scholarly journals QUALITATIVE CONTENT AND SOME PHYSICAL AND CHEMICAL PROPERTIES OF POLYSACCHARIDES FROM ONOPORDUM ACANTHIUM L. HERB

2021 ◽  
pp. 65-73
Author(s):  
Ekaterina Robertovna Garsiya ◽  
Liliya Petrovna Myikots ◽  
Liliya Veniaminovna Ligay ◽  
Arnol'd Alekseyevich Shamilov ◽  
Dmitriy Alekseyevich Konovalov
Keyword(s):  
Distribution Coefficient ◽  
Water Soluble ◽  
Similar Distribution ◽  
Herbal Drugs ◽  
Natural Polymers ◽  
Point Distribution ◽  
Onopordum Acanthium ◽  
Pharmaceutical Substances ◽  
Physical And Chemical

Natural polymers are interesting as independent pharmaceutical substances also as complex drugs including herbal drugs. The aim of this work was determination of the main features of water-soluble polysaccharides (WSPS) and pectinic substances (PS) isolated from Onopordum acanthium L. herb for using as pharmaceutical substances. The following tasks were set to achieve this aim: determination of qualitative content of monosaccharides after previous acidic hydrolysis of fractions by paper chromatography, determination of molecular weight, isoelectric point, distribution coefficient, superficial activity these fractions by physical and chemical methods. It was found that WSPS consist of xylose and rhamnose, PS – galacturonic acid. WSPS have molecular weighs 783.96 g/mol, PS – 17351.37 g/mol. Molecules WSPS are neutralize in buffer solution with pH 5.2 and PS – pH 4.7. Also WSPS and PS have similar distribution activity with distribution coefficient 2.97 and 2.59, respectively. But WSPS and PS are superficially inactive substances. Determinate features including well distribution activity may be used for development complex herbal drugs containing herb of Onopordum acanthium L. Also sorption activity should be detected in the future.

scholarly journals ДОСЛІДЖЕННЯ СПЕЦИФІКИ ВПЛИВУ НАФТОВОГО ЗАБРУДНЕННЯ НА ЗМІНУ ФІЗИКО-ХІМІЧНИХ ПОКАЗНИКІВ ҐРУНТУ

2014 ◽  
pp. 208-210
Author(s):  
І. С. Романович
Keyword(s):  
Oil Pollution ◽  
Chemical Properties ◽  
Soil Samples ◽  
Water Soluble ◽  
Physical And Chemical Properties ◽  
Physical And Chemical ◽  
The Impact ◽  
Properties Of Soil ◽  
And Chemical Properties

Експериментально досліджено основні показникипроб ґрунту, забруднених сирою нафтою. Представ-лено результати зміни фізико-хімічних показниківґрунту внаслідок нафтового забруднення, проаналі-зовано вплив нафти на основні властивості ґрунту зарізних рівнів концентрації полютанта в ґрунті. Зроб-лено висновки щодо впливу нафти на якість та водо-розчинну складову ґрунту. Проведено аналіз можли-вості впливу нафтового забруднення на ґрунтовіводи. The basic physical and chemical properties of soil samples contaminated with crude oil are studied experimentally. The results of changes in physical and chemical characteristics of the soil as a result of oil pollution are presented; the influence of oil on the basic properties of the soil at different concentration levels of pollutant in the soil was analyzed. The conclusions regarding the impact of oil on the quality and water-soluble component of soil are made. The analysis of the determination of possible influence of oil pollution on groundwater was conducted.

scholarly journals EXPLORATION OF PHYSICOCHEMICAL AND PHYTOCHEMICAL POTENTIAL OF MORINGA OLEIFERA LAM (SEHJANA) FRUITS/PODS

2018 ◽  
Vol 8 (6-s) ◽  
pp. 213-220 ◽  
Author(s):  
ZAFAR JAVED KHAN ◽  
Naeem Ahmad Khan ◽  
Imrana Naseem ◽  
A A Nami Shahab
Keyword(s):  
Quality Control ◽  
Moringa Oleifera ◽  
Water Soluble ◽  
Phytochemical Analysis ◽  
Herbal Drugs ◽  
Physicochemical Evaluation ◽  
Quality Control Check ◽  
Important Drug ◽  
Moringa Oleifera Lam

Background: The physicochemical evaluation is an important parameter in detecting adulteration or improper handling, therefore, physicochemical and phytochemical standardization is considered a prerequisite for the assessment of biological activity and determination of biological standards of the plant material, and it provides the analytical characteristics which may prove to be useful in fixing the physicochemical standard for herbal drugs. So, it becomes imperative to standardize the drugs to ensure their identity, quality and purity to ascertain therapeutic efficacy of herbal drugs. Objective: Therefore, the present study was aimed to evaluate the physicochemical and phytochemical standardization and quality control check of an important drug Sehjana (Moringa oleifera Lam) used for various diseases, Material and Methods: The test drugs, Sehjana (Moringa oleifera Lam.) were collected directly from the herbal garden of department of Ilmul Advia AMU, Aligarh. Which includes parameters recommended by National Unani Pharmacopeia Committee, Qualitative analysis and chromatographic studies (TLC) were performed for proper identification and quality control these parameter include Results: Ash values, Total ash, (6.44%) acid insoluble ash, (3.94%) water soluble ash, (2.53%) Successive extractive values in different solvent; petroleum ether (3.03%), diethyl ether (1.3%), chloroform (1.0%), acetone (1.5%), alcohol (13.1%), aqueous (18.56%), solubility in alcohol (15.2%) and water (22.93%), loss on drying (9.13%), pH at 1% (5.45), & 10% (4.81), bulk density (0.33%) and moisture content (8.6%). Conclusion: Preliminary phytochemical analysis of Sehjana (Moringa oleifera Lam.) showed presence of alkaloid, steroids, phenol, amino acid, and terpenoids, carbohydrate and protein, which may be active compound, responsible for its wide activities.

