertension. The mechanism underlying its anti-hypertensive effect is dilatation of blood vessels. Testosterone, the hormone produced by testis, is responsible for development of male sexual secondary characteristics. The aim of study was to find out the effect of Ca++ channel blocker, Amlodipine besylate on serum testosterone level in male albino Rats. Methods: Duration of study was 30 days and conducted in department of pharmacology, 24 male Albino rats were grouped into 4 groups (each having 6). Group A was control group, Group B, C and D were treated with Amlodipine Besylate drug at doses 0.07, 0.14 and 0.28mg/kg body weight respectively (Suspension of 5 mg tablet of Amlodipine dissolved in 10 ml distilled water prepared and further diluted to 1:10ml with distilled water). Independent t test and ANOVA with Tukey’s test were used for comparison of quantitative variables with in groups. Results: Serum testosterone level reduced in groups treated with Amlodipine. Serum testosterone level of control group is 11.22 while group B, C and D were 4.7, 2.6 and 0.7 respectively. Serum FSH level of control group is 0.10±0.01 while group B, C and D were 0.24±0.35, 0.34±0.40 and 0.08±0.03 respectively. It showed that increasing the dose of Amlodipine markedly reduce testosterone level and increases FSH level in male albino Rats. Conclusion: Amlodipine severely reduce level of serum testosterone (p=0.001) and increases FSH level (p=0.305) which can lead to infertility in male albino Rats.

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