THE IMPORTANCE OF THE RED BOOK OF SOILS FOR MONITORING AND JUSTIFICATION OF CONSERVATION MEASURES

2020 ◽  
Author(s):  
O.S. Bezuglova ◽  
Keyword(s):  
Chemical Properties ◽  
Natural State ◽  
Soil Maps ◽  
Rostov Region ◽  
Conservation Measures ◽  
Background Data ◽  
The Russian Federation ◽  
Physical And Chemical ◽  
And Chemical Properties

Rostov Region belongs to the highly protected natural territories characterized by the continuous plowing. There territories are the only reserves with the soils preserved in their natural state. However, these areas often lack detailed information about the soils quality and composition. Surveying soils on these territories is crucial for determination of their basic physical and chemical properties. The resulted compilation of soil maps could lay a foundation for creating the Red Book of Soils and the formation of a section in the soil-geographical database of the Russian Federation. Subsequently, such information can be used as a background data for the main types of soils in the region. It will be also valuable during monitoring and justification of conservation measures.

Simultaneous Spectrophotometric Determination of Salbutamol by Coupling with Diazotized 4-Aminobenzoic acid

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Hind Hadi ◽  
Gufran Salim
Keyword(s):  
Pharmaceutical Preparations ◽  
Coupling Reaction ◽  
Dosage Forms ◽  
Water Soluble ◽  
Trace Determination ◽  
Aminobenzoic Acid ◽  
Optimum Conditions ◽  
Colored Product ◽  
Versus Concentration

A simple, rapid and sensitive spectrophotmetric method for trace determination of salbutamol (SAL) in aqueous solution and in pharmaceutical preparations is described. The method is based on the diazotization coupling reaction of the intended compound with 4-amino benzoic acid (ABA) in alkaline medium to form an intense orange, water soluble dye that is stable and shows maximum absorption at 410 nm. A graph of absorbance versus concentration indicates that Beer’s law is obeyed over the concentration range of 0.5-30 ppm, with a molar absorbtivity 3.76×104 L.mol-1 .cm-1 depending on the concentration of SAL. The optimum conditions and stability of the colored product have been investigated and the method was applied successfully to the determination of SAL in dosage forms.

pH Dependent Release Potential of Natural Polymers in Sustained Release of Ornidazole From Colon Targeted Delivery System)

2019 ◽  
Vol 9 (02) ◽  
Author(s):  
Sharma Pankaj ◽  
Tailang Mukul
Keyword(s):  
Drug Release ◽  
Delivery System ◽  
Targeted Delivery ◽  
Guar Gum ◽  
Acidic Environment ◽  
Natural Polymers ◽  
Weight Variation ◽  
Curve Determination ◽  
Preformulation Studies

The aim of present work was to prepare colon specific delivery system of Ornidazole using different ratio of shellac, zein and guar gum. From study of various literature it revealed that shellac, zein and guar gum released drug from dosage form at the pH of 6.9, 11.5, 7-9 respectively. The main problem associated with colon targeted drug delivery system is degradation of drug in the acidic environment of stomach to circumvent the present problem different combinations of shellac, zein and guar gum were employed in the formulation of colon targeted tablet. Several preformulation parameters were determined such as melting point, FTIR spectroscopy, preparation of calibration curve, determination of λmax and partition coefficient. After the preformulation studies, next steps were preparation of core tablets, evaluation of core of tablets and coating of tablets. The data obtained from preformulation study seven formulations were developed and evaluated for various parameters. Based on evaluated parameter such as weight variation, friability, dissolution study, invitro drug release etc. the F7 formulation show better results colon targeted tablets. Drug content in F7 formulation was 95% and drug release after 6 hrs was 96%. Formulation containing combination of shellac, zein and guar gum released least amount of drug in the acidic environment of stomach and released most of the drug in colon. It is evide

Pharmaceutical Polymers - A Review

2019 ◽  
Vol 9 (01) ◽  
pp. 27-33
Author(s):  
Naveen Kumar ◽  
Sonia Pahuja ◽  
Ranjit Sharma
Keyword(s):  
Drug Release ◽  
Industrial Revolution ◽  
Pharmaceutical Formulations ◽  
Pharmaceutical Products ◽  
Water Soluble ◽  
Taste Masking ◽  
Natural Polymers ◽  
Pharmaceutical Dosage Forms ◽  
Pharmaceutical Applications ◽  
Pharmaceutical Industries

Humans have taken advantage of the adaptability of polymers for centuries in the form of resins, gums tars, and oils. However, it was not until the industrial revolution that the modern polymer industry began to develop. Polymers represent an important constituent of pharmaceutical dosage forms. Polymers have played vital roles in the formulation of pharmaceutical products. Polymers have been used as a major tool to manage the drug release rate from the formulations. Synthetic and natural-based polymers have found their way into the biomedical and pharmaceutical industries. Synthetic and Natural polymers can be produced with a broad range of strength, heat resistance, density, stiffness and even price. By constant research into the science and applications of polymers, they are playing an ever-increasing role in society. Diverse applications of polymers in the present pharmaceutical field are for controlled drug release. Based on solubility pharmaceutical polymers can be classified as water-soluble and water-insoluble. In general, the desirable polymer properties in pharmaceutical applications are film forming, adhesion, gelling, thickening, pH-dependent solubility and taste masking. General pharmaceutical applications of polymers in various pharmaceutical formulations are also discussed

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